{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T18:05:19Z","timestamp":1765908319696,"version":"3.48.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-025-04465-8","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:08:03Z","timestamp":1760526483000},"page":"1168-1172","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendocrine tumors in patients with inflammatory bowel disease: a case series"],"prefix":"10.1007","volume":"90","author":[{"given":"Roberta Elisa","family":"Rossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Masoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Migliorisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bezzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia Francesca","family":"Bertuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Uccella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Gerardo Antonio","family":"Lania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Zerbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Repici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Armuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"4465_CR1","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/ecco-jcc\/jjab217","volume":"16","author":"S Festa","year":"2022","unstructured":"S. Festa, G. Zerboni, L.A.A.P. Derikx, D.G. Ribaldone, G. Dragoni, C. Buskens, van E.N. Dijkum, D. Pugliese, F. Panzuto, I. Krela-Ka\u017amierczak et al., Gastroenteropancreatic neuroendocrine neoplasms in patients with inflammatory bowel disease: an ECCO CONFER multicentre case series. J. Crohns Colitis. 16, 940\u2013945 (2022). https:\/\/doi.org\/10.1093\/ecco-jcc\/jjab217","journal-title":"J. Crohns Colitis"},{"key":"4465_CR2","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/ecco-jcc\/jjv141","volume":"9","author":"V Annese","year":"2015","unstructured":"V. Annese, L. Beaugerie, L. Egan, L. Biancone, C. Bolling, C. Brandts, D. Dierickx, R. Dummer, G. Fiorino, J.M. Gornet et al., European Evidence-Based consensus: inflammatory bowel disease and malignancies. J. Crohns Colitis. 9, 945\u2013965 (2015). https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv141","journal-title":"J. Crohns Colitis"},{"key":"4465_CR3","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/ibd.20172","volume":"13","author":"NE West","year":"2007","unstructured":"N.E. West, P.E. Wise, A.J. Herline, R.L. Muldoon, W.V. Chopp, D.A. Schwartz, Carcinoid tumors are 15 times more common in patients with crohn\u2019s disease. Inflamm. Bowel Dis. 13, 1129\u20131134 (2007). https:\/\/doi.org\/10.1002\/ibd.20172","journal-title":"Inflamm. Bowel Dis."},{"key":"4465_CR4","first-page":"537","volume":"11","author":"JE Sigel","year":"1998","unstructured":"J.E. Sigel, J.R. Goldblum, Neuroendocrine neoplasms arising in inflammatory bowel disease: A report of 14 cases. Mod. Pathol. 11, 537\u2013542 (1998)","journal-title":"Mod. Pathol."},{"key":"4465_CR5","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"J. Satsangi, M.S. Silverberg, S. Vermeire, J.-F. Colombel, The Montreal classification of inflammatory bowel disease: Controversies, Consensus, and implications. Gut. 55, 749\u2013753 (2006). https:\/\/doi.org\/10.1136\/gut.2005.082909","journal-title":"Gut"},{"key":"4465_CR6","doi-asserted-by":"publisher","first-page":"30536","DOI":"10.1038\/s41598-024-81518-4","volume":"14","author":"J Uhlig","year":"2024","unstructured":"J. Uhlig, J. Nie, J. Gibson, M. Cecchini, S. Stein, J. Lacy, P. Kunz, H.S. Kim, Epidemiology, Treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms. Sci. Rep. 14, 30536 (2024). https:\/\/doi.org\/10.1038\/s41598-024-81518-4","journal-title":"Sci. Rep."