{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:23:07Z","timestamp":1790752987985,"version":"4.1.0"},"reference-count":206,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Endocr Pathol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s12022-021-09667-0","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T14:03:32Z","timestamp":1612361012000},"page":"102-133","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-9081","authenticated-orcid":false,"given":"C. Christofer","family":"Juhlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-3008","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Bertherat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-8873","authenticated-orcid":false,"given":"Thomas J.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-3628","authenticated-orcid":false,"given":"Gary D.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-8641","authenticated-orcid":false,"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-2801","authenticated-orcid":false,"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"9667_CR1","doi-asserted-by":"publisher","first-page":"948","DOI":"10.5858\/arpa.2014-0156-RS","volume":"139","author":"K Duan","year":"2015","unstructured":"Duan K, Mete O (2015) Clinicopathologic Correlates of Primary Aldosteronism. Arch Pathol Lab Med 139:948\u2013954. https:\/\/doi.org\/10.5858\/arpa.2014-0156-RS","journal-title":"Arch Pathol Lab Med"},{"key":"9667_CR2","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.path.2019.08.005","volume":"12","author":"A Hodgson","year":"2019","unstructured":"Hodgson A, Pakbaz S, Mete O (2019) A Diagnostic Approach to Adrenocortical Tumors. Surg Pathol Clin 12:967\u2013995. https:\/\/doi.org\/10.1016\/j.path.2019.08.005","journal-title":"Surg Pathol Clin"},{"key":"9667_CR3","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1055\/s-0035-1565198","volume":"47","author":"M-C Zennaro","year":"2015","unstructured":"Zennaro M-C, Fernandes-Rosa F, Boulkroun S, Jeunemaitre X (2015) Bilateral Idiopathic Adrenal Hyperplasia: Genetics and Beyond. Horm Metab Res 47:947\u2013952. https:\/\/doi.org\/10.1055\/s-0035-1565198","journal-title":"Horm Metab Res"},{"key":"9667_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/cen.13442","volume":"87","author":"AT Nanba","year":"2017","unstructured":"Nanba AT, Nanba K, Byrd JB, Shields JJ, Giordano TJ, Miller BS, Rainey WE, Auchus RJ, Turcu AF (2017) Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism. Clin Endocrinol (Oxf) 87:665\u2013672. https:\/\/doi.org\/10.1111\/cen.13442","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9667_CR5","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1210\/jc.2016-2986","volume":"102","author":"Y Yamazaki","year":"2017","unstructured":"Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE, Tomlins SA, Rainey WE, Ito S, Satoh F, Sasano H (2017) Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism. J Clin Endocrinol Metab 102:1182\u20131192. https:\/\/doi.org\/10.1210\/jc.2016-2986","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.7326\/0003-4819-151-5-200909010-00007","volume":"151","author":"MJE Kempers","year":"2009","unstructured":"Kempers MJE, Lenders JWM, van Outheusden L, van der Wilt GJ, Schultze Kool LJ, Hermus ARMM, Deinum J (2009) Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism. Ann Intern Med 151:329\u2013337. https:\/\/doi.org\/10.7326\/0003-4819-151-5-200909010-00007","journal-title":"Ann Intern Med"},{"key":"9667_CR7","doi-asserted-by":"publisher","unstructured":"Sung T-Y, Alobuia WM, Tyagi MV, Ghosh C, Kebebew E (2020) Adrenal Vein Sampling to Distinguish Between Unilateral and Bilateral Primary Hyperaldosteronism: To ACTH Stimulate or Not? J Clin Med 9. https:\/\/doi.org\/10.3390\/jcm9051447","DOI":"10.3390\/jcm9051447"},{"key":"9667_CR8","doi-asserted-by":"publisher","first-page":"5867","DOI":"10.1210\/jc.2019-01182","volume":"104","author":"T Wannachalee","year":"2019","unstructured":"Wannachalee T, Zhao L, Nanba K, Nanba AT, Shields JJ, Rainey WE, Auchus RJ, Turcu AF (2019) Three Discrete Patterns of Primary Aldosteronism Lateralization in Response to Cosyntropin During Adrenal Vein Sampling. J Clin Endocrinol Metab 104:5867\u20135876. https:\/\/doi.org\/10.1210\/jc.2019-01182","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR9","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1161\/HYPERTENSIONAHA.118.11382","volume":"72","author":"TA Williams","year":"2018","unstructured":"Williams TA, Burrello J, Sechi LA, Fardella CE, Matrozova J, Adolf C, Baudrand R, Bernardi S, Beuschlein F, Catena C, Doumas M, Fallo F, Giacchetti G, Heinrich DA, Saint-Hilary G, Jansen PM, Januszewicz A, Kocjan T, Nishikawa T, Quinkler M, Satoh F, Umakoshi H, Widimsk\u00fd J, Hahner S, Douma S, Stowasser M, Mulatero P, Reincke M (2018) Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism. Hypertension 72:641\u2013649. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.118.11382","journal-title":"Hypertension"},{"key":"9667_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jamcollsurg.2019.03.012","volume":"229","author":"RA Campbell","year":"2019","unstructured":"Campbell RA, Young DS, Shaver CN, Snyder SK, Milan SA, Lairmore TC, McDonald DK (2019) Influence of Adrenal Venous Sampling on Management in Patients with Primary Aldosteronism Independent of Lateralization on Cross-Sectional Imaging. J Am Coll Surg 229:116\u2013124. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2019.03.012","journal-title":"J Am Coll Surg"},{"key":"9667_CR11","first-page":"3","volume":"45","author":"JW Conn","year":"1955","unstructured":"Conn JW (1955) Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med 45:3\u201317","journal-title":"J Lab Clin Med"},{"key":"9667_CR12","first-page":"661","volume":"45","author":"JW Conn","year":"1955","unstructured":"Conn JW (1955) Primary aldosteronism. J Lab Clin Med 45:661\u2013664","journal-title":"J Lab Clin Med"},{"key":"9667_CR13","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/pgmj.36.413.198","volume":"36","author":"TM Chalmers","year":"1960","unstructured":"Chalmers TM (1960) Conn\u2019s syndrome. Postgrad Med J 36:198\u2013200. https:\/\/doi.org\/10.1136\/pgmj.36.413.198","journal-title":"Postgrad Med J"},{"key":"9667_CR14","unstructured":"Duan K, Giordano TJ, Mete O (2016) Adrenal cortical proliferations. In: In: Mete O, Asa SL, eds. Endocrine Pathology. Cambridge University Press, pp 602\u2013627"},{"key":"9667_CR15","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12022-014-9307-x","volume":"25","author":"AC Griffin","year":"2014","unstructured":"Griffin AC, Kelz R, LiVolsi VA (2014) Aldosterone-secreting adrenal cortical carcinoma. A case report and review of the literature. Endocr Pathol 25:344\u2013349. https:\/\/doi.org\/10.1007\/s12022-014-9307-x","journal-title":"Endocr Pathol"},{"key":"9667_CR16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s12022-009-9082-2","volume":"20","author":"O Mete","year":"2009","unstructured":"Mete O, Asa SL (2009) Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions. Endocr Pathol 20:182\u2013185. https:\/\/doi.org\/10.1007\/s12022-009-9082-2","journal-title":"Endocr Pathol"},{"key":"9667_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fmed.2018.00054","volume":"5","author":"O Mete","year":"2018","unstructured":"Mete O, Duan K (2018) The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity. Front Med (Lausanne) 5:54. https:\/\/doi.org\/10.3389\/fmed.2018.00054","journal-title":"Front Med (Lausanne)"},{"key":"9667_CR18","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.mce.2016.10.014","volume":"441","author":"K Nishimoto","year":"2017","unstructured":"Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K (2017) Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism. Mol Cell Endocrinol 441:124\u2013133. https:\/\/doi.org\/10.1016\/j.mce.2016.10.014","journal-title":"Mol Cell Endocrinol"},{"key":"9667_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1210\/clinem\/dgaa484","volume":"106","author":"TA Williams","year":"2021","unstructured":"Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, Satoh F, Burrello J, Schneider H, Lenders JWM, Mulatero P, Castellano I, Kn\u00f6sel T, Papotti M, Saeger W, Sasano H, Reincke M (2021) International Histopathology Consensus for Unilateral Primary Aldosteronism. J Clin Endocrinol Metab 106:42\u201354. https:\/\/doi.org\/10.1210\/clinem\/dgaa484","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/1457496918822622","volume":"109","author":"C Volpe","year":"2020","unstructured":"Volpe C, Hamberger B, Zedenius J, Juhlin CC (2020) Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up. Scand J Surg 109:133\u2013142. https:\/\/doi.org\/10.1177\/1457496918822622","journal-title":"Scand J Surg"},{"key":"9667_CR21","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/pin.12521","volume":"67","author":"A Ito","year":"2017","unstructured":"Ito A, Yamazaki Y, Sasano H, Matsubara D, Fukushima N, Tamba M, Tabata K, Ashizawa K, Takei A, Koizumi M, Sakuma Y, Sata N, Oshiro H (2017) A case of primary aldosteronism caused by unilateral multiple adrenocortical micronodules presenting as muscle cramps at rest: The importance of functional histopathology for identifying a culprit lesion. Pathol Int 67:214\u2013221. https:\/\/doi.org\/10.1111\/pin.12521","journal-title":"Pathol Int"},{"key":"9667_CR22","doi-asserted-by":"publisher","unstructured":"Stenman A, Shabo I, Ramstr\u00f6m A, Zedenius J, Juhlin CC (2019) Synchronous aldosterone- and cortisol-producing adrenocortical adenomas diagnosed using CYP11B immunohistochemistry. SAGE Open Med Case Rep 7:2050313X19883770. https:\/\/doi.org\/10.1177\/2050313X19883770","DOI":"10.1177\/2050313X19883770"},{"key":"9667_CR23","doi-asserted-by":"publisher","first-page":"2808101","DOI":"10.1155\/2020\/2808101","volume":"2020","author":"K Oba","year":"2020","unstructured":"Oba K, Chiba Y, Matsuda Y, Kumakawa T, Aoyama R, Akahoshi M, Hashimoto S, Tachibana A, Toyoshima K, Kodera R, Toyoshima K, Tamura Y, Nagata T, Yamazaki Y, Sasano H, Araki A (2020) Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma. Case Rep Endocrinol 2020:2808101. https:\/\/doi.org\/10.1155\/2020\/2808101","journal-title":"Case Rep Endocrinol"},{"key":"9667_CR24","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1210\/jc.2015-3239","volume":"101","author":"K Nanba","year":"2016","unstructured":"Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE (2016) Molecular Heterogeneity in Aldosterone-Producing Adenomas. J Clin Endocrinol Metab 101:999\u20131007. https:\/\/doi.org\/10.1210\/jc.2015-3239","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR25","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1055\/a-1139-2079","volume":"52","author":"CE Gomez-Sanchez","year":"2020","unstructured":"Gomez-Sanchez CE, Gomez-Sanchez EP, Nishimoto K (2020) Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism. Horm Metab Res 52:421\u2013426. https:\/\/doi.org\/10.1055\/a-1139-2079","journal-title":"Horm Metab Res"},{"key":"9667_CR26","doi-asserted-by":"publisher","first-page":"K1","DOI":"10.1530\/EJE-16-0262","volume":"175","author":"K Nanba","year":"2016","unstructured":"Nanba K, Omata K, Tomlins SA, Giordano TJ, Hammer GD, Rainey WE, Else T (2016) Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations. Eur J Endocrinol 175:K1-6. https:\/\/doi.org\/10.1530\/EJE-16-0262","journal-title":"Eur J Endocrinol"},{"key":"9667_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1530\/ERC-20-0128","volume":"28","author":"S Faillot","year":"2021","unstructured":"Faillot S, Foulonneau T, N\u00e9ou M, Espiard S, Garinet S, Vaczlavik A, Jouinot A, Rondof W, Septier A, Drougat L, H\u00e9cale-Perlemoine K, Ragazzon B, Rizk-Rabin M, Sibony M, Bonnet-Serrano F, Guibourdenche J, Lib\u00e9 R, Groussin L, Dousset B, de Reyni\u00e8s A, Bertherat J, Assi\u00e9 G (2021) Genomic classification of benign adrenocortical lesions. Endocr Relat Cancer 28:79\u201395. https:\/\/doi.org\/10.1530\/ERC-20-0128","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR28","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1210\/jc.2013-3495","volume":"99","author":"B Howard","year":"2014","unstructured":"Howard B, Wang Y, Xekouki P, Faucz FR, Jain M, Zhang L, Meltzer PG, Stratakis CA, Kebebew E (2014) Integrated analysis of genome-wide methylation and gene expression shows epigenetic regulation of CYP11B2 in aldosteronomas. J Clin Endocrinol Metab 99:E536-543. https:\/\/doi.org\/10.1210\/jc.2013-3495","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR29","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1210\/en.2014-1782","volume":"156","author":"K Nanba","year":"2015","unstructured":"Nanba K, Chen A, Nishimoto K, Rainey WE (2015) Role of Ca(2+)\/calmodulin-dependent protein kinase kinase in adrenal aldosterone production. Endocrinology 156:1750\u20131756. https:\/\/doi.org\/10.1210\/en.2014-1782","journal-title":"Endocrinology"},{"key":"9667_CR30","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1198785","volume":"331","author":"M Choi","year":"2011","unstructured":"Choi M, Scholl UI, Yue P, Bj\u00f6rklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, \u00c5kerstr\u00f6m G, Wang W, Carling T, Lifton RP (2011) K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 331:768\u2013772. https:\/\/doi.org\/10.1126\/science.1198785","journal-title":"Science"},{"key":"9667_CR31","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.113.01733","volume":"63","author":"TA Williams","year":"2014","unstructured":"Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P (2014) Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension 63:188\u2013195. