{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:14:20Z","timestamp":1789215260056,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr Pathol"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s12022-007-0006-8","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T08:59:35Z","timestamp":1179133175000},"page":"46-52","source":"Crossref","is-referenced-by-count":38,"title":["Acromegaly Secondary to Growth Hormone-releasing Hormone Secreted by an Incidentally Discovered Pheochromocytoma"],"prefix":"10.1007","volume":"18","author":[{"given":"L.","family":"Vieira Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. F.","family":"Taboada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chimelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rumilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Gadelha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,3]]},"reference":[{"key":"6_CR1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1590\/S0004-27302005000500004","volume":"49","author":"GF Taboada","year":"2005","unstructured":"Taboada GF, van Haute FR, Correa LL, et al. Etiologic aspects and management of acromegaly. Arq Bras Endocrinol Metabol 49:626\u201340, 2005.","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"6_CR2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM198501033120103","volume":"312","author":"S Melmed","year":"1985","unstructured":"Melmed S, Ezrin C, Kovacs K, et al. Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. N Engl J Med 312:9\u201317, 1985.","journal-title":"N Engl J Med"},{"key":"6_CR3","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1056\/NEJM200006223422504","volume":"342","author":"F Beuschlein","year":"2000","unstructured":"Beuschlein F, Strasburger CJ, Siegerstetter V, et al. Acromegaly caused by secretion of growth hormone by a non-Hodgkin\u2019s lymphoma. N Engl J M\u00e9d 342:1871\u20136, 2000.","journal-title":"N Engl J M\u00e9d"},{"key":"6_CR4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1210\/edrv-9-3-357","volume":"9","author":"T Sano","year":"1988","unstructured":"Sano T, Asa SL, Kovacs K. Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev 9:357\u201373, 1988.","journal-title":"Endocr Rev"},{"key":"6_CR5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/jcem-59-5-846","volume":"59","author":"MO Thorner","year":"1984","unstructured":"Thorner MO, Frohman LA, Leong DA, et al. Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. J Clin Endocrinol Metab 59:846\u20139, 1984.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0889-8529(18)30203-2","volume":"21","author":"G Faglia","year":"1992","unstructured":"Faglia G, Arosio M, Bazzoni N. Ectopic acromegaly. Endocrinol Metab Clin North Am 21:575\u201395, 1992.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"6_CR7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.ten.0000089860.69958.83","volume":"13","author":"VS Reuters","year":"2003","unstructured":"Reuters VS, Dias EMR, Pupo MRSR, et al. Acromegaly secondary to ectopic growth hormone-releasing hormone-secreting bronchial carcinoid cured after pneumectomy. Endocrinologist 13:376\u20139, 2003.","journal-title":"Endocrinologist"},{"key":"6_CR8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0002-9343(84)90284-5","volume":"76","author":"BW Scheithauer","year":"1984","unstructured":"Scheithauer BW, Carpenter PC, Bloch B, et al. Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor. Am J Med 76:605\u201316, 1984.","journal-title":"Am J Med"},{"key":"6_CR9","first-page":"158","volume":"53","author":"P Caron","year":"1992","unstructured":"Caron P, Guittard J, Trouillas J, et al. Acromegalie et tumeur carcinoide bronchique. A propos d\u2019une observation. Ann d\u2019Endocrinol 53:158\u201361, 1992.","journal-title":"Ann d\u2019Endocrinol"},{"key":"6_CR10","first-page":"555","volume":"78","author":"S Ezzat","year":"1994","unstructured":"Ezzat S, Asa SL, Stefaneanu L, et al. Somatotroph hyperplasia without pituitary adenoma associated with a longstanding growth hormone-releasing hormone-producing bronchial carcinoid. J Clin Endocrinol Metab 78:555\u201360, 1994.