{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:15:19Z","timestamp":1783685719101,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Development Foundation of Affiliated Hospital of Xuzhou Medical University","award":["No. XYFY202234"],"award-info":[{"award-number":["No. XYFY202234"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-026-04702-8","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:29:39Z","timestamp":1783682979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IGF2BP3 mediates the mRNA upregulation of NLRP3 to promote parathyroid cell proliferation in chronic kidney disease via an m\u2076A-dependent manner"],"prefix":"10.1007","volume":"91","author":[{"given":"Sen","family":"Kan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BianJie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhengJie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QinJun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"4702_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000491041","volume":"51","author":"P Messa","year":"2019","unstructured":"P. Messa, C.M. Alfieri, Secondary and Tertiary Hyperparathyroidism. Front. Horm. Res. 51, 91\u2013108 (2019)","journal-title":"Front. Horm. Res."},{"key":"4702_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.atherosclerosis.2018.08.046","volume":"278","author":"AB Reiss","year":"2018","unstructured":"A.B. Reiss, N. Miyawaki, J. Moon, L.J. Kasselman, I. Voloshyna, R. Jr. D\u2019Avino et al., CKD, arterial calcification, atherosclerosis and bone health: Inter-relationships and controversies. Atherosclerosis. 278, 49\u201359 (2018)","journal-title":"Atherosclerosis"},{"issue":"1\u20133","key":"4702_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000492918","volume":"47","author":"C Alfieri","year":"2019","unstructured":"C. Alfieri, A. Regalia, F. Zanoni, S. Vettoretti, M. Cozzolino, P. Messa, The Importance of Adherence in the Treatment of Secondary Hyperparathyroidism. Blood Purif. 47(1\u20133), 37\u201344 (2019)","journal-title":"Blood Purif."},{"issue":"12","key":"4702_CR4","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.3390\/ijms21124332","volume":"21","author":"T Naveh-Many","year":"2020","unstructured":"T. Naveh-Many, O. Volovelsky, Parathyroid Cell Proliferation in Secondary Hyperparathyroidism of Chronic Kidney Disease. Int. J. Mol. Sci. 21(12), 4332 (2020)","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"4702_CR5","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s40266-019-00696-3","volume":"36","author":"A Galassi","year":"2019","unstructured":"A. Galassi, P. Ciceri, E. Fasulo, S. Carugo, G. Cianciolo, M. Cozzolino, Management of Secondary Hyperparathyroidism in Chronic Kidney Disease: A Focus on the Elderly. Drugs Aging. 36(10), 885\u2013895 (2019)","journal-title":"Drugs Aging"},{"issue":"14","key":"4702_CR6","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1111\/febs.15300","volume":"287","author":"R Kilav-Levin","year":"2020","unstructured":"R. Kilav-Levin, A. Hassan, M. Nechama, V. Shilo, J. Silver, I.Z. Ben-Dov et al., Post-transcriptional mechanisms regulating parathyroid hormone gene expression in secondary hyperparathyroidism. Febs j. 287(14), 2903\u20132913 (2020)","journal-title":"Febs j."},{"issue":"6","key":"4702_CR7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s40620-018-0530-2","volume":"31","author":"S Kan","year":"2018","unstructured":"S. Kan, W. Zhang, J. Mao, M. Wang, L. Ni, M. Zhang et al., NF-\u03baB activation contributes to parathyroid cell proliferation in chronic kidney disease. J. Nephrol. 31(6), 941\u2013951 (2018)","journal-title":"J. Nephrol."},{"key":"4702_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.phrs.2016.11.004","volume":"114","author":"YY Qiu","year":"2016","unstructured":"Y.Y. Qiu, L.Q. Tang, Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy. Pharmacol. Res. 114, 251\u2013264 (2016)","journal-title":"Pharmacol. Res."},{"key":"4702_CR9","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.biopha.2018.07.036","volume":"106","author":"R Xin","year":"2018","unstructured":"R. Xin, X. Sun, Z. Wang, W. Yuan, W. Jiang, L. Wang et al., Apocynin inhibited NLRP3\/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy. Biomed. Pharmacother. 106, 1325\u20131331 (2018)","journal-title":"Biomed. Pharmacother"},{"issue":"5","key":"4702_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1159\/000539496","volume":"10","author":"Y Ji","year":"2024","unstructured":"Y. Ji, H. Hua, Z. Jia, A. Zhang, G. Ding, Therapy Targeted to the NLRP3 Inflammasome in Chronic Kidney Disease. Kidney Dis. (Basel). 10(5), 369\u2013383 (2024)","journal-title":"Kidney Dis. (Basel)"},{"key":"4702_CR11","first-page":"101417","volume":"33","author":"G Huang","year":"2023","unstructured":"G. Huang, Y. Zhang, Y. Zhang, Y. Ma, Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies. Biochem. Biophys. Rep. 33, 101417 (2023)","journal-title":"Biochem. Biophys. Rep."