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.113.01733","journal-title":"Hypertension"},{"key":"9667_CR32","doi-asserted-by":"publisher","unstructured":"Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin P-F, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro M-C, Strom TM, Reincke M (2013) Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet 45:440\u2013444, 444e1\u20132. https:\/\/doi.org\/10.1038\/ng.2550","DOI":"10.1038\/ng.2550"},{"key":"9667_CR33","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ng.2716","volume":"45","author":"EAB Azizan","year":"2013","unstructured":"Azizan EAB, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AED, Davenport AP, Dekkers T, Tops B, K\u00fcsters B, Ceral J, Yeo GSH, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ (2013) Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 45:1055\u20131060. https:\/\/doi.org\/10.1038\/ng.2716","journal-title":"Nat Genet"},{"key":"9667_CR34","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/ng.2695","volume":"45","author":"UI Scholl","year":"2013","unstructured":"Scholl UI, Goh G, St\u00f6lting G, de Oliveira RC, Choi M, Overton JD, Fonseca AL, Korah R, Starker LF, Kunstman JW, Prasad ML, Hartung EA, Mauras N, Benson MR, Brady T, Shapiro JR, Loring E, Nelson-Williams C, Libutti SK, Mane S, Hellman P, Westin G, \u00c5kerstr\u00f6m G, Bj\u00f6rklund P, Carling T, Fahlke C, Hidalgo P, Lifton RP (2013) Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet 45:1050\u20131054. https:\/\/doi.org\/10.1038\/ng.2695","journal-title":"Nat Genet"},{"key":"9667_CR35","doi-asserted-by":"publisher","unstructured":"Nanba K, Yamazaki Y, Bick N, Onodera K, Tezuka Y, Omata K, Ono Y, Blinder AR, Tomlins SA, Rainey WE, Satoh F, Sasano H (2020) Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients. J Clin Endocrinol Metab 105. https:\/\/doi.org\/10.1210\/clinem\/dgaa595","DOI":"10.1210\/clinem\/dgaa595"},{"key":"9667_CR36","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/HYPERTENSIONAHA.119.14349","volume":"75","author":"K Nanba","year":"2020","unstructured":"Nanba K, Blinder AR, Rege J, Hattangady NG, Else T, Liu C-J, Tomlins SA, Vats P, Kumar-Sinha C, Giordano TJ, Rainey WE (2020) Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma. Hypertension 75:645\u2013649. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.14349","journal-title":"Hypertension"},{"key":"9667_CR37","doi-asserted-by":"publisher","unstructured":"Rege J, Nanba K, Blinder AR, Plaska S, Udager AM, Vats P, Kumar-Sinha C, Giordano TJ, Rainey WE, Else T (2020) Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas. J Endocr Soc 4:bvaa123. https:\/\/doi.org\/10.1210\/jendso\/bvaa123","DOI":"10.1210\/jendso\/bvaa123"},{"key":"9667_CR38","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","volume":"64","author":"FL Fernandes-Rosa","year":"2014","unstructured":"Fernandes-Rosa FL, Williams TA, Riester A, Steichen O, Beuschlein F, Boulkroun S, Strom TM, Monticone S, Amar L, Meatchi T, Mantero F, Cicala M-V, Quinkler M, Fallo F, Allolio B, Bernini G, Maccario M, Giacchetti G, Jeunemaitre X, Mulatero P, Reincke M, Zennaro M-C (2014) Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension 64:354\u2013361. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03419","journal-title":"Hypertension"},{"key":"9667_CR39","doi-asserted-by":"publisher","first-page":"E1089","DOI":"10.1210\/jc.2015-2149","volume":"100","author":"Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP","year":"2015","unstructured":"Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP (2015) A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma. J Clin Endocrinol Metab 100:E1089-1095. https:\/\/doi.org\/10.1210\/jc.2015-2149","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR40","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.118.12070","volume":"73","author":"K Nanba","year":"2019","unstructured":"Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE (2019) Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks. Hypertension 73:885\u2013892. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.118.12070","journal-title":"Hypertension"},{"key":"9667_CR41","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1210\/jc.2018-01004","volume":"103","author":"K Nanba","year":"2018","unstructured":"Nanba K, Omata K, Else T, Beck PCC, Nanba AT, Turcu AF, Miller BS, Giordano TJ, Tomlins SA, Rainey WE (2018) Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans. J Clin Endocrinol Metab 103:3869\u20133876. https:\/\/doi.org\/10.1210\/jc.2018-01004","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR42","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1530\/ERC-18-0385","volume":"26","author":"IC Mouat","year":"2019","unstructured":"Mouat IC, Omata K, McDaniel AS, Hattangady NG, Talapatra D, Cani AK, Hovelson DH, Tomlins SA, Rainey WE, Hammer GD, Giordano TJ, Else T (2019) Somatic mutations in adrenocortical carcinoma with primary aldosteronism or hyperreninemic hyperaldosteronism. Endocr Relat Cancer 26:217\u2013225. https:\/\/doi.org\/10.1530\/ERC-18-0385","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR43","doi-asserted-by":"publisher","first-page":"39121","DOI":"10.1038\/srep39121","volume":"7","author":"V-C Wu","year":"2017","unstructured":"Wu V-C, Wang S-M, Chueh S-CJ, Yang S-Y, Huang K-H, Lin Y-H, Wang J-J, Connolly R, Hu Y-H, Gomez-Sanchez CE, Peng K-Y, Wu K-D (2017) The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes. Sci Rep 7:39121. https:\/\/doi.org\/10.1038\/srep39121","journal-title":"Sci Rep"},{"key":"9667_CR44","doi-asserted-by":"publisher","first-page":"19546","DOI":"10.1038\/srep19546","volume":"6","author":"T \u00c5kerstr\u00f6m","year":"2016","unstructured":"\u00c5kerstr\u00f6m T, Maharjan R, Sven Willenberg H, Cupisti K, Ip J, Moser A, St\u00e5lberg P, Robinson B, Alexander Iwen K, Dralle H, Walz MK, Lehnert H, Sidhu S, Gomez-Sanchez C, Hellman P, Bj\u00f6rklund P (2016) Activating mutations in CTNNB1 in aldosterone producing adenomas. Sci Rep 6:19546. https:\/\/doi.org\/10.1038\/srep19546","journal-title":"Sci Rep"},{"key":"9667_CR45","doi-asserted-by":"publisher","unstructured":"Zheng S, Cherniack AD, Dewal N, Moffitt RA, Danilova L, Murray BA, Lerario AM, Else T, Knijnenburg TA, Ciriello G, Kim S, Assie G, Morozova O, Akbani R, Shih J, Hoadley KA, Choueiri TK, Waldmann J, Mete O, Robertson AG, Wu H-T, Raphael BJ, Shao L, Meyerson M, Demeure MJ, Beuschlein F, Gill AJ, Sidhu SB, Almeida MQ, Fragoso MCBV, Cope LM, Kebebew E, Habra MA, Whitsett TG, Bussey KJ, Rainey WE, Asa SL, Bertherat J, Fassnacht M, Wheeler DA, Cancer Genome Atlas Research Network, Hammer GD, Giordano TJ, Verhaak RGW (2016) Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma. Cancer Cell 29:723\u2013736. https:\/\/doi.org\/10.1016\/j.ccell.2016.04.002","DOI":"10.1016\/j.ccell.2016.04.002"},{"key":"9667_CR46","doi-asserted-by":"publisher","first-page":"E493","DOI":"10.1210\/jc.2014-3282","volume":"100","author":"CC Juhlin","year":"2015","unstructured":"Juhlin CC, Goh G, Healy JM, Fonseca AL, Scholl UI, Stenman A, Kunstman JW, Brown TC, Overton JD, Mane SM, Nelson-Williams C, B\u00e4ckdahl M, Suttorp A-C, Haase M, Choi M, Schlessinger J, Rimm DL, H\u00f6\u00f6g A, Prasad ML, Korah R, Larsson C, Lifton RP, Carling T (2015) Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma. J Clin Endocrinol Metab 100:E493-502. https:\/\/doi.org\/10.1210\/jc.2014-3282","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR47","doi-asserted-by":"publisher","first-page":"E419","DOI":"10.1210\/jc.2010-1885","volume":"96","author":"S Bonnet","year":"2011","unstructured":"Bonnet S, Gaujoux S, Launay P, Baudry C, Chokri I, Ragazzon B, Lib\u00e9 R, Ren\u00e9-Corail F, Audebourg A, Vacher-Lavenu M-C, Groussin L, Bertagna X, Dousset B, Bertherat J, Tissier F (2011) Wnt\/\u03b2-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors. J Clin Endocrinol Metab 96:E419-426. https:\/\/doi.org\/10.1210\/jc.2010-1885","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR48","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/hmg\/ddt484","volume":"23","author":"A Berthon","year":"2014","unstructured":"Berthon A, Drelon C, Ragazzon B, Boulkroun S, Tissier F, Amar L, Samson-Couterie B, Zennaro M-C, Plouin P-F, Skah S, Plateroti M, Lef\u00e8bvre H, Sahut-Barnola I, Batisse-Lignier M, Assi\u00e9 G, Lefran\u00e7ois-Martinez A-M, Bertherat J, Martinez A, Val P (2014) WNT\/\u03b2-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production. Hum Mol Genet 23:889\u2013905. https:\/\/doi.org\/10.1093\/hmg\/ddt484","journal-title":"Hum Mol Genet"},{"key":"9667_CR49","doi-asserted-by":"publisher","first-page":"R571","DOI":"10.1152\/ajpregu.00070.2009","volume":"297","author":"M Bhandaru","year":"2009","unstructured":"Bhandaru M, Kempe DS, Rotte A, Rexhepaj R, Kuhl D, Lang F (2009) Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. Am J Physiol Regul Integr Comp Physiol 297:R571-575. https:\/\/doi.org\/10.1152\/ajpregu.00070.2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9667_CR50","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/hmg\/ddq029","volume":"19","author":"A Berthon","year":"2010","unstructured":"Berthon A, Sahut-Barnola I, Lambert-Langlais S, de Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefran\u00e7ois-Martinez A-M, Martinez A, Val P (2010) Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development. Hum Mol Genet 19:1561\u20131576. https:\/\/doi.org\/10.1093\/hmg\/ddq029","journal-title":"Hum Mol Genet"},{"key":"9667_CR51","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1056\/NEJMoa1504869","volume":"373","author":"AED Teo","year":"2015","unstructured":"Teo AED, Garg S, Shaikh LH, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A, Bienz M, Azizan EAB, Brown MJ (2015) Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. N Engl J Med 373:1429\u20131436. https:\/\/doi.org\/10.1056\/NEJMoa1504869","journal-title":"N Engl J Med"},{"key":"9667_CR52","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1046\/j.1365-2265.2001.01192.x","volume":"55","author":"T Ise","year":"2001","unstructured":"Ise T, Shimoda A, Takakuwa H, Kato T, Izumiya Y, Shimizu K, Suzuki T, Sasano H, Yokoyama H, Kobayashi K (2001) A chimeric CYP11B1\/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism. Clin Endocrinol (Oxf) 55:131\u2013134. https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01192.