{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:50:40Z","timestamp":1778935840761,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Ministry of Education, Culture, Sports, Science, and Technology-Japan, Grant-in-Aid for Scientific Research","award":["19K07412"],"award-info":[{"award-number":["19K07412"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocr Pathol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12022-020-09635-0","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T22:03:20Z","timestamp":1593295400000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Identification of Recurrent TERT Promoter Mutations in Intrathyroid Thymic Carcinomas"],"prefix":"10.1007","volume":"31","author":[{"given":"Ippei","family":"Tahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Hirokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"9635_CR1","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1007\/s00268-017-4339-2","volume":"42","author":"W Dong","year":"2018","unstructured":"Dong W, Zhang P, Li J, et al (2018) Outcome of Thyroid Carcinoma Showing Thymus-Like Differentiation in Patients Undergoing Radical Resection. World J Surg 42:1754\u20131761. https:\/\/doi.org\/10.1007\/s00268-017-4339-2","journal-title":"World J Surg"},{"key":"9635_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/BF01656263","volume":"9","author":"A Miyauchi","year":"1985","unstructured":"Miyauchi A, Kuma K, Matsuzuka F, et al (1985) Intrathyroidal epithelial thymoma: An entity distinct from squamous cell carcinoma of the thyroid. World J Surg 9:128\u2013134. https:\/\/doi.org\/10.1007\/BF01656263","journal-title":"World J Surg"},{"key":"9635_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jdcr.2019.02.021","volume":"22","author":"JKCRJ Chan","year":"1991","unstructured":"Chan JKC RJ (1991) Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol 22:349\u2013367. https:\/\/doi.org\/10.1016\/j.jdcr.2019.02.021","journal-title":"Hum Pathol"},{"key":"9635_CR4","volume-title":"World Health Organization Classification of Tumours of Endocrine Organs (4th)","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel G RJ (eds) (2017) World Health Organization Classification of Tumours of Endocrine Organs (4th). IARC, Lyon"},{"key":"9635_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/ajcp\/106.4.483","volume":"106","author":"K Berezowski","year":"1996","unstructured":"Berezowski K, Grimes MM, Gal A, Kornstein MJ (1996) CD5 immunoreactivity of epithelial cells in thymic carcinoma and CASTLE using paraffin-embedded tissue. Am J Clin Pathol 106:483\u2013486. https:\/\/doi.org\/10.1093\/ajcp\/106.4.483","journal-title":"Am J Clin Pathol"},{"key":"9635_CR6","doi-asserted-by":"publisher","unstructured":"Dorfman, Shahsafaei, Miyauchi (1998) Intrathyroidal epithelial thymoma (ITET)\/carcinoma showing thymus-like differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation. Histopathology 32:104\u2013109. https:\/\/doi.org\/10.1046\/j.1365-2559.1998.00318.x","DOI":"10.1046\/j.1365-2559.1998.00318.x"},{"key":"9635_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/bjs.4510","volume":"91","author":"S Roka","year":"2004","unstructured":"Roka S, Kornek G, Sch\u00fcller J, et al (2004) Carcinoma showing thymic-like elements - A rare malignancy of the thyroid gland. Br J Surg 91:142\u2013145. https:\/\/doi.org\/10.1002\/bjs.4510","journal-title":"Br J Surg"},{"key":"9635_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1507\/endocrj.K07E-147","volume":"55","author":"C Cappelli","year":"2008","unstructured":"Cappelli C, Tironi A, Marchetti G Pietro, et al (2008) Aggressive thyroid carcinoma showing thymic-like differentiation (CASTLE): case report and review of the literature. Endocr J 55:685\u201390. https:\/\/doi.org\/10.1507\/endocrj.K07E-147","journal-title":"Endocr J"},{"key":"9635_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00428-011-1117-7","volume":"459","author":"L