},{"key":"4702_CR12","doi-asserted-by":"publisher","first-page":"39551","DOI":"10.1038\/srep39551","volume":"6","author":"A Bugyei-Twum","year":"2016","unstructured":"A. Bugyei-Twum, A. Abadeh, K. Thai, Y. Zhang, M. Mitchell, G. Kabir et al., Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction. Sci. Rep. 6, 39551 (2016)","journal-title":"Sci. Rep."},{"issue":"10","key":"4702_CR13","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","volume":"71","author":"R Desrosiers","year":"1974","unstructured":"R. Desrosiers, K. Friderici, F. Rottman, Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl. Acad. Sci. U S A 71(10), 3971\u20133975 (1974)","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7397","key":"4702_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"D. Dominissini, S. Moshitch-Moshkovitz, S. Schwartz, M. Salmon-Divon, L. Ungar, S. Osenberg et al., Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 485(7397), 201\u2013206 (2012)","journal-title":"Nature"},{"issue":"7","key":"4702_CR15","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"K.D. Meyer, Y. Saletore, P. Zumbo, O. Elemento, C.E. Mason, S.R. Jaffrey, Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons. Cell. 149(7), 1635\u20131646 (2012)","journal-title":"Cell"},{"issue":"3","key":"4702_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.gpb.2017.03.002","volume":"15","author":"PJ Batista","year":"2017","unstructured":"P.J. Batista, The RNA Modification N(6)-methyladenosine and Its Implications in Human Disease. Genomics Proteom. Bioinf. 15(3), 154\u2013163 (2017)","journal-title":"Genomics Proteom. Bioinf."},{"issue":"4","key":"4702_CR17","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","volume":"74","author":"H Shi","year":"2019","unstructured":"H. Shi, J. Wei, C. He, Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. Mol. Cell. 74(4), 640\u2013650 (2019)","journal-title":"Mol. Cell."},{"issue":"3","key":"4702_CR18","doi-asserted-by":"publisher","first-page":"6740","DOI":"10.1080\/21655979.2022.2045836","volume":"13","author":"B Wang","year":"2022","unstructured":"B. Wang, Y. Liu, R. Jiang, Z. Liu, H. Gao, F. Chen et al., Emodin relieves the inflammation and pyroptosis of lipopolysaccharide-treated 1321N1 cells by regulating methyltransferase-like 3 -mediated NLR family pyrin domain containing 3 expression. Bioengineered. 13(3), 6740\u20136749 (2022)","journal-title":"Bioengineered"},{"issue":"1","key":"4702_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-022-00350-8","volume":"27","author":"J Lan","year":"2022","unstructured":"J. Lan, B. Xu, X. Shi, Q. Pan, Q. Tao, WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy. Cell. Mol. Biol. Lett. 27(1), 51 (2022)","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"7","key":"4702_CR20","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","volume":"169","author":"IA Roundtree","year":"2017","unstructured":"I.A. Roundtree, M.E. Evans, T. Pan, C. He, Dynamic RNA Modifications in Gene Expression Regulation. Cell. 169(7), 1187\u20131200 (2017)","journal-title":"Cell"},{"key":"4702_CR21","doi-asserted-by":"publisher","first-page":"111572","DOI":"10.1016\/j.cellsig.2024.111572","volume":"127","author":"Q Yang","year":"2025","unstructured":"Q. Yang, J. Xiao, Y. Liu, Z. Yang, C. Wang, J. Sun et al., METTL3-mediated m6A modifications of NLRP3 accelerate alveolar bone resorption through enhancing macrophage pyroptosis. Cell. Signal. 127, 111572 (2025)","journal-title":"Cell. Signal."},{"issue":"2","key":"4702_CR22","doi-asserted-by":"publisher","first-page":"e162060","DOI":"10.1172\/jci.insight.162060","volume":"8","author":"Song D","year":"2023","unstructured":"D. Song, J. Shang, Y. Long, M. Zhong, L. Li, J. Chen et al., Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating \u03b2-catenin signaling. JCI Insight. 8(2), e162060 (2023)","journal-title":"JCI Insight"},{"issue":"3","key":"4702_CR23","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.bbrc.2018.03.038","volume":"498","author":"LH Ni","year":"2018","unstructured":"L.H. Ni, R.N. Tang, L.L. Lv, M. Wu, B. Wang, F.M. Wang et al., A rat model of SHPT with bone abnormalities in CKD induced by adenine and a high phosphorus diet. Biochem. Biophys. Res. Commun. 498(3), 654\u2013659 (2018)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"4702_CR24","doi-asserted-by":"crossref","unstructured":"C.P. Kovesdy, Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022;12(1):7\u201311","DOI":"10.1016\/j.kisu.2021.11.003"},{"issue":"1","key":"4702_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/sj.ki.5002009","volume":"71","author":"A Levin","year":"2007","unstructured":"A. Levin, G.L. Bakris, M. Molitch, M. Smulders, J. Tian, L.A. Williams et al., Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 71(1), 31\u201338 (2007)","journal-title":"Kidney Int."},{"issue":"5","key":"4702_CR26","doi-asserted-by":"publisher","first-page":"100238","DOI":"10.1016\/j.clinme.2024.100238","volume":"24","author":"SH Tsai","year":"2024","unstructured":"S.H. Tsai, W.C. Kan, R.N. Jhen, Y.M. Chang, J.L. Kao, H.Y. Lai et al., Secondary hyperparathyroidism in chronic kidney disease: A narrative review focus on therapeutic strategy. Clin. Med. (Lond). 