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9667_CR53","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41588-018-0048-5","volume":"50","author":"UI Scholl","year":"2018","unstructured":"Scholl UI, St\u00f6lting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, Mertins P, Rump LC, Onder AM, Gamble C, McKenney D, Lash RW, Jones DP, Chune G, Gagliardi P, Choi M, Gordon R, Stowasser M, Fahlke C, Lifton RP (2018) CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Nat Genet 50:349\u2013354. https:\/\/doi.org\/10.1038\/s41588-018-0048-5","journal-title":"Nat Genet"},{"key":"9667_CR54","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1073\/pnas.1121407109","volume":"109","author":"UI Scholl","year":"2012","unstructured":"Scholl UI, Nelson-Williams C, Yue P, Grekin R, Wyatt RJ, Dillon MJ, Couch R, Hammer LK, Harley FL, Farhi A, Wang W-H, Lifton RP (2012) Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci U S A 109:2533\u20132538. https:\/\/doi.org\/10.1073\/pnas.1121407109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9667_CR55","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","volume":"59","author":"P Mulatero","year":"2012","unstructured":"Mulatero P, Tauber P, Zennaro M-C, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin P-F, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M (2012) KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension 59:235\u2013240. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.111.183996","journal-title":"Hypertension"},{"key":"9667_CR56","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ebiom.2016.10.002","volume":"13","author":"G Daniil","year":"2016","unstructured":"Daniil G, Fernandes-Rosa FL, Chemin J, Blesneac I, Beltrand J, Polak M, Jeunemaitre X, Boulkroun S, Amar L, Strom TM, Lory P, Zennaro M-C (2016) CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism. EBioMedicine 13:225\u2013236. https:\/\/doi.org\/10.1016\/j.ebiom.2016.10.002","journal-title":"EBioMedicine"},{"key":"9667_CR57","doi-asserted-by":"publisher","first-page":"e06315","DOI":"10.7554\/eLife.06315","volume":"4","author":"UI Scholl","year":"2015","unstructured":"Scholl UI, St\u00f6lting G, Nelson-Williams C, Vichot AA, Choi M, Loring E, Prasad ML, Goh G, Carling T, Juhlin CC, Quack I, Rump LC, Thiel A, Lande M, Frazier BG, Rasoulpour M, Bowlin DL, Sethna CB, Trachtman H, Fahlke C, Lifton RP (2015) Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. Elife 4:e06315. https:\/\/doi.org\/10.7554\/eLife.06315","journal-title":"Elife"},{"key":"9667_CR58","doi-asserted-by":"publisher","unstructured":"Semenova NA, Ryzhkova OR, Strokova TV, Taran NN (2018) [The third case report a patient with primary aldosteronism, seizures, and neurologic abnormalities (PASNA) syndrome de novo variant mutations in the CACNA1D gene]. Zh Nevrol Psikhiatr Im S S Korsakova 118:49\u201352. https:\/\/doi.org\/10.17116\/jnevro201811812149","DOI":"10.17116\/jnevro201811812149"},{"key":"9667_CR59","doi-asserted-by":"publisher","first-page":"E900","DOI":"10.1210\/jc.2014-4167","volume":"100","author":"M Zilbermint","year":"2015","unstructured":"Zilbermint M, Xekouki P, Faucz FR, Berthon A, Gkourogianni A, Schernthaner-Reiter MH, Batsis M, Sinaii N, Quezado MM, Merino M, Hodes A, Abraham SB, Lib\u00e9 R, Assi\u00e9 G, Espiard S, Drougat L, Ragazzon B, Davis A, Gebreab SY, Neff R, Kebebew E, Bertherat J, Lodish MB, Stratakis CA (2015) Primary Aldosteronism and ARMC5 Variants. J Clin Endocrinol Metab 100:E900-909. https:\/\/doi.org\/10.1210\/jc.2014-4167","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR60","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/jhh.2015.98","volume":"30","author":"P Mulatero","year":"2016","unstructured":"Mulatero P, Schiavi F, Williams TA, Monticone S, Barbon G, Opocher G, Fallo F (2016) ARMC5 mutation analysis in patients with primary aldosteronism and bilateral adrenal lesions. J Hum Hypertens 30:374\u2013378. https:\/\/doi.org\/10.1038\/jhh.2015.98","journal-title":"J Hum Hypertens"},{"key":"9667_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/ERC-20-0384","volume":"28","author":"M Rassi-Cruz","year":"2021","unstructured":"Rassi-Cruz M, Maria AG, Faucz FR, London E, Vilela LAP, Santana LS, Benedetti AFF, Goldbaum TS, Tanno FY, Srougi V, Chambo JL, Pereira MAA, Cavalcante ACBS, Carnevale FC, Pilan B, Bortolotto LA, F Drager L, Lerario AM, Latronico AC, Fragoso MCBV, Mendonca BB, Zerbini MCN, Stratakis CA, Almeida MQ (2021) Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism. Endocr Relat Cancer 28:1\u201313. https:\/\/doi.org\/10.1530\/ERC-20-0384","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR62","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12672-019-00375-0","volume":"11","author":"NG Hattangady","year":"2020","unstructured":"Hattangady NG, Foster J, Lerario AM, Ponce-Balbuena D, Rege J, Monticone S, Rainey WE, Mulatero P, Else T (2020) Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism. Horm Cancer 11:52\u201362. https:\/\/doi.org\/10.1007\/s12672-019-00375-0","journal-title":"Horm Cancer"},{"key":"9667_CR63","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1161\/HYPERTENSIONAHA.117.09057","volume":"70","author":"GC Tan","year":"2017","unstructured":"Tan GC, Negro G, Pinggera A, Tizen Laim NMS, Mohamed Rose I, Ceral J, Ryska A, Chin LK, Kamaruddin NA, Mohd Mokhtar N, A Jamal AR, Sukor N, Solar M, Striessnig J, Brown MJ, Azizan EA (2017) Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation. Hypertension 70:129\u2013136. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.117.09057","journal-title":"Hypertension"},{"key":"9667_CR64","doi-asserted-by":"publisher","first-page":"E819","DOI":"10.1210\/jc.2011-2965","volume":"97","author":"EAB Azizan","year":"2012","unstructured":"Azizan EAB, Lam BYH, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ (2012) Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors. J Clin Endocrinol Metab 97:E819-829. https:\/\/doi.org\/10.1210\/jc.2011-2965","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR65","doi-asserted-by":"publisher","first-page":"e41926","DOI":"10.1371\/journal.pone.0041926","volume":"7","author":"T \u00c5kerstr\u00f6m","year":"2012","unstructured":"\u00c5kerstr\u00f6m T, Crona J, Delgado Verdugo A, Starker LF, Cupisti K, Willenberg HS, Knoefel WT, Saeger W, Feller A, Ip J, Soon P, Anlauf M, Alesina PF, Schmid KW, Decaussin M, Levillain P, W\u00e4ngberg B, Peix J-L, Robinson B, Zedenius J, B\u00e4ckdahl M, Caramuta S, Iwen KA, Botling J, St\u00e5lberg P, Kraimps J-L, Dralle H, Hellman P, Sidhu S, Westin G, Lehnert H, Walz MK, \u00c5kerstr\u00f6m G, Carling T, Choi M, Lifton RP, Bj\u00f6rklund P (2012) Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS One 7:e41926. https:\/\/doi.org\/10.1371\/journal.pone.0041926","journal-title":"PLoS One"},{"key":"9667_CR66","doi-asserted-by":"publisher","first-page":"e0147590","DOI":"10.1371\/journal.pone.0147590","volume":"11","author":"AR Hong","year":"2016","unstructured":"Hong AR, Kim JH, Song YS, Lee KE, Seo SH, Seong M-W, Shin CS, Kim SW, Kim SY (2016) Genetics of Aldosterone-Producing Adenoma in Korean Patients. PLoS One 11:e0147590. https:\/\/doi.org\/10.1371\/journal.pone.0147590","journal-title":"PLoS One"},{"key":"9667_CR67","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1161\/HYPERTENSIONAHA.115.05993","volume":"66","author":"FL Fernandes-Rosa","year":"2015","unstructured":"Fernandes-Rosa FL, Giscos-Douriez I, Amar L, Gomez-Sanchez CE, Meatchi T, Boulkroun S, Zennaro M-C (2015) Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma. Hypertension 66:1014\u20131022. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.115.05993","journal-title":"Hypertension"},{"key":"9667_CR68","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12022-018-9525-8","volume":"29","author":"O Mete","year":"2018","unstructured":"Mete O, Asa SL, Giordano TJ, Papotti M, Sasano H, Volante M (2018) Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms. Endocr Pathol 29:137\u2013149. https:\/\/doi.org\/10.1007\/s12022-018-9525-8","journal-title":"Endocr Pathol"},{"key":"9667_CR69","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.mce.2015.04.022","volume":"411","author":"S Monticone","year":"2015","unstructured":"Monticone S, Castellano I, Versace K, Lucatello B, Veglio F, Gomez-Sanchez CE, Williams TA, Mulatero P (2015) Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas. Mol Cell Endocrinol 411:146\u2013154. https:\/\/doi.org\/10.1016\/j.mce.2015.04.022","journal-title":"Mol Cell Endocrinol"},{"key":"9667_CR70","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1530\/EJE-14-1113","volume":"172","author":"A Thiel","year":"2015","unstructured":"Thiel A, Reis A-C, Haase M, Goh G, Schott M, Willenberg HS, Scholl UI (2015) PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia: a single-center study of 60 cases. Eur J Endocrinol 172:677\u2013685. https:\/\/doi.org\/10.1530\/EJE-14-1113","journal-title":"Eur J Endocrinol"},{"key":"9667_CR71","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1507\/endocrj.ej12-0247","volume":"59","author":"M Yamada","year":"2012","unstructured":"Yamada M, Nakajima Y, Taguchi R, Okamura T, Ishii S, Tomaru T, Ozawa A, Shibusawa N, Yoshino S, Toki A, Ishida E, Hashimoto K, Satoh T, Mori M (2012) KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas. Endocr J 59:735\u2013741. https:\/\/doi.org\/10.1507\/endocrj.ej12-0247","journal-title":"Endocr J"},{"key":"9667_CR72","doi-asserted-by":"publisher","first-page":"4920841","DOI":"10.1155\/2018\/4920841","volume":"2018","author":"L Tang","year":"2018","unstructured":"Tang L, Li X, Wang B, Ma X, Li H, Gao Y, Gu L, Nie W, Zhang X (2018) Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism. Int J Endocrinol 2018:4920841. https:\/\/doi.org\/10.1155\/2018\/4920841","journal-title":"Int J Endocrinol"},{"key":"9667_CR73","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.path.2019.08.010","volume":"12","author":"A Vaidya","year":"2019","unstructured":"Vaidya A, Nehs M, Kilbridge K (2019) Treatment of Adrenocortical Carcinoma. Surg Pathol Clin 12:997\u20131006. https:\/\/doi.org\/10.1016\/j.path.2019.08.010","journal-title":"Surg Pathol Clin"},{"key":"9667_CR74","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/PAS.0000000000000943","volume":"42","author":"O Mete","year":"2018","unstructured":"Mete O, Gucer H, Kefeli M, Asa SL (2018) Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma. Am J Surg Pathol 42:201\u2013213. https:\/\/doi.org\/10.1097\/PAS.0000000000000943","journal-title":"Am J Surg Pathol"},{"key":"9667_CR75","doi-asserted-by":"publisher","unstructured":"Mete O, Asa SL (2012) Morphological distinction of cortisol-producing and aldosterone-producing adrenal cortical adenomas: not only possible but a critical clinical responsibility. Histopathology 60:1015\u20131016; author reply 1016\u20131017. https:\/\/doi.org\/10.1111\/j.1365-2559.2011.04141.x","DOI":"10.1111\/j.1365-2559.2011.04141.x"},{"key":"9667_CR76","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1055\/a-1061-7349","volume":"52","author":"A Berthon","year":"2020","unstructured":"Berthon A, Bertherat J (2020) Update of Genetic and Molecular Causes of Adrenocortical Hyperplasias Causing Cushing Syndrome. Horm Metab Res 52:598\u2013606. https:\/\/doi.org\/10.1055\/a-1061-7349","journal-title":"Horm Metab Res"},{"key":"9667_CR77","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1210\/jc.2002-020592","volume":"87","author":"L Groussin","year":"2002","unstructured":"Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J (2002) Mutations of the PRKAR1A gene in Cushing\u2019s syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 87:4324\u20134329. https:\/\/doi.org\/10.1210\/jc.2002-020592","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR78","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1086\/344579","volume":"71","author":"L Groussin","year":"2002","unstructured":"Groussin L, Kirschner LS, Vincent-Dejean C, Perlemoine