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In this context, real-world data on the use of levothyroxine are limited. The aim was to determine the patterns of use, persistence, effectiveness, safety, clinical inertia, and adherence related to levothyroxine treatment in a group of patients with thyroid disease in Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This was an observational study of patients treated with levothyroxine. Clinical records were reviewed, and the minimum patient follow-up was one year. Descriptive, bivariate and multivariate analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 398 patients were identified; the median age was 53.5 years, and 71.1% were women. A total of 76.9% of the patients received levothyroxine for clinical hypothyroidism, and few adverse events occurred (4.3%). 52% of the patients were not on goal at their first thyroid-stimulating hormone (TSH) checkup. Only 36.4% had a second TSH control appointment, but among them, 65.1% did not reach their goals; moreover, 31.7% demonstrated clinical inertia. The medication possession ratio was 66.8% (\u2265\u200980%: 31.4%), and 47.7% of the patients showed persistent use at one year. The presence of adverse events was associated with a lower probability of persistent use (OR:0.16; 95%CI:0.04\u20130.64).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical inertia and poor disease control were common, whereas rates of adherence to and persistence with levothyroxine treatment were low. However, patients aged\u2009\u2265\u200940 years, those with a high educational level and chronic comorbidities, and those who habitually attended TSH control appointments were more likely to be persistent with their treatment at the one-year follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-025-04488-1","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:58:22Z","timestamp":1771235902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patterns and persistence of use, effectiveness, safety, clinical inertia, and adherence related to Levothyroxine treatment with real-world evidence. An observational, longitudinal and retrospective study"],"prefix":"10.1007","volume":"91","author":[{"given":"Luis Fernando","family":"Valladales-Restrepo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Andr\u00e9s","family":"Londo\u00f1o-Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Mauricio","family":"Mu\u00f1oz-Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian Manuela","family":"Soto-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon Eleazart","family":"Tafur-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Rojas-Var\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Enrique","family":"Machado-Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"issue":"1","key":"4488_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41572-022-00373-7","volume":"8","author":"L Chaker","year":"2022","unstructured":"L. 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