},{"key":"4465_CR7","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","volume":"3","author":"A Dasari","year":"2017","unstructured":"A. Dasari, C. Shen, D. Halperin, B. Zhao, S. Zhou, Y. Xu, T. Shih, J.C. Yao, Trends in the Incidence, Prevalence, and survival outcomes in patients with neuroendocrine tumors in the united States. JAMA Oncol. 3, 1335\u20131342 (2017). https:\/\/doi.org\/10.1001\/jamaoncol.2017.0589","journal-title":"JAMA Oncol."},{"key":"4465_CR8","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000443165","volume":"103","author":"U-F Pape","year":"2016","unstructured":"U.-F. Pape, B. Niederle, F. Costa, D. Gross, F. Kelestimur, R. Kianmanesh, U. Knigge, K. \u00d6berg, M. Pavel, A. Perren et al., ENETS consensus guidelines for neuroendocrine neoplasms of the appendix (Excluding goblet cell Carcinomas). Neuroendocrinology. 103, 144\u2013152 (2016). https:\/\/doi.org\/10.1159\/000443165","journal-title":"Neuroendocrinology"},{"key":"4465_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","volume":"403","author":"M Dolinger","year":"2024","unstructured":"M. Dolinger, J. Torres, S. Vermeire, Crohn\u2019s disease. Lancet. 403, 1177\u20131191 (2024). https:\/\/doi.org\/10.1016\/S0140-6736(23)02586-2","journal-title":"Lancet"},{"key":"4465_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000362339","volume":"99","author":"M. Cigrovski Berkovic","year":"2014","unstructured":"M. Cigrovski Berkovic, T. Cacev, T. Catela Ivkovic, V. Zjacic-Rotkvic, S. Kapitanovic, New Insights into the Role of Chronic Inflammation and Cytokines in the Etiopathogenesis of Gastroenteropancreatic Neuroendocrine Tumors. Neuroendocrinology (2014), 99, 75\u201384. https:\/\/doi.org\/10.1159\/000362339","journal-title":"Neuroendocrinology"},{"key":"4465_CR11","doi-asserted-by":"publisher","unstructured":"M.T. Tran, Identification of TIMP1-Induced dysregulation of Epithelial-Mesenchymal transition as a key pathway in inflammatory bowel disease and small intestinal neuroendocrine tumors shared pathogenesis. Front. Genet. 15 (2024). https:\/\/doi.org\/10.3389\/fgene.2024.1376123","DOI":"10.3389\/fgene.2024.1376123"},{"key":"4465_CR12","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/ibd.21923","volume":"18","author":"Y D\u00f6rffel","year":"2012","unstructured":"Y. D\u00f6rffel, A. Swidsinski, V. Loening-Baucke, B. Wiedenmann, M. Pavel, Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn\u02bcs disease and the effect of therapy. Inflamm. Bowel Dis. 18, 1663\u20131671 (2012). https:\/\/doi.org\/10.1002\/ibd.21923","journal-title":"Inflamm. Bowel Dis."},{"key":"4465_CR13","doi-asserted-by":"publisher","first-page":"100566","DOI":"10.1016\/j.modpat.2024.100566","volume":"37","author":"X Liao","year":"2024","unstructured":"X. Liao, A.L. Schmidt, D. Zhang, P. Li, X. Wang, H.M. Ko, W.-T. Choi, L. Alpert, Y. Hao, S. Kovar-Peltz et al., Clinicopathologic and molecular characterization of inflammatory bowel Disease-Associated neuroendocrine carcinomas and mixed neuroendocrine-Non-Neuroendocrine neoplasms. Mod. Pathol. 37, 100566 (2024). https:\/\/doi.org\/10.1016\/j.modpat.2024.100566","journal-title":"Mod. Pathol."},{"issue":"Suppl 1","key":"4465_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ijsu.2015.12.051","volume":"28","author":"G Pellino","year":"2016","unstructured":"G. Pellino, R. Marcellinaro, G. Candilio, De G.S. Fatico, E. Guadagno, S. Campione, G. Santangelo, A. Reginelli, G. Sciaudone, G. Riegler et al., The experience of a referral centre and literature overview of GIST and carcinoid tumours in inflammatory bowel diseases. Int. J. Surg. 28(Suppl 1), 133\u2013141 (2016). https:\/\/doi.org\/10.1016\/j.ijsu.2015.12.051","journal-title":"Int. J. Surg."