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR11","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1210\/jcem.82.8.4175","volume":"82","author":"N Sanno","year":"1997","unstructured":"Sanno N, Teramoto A, Osamura RY, et al. A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. J Clin Endocrinol Metab 82:2731\u20132, 1997.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1507\/endocrj.42.331","volume":"42","author":"Y Shintani","year":"1995","unstructured":"Shintani Y, Yoshimoto K, Horie H, et al. Two different pituitary adenomas in a patient with multiple endocrine neoplasia type 1 associated with growth hormone-releasing hormone-producing pancreatic tumor: clinical and genetic features. Endocr J 42:331\u201340, 1995.","journal-title":"Endocr J"},{"key":"6_CR13","first-page":"216","volume":"76","author":"D Zimmerman","year":"1993","unstructured":"Zimmerman D, Young WF Jr, Ebersold MJ, et al. Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. J Clin Endocrinol Metab 76:216\u201322, 1993.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1952.tb13837.x","volume":"142","author":"K Iversen","year":"1952","unstructured":"Iversen K. Acromegaly associated with phaeochromocytoma. Acta Med Scand 142:1\u20135, 1952.","journal-title":"Acta Med Scand"},{"key":"6_CR15","first-page":"74","volume":"188","author":"MT Kahn","year":"1964","unstructured":"Kahn MT, Mullen DA. Pheochromocytoma without hypertension\u2014report of a patient with acromegaly. JAMA 188:74\u20135, 1964.","journal-title":"JAMA"},{"key":"6_CR16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/neurosurgery\/10.CN_suppl_1.72","volume":"10","author":"WJ German","year":"1964","unstructured":"German WJ, Flanigan S. Pituitary adenomas: a follow-up study of the Cushing series. Clin Neurosurg 10:72\u201381, 1964.","journal-title":"Clin Neurosurg"},{"key":"6_CR17","first-page":"213","volume":"60","author":"NJ O\u2019Higgins","year":"1967","unstructured":"O\u2019Higgins NJ, Cullen MJ, Heffernan AG. A case of acromegaly and phaeochromocytoma. J Ir Med Assoc 60:213\u20136, 1967.","journal-title":"J Ir Med Assoc"},{"key":"6_CR18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/archinte.1971.00310140127019","volume":"127","author":"GL Miller","year":"1971","unstructured":"Miller GL, Wynn J. Acromegaly, pheochromocytoma, toxic goiter, diabetes mellitus, and endometriosis. Arch Intern Med 127:299\u2013303, 1971.","journal-title":"Arch Intern Med"},{"key":"6_CR19","first-page":"495","volume":"100","author":"F Farhi","year":"1976","unstructured":"Farhi F, Dikman SH, Lawson W, Cobin RH, Zak FG. Paragangliomatosis associated with multiple endocrine adenomas. Arch Pathol Lab Med 100:495\u20138, 1976.","journal-title":"Arch Pathol Lab Med"},{"key":"6_CR20","first-page":"1402","volume":"31","author":"S Kodowaki","year":"1976","unstructured":"Kodowaki S, Baba Y, Kakita T, et al. A case of acromegaly associated with pheochromocytoma. Saishin-Igaku 31:1402\u20139, 1976.","journal-title":"Saishin-Igaku"},{"key":"6_CR21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/978-1-4612-9900-4","volume-title":"Pheochromocytoma","author":"WM Manger","year":"1977","unstructured":"Manger WM, Gifford RW. Pheochromocytoma. New York: Springer\u2013Velag, 284\u20136; 1977."},{"key":"6_CR22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2265.1981.tb02971.x","volume":"14","author":"RJ Anderson","year":"1981","unstructured":"Anderson RJ, Lufkin EG, Sizemore GW, et al. Acromegaly and pituitary adenoma with phaeochromocytoma: a variant of multiple endocrine neoplasia. Clin Endocrinol 14:605\u201312, 1981.","journal-title":"Clin Endocrinol"},{"key":"6_CR23","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1001\/archinte.1981.00340120129027","volume":"141","author":"JH Myers","year":"1981","unstructured":"Myers JH, Eversman JJ. Acromegaly, hyperparathyroidism, and pheochromocytoma in the same patient. A multiple endocrine disorder. Arch Intern Med 141:1521\u20132, 1981.","journal-title":"Arch Intern Med"},{"key":"6_CR24","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1210\/jcem-63-6-1421","volume":"63","author":"KA Roth","year":"1986","unstructured":"Roth KA, Wilson DM, Eberwine J, et al. Acromegaly and pheochromocytoma: a multiple endocrine syndrome caused by a plurihormonal adrenal medullary tumor. J Clin Endocrinol Metab 63:1421\u20136, 1986.