K, Jullian E, Delemer B, Zacharieva S, Pignatelli D, Carney JA, Luton JP, Bertagna X, Stratakis CA, Bertherat J (2002) Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am J Hum Genet 71:1433\u20131442. https:\/\/doi.org\/10.1086\/344579","journal-title":"Am J Hum Genet"},{"key":"9667_CR79","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1210\/jc.2005-2708","volume":"91","author":"L Groussin","year":"2006","unstructured":"Groussin L, Horvath A, Jullian E, Boikos S, Rene-Corail F, Lefebvre H, Cephise-Velayoudom F-L, Vantyghem M-C, Chanson P, Conte-Devolx B, Lucas M, Gentil A, Malchoff CD, Tissier F, Carney JA, Bertagna X, Stratakis CA, Bertherat J (2006) A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds. J Clin Endocrinol Metab 91:1943\u20131949. https:\/\/doi.org\/10.1210\/jc.2005-2708","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR80","doi-asserted-by":"publisher","first-page":"101428","DOI":"10.1016\/j.beem.2020.101428","volume":"34","author":"CDC Kamilaris","year":"2020","unstructured":"Kamilaris CDC, Hannah-Shmouni F, Stratakis CA (2020) Adrenocortical tumorigenesis: Lessons from genetics. Best Pract Res Clin Endocrinol Metab 34:101428. https:\/\/doi.org\/10.1016\/j.beem.2020.101428","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9667_CR81","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1136\/jmg.40.4.268","volume":"40","author":"L Matyakhina","year":"2003","unstructured":"Matyakhina L, Pack S, Kirschner LS, Pak E, Mannan P, Jaikumar J, Taymans SE, Sandrini F, Carney JA, Stratakis CA (2003) Chromosome 2 (2p16) abnormalities in Carney complex tumours. J Med Genet 40:268\u2013277. https:\/\/doi.org\/10.1136\/jmg.40.4.268","journal-title":"J Med Genet"},{"key":"9667_CR82","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/ejhg.2008.85","volume":"16","author":"A Horvath","year":"2008","unstructured":"Horvath A, Giatzakis C, Tsang K, Greene E, Osorio P, Boikos S, Lib\u00e8 R, Patronas Y, Robinson-White A, Remmers E, Bertherat J, Nesterova M, Stratakis CA (2008) A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Eur J Hum Genet 16:1245\u20131253. https:\/\/doi.org\/10.1038\/ejhg.2008.85","journal-title":"Eur J Hum Genet"},{"key":"9667_CR83","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1055\/s-2008-1076694","volume":"40","author":"SA Boikos","year":"2008","unstructured":"Boikos SA, Horvath A, Heyerdahl S, Stein E, Robinson-White A, Bossis I, Bertherat J, Carney JA, Stratakis CA (2008) Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions. Horm Metab Res 40:347\u2013353. https:\/\/doi.org\/10.1055\/s-2008-1076694","journal-title":"Horm Metab Res"},{"key":"9667_CR84","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.humpath.2014.09.005","volume":"46","author":"JA Carney","year":"2015","unstructured":"Carney JA, Lyssikatos C, Lodish MB, Stratakis CA (2015) Germline PRKACA amplification leads to Cushing syndrome caused by 3 adrenocortical pathologic phenotypes. Hum Pathol 46:40\u201349. https:\/\/doi.org\/10.1016\/j.humpath.2014.09.005","journal-title":"Hum Pathol"},{"key":"9667_CR85","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1530\/ERC-20-0309","volume":"27","author":"S Espiard","year":"2020","unstructured":"Espiard S, Drougat L, Settas N, Haydar S, Bathon K, London E, Levy I, Faucz FR, Calebiro D, Bertherat J, Li D, Levine MA, Stratakis CA (2020) PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A. Endocr Relat Cancer 27:647\u2013656. https:\/\/doi.org\/10.1530\/ERC-20-0309","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR86","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2265.2008.03273.x","volume":"69","author":"M Tadjine","year":"2008","unstructured":"Tadjine M, Lampron A, Ouadi L, Horvath A, Stratakis CA, Bourdeau I (2008) Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). Clin Endocrinol (Oxf) 69:367\u2013373. https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03273.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9667_CR87","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1158\/0008-5472.CAN-09-0155","volume":"69","author":"D Iliopoulos","year":"2009","unstructured":"Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA (2009) MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. Cancer Res 69:3278\u20133282. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-0155","journal-title":"Cancer Res"},{"key":"9667_CR88","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1210\/jcem-24-10-947","volume":"24","author":"MA Kirschner","year":"1964","unstructured":"Kirschner MA, Powell RD, Lipsett MB (1964) CUSHING\u2019S SYNDROME: NODULAR CORTICAL HYPERPLASIA OF ADRENAL GLANDS WITH CLINICAL AND PATHOLOGICAL FEATURES SUGGESTING ADRENOCORTICAL TUMOR. J Clin Endocrinol Metab 24:947\u2013955. https:\/\/doi.org\/10.1210\/jcem-24-10-947","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR89","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","volume":"369","author":"G Assi\u00e9","year":"2013","unstructured":"Assi\u00e9 G, Lib\u00e9 R, Espiard S, Rizk-Rabin M, Guimier A, Luscap W, Barreau O, Lef\u00e8vre L, Sibony M, Guignat L, Rodriguez S, Perlemoine K, Ren\u00e9-Corail F, Letourneur F, Trabulsi B, Poussier A, Chabbert-Buffet N, Borson-Chazot F, Groussin L, Bertagna X, Stratakis CA, Ragazzon B, Bertherat J (2013) ARMC5 mutations in macronodular adrenal hyperplasia with Cushing\u2019s syndrome. N Engl J Med 369:2105\u20132114. https:\/\/doi.org\/10.1056\/NEJMoa1304603","journal-title":"N Engl J Med"},{"key":"9667_CR90","doi-asserted-by":"publisher","first-page":"E926","DOI":"10.1210\/jc.2014-4204","volume":"100","author":"S Espiard","year":"2015","unstructured":"Espiard S, Drougat L, Lib\u00e9 R, Assi\u00e9 G, Perlemoine K, Guignat L, Barrande G, Brucker-Davis F, Doullay F, Lopez S, Sonnet E, Torremocha F, Pinsard D, Chabbert-Buffet N, Raffin-Sanson M-L, Groussin L, Borson-Chazot F, Coste J, Bertagna X, Stratakis CA, Beuschlein F, Ragazzon B, Bertherat J (2015) ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal Hyperplasia: Clinical and Functional Consequences. J Clin Endocrinol Metab 100:E926-935. https:\/\/doi.org\/10.1210\/jc.2014-4204","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR91","doi-asserted-by":"publisher","first-page":"E1113","DOI":"10.1210\/jc.2013-4280","volume":"99","author":"FR Faucz","year":"2014","unstructured":"Faucz FR, Zilbermint M, Lodish MB, Szarek E, Trivellin G, Sinaii N, Berthon A, Lib\u00e9 R, Assi\u00e9 G, Espiard S, Drougat L, Ragazzon B, Bertherat J, Stratakis CA (2014) Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation. J Clin Endocrinol Metab 99:E1113-1119. https:\/\/doi.org\/10.1210\/jc.2013-4280","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR92","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1001\/archsurg.1996.01430190021006","volume":"131","author":"JR Burgess","year":"1996","unstructured":"Burgess JR, Harle RA, Tucker P, Parameswaran V, Davies P, Greenaway TM, Shepherd JJ (1996) Adrenal lesions in a large kindred with multiple endocrine neoplasia type 1. Arch Surg 131:699\u2013702. https:\/\/doi.org\/10.1001\/archsurg.1996.01430190021006","journal-title":"Arch Surg"},{"key":"9667_CR93","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1507\/endocrj.k10e-218","volume":"58","author":"M Yoshida","year":"2011","unstructured":"Yoshida M, Hiroi M, Imai T, Kikumori T, Himeno T, Nakamura Y, Sasano H, Yamada M, Murakami Y, Nakamura S, Oiso Y (2011) A case of ACTH-independent macronodular adrenal hyperplasia associated with multiple endocrine neoplasia type 1. Endocr J 58:269\u2013277. https:\/\/doi.org\/10.1507\/endocrj.k10e-218","journal-title":"Endocr J"},{"key":"9667_CR94","doi-asserted-by":"publisher","first-page":"4016","DOI":"10.1158\/1078-0432.CCR-08-0106","volume":"14","author":"R Lib\u00e9","year":"2008","unstructured":"Lib\u00e9 R, Fratticci A, Coste J, Tissier F, Horvath A, Ragazzon B, Rene-Corail F, Groussin L, Bertagna X, Raffin-Sanson ML, Stratakis CA, Bertherat J (2008) Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors. Clin Cancer Res 14:4016\u20134024. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-0106","journal-title":"Clin Cancer Res"},{"key":"9667_CR95","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1210\/jc.2009-0516","volume":"94","author":"H-P Hsiao","year":"2009","unstructured":"Hsiao H-P, Kirschner LS, Bourdeau I, Keil MF, Boikos SA, Verma S, Robinson-White AJ, Nesterova M, Lacroix A, Stratakis CA (2009) Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors. J Clin Endocrinol Metab 94:2930\u20132937. https:\/\/doi.org\/10.1210\/jc.2009-0516","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR96","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.1158\/1078-0432.CCR-10-1497","volume":"16","author":"S Gaujoux","year":"2010","unstructured":"Gaujoux S, Pinson S, Gimenez-Roqueplo A-P, Amar L, Ragazzon B, Launay P, Meatchi T, Lib\u00e9 R, Bertagna X, Audebourg A, Zucman-Rossi J, Tissier F, Bertherat J (2010) Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. Clin Cancer Res 16:5133\u20135141. https:\/\/doi.org\/10.1158\/1078-0432.CCR-10-1497","journal-title":"Clin Cancer Res"},{"key":"9667_CR97","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fendo.2016.00111","volume":"7","author":"F Hannah-Shmouni","year":"2016","unstructured":"Hannah-Shmouni F, Faucz FR, Stratakis CA (2016) Alterations of Phosphodiesterases in Adrenocortical Tumors. Front Endocrinol (Lausanne) 7:111. https:\/\/doi.org\/10.3389\/fendo.2016.00111","journal-title":"Front Endocrinol (Lausanne)"},{"key":"9667_CR98","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1210\/jc.2004-2377","volume":"90","author":"L Matyakhina","year":"2005","unstructured":"Matyakhina L, Freedman RJ, Bourdeau I, Wei M-H, Stergiopoulos SG, Chidakel A, Walther M, Abu-Asab M, Tsokos M, Keil M, Toro J, Linehan WM, Stratakis CA (2005) Hereditary leiomyomatosis associated with bilateral, massive, macronodular adrenocortical disease and atypical cushing syndrome: a clinical and molecular genetic investigation. J Clin Endocrinol Metab 90:3773\u20133779. https:\/\/doi.org\/10.1210\/jc.2004-2377","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR99","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1507\/endocrj.k10e-003","volume":"57","author":"T Hamajima","year":"2010","unstructured":"Hamajima T, Maruwaka K, Homma K, Matsuo K, Fujieda K, Hasegawa T (2010) Unilateral adrenalectomy can be an alternative therapy for infantile onset Cushing\u2019 s syndrome caused by ACTH-independent macronodular adrenal hyperplasia with McCune-Albright syndrome. Endocr J 57:819\u2013824. https:\/\/doi.org\/10.1507\/endocrj.k10e-003","journal-title":"Endocr J"},{"key":"9667_CR100","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.tem.2004.08.007","volume":"15","author":"A Lacroix","year":"2004","unstructured":"Lacroix A, Baldacchino V, Bourdeau I, Hamet P, Tremblay J (2004) Cushing\u2019s syndrome variants secondary to aberrant hormone receptors. Trends Endocrinol Metab 15:375\u2013382. https:\/\/doi.org\/10.1016\/j.tem.2004.08.007","journal-title":"Trends Endocrinol Metab"},{"key":"9667_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03689.x","volume":"73","author":"A Lacroix","year":"2010","unstructured":"Lacroix A, Bourdeau I, Lampron A, Mazzuco TL, Tremblay J, Hamet P (2010) Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction. Clin Endocrinol (Oxf) 73:1\u201315. https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03689.