{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:02:39Z","timestamp":1757311359379},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr Pathol"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s12022-012-9200-4","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T10:53:16Z","timestamp":1330339996000},"page":"115-122","source":"Crossref","is-referenced-by-count":10,"title":["Occult Primary Medullary Thyroid Carcinoma Presenting with Pituitary and Parotid Metastases: Case Report and Review of the Literature"],"prefix":"10.1007","volume":"23","author":[{"given":"Andrea","family":"Conway","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Wiernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Rawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Mesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"9200_CR1","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s002680010166","volume":"24","author":"SA Wells","year":"2000","unstructured":"Wells SA, Franz C. Medullary carcinoma of the thyroid gland. World J Surg 24:952-956, 2000.","journal-title":"World J Surg"},{"key":"9200_CR2","unstructured":"Mills, Stacy E. Pathology of the thyroid and parathyroid disease. In: Sternberg\u2019s Diagnostic Surgical Pathology. 6th ed."},{"issue":"19","key":"9200_CR3","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1001\/jama.1996.03540190047028","volume":"276","author":"C Eng","year":"1996","unstructured":"Eng C, Clayton D, Schuffenecker I, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. JAMA 276(19):1575-1579, 1996.","journal-title":"JAMA"},{"key":"9200_CR4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2265.2004.02037.x","volume":"61","author":"S Leboulleux","year":"2004","unstructured":"Leboulleux S, Baudin E, Travagli JP, Schlumberger M. Medullary thyroid carcinoma. Clin Endocrinol 61:299\u2013310, 2004.","journal-title":"Clin Endocrinol"},{"key":"9200_CR5","unstructured":"DeLellis R.A., Lloyd R.V., Heitz, P.U., Eng C. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. IARC Press: Lyon 2004; 86\u201391."},{"issue":"6","key":"9200_CR6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/thy.2006.0229","volume":"17","author":"S Grozinsky-Glasberg","year":"2007","unstructured":"Grozinsky-Glasberg S, Benbassat CA, Tsvetov G, Feinmesser R, Peretz H, Shimon I, Lapidot M. Medullary thyroid cancer: a retrospective analysis of a cohort treated at a single tertiary care center between 1970 and 2005. Thyroid 17(6):549\u2013556, 2007.","journal-title":"Thyroid"},{"issue":"5","key":"9200_CR7","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1210\/jc.2002-021713","volume":"88","author":"C Scollo","year":"2003","unstructured":"Scollo C, Baudin E, Travagli JP, Caillou B, Bellon N, Leboulleux S, Schlumberger M. Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer. J Clin Endocrinol Metab 88(5):2070\u20132075, 2003.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"9200_CR8","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00000658-199906000-00016","volume":"229","author":"JF Moley","year":"1999","unstructured":"Moley JF, DeBenedetti MK. Patterns of nodal metastases in palpable medullary thyroid carcinoma: recommendations for extent of node dissection. Ann Surg 229(6):880\u2013888, 1999.","journal-title":"Ann Surg"},{"issue":"6","key":"9200_CR9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00005792-198411000-00001","volume":"63","author":"MF Saad","year":"1984","unstructured":"Saad MF, Ordonez NG, Rashid RK, Guido JJ, Hill CS Jr, Hickey RC, Samaan NA. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Medicine (Baltimore) 63(6):319\u201342, 1984.","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"9200_CR10","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1007\/s00268-007-9185-1","volume":"31","author":"A Machens","year":"2007","unstructured":"Machens A, Hauptmann S, Dralle H. Increased risk of lymph node metastasis in multifocal hereditary and sporadic medullary thyroid cancer. World J Surg 31(10):1960\u20131965, 2007.","journal-title":"World J Surg"},{"key":"9200_CR11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jso.20184","volume":"89","author":"FJ Quayle","year":"2005","unstructured":"Quayle FJ, Moley JF. Medullary thyroid carcinoma: including MEN2A and 2B syndromes. J Surg Oncol 89:122\u2013129, 2005.","journal-title":"J Surg