Veits","year":"2011","unstructured":"Veits L, Mechtersheimer G, Steger C, et al (2011) Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE). Virchows Arch 459:221\u2013226. https:\/\/doi.org\/10.1007\/s00428-011-1117-7","journal-title":"Virchows Arch"},{"key":"9635_CR10","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/apm.12017","volume":"121","author":"M Hirokawa","year":"2013","unstructured":"Hirokawa M, Miyauchi A, Minato H, et al (2013) Intrathyroidal epithelial thymoma\/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. Apmis 121:523\u2013530. https:\/\/doi.org\/10.1111\/apm.12017","journal-title":"Apmis"},{"key":"9635_CR11","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.prp.2013.06.021","volume":"209","author":"C Huang","year":"2013","unstructured":"Huang C, Wang L, Wang Y, et al (2013) Carcinoma showing thymus-like differentiation of the thyroid (CASTLE). Pathol Res Pract 209:662\u2013665. https:\/\/doi.org\/10.1016\/j.prp.2013.06.021","journal-title":"Pathol Res Pract"},{"key":"9635_CR12","doi-asserted-by":"publisher","first-page":"718","DOI":"10.21037\/jtd.2016.03.24","volume":"8","author":"L Zhu","year":"2016","unstructured":"Zhu L, Zhang J, Marx A, et al (2016) Clinicopathological analysis of 241 thymic epithelial tumors-Experience in the Shanghai Chest Hospital from 1997-2004. J Thorac Dis 8:718\u2013726. https:\/\/doi.org\/10.21037\/jtd.2016.03.24","journal-title":"J Thorac Dis"},{"key":"9635_CR13","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1309\/VM7E52B6U9Q729DQ","volume":"127","author":"Y Ito","year":"2007","unstructured":"Ito Y, Miyauchi A, Nakamura Y, et al (2007) Clinicopathologic significance of intrathyroidal epithelial thymoma\/carcinoma showing thymus-like differentiation: A collaborative study with member Institutes of the Japanese Society of Thyroid Surgery. Am J Clin Pathol 127:230\u2013236. https:\/\/doi.org\/10.1309\/VM7E52B6U9Q729DQ","journal-title":"Am J Clin Pathol"},{"key":"9635_CR14","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.lungcan.2008.03.013","volume":"62","author":"K Yoh","year":"2008","unstructured":"Yoh K, Nishiwaki Y, Ishii G, et al (2008) Mutational status of EGFR and KIT in thymoma and thymic carcinoma. Lung Cancer 62:316\u2013320. https:\/\/doi.org\/10.1016\/j.lungcan.2008.03.013","journal-title":"Lung Cancer"},{"key":"9635_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.lungcan.2012.05.108","volume":"77","author":"A Weissferdt","year":"2012","unstructured":"Weissferdt A, Lin H, Woods D, et al (2012) HER family receptor and ligand status in thymic carcinoma. Lung Cancer 77:515\u2013521. https:\/\/doi.org\/10.1016\/j.lungcan.2012.05.108","journal-title":"Lung Cancer"},{"key":"9635_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.lungcan.2012.08.002","volume":"78","author":"A Weissferdt","year":"2012","unstructured":"Weissferdt A, Wistuba II, Moran CA (2012) Molecular aspects of thymic carcinoma. Lung Cancer 78:127\u2013132. https:\/\/doi.org\/10.1016\/j.lungcan.2012.08.002","journal-title":"Lung Cancer"},{"key":"9635_CR17","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1097\/JTO.0b013e3182a7d22e","volume":"9","author":"IS Hagemann","year":"2014","unstructured":"Hagemann IS, Govindan R, Javidan-Nejad C, et al (2014) Stabilization of Disease after Targeted Therapy in a Thymic Carcinoma with KIT Mutation Detected by Clinical Next-Generation Sequencing. J Thorac Oncol 9:e12\u2013e16. https:\/\/doi.org\/10.1097\/JTO.0b013e3182a7d22e","journal-title":"J Thorac Oncol"},{"key":"9635_CR18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.lungcan.2014.08.020","volume":"86","author":"M Shitara","year":"2014","unstructured":"Shitara M, Okuda K, Suzuki A, et al (2014) Genetic profiling of thymic carcinoma using targeted next-generation sequencing. Lung Cancer 86:174\u2013179. https:\/\/doi.org\/10.1016\/j.lungcan.2014.08.020","journal-title":"Lung