{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:55:13Z","timestamp":1785761713058,"version":"3.56.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211376"],"award-info":[{"award-number":["tsqn202211376"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172616"],"award-info":[{"award-number":["82172616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH097"],"award-info":[{"award-number":["ZR2021MH097"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y-2019genecast-020"],"award-info":[{"award-number":["Y-2019genecast-020"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocrine"],"DOI":"10.1007\/s12020-026-04729-x","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:21:35Z","timestamp":1785759695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["STK11 c.1062\u00a0C\u2009&gt;\u2009G germline variant in medullary thyroid carcinoma: implications for familial predisposition and genetic counseling"],"prefix":"10.1007","volume":"91","author":[{"given":"Weimao","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longnv","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-0232","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"4729_CR1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.isci.2019.09.030","volume":"20","author":"R Ciampi","year":"2019","unstructured":"R. Ciampi, C. Romei, T. Ramone, A. Prete, A. Tacito, V. Cappagli, V. Bottici, D. Viola, L. Torregrossa, C. Ugolini et al., Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing. iScience. 20, 324\u2013336 (2019)","journal-title":"iScience"},{"issue":"3","key":"4729_CR2","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1210\/jc.2007-1714","volume":"93","author":"R Elisei","year":"2008","unstructured":"R. Elisei, B. Cosci, C. Romei, V. Bottici, G. Renzini, E. Molinaro, L. Agate, A. Vivaldi, P. Faviana, F. Basolo et al., Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. J. Clin. Endocrinol. Metab. 93(3), 682\u2013687 (2008)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"4729_CR3","doi-asserted-by":"crossref","unstructured":"E. Minna, P. Romeo, M. Dugo, De L. Cecco, A. Aiello, F. Pistore, A. Carenzo, A. Greco, M.G. Borrello, Medullary Thyroid Carcinoma Mutational Spectrum Update and Signaling-Type Inference by Transcriptional Profiles: Literature Meta-Analysis and Study of Tumor Samples. Cancers (Basel) 2022, 14(8)","DOI":"10.3390\/cancers14081951"},{"issue":"1","key":"4729_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00428-014-1589-3","volume":"465","author":"M Simbolo","year":"2014","unstructured":"M. Simbolo, C. Mian, S. Barollo, M. Fassan, A. Mafficini, D. Neves, M. Scardoni, G. Pennelli, M. Rugge, M.R. Pelizzo et al., High-throughput mutation profiling improves diagnostic stratification of sporadic medullary thyroid carcinomas. Virchows Arch. 465(1), 73\u201378 (2014)","journal-title":"Virchows Arch."},{"issue":"8","key":"4729_CR5","doi-asserted-by":"publisher","first-page":"e1005467","DOI":"10.1371\/journal.pgen.1005467","volume":"11","author":"JH Ji","year":"2015","unstructured":"J.H. Ji, Y.L. Oh, M. Hong, J.W. Yun, H.W. Lee, D. Kim, Y. Ji, D.H. Kim, W.Y. Park, H.T. Shin et al., Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. PLoS Genet. 11(8), e1005467 (2015)","journal-title":"PLoS Genet."},{"issue":"10","key":"4729_CR6","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1093\/hmg\/ddi139","volume":"14","author":"C Forcet","year":"2005","unstructured":"C. Forcet, S. Etienne-Manneville, H. Gaude, L. Fournier, S. Debilly, M. Salmi, A. Baas, S. Olschwang, H. Clevers, M. Billaud, Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum. Mol. Genet. 14(10), 1283\u20131292 (2005)","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"4729_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10689-016-9963-8","volume":"16","author":"H Tan","year":"2017","unstructured":"H. Tan, X. Wei, P. Yang, Y. Huang, H. Li, D. Liang, L. Wu, A lesson from a reported pathogenic variant in Peutz-Jeghers syndrome: a case report. Fam Cancer. 16(3), 417\u2013422 (2017)","journal-title":"Fam Cancer"},{"issue":"1","key":"4729_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12022-015-9411-6","volume":"27","author":"S Wei","year":"2016","unstructured":"S. Wei, V.A. LiVolsi, M.S. Brose, K.T. Montone, J.J. Morrissette, Z.W. Baloch, STK11 Mutation Identified in Thyroid Carcinoma. Endocr. Pathol. 27(1), 65\u201369 (2016)","journal-title":"Endocr. Pathol."},{"issue":"4","key":"4729_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2350\/15-01-1597-CR.1","volume":"18","author":"MA Buryk","year":"2015","unstructured":"M.A. Buryk, J.L. Picarsic, S.E. Creary, P.H. Shaw, J.P. Simons, M. Deutsch, S.E. Monaco, Y.E. Nikiforov, S.F. Witchel, Identification of Unique, Heterozygous Germline Mutation, STK11 (p.F354L), in a Child with an Encapsulated Follicular Variant of Papillary Thyroid Carcinoma within Six Months of Completing Treatment for Neuroblastoma. Pediatr. Dev. Pathol. 18(4), 318\u2013323 (2015)","journal-title":"Pediatr. Dev. Pathol."},{"issue":"12","key":"4729_CR10","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1093\/carcin\/bgab104","volume":"42","author":"LL Donnelly","year":"2021","unstructured":"L.L. Donnelly, T.C. Hogan, S.M. Lenahan, G. Nandagopal, J.G. Eaton, M.A. Lebeau, C.L. McCann, H.M. Sarausky, K.J. Hampel, J.D. Armstrong et al., Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis. 42(12), 1428\u20131438 (2021)","journal-title":"Carcinogenesis"},{"issue":"2","key":"4729_CR11","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/10668969231177256","volume":"32","author":"H Yoshida","year":"2024","unstructured":"H. Yoshida, K. Hiranuma, M. Nakahara, M. Kobayashi-Kato, Y. Tanase, M. Uno, K. Shiraishi, M. Ishikawa, T. Kato, Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report. Int. J. Surg. Pathol. 32(2), 394\u2013400 (2024)","journal-title":"Int. J. Surg. Pathol."},{"issue":"1","key":"4729_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s12022-025-09850-7","volume":"36","author":"Y Liu","year":"2025","unstructured":"Y. Liu, L. Bao, G. Li, W. Kong, X. Li, J. Wang, X. Pan, Z. Zhang, J. Wang, Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: BEND7::ALK, DLG5::RET, and CCDC30::ROS1 Fusions Induce MAPK Pathway Activation. Endocr. Pathol. 36(1), 5 (2025)","journal-title":"Endocr. Pathol."},{"key":"4729_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ejca.2021.01.050","volume":"148","author":"N Krishnamurthy","year":"2021","unstructured":"N. Krishnamurthy, A.M. Goodman, D.A. Barkauskas, R. Kurzrock, STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications. Eur. J. Cancer. 148, 215\u2013229 (2021)","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"4729_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/XCS.0000000000001098","volume":"239","author":"S Darabi","year":"2024","unstructured":"S. Darabi, T. Adeyelu, A. Elliott, A. Sukari, K. Hodges, F. Abdulla, C.E. Zuazo, T. Wise-Draper, T. Wang, M.J. Demeure, Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy. J. Am. Coll. Surg. 239(1), 50\u201360 (2024)","journal-title":"J. Am. Coll. Surg."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04729-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12020-026-04729-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-026-04729-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:21:36Z","timestamp":1785759696000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12020-026-04729-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4729"],"URL":"https:\/\/doi.org\/10.1007\/s12020-026-04729-x","relation":{},"ISSN":["1559-0100"],"issn-type":[{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"252"}}