Oncol"},{"issue":"6","key":"9200_CR12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/MPA.0b013e3181ebb4f0","volume":"39","author":"H Chen","year":"2010","unstructured":"Chen H, Sipper RS, O\u2019Dorisio MS, Vinik Al, Lloyd RV, Pacak K; North American Neuroendocrine Tumor Society (NANETS). The North American Neuroendocrine Tumor Society Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 39(6):775\u2013783, 2010.","journal-title":"Pancreas"},{"key":"9200_CR13","first-page":"137","volume":"2","author":"J Albores-Saavedra","year":"1985","unstructured":"Albores-Saavedra J, LiVolsi VA, Williams ED. Medullary carcinoma. Semin Diagn Pathol 2:137\u2013146, 1985.","journal-title":"Semin Diagn Pathol"},{"issue":"3","key":"9200_CR14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1097-0339(199909)21:3<203::AID-DC12>3.0.CO;2-T","volume":"21","author":"M Sironi","year":"1999","unstructured":"Sironi M, Cozzi L, Pareschi R, Spreafic GL, Assi A. Occult sporadic medullary microcarcinoma with lymph node metastases. Diagn Cytopathol 21(3):203\u2013206, 1999.","journal-title":"Diagn Cytopathol"},{"issue":"11","key":"9200_CR15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1089\/thy.1998.8.1039","volume":"8","author":"N Beressi","year":"1998","unstructured":"Beressi N, Campos JM, Beressi JP, Franc B, Niccoli-Sire P, Conte-Devolx B, Murat A, Caron P, Baldet L, Kraimps JL, Cohen R, Bigorgne JC, Chabre O, Lecomte P, Modigliani E. Thyroid. Sporadic medullary microcarcinoma of the thyroid: a retrospective analysis of eighty cases. Thyroid 8(11):1039\u20131044, 1998.","journal-title":"Thyroid"},{"issue":"4","key":"9200_CR16","first-page":"E8","volume":"16","author":"DR Fassett","year":"2004","unstructured":"Fassett DR, Couldwell WT. Metastasis to the pituitary gland. Neurosurg Focus 16(4):E8, 2004.","journal-title":"Neurosurg Focus"},{"key":"9200_CR17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/1097-0142(197507)36:1<216::AID-CNCR2820360123>3.0.CO;2-E","volume":"36","author":"RJ Teears","year":"1975","unstructured":"Teears RJ, Silverman EM. Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland. Cancer 36:216\u2013220, 1975.","journal-title":"Cancer"},{"key":"9200_CR18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.5858\/2008-132-1231-PPPWDT","volume":"132","author":"SL Asa","year":"2008","unstructured":"Asa SL. Practical pituitary pathology: what does the pathologist need to know? Arch Pathol Lab Med 132:1231\u20131240, 2008.","journal-title":"Arch Pathol Lab Med"},{"key":"9200_CR19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3171\/jns.1998.89.1.0069","volume":"89","author":"A Morita","year":"1998","unstructured":"Morita A, Meyer FB, Laws ER Jr. Symptomatic pituitary metastases. J Neurosurg 89: 69\u201373, 1998.","journal-title":"J Neurosurg"},{"key":"9200_CR20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/1097-0142(197002)25:2<478::AID-CNCR2820250227>3.0.CO;2-X","volume":"25","author":"U Roessmann","year":"1970","unstructured":"Roessmann U, Kaufman B, and Friede RL. Metastatic lesions in the sella turcica and pituitary gland. Cancer 25:478\u2013480, 1970.","journal-title":"Cancer"},{"key":"9200_CR21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11060-008-9586-5","volume":"89","author":"HS Bhatoe","year":"2008","unstructured":"Bhatoe HS, Badwal S, Dutta V, Kannan N. Pituitary metastasis from medullary carcinoma of thyroid: case report and review of literature. J Neurooncol 89:63\u201367, 2008.","journal-title":"J Neurooncol"},{"issue":"3","key":"9200_CR22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/hed.20911","volume":"31","author":"L Santarpia","year":"2009","unstructured":"Santarpia L, Gagel RF, Sherman SI, Sarlis NJ, Evans DB, Hoff AO. Diabetes insipidus and panhypopituitarism due to intrasellar metastasis from medullary thyroid cancer. Head Neck 31(3): 419\u2013423, 2009.","journal-title":"Head Neck"},{"key":"9200_CR23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/000348948309200224","volume":"92","author":"JG Batsakis","year":"1983","unstructured":"Batsakis JG. Pathology consultation. Parotid gland and its lymph nodes as metastatic sites. Ann Otol Rhinol Laryngol 92:209\u2013210, 1983.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"9200_CR24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.otohns.2006.05.010","volume":"135","author":"M Nuyens","year":"2006","unstructured":"Nuyens M, Sch\u00fcpbach J, Stauffer E, Zb\u00e4ren P. Metastatic disease to the parotid gland. Otolaryngol Head Neck Surg 135:844\u2013848, 2006.