{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:07:07Z","timestamp":1777950427740,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-026-04650-3","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:29Z","timestamp":1777879049000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased prevalence of abdominal aortic aneurysm in biochemically confirmed primary aldosteronism: a new complication?"],"prefix":"10.1007","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-4463","authenticated-orcid":false,"given":"Burcak Cavnar","family":"Helvaci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceren Karacalik","family":"Unver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Durantas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Hepsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcu","family":"Candemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lknur Ozturk","family":"Unsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Kizilgul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Ucan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erman","family":"Cakal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"issue":"3","key":"4650_CR1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1067\/mva.1991.26737","volume":"13","author":"KW Johnston","year":"1991","unstructured":"K.W. Johnston, R.B. Rutherford, M.D. Tilson, D.M. Shah, L. Hollier, J.C. Stanley, Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery. J. Vasc Surg. 13(3), 452\u2013458 (1991). https:\/\/doi.org\/10.1067\/mva.1991.26737","journal-title":"J. Vasc Surg."},{"issue":"2","key":"4650_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/145749690809700204","volume":"97","author":"A Wanhainen","year":"2008","unstructured":"A. Wanhainen, How to define an abdominal aortic aneurysm\u2013influence on epidemiology and clinical practice. Scand. J. Surg. 97(2), 105\u2013109 (2008). discussion 109. https:\/\/doi.org\/10.1177\/145749690809700204","journal-title":"Scand. J. Surg."},{"issue":"1","key":"4650_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41572-018-0030-7","volume":"18","author":"N Sakalihasan","year":"2018","unstructured":"N. Sakalihasan, J.B. Michel, A. Katsargyris, H. Kuivaniemi, J.O. Defraigne, A. Nchimi, J.T. Powell, K. Yoshimura, R. Hultgren, Abdominal aortic aneurysms. Nat. Rev. Dis. Primers 2018 18;4(1):34. https:\/\/doi.org\/10.1038\/s41572-018-0030-7","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"4650_CR4","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/HCO.0b013e328330c2d3","volume":"24","author":"J Golledge","year":"2009","unstructured":"J. Golledge, P.E. Norman, Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients\u2019 management. Curr. Opin. Cardiol. 24(6), 532\u2013538 (2009). https:\/\/doi.org\/10.1097\/HCO.0b013e328330c2d3","journal-title":"Curr. Opin. Cardiol."},{"issue":"6","key":"4650_CR5","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1161\/ATVBAHA.110.203588","volume":"30","author":"SH Johnsen","year":"2010","unstructured":"S.H. Johnsen, S.H. Forsdahl, K. Singh, B.K. Jacobsen, Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel? The Troms\u00f8 study. Arterioscler. Thromb. Vasc Biol. 30(6), 1263\u20131268 (2010). https:\/\/doi.org\/10.1161\/ATVBAHA.110.203588","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"issue":"5","key":"4650_CR6","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.jvs.2018.11.045","volume":"70","author":"J Stegbauer","year":"2019","unstructured":"J. Stegbauer, S.E. Thatcher, G. Yang, K. Bottermann, L.C. Rump, A. Daugherty, L.A. Cassis, Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice. J. Vasc Surg. 70(5), 1658\u20131668e1 (2019). https:\/\/doi.org\/10.1016\/j.jvs.2018.11.045","journal-title":"J. Vasc Surg."},{"issue":"6","key":"4650_CR7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1001\/archinte.160.6.833","volume":"160","author":"HA Fink","year":"2000","unstructured":"H.A. Fink, F.A. Lederle, C.S. Roth, C.A. Bowles, D.B. Nelson, M.A. Haas, The accuracy of physical examination to detect abdominal aortic aneurysm. Arch. Intern. Med. 160(6), 833\u2013836 (2000). https:\/\/doi.org\/10.1001\/archinte.160.6.833","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"4650_CR8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.2214\/ajr.152.4.785","volume":"152","author":"LL LaRoy","year":"1989","unstructured":"L.L. LaRoy, P.J. Cormier, T.A. Matalon, S.K. Patel, D.A. Turner, B. Silver, Imaging of abdominal aortic aneurysms. AJR Am. J. Roentgenol. 152(4), 785\u2013792 (1989). https:\/\/doi.org\/10.2214\/ajr.152.4.785","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2","key":"4650_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3904\/kjim.2020.138","volume":"36","author":"HY Jin","year":"2021","unstructured":"H.Y. Jin, K.A. Lee, Primary hyperaldosteronism: a rare cause of acute aortic dissection. Korean J. Intern. Med. 36(2), 477\u2013478 (2021). https:\/\/doi.org\/10.3904\/kjim.2020.138","journal-title":"Korean J. Intern. Med."