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1530\/acta.0.1290246","volume":"129","author":"H Saito","year":"1993","unstructured":"Saito H, Sano T, Yamasaki R, Mitsuhashi S, Hosoi E, Saito S. Demonstration of biological activity of a growth hormone-releasing hormone-like substance produced by a pheochromocytoma. Acta Endocrinol 129:246\u201350, 1993.","journal-title":"Acta Endocrinol"},{"key":"6_CR26","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/bjs.1800830832","volume":"83","author":"BT Teh","year":"1996","unstructured":"Teh BT, Hansen J, Svensson PJ, Hartley L. Bilateral recurrent phaeochromocytoma associated with a growth hormone-secreting pituitary tumour. Br J Surg 83:1132, 1996.","journal-title":"Br J Surg"},{"key":"6_CR27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0002-9610(01)00678-X","volume":"182","author":"J Baughan","year":"2001","unstructured":"Baughan J, de Gara C, Morrish D. A rare association between acromegaly and pheochromocytoma. Am J Surg 182:185\u20137, 2001.","journal-title":"Am J Surg"},{"key":"6_CR28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4158\/EP.8.1.54","volume":"8","author":"GG Sleilati","year":"2002","unstructured":"Sleilati GG, Kovacs KT, Honasoge M. Acromegaly and pheochromocytoma: report of a rare coexistence. Endocr Pract 8:54\u201360, 2002.","journal-title":"Endocr Pract"},{"key":"6_CR29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1023\/B:PITU.0000023429.89644.7b","volume":"6","author":"SM Breckenridge","year":"2003","unstructured":"Breckenridge SM, Hamrahian AH, Faiman C, Suh J, Prayson R, Mayberg M. Coexistence of a pituitary macroadenoma and pheochromocytoma\u2014a case report and review of the literature. Pituitary 6:221\u20135, 2003.","journal-title":"Pituitary"},{"key":"6_CR30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI109658","volume":"65","author":"L Frohman","year":"1980","unstructured":"Frohman L, Szabo M, Berelowitz M, et al. Partial purification and characterization of a peptide with growth hormone-releasing activity from extra pituitary tumors in patients with acromegaly. J Clin Invest 65:43\u201354, 1980.","journal-title":"J Clin Invest"},{"key":"6_CR31","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/1097-0142(19841115)54:10<2097::AID-CNCR2820541009>3.0.CO;2-X","volume":"54","author":"G Berger","year":"1984","unstructured":"Berger G, Trouillas J, Bloch B, et al. Multihormonal carcinoid tumor of the pancreas secreting growth hormone-releasing factor as a cause of acromegaly. Cancer 54:2097\u2013108, 1984.","journal-title":"Cancer"},{"key":"6_CR32","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1172\/JCI111864","volume":"75","author":"ML Vance","year":"1985","unstructured":"Vance ML, Kaiser DL, Evans WS, et al. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1\u201340). Evidence for intermittent somatostatin secretion. J Clin Invest 75:1584\u201390, 1985.","journal-title":"J Clin Invest"},{"key":"6_CR33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0002-9343(85)90559-5","volume":"79","author":"JLC Ch\u2019ng","year":"1985","unstructured":"Ch\u2019ng JLC, Chritofides ND, Kraezlin ME, et al. Growth hormone secretion dynamics in a patient with ectopic growth hormone-releasing factor production. Am J Med 79:135\u20138, 1985.","journal-title":"Am J Med"},{"key":"6_CR34","first-page":"167","volume":"24","author":"V Popovic","year":"1990","unstructured":"Popovic V, Micic D, Damjanovic S, et al. Discordance between growth hormone responses after growth hormone-releasing hormone (GHRH) and insulin hypoglycemia in ectopic GHRH syndrome. Endocrinol Exp 24:167\u201373, 1990.","journal-title":"Endocrinol Exp"},{"key":"6_CR35","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1210\/jcem-63-5-1057","volume":"63","author":"AL Barkan","year":"1986","unstructured":"Barkan AL, Shenker Y, Grekin RJ, et al. Acromegaly due to ectopic growth hormone (GH)-releasing hormone (GHRH) production: dynamic studies of GH and ectopic GHRH secretion. J Clin Endocrinol Metab 63:1057\u201364, 1986.