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"9200_CR25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1017\/S0022215110002987","volume":"125","author":"H Mohyuddin","year":"2011","unstructured":"Mohyuddin H, Mahrous A, Sharma V, Gluckman P. Parotid mass: an unusual presentation of gastroesophageal malignancy. J Laryngol Otol 125(5):546\u2013548, 2011.","journal-title":"J Laryngol Otol"},{"issue":"3","key":"9200_CR26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/SCS.0b013e3181d7f186","volume":"21","author":"B Ulubas","year":"2010","unstructured":"Ulubas B, Ozcan C, Polat A. Small cell lung cancer diagnosed with metastasis in parotid gland. J Craniofac Surg 21(3):781\u2013783, 2010.","journal-title":"J Craniofac Surg"},{"key":"9200_CR27","first-page":"19","volume":"288","author":"A Moutaouakil","year":"2003","unstructured":"Moutaouakil A, Baha AT, and Amraoui A. Metastase choroidienne d\u2019un carcinome de la thyroide (a propos d\u2019un cas). Bull Soc Belge Ophtalmol 288:19\u201322, 2003.","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"9200_CR28","doi-asserted-by":"crossref","unstructured":"Pelosi S, Genden EM. Medullary thyroid carcinoma metastatic to the parotid gland. The Laryngoscope (Meeting Abstracts) 119(Supplement S3):S253, 2009.","DOI":"10.1002\/lary.21511"},{"key":"9200_CR29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/MCG.0b013e3181d6bc3e","volume":"44","author":"EC Ebert","year":"2010","unstructured":"Ebert EC. The thyroid and the gut. J Clin Gastroenterol 44:402\u2013406, 2010.","journal-title":"J Clin Gastroenterol"},{"issue":"2","key":"9200_CR30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/10520295.2010.515492","volume":"86","author":"KP Krafts","year":"2011","unstructured":"Krafts KP, Pambuccian SE. Romanowsky staining in cytopathology: history, advantages and limitations. Biotech Histochem 86(2):82\u201393, 2011.","journal-title":"Biotech Histochem"},{"issue":"3","key":"9200_CR31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/modpathol.3880044","volume":"13","author":"SN Agoff","year":"2000","unstructured":"Agoff SN, Lamps LW, Philip AT, Amin MB, Schmidt RA, True LD, Folpe AL. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 13(3):238\u2013242, 2000.","journal-title":"Mod Pathol"},{"key":"9200_CR32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/modpathol.3801002","volume":"21","author":"D Nonaka","year":"2008","unstructured":"Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol 21:192\u2013200, 2008.","journal-title":"Mod Pathol"},{"issue":"3","key":"9200_CR33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/modpathol.3880522","volume":"15","author":"SE Mills","year":"2002","unstructured":"Mills SE. Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 15(3):264\u2013278, 2002.","journal-title":"Mod Pathol"},{"key":"9200_CR34","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1002\/1097-0142(19881215)62:12<2658::AID-CNCR2820621235>3.0.CO;2-M","volume":"62","author":"BM Wenig","year":"1988","unstructured":"Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathologic study of 54 cases. Cancer 62:2658\u20132676, 1988.","journal-title":"Cancer"},{"issue":"5","key":"9200_CR35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1159\/000051953","volume":"17","author":"A Machens","year":"2000","unstructured":"Machens A, Haedecke J, Hinze R, Thomusch O, Schneyer U, Dralle H. Hypercalcitoninemia in a sporadic asymptomatic neuroendocrine tumor of the pancreatic tail. Dig Surg 17(5):522\u20134, 2000.","journal-title":"Dig Surg"},{"issue":"2","key":"9200_CR36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12020-010-9433-2","volume":"39","author":"DV Alapat","year":"2011","unstructured":"Alapat DV, Ain KB, Sloan DA, Monaghan KG, Karabakhtsian RG. Disparity between tissue and serum calcitonin and carcinoembryonic antigen in a patient with medullary thyroid carcinoma. Endocrine 39(2):148-52, 2011.","journal-title":"Endocrine"},{"key":"9200_CR37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/eje.0.1400187","volume":"140","author":"S Leboulleux","year":"1999","unstructured":"Leboulleux S, Baudin E, Young J, Caillou B, Lazar V, Pellegriti G, Ducreux M, Schaison G, Schlumberger M. Gastroenteropancreatic neuroendocrine tumor metastases to the thyroid gland: differential diagnosis with medullary thyroid carcinoma. Eur J Endocrinol 140:187\u2013191, 1999.","journal-title":"Eur J Endocrinol"},{"key":"9200_CR38","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/030089161009600533","volume":"96","author":"M Milione","year":"2010","unstructured":"Milione M, Seregni E. Pathological diagnosis and tumor markers. Tumori 96: 810\u2013816, 2010.","journal-title":"Tumori"},{"key":"9200_CR39","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<858::AID-CNCR23>3.0.CO;2-8","volume":"86","author":"E Bajetta","year":"1999","unstructured":"Bajetta E, Ferrari L,Martinetti A, Celio L, Procopio G, Artale S, Zilembo N, Di Bartolomeo M, Seregni E, Bombardieri E. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer 86: 858\u2013865, 1999.","journal-title":"Cancer"},{"key":"9200_CR40","unstructured":"Rosai and Ackerman\u2019s Surgical Pathology, 10th edn; 48, 329\u2013330, 526\u2013531, 822\u2013840."},{"issue":"1","key":"9200_CR41","first-page":"183","volume":"32","author":"CH Su","year":"2012","unstructured":"Su CH, Chang H, Chen CJ, Liu LC, Wang HC, Lane HY, Bau DT. The carcinoembryonic antigen as a potential prognostic marker for neuroendocrine carcinoma of the breast. Anticancer Res 32(1):183\u2013188, 2012.","journal-title":"Anticancer Res"},{"key":"9200_CR42","unstructured":"Kleinschmidt\u2013DeMasters. Pituitary Gland. In: Rosai and Ackerman\u2019s Surgical Pathology, 10th edn."},{"key":"9200_CR43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/EP:16:3:201","volume":"16","author":"SW Coons","year":"2005","unstructured":"Coons SW, Etrada SI, Gamez R, White WL. Cytokeratin CK7 and CK 20 expression in pituitary adenomas. Endocr Pathol 16: 201\u2013210, 2005.","journal-title":"Endocr Pathol"},{"issue":"5","key":"9200_CR44","first-page":"482","volume":"68","author":"EB Lee","year":"2009","unstructured":"Lee EB, Tihan T, Scheithauer BW, Zhang PJ, Gonatas NK. Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?. JNEN 68(5):482\u20138, 2009.","journal-title":"JNEN"},{"key":"9200_CR45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1440-1827.2005.01890.x","volume":"55","author":"H Takei","year":"2005","unstructured":"Takei H, Goodman JC, Tanaka S, Bhattacharjee MB, Bahrami A Powell, SZ. Pituicytoma incidentally found at autopsy. Pathol Int 55:745\u2013749, 2005.","journal-title":"Pathol Int"},{"issue":"1","key":"9200_CR46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1012535230135","volume":"54","author":"K Salame","year":"2001","unstructured":"Salame K, Ouaknine GE, Yossipov J, Rochkind S. Paraganglioma of the pituitary fossa: diagnosis and management. J Neurooncol 54(1):49\u201352, 2001.","journal-title":"J Neurooncol"},{"issue":"3","key":"9200_CR47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11102-005-1758-0","volume":"7","author":"DM McLaughlin","year":"2004","unstructured":"McLaughlin DM, Gray WJ, Jones FG, Mirakhur M, McCance DR, Sheridan B, Atkinson AB. Plasmacytoma: an unusual cause of a pituitary mass lesion. A case report and a review of the literature. Pituitary 7(3):179\u201381, 2004.","journal-title":"Pituitary"},{"issue":"11","key":"9200_CR48","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1210\/jc.2007-1211","volume":"92","author":"AL Giraudet","year":"2007","unstructured":"Giraudet AL, Vanel D, Leboulleux S, Aup\u00e9rin A, Dromain C, Chami L, Ny Tovo N, Lumbroso J, Lassau N, Bonniaud G, Hartl D, Travagli JP, Baudin E and Schlumberger M. Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 92(11):4185\u20134190, 2007.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"9200_CR49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00005792-198411000-00001","volume":"63","author":"MF Saad","year":"1984","unstructured":"Saad MF, Ordonez NG, Rashid RK, Guido JJ, Hill CS Jr, Hickey RC, Samaan NA. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Medicine (Baltimore) 63(6):319\u2013342, 1984.","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"9200_CR50","first-page":"1017","volume":"116","author":"DS O\u2019Riordain","year":"1994","unstructured":"O\u2019Riordain DS, O\u2019Brien T, Weaver AL, Gharib H, Hay ID, Grant CS, van Heerden JA. Medullary thyroid carcinoma in multiple endocrine neoplasia types 2A and 2B. Surgery 116(6):1017\u20131023, 1994.","journal-title":"Surgery"},{"issue":"5","key":"9200_CR51","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1139::AID-CNCR26>3.0.CO;2-Z","volume":"88","author":"E Kebebew","year":"2000","unstructured":"Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer 88(5):1139\u20131148, 2000.","journal-title":"Cancer"},{"issue":"4","key":"9200_CR52","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1210\/jcem-67-4-801","volume":"67","author":"NA Samaan","year":"1988","unstructured":"Samaan NA, Schultz PN, Hickey RC. Medullary thyroid carcinoma: prognosis of familial versus sporadic disease and the role of radiotherapy. J Clin Endocrinol Metab 67(4):801\u2013805, 1988.