Cancer"},{"key":"9635_CR19","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1093\/carcin\/bgx094","volume":"38","author":"M Saito","year":"2017","unstructured":"Saito M, Fujiwara Y, Asao T, et al (2017) The genomic and epigenomic landscape in thymic carcinoma. Carcinogenesis 38:1084\u20131091. https:\/\/doi.org\/10.1093\/carcin\/bgx094","journal-title":"Carcinogenesis"},{"key":"9635_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.ccell.2018.01.003","volume":"33","author":"M Radovich","year":"2018","unstructured":"Radovich M, Pickering CR, Felau I, et al (2018) The Integrated Genomic Landscape of Thymic Epithelial Tumors. Cancer Cell 33:244-258.e10. https:\/\/doi.org\/10.1016\/j.ccell.2018.01.003","journal-title":"Cancer Cell"},{"key":"9635_CR21","doi-asserted-by":"publisher","unstructured":"Yuan X, Larsson C, Xu D (2019) Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players. Oncogene. https:\/\/doi.org\/10.1038\/s41388-019-0872-9","DOI":"10.1038\/s41388-019-0872-9"},{"key":"9635_CR22","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.ejca.2015.03.010","volume":"51","author":"DS Huang","year":"2015","unstructured":"Huang DS, Wang Z, He XJ, et al (2015) Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. Eur J Cancer 51:969\u2013976. https:\/\/doi.org\/10.1016\/j.ejca.2015.03.010","journal-title":"Eur J Cancer"},{"key":"9635_CR23","doi-asserted-by":"publisher","unstructured":"Veits L, Schupfner R, Hufnagel P, et al (2014) KRAS, EGFR, PDGFR-\u03b1, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE). Disgnostic Pathol 9:. https:\/\/doi.org\/10.1186\/1746-1596-9-116","DOI":"10.1186\/1746-1596-9-116"},{"key":"9635_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/dc.23859","volume":"46","author":"M Rajeshwari","year":"2018","unstructured":"Rajeshwari M, Singh V, Nambirajan A, et al (2018) Carcinoma showing thymus like elements: report of a case with EGFR T790M mutation. Diagn Cytopathol 46:413\u2013418. https:\/\/doi.org\/10.1002\/dc.23859","journal-title":"Diagn Cytopathol"},{"key":"9635_CR25","volume-title":"World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart (4th)","year":"2015","unstructured":"Travis, W.D., Brambilla, E., Burke, A.P., Marx, A., Nicholson AG (eds) (2015) World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart (4th). IARC, Lyon"},{"key":"9635_CR26","doi-asserted-by":"publisher","first-page":"543","DOI":"10.14670\/HH-28.543","volume":"28","author":"K Kakudo","year":"2013","unstructured":"Kakudo K, Bai Y, Ozaki T, et al (2013) Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE). CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid. Histol Histopathol 28:543\u2013556. https:\/\/doi.org\/10.14670\/HH-28.543","journal-title":"Histol Histopathol"},{"key":"9635_CR27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/JTO.0000000000000397","volume":"10","author":"AL Moreira","year":"2015","unstructured":"Moreira AL, Won HH, Mcmillan R, et al (2015) Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated with poor prognosis. J Thorac Oncol 10:373\u2013380. https:\/\/doi.org\/10.1097\/JTO.0000000000000397","journal-title":"J Thorac Oncol"},{"key":"9635_CR28","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.lungcan.2015.03.003","volume":"88","author":"Y Katsuya","year":"2015","unstructured":"Katsuya Y, Fujita Y, Horinouchi H, et al (2015) Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. Lung Cancer 88:154\u2013159. https:\/\/doi.org\/10.1016\/j.lungcan.2015.03.003","journal-title":"Lung Cancer"},{"key":"9635_CR29","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.humpath.2013.12.018","volume":"45","author":"N Oishi","year":"2014","unstructured":"Oishi N, Kondo T, Mochizuki K, et al (2014) Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: A case report with immunohistochemical and genetic analyses. Hum Pathol 