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However, the impact of concomitant CD on diabetes-related complications and metabolic outcomes in patients with T2DM remains poorly characterized. We aimed to compare clinical outcomes between patients with T2DM and CD versus patients without CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective multicenter electronic health record (EHR)-based cohort study using the TriNetX research network. Adults with T2DM and concomitant CD were identified using ICD-10-CM codes for T2DM and CD, along with either markedly elevated tissue transglutaminase IgA levels or upper endoscopy procedures.<\/jats:p>\n                    <jats:p>Propensity score matching (1:1) was performed for demographics, cardiovascular risk factors, lipid disorders, medications, and laboratory markers, yielding 8,760 patients per cohort.<\/jats:p>\n                    <jats:p>Outcomes included albuminuria, depression, anxiety, severe hyperglycemia, ophthalmic complications, hospitalization, neuropathy, nephropathy, and a composite cardiovascular outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, patients with T2DM and CD had significantly higher hazards of albuminuria (HR 1.30, 95% CI 1.15\u20131.46), depression (HR 1.14, 95% CI 1.07\u20131.21), anxiety (HR 1.12, 95% CI 1.06\u20131.18), severe hyperglycemia (HR 1.39, 95% CI 1.27\u20131.53), ophthalmic complications (HR 1.77, 95% CI 1.55\u20132.02), neuropathy (HR 1.73, 95% CI 1.59\u20131.88), nephropathy (HR 1.13, 95% CI 1.04\u20131.22), and a composite cardiovascular outcome (HR 1.09, 95% CI 1.01\u20131.17) compared with matched controls. Hospitalization risk did not differ between cohorts (HR 0.97, 95% CI 0.92\u20131.01). Mean follow-up after matching were 1,574 days and 1,438 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with T2DM, concomitant CD was associated with significantly higher risks of macro and microvascular diabetic complications, and psychiatric comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12020-026-04769-3","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:00:28Z","timestamp":1790578828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of coexisting celiac disease with macrovascular and microvascular complications in adults with type 2 diabetes mellitus: a retrospective propensity score\u2013matched cohort study"],"prefix":"10.1007","volume":"91","author":[{"given":"Renan","family":"Prado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Lou","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"4769_CR1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1001\/jama.2026.0872","volume":"335","author":"P Singh","year":"2026","unstructured":"P. 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