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9667_CR102","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3109\/07435809809032694","volume":"24","author":"A Lacroix","year":"1998","unstructured":"Lacroix A, N\u2019Diaye N, Mircescu H, Hamet P, Tremblay J (1998) Abnormal expression and function of hormone receptors in adrenal Cushing\u2019s syndrome. Endocr Res 24:835\u2013843. https:\/\/doi.org\/10.3109\/07435809809032694","journal-title":"Endocr Res"},{"key":"9667_CR103","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1590\/s0004-27302007000900007","volume":"51","author":"TL Mazzuco","year":"2007","unstructured":"Mazzuco TL, Thomas M, Martinie M, Cherradi N, Sturm N, Feige J-J, Chabre O (2007) Cellular and molecular abnormalities of a macronodular adrenal hyperplasia causing beta-blocker-sensitive Cushing\u2019s syndrome. Arq Bras Endocrinol Metabol 51:1452\u20131462. https:\/\/doi.org\/10.1590\/s0004-27302007000900007","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"9667_CR104","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1056\/NEJMoa1215245","volume":"369","author":"E Louiset","year":"2013","unstructured":"Louiset E, Duparc C, Young J, Renouf S, Tetsi Nomigni M, Boutelet I, Lib\u00e9 R, Bram Z, Groussin L, Caron P, Tabarin A, Grunenberger F, Christin-Maitre S, Bertagna X, Kuhn J-M, Anouar Y, Bertherat J, Lefebvre H (2013) Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia. N Engl J Med 369:2115\u20132125. https:\/\/doi.org\/10.1056\/NEJMoa1215245","journal-title":"N Engl J Med"},{"key":"9667_CR105","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1210\/jc.2002-030014","volume":"88","author":"H Lefebvre","year":"2003","unstructured":"Lefebvre H, Duparc C, Chartrel N, Jegou S, Pellerin A, Laquerriere A, Ivell R, Vaudry H, Kuhn J-M (2003) Intraadrenal adrenocorticotropin production in a case of bilateral macronodular adrenal hyperplasia causing Cushing\u2019s syndrome. J Clin Endocrinol Metab 88:3035\u20133042. https:\/\/doi.org\/10.1210\/jc.2002-030014","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR106","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1210\/jc.2005-2608","volume":"91","author":"I Bourdeau","year":"2006","unstructured":"Bourdeau I, Matyakhina L, Stergiopoulos SG, Sandrini F, Boikos S, Stratakis CA (2006) 17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. J Clin Endocrinol Metab 91:3626\u20133632. https:\/\/doi.org\/10.1210\/jc.2005-2608","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR107","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1056\/NEJM199210013271402","volume":"327","author":"A Lacroix","year":"1992","unstructured":"Lacroix A, Bolt\u00e9 E, Tremblay J, Dupr\u00e9 J, Poitras P, Fournier H, Garon J, Garrel D, Bayard F, Taillefer R (1992) Gastric inhibitory polypeptide-dependent cortisol hypersecretion--a new cause of Cushing\u2019s syndrome. N Engl J Med 327:974\u2013980. https:\/\/doi.org\/10.1056\/NEJM199210013271402","journal-title":"N Engl J Med"},{"key":"9667_CR108","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1310359","volume":"370","author":"F Beuschlein","year":"2014","unstructured":"Beuschlein F, Fassnacht M, Assi\u00e9 G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B (2014) Constitutive activation of PKA catalytic subunit in adrenal Cushing\u2019s syndrome. N Engl J Med 370:1019\u20131028. https:\/\/doi.org\/10.1056\/NEJMoa1310359","journal-title":"N Engl J Med"},{"key":"9667_CR109","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/ng.2956","volume":"46","author":"G Goh","year":"2014","unstructured":"Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kunstman JW, Kuntsman JW, Korah R, Suttorp A-C, Dietrich D, Haase M, Willenberg HS, St\u00e5lberg P, Hellman P, Akerstr\u00f6m G, Bj\u00f6rklund P, Carling T, Lifton RP (2014) Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. Nat Genet 46:613\u2013617. https:\/\/doi.org\/10.1038\/ng.2956","journal-title":"Nat Genet"},{"key":"9667_CR110","doi-asserted-by":"publisher","first-page":"E2093","DOI":"10.1210\/jc.2014-2152","volume":"99","author":"G Di Dalmazi","year":"2014","unstructured":"Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Julli\u00e9 M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M (2014) Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing\u2019s syndrome: a European multicentric study. J Clin Endocrinol Metab 99:E2093-2100. https:\/\/doi.org\/10.1210\/jc.2014-2152","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR111","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1507\/endocrj.ej14-0282","volume":"61","author":"Y Nakajima","year":"2014","unstructured":"Nakajima Y, Okamura T, Gohko T, Satoh T, Hashimoto K, Shibusawa N, Ozawa A, Ishii S, Tomaru T, Horiguchi K, Okada S, Takata D, Rokutanda N, Horiguchi J, Tsushima Y, Oyama T, Takeyoshi I, Yamada M (2014) Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. Endocr J 61:825\u2013832. https:\/\/doi.org\/10.1507\/endocrj.ej14-0282","journal-title":"Endocr J"},{"key":"9667_CR112","first-page":"5308","volume":"63","author":"J Bertherat","year":"2003","unstructured":"Bertherat J, Groussin L, Sandrini F, Matyakhina L, Bei T, Stergiopoulos S, Papageorgiou T, Bourdeau I, Kirschner LS, Vincent-Dejean C, Perlemoine K, Gicquel C, Bertagna X, Stratakis CA (2003) Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity. Cancer Res 63:5308\u20135319","journal-title":"Cancer Res"},{"key":"9667_CR113","doi-asserted-by":"publisher","unstructured":"Espiard S, Knape MJ, Bathon K, Assi\u00e9 G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J (2018) Activating PRKACB somatic mutation in cortisol-producing adenomas. JCI Insight 3. https:\/\/doi.org\/10.1172\/jci.insight.98296","DOI":"10.1172\/jci.insight.98296"},{"key":"9667_CR114","doi-asserted-by":"publisher","unstructured":"Ronchi CL, Di Dalmazi G, Faillot S, Sbiera S, Assi\u00e9 G, Weigand I, Calebiro D, Schwarzmayr T, Appenzeller S, Rubin B, Waldmann J, Scaroni C, Bartsch DK, Mantero F, Mannelli M, Kastelan D, Chiodini I, Bertherat J, Reincke M, Strom TM, Fassnacht M, Beuschlein F, European Network for the Study of Adrenocortical Tumors (ENSAT) (2016) Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation. J Clin Endocrinol Metab 101:3526\u20133538. https:\/\/doi.org\/10.1210\/jc.2016-1586","DOI":"10.1210\/jc.2016-1586"},{"key":"9667_CR115","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1126\/science.1252328","volume":"344","author":"Y Sato","year":"2014","unstructured":"Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H, Shiozawa Y, Kataoka K, Kon A, Aoki K, Chiba K, Tanaka H, Kume H, Miyano S, Fukayama M, Nureki O, Homma Y, Ogawa S (2014) Recurrent somatic mutations underlie corticotropin-independent Cushing\u2019s syndrome. Science 344:917\u2013920. https:\/\/doi.org\/10.1126\/science.1252328","journal-title":"Science"},{"key":"9667_CR116","doi-asserted-by":"publisher","first-page":"105764","DOI":"10.1016\/j.jsbmb.2020.105764","volume":"204","author":"X Gao","year":"2020","unstructured":"Gao X, Yamazaki Y, Tezuka Y, Pieroni J, Ishii K, Atsumi N, Ono Y, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H (2020) Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; \u223cAn association among morphometry, genotype and cellular senescence\u223c. J Steroid Biochem Mol Biol 204:105764. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105764","journal-title":"J Steroid Biochem Mol Biol"},{"key":"9667_CR117","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1210\/jc.2009-0031","volume":"94","author":"E Louiset","year":"2009","unstructured":"Louiset E, Stratakis CA, Perraudin V, Griffin KJ, Lib\u00e9 R, Cabrol S, F\u00e8ve B, Young J, Groussin L, Bertherat J, Lefebvre H (2009) The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. J Clin Endocrinol Metab 94:2406\u20132413. https:\/\/doi.org\/10.1210\/jc.2009-0031","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR118","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1530\/EJE-15-0209","volume":"173","author":"R Correa","year":"2015","unstructured":"Correa R, Salpea P, Stratakis CA (2015) Carney complex: an update. Eur J Endocrinol 173:M85-97. https:\/\/doi.org\/10.1530\/EJE-15-0209","journal-title":"Eur J Endocrinol"},{"key":"9667_CR119","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1530\/ERC-20-0273","volume":"27","author":"AG Maria","year":"2020","unstructured":"Maria AG, Tatsi C, Berthon A, Drougat L, Settas N, Hannah-Shmouni F, Bertherat J, Faucz FR, Stratakis CA (2020) ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing\u2019s syndrome. Endocr Relat Cancer 27:509\u2013517. https:\/\/doi.org\/10.1530\/ERC-20-0273","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR120","doi-asserted-by":"publisher","first-page":"E202","DOI":"10.1210\/jc.2011-2321","volume":"97","author":"E Morin","year":"2012","unstructured":"Morin E, Mete O, Wasserman JD, Joshua AM, Asa SL, Ezzat S (2012) Carney complex with adrenal cortical carcinoma. J Clin Endocrinol Metab 97:E202-206. https:\/\/doi.org\/10.1210\/jc.2011-2321","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR121","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1210\/jc.2011-2244","volume":"97","author":"J Anselmo","year":"2012","unstructured":"Anselmo J, Medeiros S, Carneiro V, Greene E, Levy I, Nesterova M, Lyssikatos C, Horvath A, Carney JA, Stratakis CA (2012) A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer. J Clin Endocrinol Metab 97:351\u2013359. https:\/\/doi.org\/10.1210\/jc.2011-2244","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR122","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1530\/EJE-15-0205","volume":"173","author":"R Correa","year":"2015","unstructured":"Correa R, Zilbermint M, Berthon A, Espiard S, Batsis M, Papadakis GZ, Xekouki P, Lodish MB, Bertherat J, Faucz FR, Stratakis CA (2015) The ARMC5 gene shows extensive genetic variance in primary macronodular adrenocortical hyperplasia. Eur J Endocrinol 173:435\u2013440. https:\/\/doi.org\/10.1530\/EJE-15-0205","journal-title":"Eur J Endocrinol"},{"key":"9667_CR123","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.coemr.2019.07.010","volume":"8","author":"CA Stratakis","year":"2019","unstructured":"Stratakis CA, Berthon A (2019) Molecular mechanisms of ARMC5 mutations in adrenal pathophysiology. Curr Opin Endocr Metab Res 8:104\u2013111. https:\/\/doi.org\/10.1016\/j.coemr.2019.07.010","journal-title":"Curr Opin Endocr Metab Res"},{"key":"9667_CR124","volume-title":"WHO classification of tumours of endocrine organs","author":"Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J, International Agency for Research on Cancer","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J, International Agency for Research on Cancer (2017) WHO classification of tumours of endocrine organs, 4th edition. International Agency for Research on Cancer, Lyon","edition":"4"},{"key":"9667_CR125","doi-asserted-by":"publisher","unstructured":"Lib\u00e9 R (2019) Clinical and molecular prognostic factors in adrenocortical carcinoma. Minerva Endocrinol 44:58\u201369. https:\/\/doi.org\/10.23736\/S0391-1977.18.02900-0","DOI":"10.23736\/S0391-1977.18.02900-0"},{"key":"9667_CR126","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/bjs.9743","volume":"102","author":"R Mihai","year":"2015","unstructured":"Mihai R (2015) Diagnosis, treatment and outcome of adrenocortical cancer. Br J Surg 102:291\u2013306. https:\/\/doi.org\/10.1002\/bjs.9743","journal-title":"Br J Surg"},{"key":"9667_CR127","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1530\/EJE-13-0519","volume":"169","author":"M Ayala-Ramirez","year":"2013","unstructured":"Ayala-Ramirez M, Jasim S, Feng L, Ejaz S, Deniz F, Busaidy N, Waguespack SG, Naing A, Sircar K, Wood CG, Pagliaro L, Jimenez C, Vassilopoulou-Sellin R, Habra MA (2013) Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care center. Eur J Endocrinol 169:891\u2013899. https:\/\/doi.org\/10.1530\/EJE-13-0519","journal-title":"Eur J Endocrinol"},{"key":"9667_CR128","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14721","author":"CR Corso","year":"2020","unstructured":"Corso CR, Acco A, Bach C, Bonatto SJR, de Figueiredo BC, de Souza LM (2020) Pharmacological profile and effects of mitotane in adrenocortical carcinoma. Br J Clin Pharmacol. https:\/\/doi.org\/10.1111\/bcp.14721","journal-title":"Br J Clin Pharmacol"},{"key":"9667_CR129","doi-asserted-by":"publisher","first-page":"101415","DOI":"10.1016\/j.beem.2020.101415","volume":"34","author":"S Puglisi","year":"2020","unstructured":"Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M (2020) New perspectives for mitotane treatment of adrenocortical carcinoma. Best Pract Res Clin Endocrinol Metab 34:101415. https:\/\/doi.org\/10.1016\/j.beem.2020.101415","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9667_CR130","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1055\/a-0715-1946","volume":"127","author":"F Megerle","year":"2019","unstructured":"Megerle F, Kroiss M, Hahner S, Fassnacht M (2019) Advanced Adrenocortical Carcinoma - What to do when First-Line Therapy Fails? Exp Clin Endocrinol Diabetes 127:109\u2013116. https:\/\/doi.org\/10.1055\/a-0715-1946","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"9667_CR131","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.surg.2019.05.049","volume":"166","author":"JK Mills","year":"2019","unstructured":"Mills JK, Khalil M, Pasieka J, Kong S, Xu Y, Harvey A (2019) Oncocytic subtypes of adrenal cortical carcinoma: Aggressive in appearance yet more indolent in behavior? Surgery 166:524\u2013533. https:\/\/doi.org\/10.1016\/j.surg.2019.05.049","journal-title":"Surgery"},{"key":"9667_CR132","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/his.13255","volume":"72","author":"LA Erickson","year":"2018","unstructured":"Erickson LA (2018) Challenges in surgical pathology of adrenocortical tumours. Histopathology 72:82\u201396. https:\/\/doi.org\/10.1111\/his.13255","journal-title":"Histopathology"},{"key":"9667_CR133","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3346\/jkms.2017.32.5.764","volume":"32","author":"TY Sung","year":"2017","unstructured":"Sung TY, Choi YM, Kim WG, Lee YM, Kim TY, Shong YK, Kim WB, Song DE (2017) Myxoid and Sarcomatoid Variants of Adrenocortical Carcinoma: Analysis of Rare Variants in Single Tertiary Care Center. J Korean Med Sci 32:764\u2013771. https:\/\/doi.org\/10.3346\/jkms.2017.32.5.764","journal-title":"J Korean Med Sci"},{"key":"9667_CR134","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1309\/AJCPCDZLC13RSXRZ","volume":"139","author":"A Weissferdt","year":"2013","unstructured":"Weissferdt A, Phan A, Suster S, Moran CA (2013) Myxoid adrenocortical carcinoma: a clinicopathologic and immunohistochemical study of 7 cases, including 1 case with lipomatous metaplasia. Am J Clin Pathol 139:780\u2013786. https:\/\/doi.org\/10.1309\/AJCPCDZLC13RSXRZ","journal-title":"Am J Clin Pathol"},{"key":"9667_CR135","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.humpath.2016.08.006","volume":"58","author":"TG Papathomas","year":"2016","unstructured":"Papathomas TG, Duregon E, Korpershoek E, Restuccia DF, van Marion R, Cappellesso R, Sturm N, Rossi G, Coli A, Zucchini N, Stoop H, Oosterhuis W, Ventura L, Volante M, Fassina A, Dinjens WNM, Papotti M, de Krijger RR (2016) Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis. Hum Pathol 58:113\u2013122. https:\/\/doi.org\/10.1016\/j.humpath.2016.08.006","journal-title":"Hum Pathol"},{"key":"9667_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.10.001","author":"TJ Giordano","year":"2020","unstructured":"Giordano TJ, Berney D, de Krijger RR, Erickson L, Fassnacht M, Mete O, Papathomas T, Papotti M, Sasano H, Thompson LDR, Volante M, Gill AJ (2020) Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Hum Pathol. https:\/\/doi.org\/10.1016\/j.humpath.2020.10.001","journal-title":"Hum Pathol"},{"key":"9667_CR137","first-page":"343","volume":"122","author":"MR Wick","year":"1986","unstructured":"Wick MR, Cherwitz DL, McGlennen RC, Dehner LP (1986) Adrenocortical carcinoma. An immunohistochemical comparison with renal cell carcinoma. Am J Pathol 122:343\u2013352","journal-title":"Am J Pathol"},{"key":"9667_CR138","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1053\/hupa.2003.24","volume":"34","author":"W Saeger","year":"2003","unstructured":"Saeger W, Fassnacht M, Chita R, Prager G, Nies C, Lorenz K, B\u00e4rlehner E, Simon D, Niederle B, Beuschlein F, Allolio B, Reincke M (2003) High diagnostic accuracy of adrenal core biopsy: results of the German and Austrian adrenal network multicenter trial in 220 consecutive patients. Hum Pathol 34:180\u2013186. https:\/\/doi.org\/10.1053\/hupa.2003.24","journal-title":"Hum Pathol"},{"key":"9667_CR139","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1136\/jcp.51.6.477","volume":"51","author":"R Chetty","year":"1998","unstructured":"Chetty R, Pillay P, Jaichand V (1998) Cytokeratin expression in adrenal phaeochromocytomas and extra-adrenal paragangliomas. J Clin Pathol 51:477\u2013478. https:\/\/doi.org\/10.1136\/jcp.51.6.477","journal-title":"J Clin Pathol"},{"key":"9667_CR140","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12022-013-9291-6","volume":"25","author":"M Papotti","year":"2014","unstructured":"Papotti M, Duregon E, Volante M, McNicol AM (2014) Pathology of the adrenal cortex: a reappraisal of the past 25 years focusing on adrenal cortical tumors. Endocr Pathol 25:35\u201348. https:\/\/doi.org\/10.1007\/s12022-013-9291-6","journal-title":"Endocr Pathol"},{"key":"9667_CR141","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","volume":"13","author":"LM Weiss","year":"1989","unstructured":"Weiss LM, Medeiros LJ, Vickery AL (1989) Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 13:202\u2013206. https:\/\/doi.org\/10.1097\/00000478-198903000-00004","journal-title":"Am J Surg Pathol"},{"key":"9667_CR142","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/106689690401200304","volume":"12","author":"M Bisceglia","year":"2004","unstructured":"Bisceglia M, Ludovico O, Di Mattia A, Ben-Dor D, Sandbank J, Pasquinelli G, Lau SK, Weiss LM (2004) Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 12:231\u2013243. https:\/\/doi.org\/10.1177\/106689690401200304","journal-title":"Int J Surg Pathol"},{"key":"9667_CR143","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1097\/00000478-200307000-00001","volume":"27","author":"JA Wieneke","year":"2003","unstructured":"Wieneke JA, Thompson LDR, Heffess CS (2003) Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol 27:867\u2013881. https:\/\/doi.org\/10.1097\/00000478-200307000-00001","journal-title":"Am J Surg Pathol"},{"key":"9667_CR144","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1097\/00000478-200212000-00009","volume":"26","author":"S Aubert","year":"2002","unstructured":"Aubert S, Wacrenier A, Leroy X, Devos P, Carnaille B, Proye C, Wemeau JL, Lecomte-Houcke M, Leteurtre E (2002) Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg Pathol 26:1612\u20131619. https:\/\/doi.org\/10.1097\/00000478-200212000-00009","journal-title":"Am J Surg Pathol"},{"key":"9667_CR145","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/his.12283","volume":"64","author":"C Wang","year":"2014","unstructured":"Wang C, Sun Y, Wu H, Zhao D, Chen J (2014) Distinguishing adrenal cortical carcinomas and adenomas: a study of clinicopathological features and biomarkers. Histopathology 64:567\u2013576. https:\/\/doi.org\/10.1111\/his.12283","journal-title":"Histopathology"},{"key":"9667_CR146","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.jpedsurg.2016.07.014","volume":"51","author":"S Das","year":"2016","unstructured":"Das S, Sengupta M, Islam N, Roy P, Datta C, Mishra PK, Banerjee S, Chaudhuri MK, Chatterjee U (2016) Weineke criteria, Ki-67 index and p53 status to study pediatric adrenocortical tumors: Is there a correlation? J Pediatr Surg 51:1795\u20131800. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.07.014","journal-title":"J Pediatr Surg"},{"key":"9667_CR147","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/j.jpedsurg.2018.12.002","volume":"54","author":"VA Guntiboina","year":"2019","unstructured":"Guntiboina VA, Sengupta M, Islam N, Barman S, Biswas SK, Chatterjee U, Mishra PK, Roy P, Mallick MG, Datta C (2019) Diagnostic and prognostic utility of SF1, IGF2 and p57 immunoexpression in pediatric adrenal cortical tumors. J Pediatr Surg 54:1906\u20131912. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.12.002","journal-title":"J Pediatr Surg"},{"key":"9667_CR148","doi-asserted-by":"publisher","unstructured":"Magro G, Esposito G, Cecchetto G, Dall\u2019Igna P, Marcato R, Gambini C, Boldrini R, Collini P, D\u2019Onofrio V, Salfi N, d\u2019Amore E, Ferrari A, Bisogno G, Alaggio R (2012) Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohistochemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (HLA) class II antigens. Results from the Italian Pediatric Rare Tumor (TREP) Study project. Hum Pathol 43:31\u201339. https:\/\/doi.org\/10.1016\/j.humpath.2011.04.016","DOI":"10.1016\/j.humpath.2011.04.016"},{"key":"9667_CR149","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1097\/PAS.0b013e31828d387b","volume":"37","author":"E Duregon","year":"2013","unstructured":"Duregon E, Fassina A, Volante M, Nesi G, Santi R, Gatti G, Cappellesso R, Dalino Ciaramella P, Ventura L, Gambacorta M, Dei Tos AP, Loli P, Mannelli M, Mantero F, Berruti A, Terzolo M, Papotti M (2013) The reticulin algorithm for adrenocortical tumor diagnosis: a multicentric validation study on 245 unpublished cases. Am J Surg Pathol 37:1433\u20131440. https:\/\/doi.org\/10.1097\/PAS.0b013e31828d387b","journal-title":"Am J Surg Pathol"},{"key":"9667_CR150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humpath.2016.09.035","volume":"62","author":"E Duregon","year":"2017","unstructured":"Duregon E, Cappellesso R, Maffeis V, Zaggia B, Ventura L, Berruti A, Terzolo M, Fassina A, Volante M, Papotti M (2017) Validation of the prognostic role of the \u201cHelsinki Score\u201d in 225 cases of adrenocortical carcinoma. Hum Pathol 62:1\u20137. https:\/\/doi.org\/10.1016\/j.humpath.2016.09.035","journal-title":"Hum Pathol"},{"key":"9667_CR151","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.humpath.2014.11.015","volume":"46","author":"M Pennanen","year":"2015","unstructured":"Pennanen M, Heiskanen I, Sane T, Remes S, Mustonen H, Haglund C, Arola J (2015) Helsinki score-a novel model for prediction of metastases in adrenocortical carcinomas. Hum Pathol 46:404\u2013410. https:\/\/doi.org\/10.1016\/j.humpath.2014.11.015","journal-title":"Hum Pathol"},{"key":"9667_CR152","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/s41379-018-0077-8","volume":"31","author":"K Renaudin","year":"2018","unstructured":"Renaudin K, Smati S, Wargny M, Al Ghuzlan A, Aubert S, Leteurtre E, Patey M, Sibony M, Sturm N, Tissier F, Amar L, Bertherat J, Berthozat C, Chabre O, Do Cao C, Haissaguerre M, Pierre P, Briet C, Vezzosi D, Lifante JC, Pattou F, Mirallie E, Baudin E, Cariou B, Libe R, Drui D, for Comete-Cancer Network (2018) Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation. Mod Pathol 31:1708\u20131716. https:\/\/doi.org\/10.1038\/s41379-018-0077-8","journal-title":"Mod Pathol"},{"key":"9667_CR153","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/(SICI)1096-9896(199702)181:2<146::AID-PATH744>3.0.CO;2-7","volume":"181","author":"AM McNicol","year":"1997","unstructured":"McNicol AM, Nolan CE, Struthers AJ, Farquharson MA, Hermans J, Haak HR (1997) Expression of p53 in adrenocortical tumours: clinicopathological correlations. J Pathol 181:146\u2013152. https:\/\/doi.org\/10.1002\/(SICI)1096-9896(199702)181:2146::AID-PATH7443.0.CO;2-7","journal-title":"J Pathol"},{"key":"9667_CR154","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1210\/jcem.78.3.8126158","volume":"78","author":"M Reincke","year":"1994","unstructured":"Reincke M, Karl M, Travis WH, Mastorakos G, Allolio B, Linehan HM, Chrousos GP (1994) p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies. J Clin Endocrinol Metab 78:790\u2013794. https:\/\/doi.org\/10.1210\/jcem.78.3.8126158","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR155","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1097\/01.MP.0000081730.72305.81","volume":"16","author":"A Stojadinovic","year":"2003","unstructured":"Stojadinovic A, Brennan MF, Hoos A, Omeroglu A, Leung DHY, Dudas ME, Nissan A, Cordon-Cardo C, Ghossein RA (2003) Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Mod Pathol 16:742\u2013751. https:\/\/doi.org\/10.1097\/01.MP.0000081730.72305.81","journal-title":"Mod Pathol"},{"key":"9667_CR156","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1055\/s-2007-993164","volume":"116","author":"A Babinska","year":"2008","unstructured":"Babinska A, Sworczak K, Wisniewski P, Na\u0142ecz A, Jaskiewicz K (2008) The role of immunohistochemistry in histopathological diagnostics of clinically \u201csilent\u201d incidentally detected adrenal masses. Exp Clin Endocrinol Diabetes 116:246\u2013251. https:\/\/doi.org\/10.1055\/s-2007-993164","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"9667_CR157","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1158\/1078-0432.CCR-08-1067","volume":"15","author":"TJ Giordano","year":"2009","unstructured":"Giordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G, Hammer G (2009) Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res 15:668\u2013676. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-1067","journal-title":"Clin Cancer Res"},{"key":"9667_CR158","doi-asserted-by":"publisher","unstructured":"Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M, Phaeochromocytoma Study Group in Japan (2014) Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer 21:405\u2013414. https:\/\/doi.org\/10.1530\/ERC-13-0494","DOI":"10.1530\/ERC-13-0494"},{"key":"9667_CR159","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/PAS.0000000000000574","volume":"40","author":"TG Papathomas","year":"2016","unstructured":"Papathomas TG, Pucci E, Giordano TJ, Lu H, Duregon E, Volante M, Papotti M, Lloyd RV, Tischler AS, van Nederveen FH, Nose V, Erickson L, Mete O, Asa SL, Turchini J, Gill AJ, Matias-Guiu X, Skordilis K, Stephenson TJ, Tissier F, Feelders RA, Smid M, Nigg A, Korpershoek E, van der Spek PJ, Dinjens WNM, Stubbs AP, de Krijger RR (2016) An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma. Am J Surg Pathol 40:569\u2013576. https:\/\/doi.org\/10.1097\/PAS.0000000000000574","journal-title":"Am J Surg Pathol"},{"key":"9667_CR160","unstructured":"Mete O, Davis J, Rudzinski E, Asa S, Baker T, Berman M, Erickson L, Giordano T, Thompson L, Tischler A, Weiss L (2020) College of American Pathologists (CAP) Protocol for the Examination of Specimens From Patients With Carcinoma of the Adrenal Gland. Version: 4.1.0.0."},{"key":"9667_CR161","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1126\/science.1978757","volume":"250","author":"D Malkin","year":"1990","unstructured":"Malkin D, Li FP, Strong LC, Fraumeni JF, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233\u20131238. https:\/\/doi.org\/10.1126\/science.1978757","journal-title":"Science"},{"key":"9667_CR162","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/348747a0","volume":"348","author":"S Srivastava","year":"1990","unstructured":"Srivastava S, Zou ZQ, Pirollo K, Blattner W, Chang EH (1990) Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348:747\u2013749. https:\/\/doi.org\/10.1038\/348747a0","journal-title":"Nature"},{"key":"9667_CR163","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/ijc.2910540310","volume":"54","author":"H Ohgaki","year":"1993","unstructured":"Ohgaki H, Kleihues P, Heitz PU (1993) p53 mutations in sporadic adrenocortical tumors. Int J Cancer 54:408\u2013410. https:\/\/doi.org\/10.1002\/ijc.2910540310","journal-title":"Int J Cancer"},{"key":"9667_CR164","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/ng.2953","volume":"46","author":"G Assi\u00e9","year":"2014","unstructured":"Assi\u00e9 G, Letouz\u00e9 E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, Ren\u00e9-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Lib\u00e9 R, de Reyni\u00e8s A, Bertherat J (2014) Integrated genomic characterization of adrenocortical carcinoma. Nat Genet 46:607\u2013612. https:\/\/doi.org\/10.1038\/ng.2953","journal-title":"Nat Genet"},{"key":"9667_CR165","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s10689-010-9416-8","volume":"10","author":"V Medina-Arana","year":"2011","unstructured":"Medina-Arana V, Delgado L, Gonz\u00e1lez L, Bravo A, D\u00edaz H, Salido E, Riverol D, Gonz\u00e1lez-Aguilera JJ, Fern\u00e1ndez-Peralta AM (2011) Adrenocortical carcinoma, an unusual extracolonic tumor associated with Lynch II syndrome. Fam Cancer 10:265\u2013271. https:\/\/doi.org\/10.1007\/s10689-010-9416-8","journal-title":"Fam Cancer"},{"key":"9667_CR166","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1053\/hupa.2000.20409","volume":"31","author":"MJ Berends","year":"2000","unstructured":"Berends MJ, Cats A, Hollema H, Karrenbeld A, Beentjes JA, Sijmons RH, Mensink RG, Hofstra RM, Verschueren RC, Kleibeuker JH (2000) Adrenocortical adenocarcinoma in an MSH2 carrier: coincidence or causal relation? Hum Pathol 31:1522\u20131527. https:\/\/doi.org\/10.1053\/hupa.2000.20409","journal-title":"Hum Pathol"},{"key":"9667_CR167","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1007\/BF02236860","volume":"43","author":"TG Smith","year":"2000","unstructured":"Smith TG, Clark SK, Katz DE, Reznek RH, Phillips RK (2000) Adrenal masses are associated with familial adenomatous polyposis. Dis Colon Rectum 43:1739\u20131742. https:\/\/doi.org\/10.1007\/BF02236860","journal-title":"Dis Colon Rectum"},{"key":"9667_CR168","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1210\/jcem.75.1.1352309","volume":"75","author":"B Skogseid","year":"1992","unstructured":"Skogseid B, Larsson C, Lindgren PG, Kvanta E, Rastad J, Theodorsson E, Wide L, Wilander E, Oberg K (1992) Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 75:76\u201381. https:\/\/doi.org\/10.1210\/jcem.75.1.1352309","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR169","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s12020-010-9424-3","volume":"39","author":"M Haase","year":"2011","unstructured":"Haase M, Anlauf M, Schott M, Schinner S, Kaminsky E, Scherbaum WA, Willenberg HS (2011) A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma. Endocrine 39:153\u2013159. https:\/\/doi.org\/10.1007\/s12020-010-9424-3","journal-title":"Endocrine"},{"key":"9667_CR170","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1477-7819-9-6","volume":"9","author":"JE Griniatsos","year":"2011","unstructured":"Griniatsos JE, Dimitriou N, Zilos A, Sakellariou S, Evangelou K, Kamakari S, Korkolopoulou P, Kaltsas G (2011) Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene. World J Surg Oncol 9:6. https:\/\/doi.org\/10.1186\/1477-7819-9-6","journal-title":"World J Surg Oncol"},{"key":"9667_CR171","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11060-005-0376-z","volume":"75","author":"AS Wagner","year":"2005","unstructured":"Wagner AS, Fleitz JM, Kleinschmidt-Demasters BK (2005) Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature. J Neurooncol 75:127\u2013133. https:\/\/doi.org\/10.1007\/s11060-005-0376-z","journal-title":"J Neurooncol"},{"key":"9667_CR172","doi-asserted-by":"publisher","first-page":"140074","DOI":"10.1530\/EDM-14-0074","volume":"2014","author":"RK Menon","year":"2014","unstructured":"Menon RK, Ferrau F, Kurzawinski TR, Rumsby G, Freeman A, Amin Z, Korbonits M, Chung T-TLL (2014) Adrenal cancer in neurofibromatosis type 1: case report and DNA analysis. Endocrinol Diabetes Metab Case Rep 2014:140074. https:\/\/doi.org\/10.1530\/EDM-14-0074","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"9667_CR173","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1159\/000486678","volume":"94","author":"M Kieler","year":"2018","unstructured":"Kieler M, M\u00fcllauer L, Koperek O, Bianconi D, Unseld M, Raderer M, Prager GW (2018) Analysis of 10 Adrenocortical Carcinoma Patients in the Cohort of the Precision Medicine Platform MONDTI. Oncology 94:306\u2013310. https:\/\/doi.org\/10.1159\/000486678","journal-title":"Oncology"},{"key":"9667_CR174","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF00279003","volume":"81","author":"I Henry","year":"1989","unstructured":"Henry I, Jeanpierre M, Couillin P, Barichard F, Serre JL, Journel H, Lamouroux A, Turleau C, de Grouchy J, Junien C (1989) Molecular definition of the 11p15.5 region involved in Beckwith-Wiedemann syndrome and probably in predisposition to adrenocortical carcinoma. Hum Genet 81:273\u2013277. https:\/\/doi.org\/10.1007\/BF00279003","journal-title":"Hum Genet"},{"key":"9667_CR175","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1210\/jcem.78.6.7911125","volume":"78","author":"C Gicquel","year":"1994","unstructured":"Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton JP, Girard F, Le Bouc Y (1994) Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors. J Clin Endocrinol Metab 78:1444\u20131453. https:\/\/doi.org\/10.1210\/jcem.78.6.7911125","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR176","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1530\/ERC-15-0086","volume":"22","author":"HM Nielsen","year":"2015","unstructured":"Nielsen HM, How-Kit A, Guerin C, Castinetti F, Vollan HKM, De Micco C, Daunay A, Taieb D, Van Loo P, Besse C, Kristensen VN, Hansen LL, Barlier A, Sebag F, Tost J (2015) Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors. Endocr Relat Cancer 22:953\u2013967. https:\/\/doi.org\/10.1530\/ERC-15-0086","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR177","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/oxfordjournals.jbchem.a022661","volume":"127","author":"H Sasaki","year":"2000","unstructured":"Sasaki H, Ishihara K, Kato R (2000) Mechanisms of Igf2\/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation. J Biochem 127:711\u2013715. https:\/\/doi.org\/10.1093\/oxfordjournals.jbchem.a022661","journal-title":"J Biochem"},{"key":"9667_CR178","doi-asserted-by":"publisher","first-page":"12417","DOI":"10.1073\/pnas.0801540105","volume":"105","author":"T Yoshimizu","year":"2008","unstructured":"Yoshimizu T, Miroglio A, Ripoche M-A, Gabory A, Vernucci M, Riccio A, Colnot S, Godard C, Terris B, Jammes H, Dandolo L (2008) The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A 105:12417\u201312422. https:\/\/doi.org\/10.1073\/pnas.0801540105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9667_CR179","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/ng0593-94","volume":"4","author":"R Ohlsson","year":"1993","unstructured":"Ohlsson R, Nystr\u00f6m A, Pfeifer-Ohlsson S, T\u00f6h\u00f6nen V, Hedborg F, Schofield P, Flam F, Ekstr\u00f6m TJ (1993) IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome. Nat Genet 4:94\u201397. https:\/\/doi.org\/10.1038\/ng0593-94","journal-title":"Nat Genet"},{"key":"9667_CR180","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/351665a0","volume":"351","author":"I Henry","year":"1991","unstructured":"Henry I, Bonaiti-Pelli\u00e9 C, Chehensse V, Beldjord C, Schwartz C, Utermann G, Junien C (1991) Uniparental paternal disomy in a genetic cancer-predisposing syndrome. Nature 351:665\u2013667. https:\/\/doi.org\/10.1038\/351665a0","journal-title":"Nature"},{"key":"9667_CR181","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<145::AID-GCC3>3.0.CO;2-7","volume":"28","author":"M Dohna","year":"2000","unstructured":"Dohna M, Reincke M, Mincheva A, Allolio B, Solinas-Toldo S, Lichter P (2000) Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications. Genes Chromosomes Cancer 28:145\u2013152","journal-title":"Genes Chromosomes Cancer"},{"key":"9667_CR182","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1210\/me.2007-0120","volume":"21","author":"M Doghman","year":"2007","unstructured":"Doghman M, Karpova T, Rodrigues GA, Arhatte M, De Moura J, Cavalli LR, Virolle V, Barbry P, Zambetti GP, Figueiredo BC, Heckert LL, Lalli E (2007) Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Mol Endocrinol 21:2968\u20132987. https:\/\/doi.org\/10.1210\/me.2007-0120","journal-title":"Mol Endocrinol"},{"key":"9667_CR183","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1530\/ERC-14-0016","volume":"21","author":"T Liu","year":"2014","unstructured":"Liu T, Brown TC, Juhlin CC, Andreasson A, Wang N, B\u00e4ckdahl M, Healy JM, Prasad ML, Korah R, Carling T, Xu D, Larsson C (2014) The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors. Endocr Relat Cancer 21:427\u2013434. https:\/\/doi.org\/10.1530\/ERC-14-0016","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR184","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1530\/EJE-13-0778","volume":"170","author":"B Ragazzon","year":"2014","unstructured":"Ragazzon B, Lib\u00e9 R, Assi\u00e9 G, Tissier F, Barreau O, Houdayer C, Perlemoine K, Audebourg A, Clauser E, Ren\u00e9-Corail F, Bertagna X, Dousset B, Bertherat J, Groussin L (2014) Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas. Eur J Endocrinol 170:385\u2013391. https:\/\/doi.org\/10.1530\/EJE-13-0778","journal-title":"Eur J Endocrinol"},{"key":"9667_CR185","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1210\/jcem.84.1.5388","volume":"84","author":"C Heppner","year":"1999","unstructured":"Heppner C, Reincke M, Agarwal SK, Mora P, Allolio B, Burns AL, Spiegel AM, Marx SJ (1999) MEN1 gene analysis in sporadic adrenocortical neoplasms. J Clin Endocrinol Metab 84:216\u2013219. https:\/\/doi.org\/10.1210\/jcem.84.1.5388","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR186","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/s0046-8177(98)90069-7","volume":"29","author":"F Fogt","year":"1998","unstructured":"Fogt F, Vargas MP, Zhuang Z, Merino MJ (1998) Utilization of molecular genetics in the differentiation between adrenal cortical adenomas and carcinomas. Hum Pathol 29:518\u2013521. https:\/\/doi.org\/10.1016\/s0046-8177(98)90069-7","journal-title":"Hum Pathol"},{"key":"9667_CR187","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0002-9440(10)63846-1","volume":"162","author":"TJ Giordano","year":"2003","unstructured":"Giordano TJ, Thomas DG, Kuick R, Lizyness M, Misek DE, Smith AL, Sanders D, Aljundi RT, Gauger PG, Thompson NW, Taylor JMG, Hanash SM (2003) Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 162:521\u2013531. https:\/\/doi.org\/10.1016\/S0002-9440(10)63846-1","journal-title":"Am J Pathol"},{"key":"9667_CR188","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1210\/jc.2004-1075","volume":"90","author":"F de Fraipont","year":"2005","unstructured":"de Fraipont F, El Atifi M, Cherradi N, Le Moigne G, Defaye G, Houlgatte R, Bertherat J, Bertagna X, Plouin P-F, Baudin E, Berger F, Gicquel C, Chabre O, Feige J-J (2005) Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic Acid microarrays identifies several candidate genes as markers of malignancy. J Clin Endocrinol Metab 90:1819\u20131829. https:\/\/doi.org\/10.1210\/jc.2004-1075","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR189","doi-asserted-by":"publisher","unstructured":"Fernandez-Ranvier GG, Weng J, Yeh R-F, Khanafshar E, Suh I, Barker C, Duh QY, Clark OH, Kebebew E (2008) Identification of biomarkers of adrenocortical carcinoma using genomewide gene expression profiling. Arch Surg 143:841\u2013846; discussion 846. https:\/\/doi.org\/10.1001\/archsurg.143.9.841","DOI":"10.1001\/archsurg.143.9.841"},{"key":"9667_CR190","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1200\/JCO.2008.18.5678","volume":"27","author":"A de Reyni\u00e8s","year":"2009","unstructured":"de Reyni\u00e8s A, Assi\u00e9 G, Rickman DS, Tissier F, Groussin L, Ren\u00e9-Corail F, Dousset B, Bertagna X, Clauser E, Bertherat J (2009) Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 27:1108\u20131115. https:\/\/doi.org\/10.1200\/JCO.2008.18.5678","journal-title":"J Clin Oncol"},{"key":"9667_CR191","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1530\/EJE-09-0068","volume":"161","author":"C Laurell","year":"2009","unstructured":"Laurell C, Vel\u00e1zquez-Fern\u00e1ndez D, Lindsten K, Juhlin C, Enberg U, Geli J, H\u00f6\u00f6g A, Kjellman M, Lundeberg J, Hamberger B, Larsson C, Nilsson P, B\u00e4ckdahl M (2009) Transcriptional profiling enables molecular classification of adrenocortical tumours. Eur J Endocrinol 161:141\u2013152. https:\/\/doi.org\/10.1530\/EJE-09-0068","journal-title":"Eur J Endocrinol"},{"key":"9667_CR192","doi-asserted-by":"publisher","first-page":"8276","DOI":"10.1158\/0008-5472.CAN-10-2014","volume":"70","author":"B Ragazzon","year":"2010","unstructured":"Ragazzon B, Lib\u00e9 R, Gaujoux S, Assi\u00e9 G, Fratticci A, Launay P, Clauser E, Bertagna X, Tissier F, de Reyni\u00e8s A, Bertherat J (2010) Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers. Cancer Res 70:8276\u20138281. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-2014","journal-title":"Cancer Res"},{"key":"9667_CR193","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/gcc.21978","volume":"51","author":"AL Fonseca","year":"2012","unstructured":"Fonseca AL, Kugelberg J, Starker LF, Scholl U, Choi M, Hellman P, \u00c5kerstr\u00f6m G, Westin G, Lifton RP, Bj\u00f6rklund P, Carling T (2012) Comprehensive DNA methylation analysis of benign and malignant adrenocortical tumors. Genes Chromosomes Cancer 51:949\u2013960. https:\/\/doi.org\/10.1002\/gcc.21978","journal-title":"Genes Chromosomes Cancer"},{"key":"9667_CR194","doi-asserted-by":"publisher","first-page":"E1004","DOI":"10.1210\/jc.2011-3298","volume":"97","author":"NS Rechache","year":"2012","unstructured":"Rechache NS, Wang Y, Stevenson HS, Killian JK, Edelman DC, Merino M, Zhang L, Nilubol N, Stratakis CA, Meltzer PS, Kebebew E (2012) DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors. J Clin Endocrinol Metab 97:E1004-1013. https:\/\/doi.org\/10.1210\/jc.2011-3298","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR195","doi-asserted-by":"publisher","first-page":"E174","DOI":"10.1210\/jc.2012-2993","volume":"98","author":"O Barreau","year":"2013","unstructured":"Barreau O, Assi\u00e9 G, Wilmot-Roussel H, Ragazzon B, Baudry C, Perlemoine K, Ren\u00e9-Corail F, Bertagna X, Dousset B, Hamzaoui N, Tissier F, de Reynies A, Bertherat J (2013) Identification of a CpG island methylator phenotype in adrenocortical carcinomas. J Clin Endocrinol Metab 98:E174-184. https:\/\/doi.org\/10.1210\/jc.2012-2993","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR196","doi-asserted-by":"publisher","unstructured":"Chehade M, Bullock M, Glover A, Hutvagner G, Sidhu S (2020) Key MicroRNA\u2019s and Their Targetome in Adrenocortical Cancer. Cancers (Basel) 12. https:\/\/doi.org\/10.3390\/cancers12082198","DOI":"10.3390\/cancers12082198"},{"key":"9667_CR197","doi-asserted-by":"publisher","first-page":"7684","DOI":"10.1158\/1078-0432.CCR-09-1587","volume":"15","author":"PSH Soon","year":"2009","unstructured":"Soon PSH, Tacon LJ, Gill AJ, Bambach CP, Sywak MS, Campbell PR, Yeh MW, Wong SG, Clifton-Bligh RJ, Robinson BG, Sidhu SB (2009) miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer. Clin Cancer Res 15:7684\u20137692. https:\/\/doi.org\/10.1158\/1078-0432.CCR-09-1587","journal-title":"Clin Cancer Res"},{"key":"9667_CR198","doi-asserted-by":"publisher","unstructured":"Hao H-X, Jiang X, Cong F (2016) Control of Wnt Receptor Turnover by R-spondin-ZNRF3\/RNF43 Signaling Module and Its Dysregulation in Cancer. Cancers (Basel) 8. https:\/\/doi.org\/10.3390\/cancers8060054","DOI":"10.3390\/cancers8060054"},{"key":"9667_CR199","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1158\/1078-0432.CCR-10-2006","volume":"17","author":"S Gaujoux","year":"2011","unstructured":"Gaujoux S, Grabar S, Fassnacht M, Ragazzon B, Launay P, Lib\u00e9 R, Chokri I, Audebourg A, Royer B, Sbiera S, Vacher-Lavenu M-C, Dousset B, Bertagna X, Allolio B, Bertherat J, Tissier F (2011) \u03b2-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma. Clin Cancer Res 17:328\u2013336. https:\/\/doi.org\/10.1158\/1078-0432.CCR-10-2006","journal-title":"Clin Cancer Res"},{"key":"9667_CR200","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1158\/1078-0432.CCR-18-2693","volume":"25","author":"DR Mohan","year":"2019","unstructured":"Mohan DR, Lerario AM, Else T, Mukherjee B, Almeida MQ, Vinco M, Rege J, Mariani BMP, Zerbini MCN, Mendonca BB, Latronico AC, Marie SKN, Rainey WE, Giordano TJ, Fragoso MCBV, Hammer GD (2019) Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma. Clin Cancer Res 25:3276\u20133288. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-2693","journal-title":"Clin Cancer Res"},{"key":"9667_CR201","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1530\/ERC-13-0429","volume":"21","author":"TG Papathomas","year":"2014","unstructured":"Papathomas TG, Oudijk L, Zwarthoff EC, Post E, Duijkers FA, van Noesel MM, Hofland LJ, Pollard PJ, Maher ER, Restuccia DF, Feelders RA, Franssen GJH, Timmers HJ, Sleijfer S, de Herder WW, de Krijger RR, Dinjens WNM, Korpershoek E (2014) Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia. Endocr Relat Cancer 21:653\u2013661. https:\/\/doi.org\/10.1530\/ERC-13-0429","journal-title":"Endocr Relat Cancer"},{"key":"9667_CR202","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.3892\/ijmm.2018.3735","volume":"42","author":"F Svahn","year":"2018","unstructured":"Svahn F, Paulsson JO, Stenman A, Fotouhi O, Mu N, Murtha TD, Korah R, Carling T, B\u00e4ckdahl M, Wang N, Juhlin CC, Larsson C (2018) TERT promoter hypermethylation is associated with poor prognosis in adrenocortical carcinoma. Int J Mol Med 42:1675\u20131683. https:\/\/doi.org\/10.3892\/ijmm.2018.3735","journal-title":"Int J Mol Med"},{"key":"9667_CR203","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1530\/EC-20-0228","volume":"9","author":"A Jouinot","year":"2020","unstructured":"Jouinot A, Lippert J, Fassnacht M, de La Villeon B, Septier A, Neou M, Perlemoine K, Appenzeller S, Sibony M, Gaujoux S, Dousset B, Libe R, Groussin L, Ronchi CL, Assi\u00e9 G, Bertherat J (2020) Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma. Endocr Connect 9:705\u2013714. https:\/\/doi.org\/10.1530\/EC-20-0228","journal-title":"Endocr Connect"},{"key":"9667_CR204","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s12672-015-0244-z","volume":"7","author":"T Else","year":"2016","unstructured":"Else T, Rodriguez-Galindo C (2016) 5th International ACC Symposium: Hereditary Predisposition to Childhood ACC and the Associated Molecular Phenotype: 5th International ACC Symposium Session: Not Just for Kids! Horm Cancer 7:36\u201339. https:\/\/doi.org\/10.1007\/s12672-015-0244-z","journal-title":"Horm Cancer"},{"key":"9667_CR205","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa833","author":"M Dom\u00e8nech","year":"2020","unstructured":"Dom\u00e8nech M, Grau E, Solanes A, Izquierdo A, Del Valle J, Carrato C, Pineda M, Due\u00f1as N, Pujol M, L\u00e1zaro C, Capell\u00e0 G, Brunet J, Navarro M (2020) Characteristics of adrenocortical carcinoma associated with Lynch Syndrome. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgaa833","journal-title":"J Clin Endocrinol Metab"},{"key":"9667_CR206","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1530\/EJE-17-0358","volume":"177","author":"T Else","year":"2017","unstructured":"Else T, Lerario AM, Everett J, Haymon L, Wham D, Mullane M, Wilson TL, Rainville I, Rana H, Worth AJ, Snyder NW, Blair IA, McKay R, Kilbridge K, Hammer G, Barletta J, Vaidya A (2017) Adrenocortical carcinoma and succinate dehydrogenase gene mutations: an observational case series. Eur J Endocrinol 177:439\u2013444. https:\/\/doi.org\/10.1530\/EJE-17-0358","journal-title":"Eur J Endocrinol"}],"container-title":["Endocrine Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-021-09667-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12022-021-09667-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12022-021-09667-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T09:01:50Z","timestamp":1615798910000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12022-021-09667-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":206,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["9667"],"URL":"https:\/\/doi.org\/10.1007\/s12022-021-09667-0","relation":{},"ISSN":["1046-3976","1559-0097"],"issn-type":[{"value":"1046-3976","type":"print"},{"value":"1559-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"assertion":[{"value":"12 January 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}