{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:56:44Z","timestamp":1774436204039,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Forensic Sci Med Pathol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12024-019-00134-1","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T08:51:44Z","timestamp":1562835104000},"page":"369-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Medical and pathologic characteristics of fatal anaphylaxis: a Spanish nationwide 17-year series"],"prefix":"10.1007","volume":"15","author":[{"given":"Pilar","family":"Mart\u00ednez-Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Vallejo-de-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Soledad","family":"S\u00e1nchez-de-Le\u00f3n-Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"Navarro-Escayola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Moro-Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Alberti-Masgrau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-8220","authenticated-orcid":false,"given":"Miguel A.","family":"Tejedor-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"134_CR1","unstructured":"Brown SGA, Kemp SF, Lieberman PL. Anaphylxis. In: Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O'Hehir RE, editors. Middleton's allergy: principles and practice. 8th ed. Philadelphia: Saunders. pp. 1237\u201359."},{"key":"134_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jaci.2005.12.1303","volume":"117","author":"HA Sampson","year":"2006","unstructured":"Sampson HA, Mu\u00f1oz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report \u2013 second National Institute of Allergy and Infectious Diseases\/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117:391\u20137.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR3","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1111\/cea.12418","volume":"45","author":"MA Tejedor Alonso","year":"2015","unstructured":"Tejedor Alonso MA, Moro Moro M, M\u00fagica Garc\u00eda MV. Epidemiology of anaphylaxis. Clin Exp Allergy. 2015;45:1027\u201339.","journal-title":"Clin Exp Allergy"},{"key":"134_CR4","first-page":"163","volume":"25","author":"MA Tejedor-Alonso","year":"2015","unstructured":"Tejedor-Alonso MA, Moro-Moro M, M\u00fagica-Garc\u00eda MV. Epidemiology of anaphylaxis: contributions from the last 10 years. J Investig Allergol Clin Immunol. 2015;25:163\u201375.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"134_CR5","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0091-6749(99)70392-1","volume":"104","author":"MW Yocum","year":"1999","unstructured":"Yocum MW, Butterfield JH, Klein JS, Volcheck GW, Schroeder DR, Silverstein MD. Epidemiology of anaphylaxis in Olmsted County: a population-based study. J Allergy Clin Immunol. 1999;104:452\u20136.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2222.2004.01882.x","volume":"34","author":"A Helbling","year":"2004","unstructured":"Helbling A, Hurni T, Mueller UR, Pichler WJ. Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern. Clin Exp Allergy. 2004;34:285\u201390.","journal-title":"Clin Exp Allergy"},{"key":"134_CR7","doi-asserted-by":"crossref","unstructured":"Pumphrey RS, Gowland MH. Further fatal allergic reactions to food in the United Kingdom, 1999\u20132006. J Allergy Clin Immunol. 119:1018\u20139.","DOI":"10.1016\/j.jaci.2007.01.021"},{"key":"134_CR8","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/j.1398-9995.2008.01737.x","volume":"63","author":"MR Simon","year":"2008","unstructured":"Simon MR, Mulla ZD. A population-based epidemiologic analysis of deaths from anaphylaxis in Florida. Allergy. 2008;63:1077\u201383.","journal-title":"Allergy."},{"key":"134_CR9","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jaci.2008.10.049","volume":"123","author":"WK Liew","year":"2009","unstructured":"Liew WK, Williamson E, Tang ML. Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol. 2009;123:434\u201342.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR10","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/cea.12748","volume":"46","author":"RJ Mullins","year":"2016","unstructured":"Mullins RJ, Wainstein BK, Barnes EH, Liew WK, Campbell DE. Increases in anaphylaxis fatalities in Australia from 1997 to 2013. Clin Exp Allergy. 2016;46:1099\u2013110.","journal-title":"Clin Exp Allergy"},{"key":"134_CR11","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1398-9995.2012.02829.x","volume":"67","author":"LK Tanno","year":"2012","unstructured":"Tanno LK, Ganem F, Demoly P, Toscano CM, Bierrenbach AL. Undernotification of anaphylaxis deaths in Brazil due to difficult coding under the ICD-10. Allergy. 2012;67:783\u20139.","journal-title":"Allergy."},{"key":"134_CR12","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.jaci.2013.10.029","volume":"133","author":"L Ma","year":"2014","unstructured":"Ma L, Danoff TM, Borish L. Case fatality and population mortality associated with anaphylaxis in the United States. J Allergy Clin Immunol. 2014;133:1075\u201383.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1056\/NEJM196403192701202","volume":"270","author":"LP James Jr","year":"1964","unstructured":"James LP Jr, Austen KF. Fatal systemic anaphylaxis in man. N Engl J Med. 1964;270:597\u2013603.","journal-title":"N Engl J Med"},{"key":"134_CR14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1520\/JFS10141J","volume":"17","author":"C Delage","year":"1972","unstructured":"Delage C, Irey NS. Anaphylactic deaths: a clinicopathologic study of 43 cases. J Forensic Sci. 1972;17:525\u201340.","journal-title":"J Forensic Sci"},{"key":"134_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.forsciint.2010.04.039","volume":"204","author":"U Da Broi","year":"2011","unstructured":"Da Broi U, Moreschi C. Post-mortem diagnosis of anaphylaxis: a difficult task in forensic medicine. Forensic Sci Int. 2011;204:1\u20135.","journal-title":"Forensic Sci Int"},{"key":"134_CR16","doi-asserted-by":"crossref","unstructured":"Pumphrey RS, Roberts IS. Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 200. 53:273\u20136.","DOI":"10.1136\/jcp.53.4.273"},{"key":"134_CR17","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1398-9995.1983.tb01606.x","volume":"38","author":"H Mosbech","year":"1983","unstructured":"Mosbech H. Death caused by wasp and bee stings in Denmark 1960-1980. Allergy. 1983;38:195\u2013200.","journal-title":"Allergy"},{"key":"134_CR18","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/S1081-1206(10)60714-4","volume":"98","author":"PA Greenberger","year":"2007","unstructured":"Greenberger PA, Rotskoff BD, Lifschultz B. Fatal anaphylaxis: postmortem findings and associated comorbid diseases. Ann Allergy Asthma Immunol. 2007;98:252\u20137.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"134_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1080\/00313020600820831","volume":"38","author":"I Low","year":"2006","unstructured":"Low I, Stables S. Anaphylactic deaths in Auckland, New Zealand: a review of coronial autopsies from 1985 to 2005. Pathology. 2006;38:328\u201332.","journal-title":"Pathology."},{"key":"134_CR20","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/PAF.0b013e3181c0e7bb","volume":"30","author":"R Yilmaz","year":"2009","unstructured":"Yilmaz R, Yuksekbas O, