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The impact on tumor recurrence and patient survival in papillary thyroid carcinoma (PTC) remains unknown. Thirteen cancer cell lines and 215 tumor samples from 91 patients, who underwent surgery for PTC (41), poorly differentiated thyroid carcinoma (PDC\u2009=\u200915), or anaplastic thyroid carcinoma (ATC\u2009=\u200935), were analyzed. Clonality, spread with tumor dedifferentiation or metastatic PTC cells, and coexistence with\n                    <jats:italic>TERTp<\/jats:italic>\n                    ,\n                    <jats:italic>BRAF<\/jats:italic>\n                    ,\n                    <jats:italic>RAS<\/jats:italic>\n                    , and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    mutations were also investigated.\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification was found in 17%, 20%, and 17% of the PTC, PDC, and ATC, respectively. It was more frequent in follicular variant PTC and PTC with distant metastases (86%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0448). The cell lines HTh74, SW1736, and T242 had amplification. In PTC,\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification was a subclonal event. The increase in\n                    <jats:italic>TERT<\/jats:italic>\n                    copy number spread in all cases with metastatic PTC cells. In 67% of the PDC and 100% of the ATC,\n                    <jats:italic>TERT<\/jats:italic>\n                    activation segregated with tumor dedifferentiation.\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification correlated with\n                    <jats:italic>TERTp<\/jats:italic>\n                    mutations in PTC (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0313) and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    mutations in ATC (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0272).\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification significantly correlated with vascular invasion (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03637), distant metastases at diagnosis and\/or follow-up (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.04482), metachronous distant metastases (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03131), death patient status (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000829), stage at diagnosis (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01995), and stage III\/IV at last follow-up (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01552).\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification associated independently with tumor-related recurrence and death. Our study shows that PTC can be stratified into clinically prognostic relevant categories based on the presence or not of\n                    <jats:italic>TERT<\/jats:italic>\n                    amplification in the cells.\n                  <\/jats:p>","DOI":"10.1007\/s12022-025-09853-4","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:20:17Z","timestamp":1745472017000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TERT Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0199-6893","authenticated-orcid":false,"given":"Sara","family":"Gil-Bernab\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-916X","authenticated-orcid":false,"given":"Noa","family":"Fe\u00e1s-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-6803","authenticated-orcid":false,"given":"Enrique","family":"P\u00e9rez-Riesgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1417-2757","authenticated-orcid":false,"given":"Miriam","family":"Corraliza-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-1572","authenticated-orcid":false,"given":"Joaqu\u00edn Fra","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-1263","authenticated-orcid":false,"given":"Ginesa","family":"Garc\u00eda-Rost\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"7283","key":"9853_CR1","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nature08822","volume":"463","author":"R Beroukhim","year":"2010","unstructured":"Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M. 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From \"Gil-Bernab\u00e9 Sara, Fe\u00e1s-Rodr\u00edguez Noa, P\u00e9rez-Riesgo Enrique, Corraliza-G\u00f3mez Miriam, Fra Rodr\u00edguez Joaqu\u00edn, Garc\u00eda-Rost\u00e1n Ginesa\" should be corrected to \"Sara Gil-Bernabe, Noa Fe\u00e1s-Rodr\u00edguez, Enrique P\u00e9rez-Riesgo, Miriam Corraliza-G\u00f3mez, Joaqu\u00edn Fra Rodr\u00edguez, Ginesa Garc\u00eda-Rost\u00e1n.\"","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12022-025-09881-0","URL":"https:\/\/doi.org\/10.1007\/s12022-025-09881-0","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"15"}}