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The condition typically goes unrecognised until the first spermiogram reveals azoospermia or severe oligozoospermia. This review examines the pathophysiology, available diagnostic tools, and clinical management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across SciSpace, PubMed, and Google Scholar covering Sertoli cell biology, AMH and Inhibin B as biomarkers, minipuberty physiology, endocrine disruptors, cryptorchidism, maternal metabolic disorders, and nutritional influences on testicular development. More than 500 relevant publications were retrieved and synthesised. This is a narrative review; no standardized or systematic methodology was applied for manuscript selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Minipuberty (months 1\u20136 of life) represents the earliest and most informative diagnostic window: Inhibin B peaks at 378\u2009\u00b1\u200923 pg\/mL and AMH rises sharply, both reflecting Sertoli cell mass and function. Inhibin B below 60 pg\/mL during this window predicts poor spermatogenic outcomes. Pubertal testicular volume progression below the P10 centile, or failure to reach\u2009\u226512 mL in adulthood, constitutes a cardinal sign. High-risk categories include cryptorchidism (bilateral Sertoli impairment in 70% of unilateral cases), offspring of diabetic or hypothyroid mothers, and boys exposed to endocrine-disrupting chemicals in utero.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A structured surveillance protocol combining early infancy hormonal screening during minipuberty, serial orchidometry throughout childhood, and targeted Sertoli cell stimulation tests can identify incomplete male puberty years before irreversible spermatogenic failure. Early recognition enables timely intervention and counselling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-026-04732-2","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:28:13Z","timestamp":1786188493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incomplete male puberty: a new nosographic entity"],"prefix":"10.1007","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-2372","authenticated-orcid":false,"given":"Sandro","family":"La Vignera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita A.","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"4732_CR1","first-page":"1363","volume-title":"The Physiology of Reproduction","author":"RM Sharpe","year":"1994","unstructured":"R.M. 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