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"9200_CR53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/thy.1996.6.305","volume":"6","author":"J Brierley","year":"1996","unstructured":"Brierley J, Tsang R, Simpson WJ, Gospodarowicz M, Sutcliffe S, Panzarella T. Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid 6(4):305\u2013310, 1996.","journal-title":"Thyroid"},{"issue":"6","key":"9200_CR54","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1054\/bjoc.2000.1314","volume":"83","author":"M Nocera","year":"2000","unstructured":"Nocera M, Baudin E, Pellegriti G, Cailleux AF, Mechelany-Corone C, Schlumberger M. Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU-dacarbazine. Groupe d'Etude des Tumeurs \u00e0 Calcitonine (GETC). Br J Cancer 83(6):715\u2013718, 2000.","journal-title":"Br J Cancer"},{"issue":"2","key":"9200_CR55","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/1097-0142(19940115)73:2<432::AID-CNCR2820730231>3.0.CO;2-K","volume":"73","author":"LT Wu","year":"1994","unstructured":"Wu LT, Averbuch SD, Ball DW, de Bustros A, Baylin SB, McGuire WP 3rd. Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine. Cancer 73(2):432\u2013436, 1994.","journal-title":"Cancer"},{"issue":"7","key":"9200_CR56","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/bjc.2011.76","volume":"104","author":"L Medley","year":"2011","unstructured":"Medley L, Morel AN, Farrugia D, Reed N, Hayward N, Davies JM, Kirichek O, Thakker RV, Talbot DC. Phase II study of single agent capecitabine in the treatment of metastatic non-pancreatic neuroendocrine tumours. Br J Cancer 104(7):1067\u20131070, 2011.","journal-title":"Br J Cancer"},{"issue":"2","key":"9200_CR57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00280-007-0590-9","volume":"61","author":"G F\u00fcrstenberger","year":"2008","unstructured":"F\u00fcrstenberger G, Schmid P, Duquesne A, Ammann M, Senn HJ. Complete remission of a metastatic neuroendocrine tumor of the pancreas with capecitabine (Xeloda) monotherapy. Cancer Chemother Pharmacol 61(2):347\u2013348, 2008.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"9200_CR58","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1200\/JCO.2005.03.6046","volume":"24","author":"MH Kulke","year":"2006","unstructured":"Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, Vincitore M, Michelini A, Fuchs CS. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24(3):401\u2013406, 2006.","journal-title":"J Clin Oncol"},{"issue":"10","key":"9200_CR59","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1158\/1078-0432.CCR-06-2053","volume":"13","author":"S Ekeblad","year":"2007","unstructured":"Ekeblad S, Sundin A, Janson ET, Welin S, Granberg D, Kindmark H, Dunder K, Kozlovacki G, Orlefors H, Sigurd M, Oberg K, Eriksson B, Skogseid B.Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res 13(10):2986\u20132991, 2007.","journal-title":"Clin Cancer Res"},{"issue":"Suppl 16S","key":"9200_CR60","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1200\/jco.2005.23.16_suppl.4216","volume":"23","author":"RL Fine","year":"2005","unstructured":"R. L. Fine, D. R. Fogelman, S. M. Schreibman. Effective Treatment of Neuroendocrine Tumors With Temozolomide and Capecitabine. Journal of Clinical Oncology (Meeting Abstracts) 23(Suppl 16S):4216, 2005.","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"9200_CR61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1089\/thy.2007.0220","volume":"18","author":"CE Paiva","year":"2008","unstructured":"Paiva CE, Michelin OC. Use of capecitabine in refractory metastatic medullary thyroid carcinoma. Thyroid 18(5):587, 2008.","journal-title":"Thyroid"},{"issue":"8","key":"9200_CR62","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/thy.2006.16.801","volume":"16","author":"LK Gilliam","year":"2006","unstructured":"Gilliam LK, Kohn AD, Lalani T, Swanson PE, Vasko V, Patel A, Livingston RB, Pickett CA.Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. Thyroid 16(8):801\u2013810, 2006.","journal-title":"Thyroid"},{"issue":"7","key":"9200_CR63","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/CAD.0b013e3280adc8f3","volume":"18","author":"SI Labidi","year":"2007","unstructured":"Labidi SI, Gravis G, Tarpin C, Brun V, Viens P. Medullary thyroid cancer treated by capecitabine. Anticancer Drugs 18(7):831\u2013834, 2007.","journal-title":"Anticancer Drugs"},{"issue":"4","key":"9200_CR64","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/CCO.0b013e32833adee2","volume":"22","author":"B Eriksson","year":"2010","unstructured":"Eriksson B. New drugs in neuroendocrine tumors: rising of new therapeutic philosophies? Curr Opin Oncol 22(4):381\u2013386, 2010.","journal-title":"Curr Opin Oncol"},{"issue":"5","key":"9200_CR65","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5):646\u201374, 2011.","journal-title":"Cell"},{"issue":"1","key":"9200_CR66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc2559","volume":"9","author":"J Zhang","year":"2009","unstructured":"Zhang J, Yang PL, Gray NS.Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 9(1):28\u201339, 2009.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"9200_CR67","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/02841860903147532","volume":"49","author":"E Spector","year":"2010","unstructured":"Spector E, Franklin MJ, Truskinovsky AM, Dudek AZ. Sorafenib induces partial response in metastatic medullary thyroid carcinoma. Acta Oncol 49(1):104\u2013106, 2010.","journal-title":"Acta Oncol"},{"issue":"14","key":"9200_CR68","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1200\/JCO.2009.25.0068","volume":"28","author":"ET Lam","year":"2010","unstructured":"Lam ET, Ringel MD, Kloos RT, Prior TW, Knopp MV, Liang J, Sammet S, Hall NC, Wakely PE Jr, Vasko VV, Saji M, Snyder PJ, Wei L, Arbogast D, Collamore M, Wright JJ, Moley JF, Villalona-Calero MA, Shah MH. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 28(14):2323\u20132330, 2010.","journal-title":"J Clin Oncol"},{"key":"9200_CR69","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1200\/jco.2008.26.15_suppl.6025","volume":"26","author":"EEW Cohen","year":"2008","unstructured":"Cohen, EEW, Needles, BM, Cullen, KJ, et al. Phase 2 study of sunitinib in refractory thyroid cancer. J Clin Oncol (Meeting Abstracts) 26:6025, 2008.","journal-title":"J Clin Oncol"},{"key":"9200_CR70","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1200\/JCO.2007.14.5029","volume":"26","author":"A Ravaud","year":"2008","unstructured":"Ravaud, A, de la Fouchardi\u00e8re, C, Courbon, F, et al. Sunitinib in patients with refractory advanced thyroid cancer: the THYSU phase II trial. J Clin Oncol (Meeting Abstracts) 26:6058, 2008.","journal-title":"J Clin Oncol"},{"issue":"23","key":"9200_CR71","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1200\/JCO.2008.18.7815","volume":"27","author":"MJ Schlumberger","year":"2009","unstructured":"Schlumberger MJ, Elisei R, Bastholt L, Wirth LJ, Martins RG, Locati LD, Jarzab B, Pacini F, Daumerie C, Droz JP, Eschenberg MJ, Sun YN, Juan T, Stepan DE, Sherman SI. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 27(23):3794\u2013801, 2009.","journal-title":"J Clin Oncol"},{"issue":"5","key":"9200_CR72","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1200\/JCO.2009.23.6604","volume":"28","author":"SA Wells Jr","year":"2010","unstructured":"Wells SA Jr, Gosnell JE, Gagel RF, Moley J, Pfister D, Sosa JA, Skinner M, Krebs A, Vasselli J, Schlumberger M. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 28(5):767\u201372, 2010.","journal-title":"J Clin Oncol"}],"container-title":["Endocrine Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-012-9200-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12022-012-9200-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-012-9200-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T14:06:31Z","timestamp":1640959591000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12022-012-9200-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["9200"],"URL":"https:\/\/doi.org\/10.1007\/s12022-012-9200-4","relation":{},"ISSN":["1046-3976","1559-0097"],"issn-type":[{"value":"1046-3976","type":"print"},{"value":"1559-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}