24(5), 100238 (2024)","journal-title":"Clin. Med. (Lond)"},{"issue":"5","key":"4702_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1267\/ahc.25-00039","volume":"58","author":"R Kitazawa","year":"2025","unstructured":"R. Kitazawa, A. Kobayashi, S. Kitazawa, Hypermethylation of the p16INK4a Promoter as an Early Epigenetic Event in Nodular Hyperplasia Associated with Secondary Hyperparathyroidism. Acta Histochem. Cytochem. 58(5), 161\u2013172 (2025)","journal-title":"Acta Histochem. Cytochem."},{"key":"4702_CR28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","volume":"29","author":"BK Davis","year":"2011","unstructured":"B.K. Davis, H. Wen, J.P. Ting, The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29, 707\u2013735 (2011)","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"4702_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41392-020-0145-7","volume":"5","author":"Y Zhang","year":"2020","unstructured":"Y. Zhang, Z. Dong, W. Song, NLRP3 inflammasome as a novel therapeutic target for Alzheimer\u2019s disease. Signal. Transduct. Target. Ther. 5(1), 37 (2020)","journal-title":"Signal. Transduct. Target. Ther."},{"key":"4702_CR30","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.12659\/MSM.903269","volume":"23","author":"Y Fu","year":"2017","unstructured":"Y. Fu, N. Wu, D. Zhao, Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy. Med. Sci. Monit. 23, 3878\u20133884 (2017)","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"4702_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11882-010-0160-9","volume":"11","author":"JR Yu","year":"2011","unstructured":"J.R. Yu, K.S. Leslie, Cryopyrin-associated periodic syndrome: an update on diagnosis and treatment response. Curr. Allergy Asthma Rep. 11(1), 12\u201320 (2011)","journal-title":"Curr. Allergy Asthma Rep."},{"key":"4702_CR32","first-page":"39","volume":"4","author":"SR Kingsbury","year":"2011","unstructured":"S.R. Kingsbury, P.G. Conaghan, M.F. McDermott, The role of the NLRP3 inflammasome in gout. J. Inflamm. Res. 4, 39\u201349 (2011)","journal-title":"J. Inflamm. Res."},{"key":"4702_CR33","doi-asserted-by":"publisher","first-page":"112222","DOI":"10.1016\/j.intimp.2024.112222","volume":"134","author":"YS Zhang","year":"2024","unstructured":"Y.S. Zhang, Z.Y. Liu, Z.Y. Liu, L.C. Lin, Q. Chen, J.Y. Zhao et al., m6A epitranscriptomic modification of inflammation in cardiovascular disease. Int. Immunopharmacol. 134, 112222 (2024)","journal-title":"Int. Immunopharmacol."},{"key":"4702_CR34","doi-asserted-by":"publisher","first-page":"670711","DOI":"10.3389\/fcell.2021.670711","volume":"9","author":"J Luo","year":"2021","unstructured":"J. Luo, T. Xu, K. Sun, N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications. Front. Cell. Dev. Biol. 9, 670711 (2021)","journal-title":"Front. Cell. Dev. Biol."},{"issue":"2","key":"4702_CR35","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s12276-022-00735-x","volume":"54","author":"N Zhang","year":"2022","unstructured":"N. Zhang, Y. Shen, H. Li, Y. Chen, P. Zhang, S. Lou et al., The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability. Exp. Mol. Med. 54(2), 194\u2013205 (2022)","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"4702_CR36","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s13046-020-01772-y","volume":"39","author":"CC Hao","year":"2020","unstructured":"C.C. Hao, C.Y. Xu, X.Y. Zhao, J.N. Luo, G. Wang, L.H. Zhao et al., Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma. J. Exp. Clin. Cancer Res. 39(1), 256 (2020)","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"4702_CR37","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","volume":"20","author":"H Huang","year":"2018","unstructured":"H. Huang, H. Weng, W. Sun, X. Qin, H. Shi, H. Wu et al., Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell. Biol. 20(3), 285\u2013295 (2018)","journal-title":"Nat. Cell. Biol."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04702-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-026-04702-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04702-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:29:42Z","timestamp":1783682982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-026-04702-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4702"],"URL":"https:\/\/doi.org\/10.1007\/s12020-026-04702-8","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"20 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University (No. XZMH-2023-21). The animal experiments complied with the ARRIVE guidelines and were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The experiments were approved by the Institutional Animal Care and Use Committee of the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University (No. XZMH-2023-97).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Written informed consent was obtained from each subject.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"223"}}