},{"issue":"1","key":"4650_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s12902-020-00601-9","volume":"20","author":"Y Zhang","year":"2020","unstructured":"Y. Zhang, F. Luo, P. Fan, X. Meng, K. Yang, X. Zhou, Is primary aldosteronism a potential risk factor for aortic dissection? A case report and literature review. BMC Endocr. Disord. 20(1), 115 (2020). https:\/\/doi.org\/10.1186\/s12902-020-00601-9","journal-title":"BMC Endocr. Disord"},{"issue":"3","key":"4650_CR11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s12020-018-1801-3","volume":"63","author":"G Zavatta","year":"2019","unstructured":"G. Zavatta, G. Di Dalmazi, C. Pizzi, G. Bracchetti, C. Mosconi, C. Balacchi, U. Pagotto, V. Vicennati, Larger ascending aorta in primary aldosteronism: a 3-year prospective evaluation of adrenalectomy vs. medical treatment. Endocrine. 63(3), 470\u2013475 (2019). https:\/\/doi.org\/10.1007\/s12020-018-1801-3","journal-title":"Endocrine"},{"key":"4650_CR12","doi-asserted-by":"publisher","first-page":"2017571","DOI":"10.1155\/2016\/2017571","volume":"2016","author":"A Shahrrava","year":"2016","unstructured":"A. Shahrrava, S. Moinuddin, P. Boddu, R. Shah, A Case of Glucocorticoid Remediable Aldosteronism and Thoracoabdominal Aneurysms. Case Rep. Endocrinol. 2016, 2017571 (2016). https:\/\/doi.org\/10.1155\/2016\/2017571","journal-title":"Case Rep. Endocrinol."},{"issue":"2","key":"4650_CR13","first-page":"156","volume":"69","author":"M Podg\u00f3rski","year":"2011","unstructured":"M. Podg\u00f3rski, A. Derkacz, R. Por\u0119ba, K. Belowska-Bie\u0144, K. Gruber, A. Szuba, R. Andrzejak, Rozwarstwienie aorty zst\u0119puj\u0105cej jako powik\u0142anie wt\u00f3rnego nadci\u015bnienia t\u0119tniczego w przebiegu hiperaldosteronizmu pierwotnego [Aortic dissection - a rare complication of primary aldosteronism - a case report]. Kardiol Pol. 69(2), 156\u2013158 (2011)","journal-title":"Kardiol Pol."},{"issue":"4","key":"4650_CR14","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/HYPERTENSIONAHA.121.18342","volume":"79","author":"Q Zhu","year":"2022","unstructured":"Q. Zhu, M. Heizhati, M. Lin, M. Wang, X. Yao, L. Gan, Q. Luo, W. Zhang, J. Hong, N. Yue, N. Li, Higher Plasma Aldosterone Concentrations Are Associated With Elevated Risk of Aortic Dissection and Aneurysm: a Case-Control Study. Hypertension. 79(4), 736\u2013746 (2022). https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.18342","journal-title":"Hypertension"},{"issue":"5","key":"4650_CR15","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1210\/jc.2015-4061","volume":"101","author":"JW Funder","year":"2016","unstructured":"J.W. Funder et al., The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. metabolism vol. 101(5), 1889\u20131916 (2016). https:\/\/doi.org\/10.1210\/jc.2015-4061","journal-title":"J. Clin. Endocrinol. metabolism vol"},{"issue":"2","key":"4650_CR16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000345243","volume":"50","author":"M Briet","year":"2013","unstructured":"M. Briet, E.L. Schiffrin, Vascular actions of aldosterone. J. Vasc Res. 50(2), 89\u201399 (2013). https:\/\/doi.org\/10.1159\/000345243","journal-title":"J. Vasc Res."},{"issue":"2","key":"4650_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/MNH.0b013e32801245bb","volume":"16","author":"A Fiebeler","year":"2007","unstructured":"A. Fiebeler, D.N. Muller, E. Shagdarsuren, F.C. Luft, Aldosterone, mineralocorticoid receptors, and vascular inflammation. Curr. Opin. Nephrol. Hypertens. 16(2), 134\u2013142 (2007). https:\/\/doi.org\/10.1097\/MNH.0b013e32801245bb","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"5","key":"4650_CR18","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1046\/j.1523-1755.2003.00929.x","volume":"63","author":"ER Blasi","year":"2003","unstructured":"E.R. Blasi, R. Rocha, A.E. Rudolph, E.A. Blomme, M.L. Polly, E.G. McMahon, Aldosterone\/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int. 63(5), 1791\u20131800 (2003). https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00929.x","journal-title":"Kidney Int."},{"issue":"2","key":"4650_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/ATVBAHA.113.302854","volume":"34","author":"D Pruthi","year":"2014","unstructured":"D. Pruthi, A. McCurley, M. Aronovitz, C. Galayda, S.A. Karumanchi, I.Z. Jaffe, Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors. Arterioscler. Thromb. Vasc Biol. 34(2), 355\u2013364 (2014). https:\/\/doi.org\/10.1161\/ATVBAHA.113.302854","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"issue":"12","key":"4650_CR20","doi-asserted-by":"publisher","first-page":"e41951","DOI":"10.1097\/MD.0000000000041951","volume":"104","author":"S Liu","year":"2025","unstructured":"S. Liu, J. Wan, Y. Yang, D. Wang, J. Hou, P. Wang, Causal association between genetically predicted primary aldosteronism and aortic aneurysm and aortic dissection: A Mendelian randomization study. Med. (Baltim). 