{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:20:56Z","timestamp":1783549256935,"version":"3.55.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["23791043"],"award-info":[{"award-number":["23791043"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["26893261"],"award-info":[{"award-number":["26893261"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["26461387"],"award-info":[{"award-number":["26461387"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008672","name":"Yamaguchi Endocrine Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Federation of National Public Service Personnel Mutual Aid Associations"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL027255"],"award-info":[{"award-number":["HL027255"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"crossref","award":["Initiative for Rare and Undiagnosed Diseases"],"award-info":[{"award-number":["Initiative for Rare and Undiagnosed Diseases"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocr Pathol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s12022-016-9441-8","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T08:14:41Z","timestamp":1468829681000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study"],"prefix":"10.1007","volume":"28","author":[{"given":"Toyoyoshi","family":"Uchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fukumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Asahina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tsujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsugio","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Kabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,18]]},"reference":[{"key":"9441_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1210\/er.2013-1029","volume":"35","author":"T Else","year":"2014","unstructured":"Else T, Kim AC, Sabolch A, et al. Adrenocortical carcinoma. Endocr Rev 35: 282\u2013326, 2014.","journal-title":"Endocr Rev"},{"key":"9441_CR2","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1210\/jc.2009-2010","volume":"95","author":"K Nishimoto","year":"2010","unstructured":"Nishimoto K, Nakagawa K, Li D, et al. Adrenocortical zonation in humans under normal and pathological conditions. The Journal of clinical endocrinology and metabolism 95: 2296\u20132305, 2010.","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"9441_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.mce.2011.07.034","volume":"350","author":"NG Hattangady","year":"2012","unstructured":"Hattangady NG, Olala LO, Bollag WB, Rainey WE. Acute and chronic regulation of aldosterone production. Molecular and cellular endocrinology 350: 151\u2013162, 2012.","journal-title":"Molecular and cellular endocrinology"},{"key":"9441_CR4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mce.2013.11.022","volume":"383","author":"CE Gomez-Sanchez","year":"2014","unstructured":"Gomez-Sanchez CE, Qi X, Velarde-Miranda C, et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Molecular and cellular endocrinology 383: 111\u2013117, 2014.","journal-title":"Molecular and cellular endocrinology"},{"key":"9441_CR5","doi-asserted-by":"publisher","first-page":"E4591","DOI":"10.1073\/pnas.1505529112","volume":"112","author":"K Nishimoto","year":"2015","unstructured":"Nishimoto K, Tomlins SA, Kuick R, et al. Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands. Proceedings of the National Academy of Sciences of the United States of America 112: E4591-4599, 2015.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9441_CR6","unstructured":"Ruifrok AC, Johnston DA Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 23: 291\u2013299, 2001."},{"key":"9441_CR7","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1507\/endocrj.EJ12-0458","volume":"60","author":"Y Akehi","year":"2013","unstructured":"Akehi Y, Kawate H, Murase K, et al. Proposed diagnostic criteria for subclinical Cushing\u2019s syndrome associated with adrenal incidentaloma. Endocr J 60: 903\u2013912, 2013.","journal-title":"Endocr J"},{"key":"9441_CR8","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1210\/jc.2008-0104","volume":"93","author":"JW Funder","year":"2008","unstructured":"Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. The Journal of clinical endocrinology and metabolism 93: 3266\u20133281, 2008.","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"9441_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.humpath.2009.03.010","volume":"40","author":"SK Lau","year":"2009","unstructured":"Lau SK, Weiss LM. The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Human pathology 40: 757\u2013768, 2009.","journal-title":"Human pathology"},{"key":"9441_CR10","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1210\/jc.2015-3285","volume":"101","author":"K Nishimoto","year":"2016","unstructured":"Nishimoto K, Seki T, Kurihara I, et al. Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism. The Journal of clinical endocrinology and metabolism 101: 6\u20139, 2016","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"9441_CR11","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0046-8177(93)90088-X","volume":"24","author":"H Sasano","year":"1993","unstructured":"Sasano H, Suzuki T, Nagura H, Nishikawa T. Steroidogenesis in human adrenocortical carcinoma: biochemical activities, immunohistochemistry, and in situ hybridization of steroidogenic enzymes and histopathologic study in nine cases. Human pathology 24: 397\u2013404, 1993.","journal-title":"Human pathology"},{"key":"9441_CR12","first-page":"23","volume":"5","author":"H Sasano","year":"1992","unstructured":"Sasano H, Miyazaki S, Sawai T, et al. Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases. Mod Pathol 5: 23\u201329, 1992.","journal-title":"Mod Pathol"},{"key":"9441_CR13","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1210\/jc.2011-1565","volume":"96","author":"W Arlt","year":"2011","unstructured":"Arlt W, Biehl M, Taylor AE, et al. Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. The Journal of clinical endocrinology and metabolism 96: 3775\u20133784, 2011.","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"9441_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mce.2014.05.002","volume":"392","author":"Y Nakamura","year":"2014","unstructured":"Nakamura Y, Maekawa T, Felizola SJ, et al. Adrenal CYP11B1\/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies. Molecular and cellular endocrinology 392: 73\u201379, 2014.","journal-title":"Molecular and cellular endocrinology"}],"container-title":["Endocrine Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-016-9441-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12022-016-9441-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-016-9441-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-016-9441-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:10:30Z","timestamp":1589739030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12022-016-9441-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,18]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["9441"],"URL":"https:\/\/doi.org\/10.1007\/s12022-016-9441-8","relation":{},"ISSN":["1046-3976","1559-0097"],"issn-type":[{"value":"1046-3976","type":"print"},{"value":"1559-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,18]]},"assertion":[{"value":"18 July 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}