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR36","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1210\/jcem-59-5-1002","volume":"59","author":"DM Wilson","year":"1984","unstructured":"Wilson DM, Ceda GP, Bostwick DG, et al. Acromegaly and Zollinger\u2013Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor. J Clin Endocrinol Metab 59:1002\u20135, 1984.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1009952930425","volume":"1","author":"E Horvath","year":"1999","unstructured":"Horvath E, Kovacs K, Scheithauer BW. Pituitary hyperplasia. Pituitary 1:169\u201380, 1999.","journal-title":"Pituitary"},{"key":"6_CR38","first-page":"898","volume-title":"Functional endocrine pathology","author":"S Reichlin","year":"1991","unstructured":"Reichlin S. Functional aspects of endocrine neoplasms. In: Kovacs K, Asa SL, editors. Functional endocrine pathology. Boston: Blackwell Scientific Publications, p 898, 1991."},{"key":"6_CR39","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1172\/JCI110708","volume":"70","author":"MO Thorner","year":"1982","unstructured":"Thorner MO, Perryman RL, Cronin MJ, et al. Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965\u201377, 1982.","journal-title":"J Clin Invest"},{"key":"6_CR40","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1210\/endo.131.5.1425411","volume":"131","author":"S Asa","year":"1992","unstructured":"Asa S, Kovacs K, Stefaneanu L, et al. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Endocrinology 131:2083\u20139, 1992.","journal-title":"Endocrinology"},{"key":"6_CR41","first-page":"895","volume":"141","author":"RV Lloyd","year":"1992","unstructured":"Lloyd RV, Jin L, Chang A, et al. Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. Am J Pathol 141:895\u2013906, 1992.","journal-title":"Am J Pathol"},{"key":"6_CR42","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1210\/jcem-58-5-796","volume":"58","author":"SL Asa","year":"1984","unstructured":"Asa SL, Scheithauer BW, Bilbao JM, et al. A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58:796\u2013803, 1984.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2265.1997.2311048.x","volume":"47","author":"M Losa","year":"1997","unstructured":"Losa M, von Werder K. Pathophysiology and clinical aspects of the ectopic GH-releasing hormone syndrome. Clin Endocrinol 47:123\u201335, 1997.","journal-title":"Clin Endocrinol"},{"key":"6_CR44","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/00003072-200412000-00025","volume":"29","author":"O Morel","year":"2004","unstructured":"Morel O, Giraud P, Bernier MO, et al. Ectopic acromegaly: localization of the pituitary growth hormone-releasing hormone producing tumor by In-111 pentetreotide scintigraphy and report of two cases. Clin Nucl Med 29:841\u20133, 2004.","journal-title":"Clin Nucl Med"},{"key":"6_CR45","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1210\/jcem-70-4-996","volume":"70","author":"A Sasaki","year":"1990","unstructured":"Sasaki A, Yumita S, Kimura S, et al. Immunoreactive corticotropin-releasing hormone, growth hormone-releasing hormone, somatostatin, and peptide histidine methionine are present in adrenal pheochromocytomas, but not in extra-adrenal pheochromocytoma. J Clin Endocrinol Metab 70:996\u20139, 1990.","journal-title":"J Clin Endocrinol Metab"},{"key":"6_CR46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1615\/CritRevNeurobiol.v11.i2-3.40","volume":"11","author":"SJ Wimalawansa","year":"1997","unstructured":"Wimalawansa SJ. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol 11:167\u2013239, 1997.","journal-title":"Crit Rev Neurobiol"}],"container-title":["Endocrine Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-007-0006-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12022-007-0006-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-007-0006-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T21:57:27Z","timestamp":1559426247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12022-007-0006-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["6"],"URL":"https:\/\/doi.org\/10.1007\/s12022-007-0006-8","relation":{},"ISSN":["1046-3976","1559-0097"],"issn-type":[{"value":"1046-3976","type":"print"},{"value":"1559-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}