45:1302\u20131305. https:\/\/doi.org\/10.1016\/j.humpath.2013.12.018","journal-title":"Hum Pathol"},{"key":"9635_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/JTO.0b013e3181653c71","volume":"3","author":"M Yano","year":"2008","unstructured":"Yano M, Sasaki H, Yokoyama T, et al (2008) Thymic carcinoma: 30 Cases at a single institution. J Thorac Oncol 3:265\u2013269. https:\/\/doi.org\/10.1097\/JTO.0b013e3181653c71","journal-title":"J Thorac Oncol"},{"key":"9635_CR31","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1200\/JCO.2012.45.7739","volume":"29","author":"S Buti","year":"2011","unstructured":"Buti S, Donini M, Sergio P, Garagnani L, Schirosi L, Passalacqua R RG (2011) Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma. JClinOncol 29:803\u2013805. https:\/\/doi.org\/10.1200\/JCO.2012.45.7739","journal-title":"JClinOncol"},{"key":"9635_CR32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.athoracsur.2012.09.006","volume":"95","author":"B Weksler","year":"2013","unstructured":"Weksler B, Dhupar R, Parikh V, et al (2013) Thymic carcinoma: A multivariate analysis of factors predictive of survival in 290 patients. Ann Thorac Surg 95:299\u2013303. https:\/\/doi.org\/10.1016\/j.athoracsur.2012.09.006","journal-title":"Ann Thorac Surg"},{"key":"9635_CR33","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/JTO.0000000000000128","volume":"9","author":"E Ruffini","year":"2014","unstructured":"Ruffini E, Detterbeck F, van Raemdonck D, et al (2014) Thymic carcinoma: A cohort study of patients from the European society of thoracic surgeons database. J Thorac Oncol 9:541\u2013548. https:\/\/doi.org\/10.1097\/JTO.0000000000000128","journal-title":"J Thorac Oncol"},{"key":"9635_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2018.00477","volume":"8","author":"R Gao","year":"2018","unstructured":"Gao R, Jia X, Ji T, et al (2018) Management and Prognostic Factors for Thyroid Carcinoma Showing Thymus-Like Elements (CASTLE): A Case Series Study. Front Oncol 8:1\u20139. https:\/\/doi.org\/10.3389\/fonc.2018.00477","journal-title":"Front Oncol"},{"key":"9635_CR35","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1097\/JTO.0000000000000363","volume":"9","author":"AM Litvak","year":"2014","unstructured":"Litvak AM, , Kaitlin Woo, Sara Hayes, James Huang, Andreas Rimner, Camelia S Sima, Andre L Moreira, Maria Tsukazan GJR (2014) Clinical Characteristics and Outcomes for Patients With Thymic Carcinoma: Evaluation of Masaoka Staging. J Thorac Oncol 9:1810\u20131815. https:\/\/doi.org\/10.1097\/JTO.0000000000000363","journal-title":"J Thorac Oncol"},{"key":"9635_CR36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1309\/AJCPB7PS6QHWEFRK","volume":"143","author":"YF Wang","year":"2015","unstructured":"Wang YF, Liu B, Fan XS, et al (2015) Thyroid carcinoma showing thymus-like elements: A clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis. Am J Clin Pathol 143:223\u2013233. https:\/\/doi.org\/10.1309\/AJCPB7PS6QHWEFRK","journal-title":"Am J Clin Pathol"},{"key":"9635_CR37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00428-010-1000-y","volume":"458","author":"R Penzel","year":"2011","unstructured":"Penzel R, Sers C, Chen Y, et al (2011) EGFR mutation detection in NSCLC-assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Arch 458:95\u201398. https:\/\/doi.org\/10.1007\/s00428-010-1000-y","journal-title":"Virchows Arch"},{"key":"9635_CR38","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3892\/mco.2019.1926","volume":"11","author":"T Ito","year":"2019","unstructured":"Ito T, Matoba R, Maekawa H, et al (2019) Detection of gene mutations in gastric cancer tissues using a commercial sequencing panel. Mol Clin Oncol 11:455\u2013460. https:\/\/doi.org\/10.3892\/mco.2019.1926","journal-title":"Mol Clin Oncol"},{"key":"9635_CR39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.lungcan.2005.12.015","volume":"52","author":"S Murray","year":"2006","unstructured":"Murray