104(12), e41951 (2025). https:\/\/doi.org\/10.1097\/MD.0000000000041951","journal-title":"Med. (Baltim)."},{"issue":"2","key":"4650_CR21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jccase.2022.04.013","volume":"24","author":"M Yamasaki","year":"2022","unstructured":"M. Yamasaki, K. Yamamoto, K. Abe, R. Nakamura, R. Tamaki, H. Misumi, Aortic dissection due to primary aldosteronism in a young adult with adrenal adenoma: A case report. J. Cardiol. Cases 2022 24;26(2):154\u2013156. https:\/\/doi.org\/10.1016\/j.jccase.2022.04.013","journal-title":"J. Cardiol. Cases"},{"issue":"12","key":"4650_CR22","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/jhh.2017.34","volume":"31","author":"S Monticone","year":"2017","unstructured":"S. Monticone et al., Familial hyperaldosteronism type III. J. Hum. Hypertens. vol. 31(12), 776\u2013781 (2017). https:\/\/doi.org\/10.1038\/jhh.2017.34","journal-title":"J. Hum. Hypertens. vol"},{"key":"4650_CR23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1507\/endocrj.ej11-0406","volume":"59","author":"A Mussa","year":"2012","unstructured":"A. Mussa et al., Polyuric-polydipsic syndrome in a pediatric case of non-glucocorticoid remediable familial hyperaldosteronism. Endocr. J. vol. 59, 497\u2013502 (2012). https:\/\/doi.org\/10.1507\/endocrj.ej11-0406","journal-title":"Endocr. J. vol"},{"issue":"3","key":"4650_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.14712\/23362936.2025.23","volume":"126","author":"J Zeman","year":"2025","unstructured":"J. Zeman, C. Kamilaris, Glucocorticoid Remediable Aldosteronism in a Family with a Strong History of Cerebral Aneurysms and Hypertension. Prague Med. Rep. 126(3), 151\u2013154 (2025). https:\/\/doi.org\/10.14712\/23362936.2025.23","journal-title":"Prague Med. Rep."},{"issue":"5","key":"4650_CR25","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3109\/02688697.2015.1023775","volume":"29","author":"B Al Romhain","year":"2015","unstructured":"B. Al Romhain, A.M. Young, J.J. Battacharya, N. Suttner, Intracranial aneurysm in a patient with glucocorticoid-remediable aldosteronism. Br. J. Neurosurg. 29(5), 715\u2013717 (2015). https:\/\/doi.org\/10.3109\/02688697.2015.1023775","journal-title":"Br. J. Neurosurg."},{"issue":"4","key":"4650_CR26","first-page":"347","volume":"38","author":"K Sawada","year":"2010","unstructured":"K. Sawada, T. Maehara, M. Inaji, H. Toriyama, T. Okada, T. Nariai, M. Aoyagi, M. Doi, K. Ohno, [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism]. No Shinkei Geka. 38(4), 347\u2013351 (2010)","journal-title":"No Shinkei Geka"},{"issue":"1 Pt 2","key":"4650_CR27","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1161\/01.hyp.31.1.445","volume":"31","author":"WR Litchfield","year":"1998","unstructured":"W.R. Litchfield, B.F. Anderson, R.J. Weiss, R.P. Lifton, R.G. Dluhy, Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism. Hypertension. 31(1 Pt 2), 445\u2013450 (1998). https:\/\/doi.org\/10.1161\/01.hyp.31.1.445","journal-title":"Hypertension"},{"issue":"1","key":"4650_CR28","first-page":"46","volume":"141","author":"CO Hausser","year":"1985","unstructured":"C.O. Hausser, G.E. Ouaknine, F. Primeau, O. Kuchel, An\u00e9vrysmes intracr\u00e2niens multiples associ\u00e9s \u00e0 un hyperaldost\u00e9ronisme primaire [Multiple intracranial aneurysms associated with primary hyperaldosteronism]. Rev. Neurol. (Paris). 141(1), 46\u201348 (1985)","journal-title":"Rev. Neurol. (Paris)"},{"issue":"1","key":"4650_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ando.2016.07.993","volume":"78","author":"A Nasri","year":"2017","unstructured":"A. Nasri, M. Mansour, Z. Brahem, A. Kacem, A.A. Hassan, H. Derbali, M. Messelmani, J. Zaouali, R. Mrissa, Stroke disclosing primary aldosteronism: Report on three cases and review of the literature. Ann. Endocrinol. (Paris). 78(1), 9\u201313 (2017). https:\/\/doi.org\/10.1016\/j.ando.2016.07.993","journal-title":"Ann. Endocrinol. (Paris)"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04650-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-026-04650-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04650-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:30Z","timestamp":1777879050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-026-04650-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4650"],"URL":"https:\/\/doi.org\/10.1007\/s12020-026-04650-3","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"181"}}