},{"key":"4465_CR15","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/s41395-018-0098-4","volume":"113","author":"G D\u02bcHaens","year":"2018","unstructured":"G. D\u02bcHaens, W. Reinisch, R. Panaccione, J. Satsangi, J. Petersson, M. Bereswill, D. Arikan, E. Perotti, A.M. Robinson, J. Kalabic et al., Lymphoma risk and overall safety profile of adalimumab in patients with crohn\u2019s disease with up to 6 years of Follow-Up in the pyramid registry. Am. J. Gastroenterol. 113, 872\u2013882 (2018). https:\/\/doi.org\/10.1038\/s41395-018-0098-4","journal-title":"Am. J. Gastroenterol."},{"key":"4465_CR16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/ecco-jcc\/jjw221","volume":"11","author":"G D\u2019Haens","year":"2017","unstructured":"G. D\u2019Haens, W. Reinisch, J.-F. Colombel, J. Panes, S. Ghosh, C. Prantera, S. Lindgren, D.W. Hommes, Z. Huang, J. Boice et al., Five-Year safety data from ENCORE, a European observational safety registry for adults with crohn\u2019s disease treated with Infliximab [Remicade\u00ae] or conventional therapy. J. Crohns Colitis. 11, 680\u2013689 (2017). https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw221","journal-title":"J. Crohns Colitis"},{"issue":"e5","key":"4465_CR17","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cgh.2024.05.006","volume":"23","author":"SH Itzkowitz","year":"2025","unstructured":"S.H. Itzkowitz, Y. Jiang, C. Villagra, J.F. Colombel, K. Sultan, D.J. Lukin, D.M. Faleck, E. Scherl, S. Chang, L.A. Chen et al., Safety of immunosuppression in a prospective cohort of inflammatory bowel disease patients with a history of cancer: SAPPHIRE registry. Clin. Gastroenterol. Hepatol. 23(e5), 855\u2013865 (2025). https:\/\/doi.org\/10.1016\/j.cgh.2024.05.006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"4465_CR18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ecco-jcc\/jjac187","volume":"17","author":"H Gordon","year":"2023","unstructured":"H. Gordon, L. Biancone, G. Fiorino, K.H. Katsanos, U. Kopylov, E. Al Sulais, J.E. Axelrad, K. Balendran, J. Burisch, de L. Ridder et al., ECCO guidelines on inflammatory bowel disease and malignancies. J. Crohns Colitis. 17, 827\u2013854 (2023). https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac187","journal-title":"J. Crohns Colitis"},{"key":"4465_CR19","doi-asserted-by":"publisher","first-page":"189007","DOI":"10.1016\/J.BBCAN.2023.189007","volume":"1878","author":"J. Li","year":"2023","unstructured":"J. Li, M. Che, B. Zhang, K. Zhao, C. Wan, K. Yang, The association between the neuroendocrine system and the tumor immune microenvironment: emerging directions for cancer immunotherapy. Biochimica et Biophysica Acta (BBA).  (2023), 1878, 189007. https:\/\/doi.org\/10.1016\/J.BBCAN.2023.189007","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"4465_CR20","doi-asserted-by":"publisher","unstructured":"R. Modica, A. Liccardi, E. Benevento, R. Minotta, G. Cannavale, A. Colao, Neuroendocrine Tumors Immune Syst. 83\u2013109 (2023) https:\/\/doi.org\/10.1007\/16833_2023_147","DOI":"10.1007\/16833_2023_147"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-025-04465-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-025-04465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T18:02:50Z","timestamp":1765908170000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-025-04465-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4465"],"URL":"https:\/\/doi.org\/10.1007\/s12020-025-04465-8","relation":{},"ISSN":["1559-0100"],"issn-type":[{"type":"electronic","value":"1559-0100"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"24 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}