S, Timotheadou E, Linardou H, et al (2006) Mutations of the epidermal growth factor receptor tyrosine kinase domain and associations with clinicopathological features in non-small cell lung cancer patients. Lung Cancer 52:225\u2013233. https:\/\/doi.org\/10.1016\/j.lungcan.2005.12.015","journal-title":"Lung Cancer"},{"key":"9635_CR40","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.5964\/ejop.v13i4.1198","volume":"11","author":"DA Douglas","year":"2006","unstructured":"Diah A Douglas, Hong Zhong, Jae Y Ro, Carole Oddoux, Aaron D Berger, Matthew R Pincus, Jaya M Satagopan, William L Gerald, Howard I Scher, Peng Lee IO (2006) Novel Mutations of Epidermal Growth Factor Receptor in Localized Prostate Cancer. Front Biosci 11:2518\u20132525. https:\/\/doi.org\/10.5964\/ejop.v13i4.1198","journal-title":"Front Biosci"},{"key":"9635_CR41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mrrev.2016.11.002","volume":"771","author":"B Heidenreich","year":"2017","unstructured":"Heidenreich B, Kumar R (2017) TERT promoter mutations in telomere biology. Mutat Res - Rev Mutat Res 771:15\u201331. https:\/\/doi.org\/10.1016\/j.mrrev.2016.11.002","journal-title":"Mutat Res - Rev Mutat Res"},{"key":"9635_CR42","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.biotechadv.2011.08.021.Secreted","volume":"20","author":"X Liu","year":"2013","unstructured":"Xiaoli Liu, Justin Bishop, Yuan Shan, Sara Pai DL (2013) Higyly prevalent TERT promotor mutations in aggressive thyoid cancers. Endocr Relat Cancer 20:603\u2013610. https:\/\/doi.org\/10.1016\/j.biotechadv.2011.08.021.Secreted","journal-title":"Endocr Relat Cancer"},{"key":"9635_CR43","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1038\/modpathol.2017.75","volume":"30","author":"N Oishi","year":"2017","unstructured":"Oishi N, Kondo T, Ebina A, et al (2017) Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: Identification of TERT mutation as an independent risk factor for transformation. Mod Pathol 30:1527\u20131537. https:\/\/doi.org\/10.1038\/modpathol.2017.75","journal-title":"Mod Pathol"},{"key":"9635_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers11101443","volume":"11","author":"M Hysek","year":"2019","unstructured":"Hysek M, Paulsson JO, Jatta K, et al (2019) Clinical routine tert promoter mutational screening of follicular thyroid tumors of uncertain malignant potential (Ft-umps): A useful predictor of metastatic disease. Cancers (Basel) 11:1\u201310. https:\/\/doi.org\/10.3390\/cancers11101443","journal-title":"Cancers (Basel)"},{"key":"9635_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-19-0073","volume":"181","author":"S Censi","year":"2019","unstructured":"Censi S, Barollo S, Grespan E, et al (2019) Prognostic significance of TERT promoter and BRAF mutations in TIR-4 and TIR-5 thyroid cytology. Eur J Endocrinol 181:1\u201311. https:\/\/doi.org\/10.1530\/EJE-19-0073","journal-title":"Eur J Endocrinol"}],"container-title":["Endocrine Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-020-09635-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12022-020-09635-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-020-09635-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T23:12:38Z","timestamp":1624749158000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12022-020-09635-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,27]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["9635"],"URL":"https:\/\/doi.org\/10.1007\/s12022-020-09635-0","relation":{},"ISSN":["1046-3976","1559-0097"],"issn-type":[{"value":"1046-3976","type":"print"},{"value":"1559-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,27]]},"assertion":[{"value":"27 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was conducted under the approval of the Institutional Ethical Review Board of University of Yamanashi (approval code: 1723).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}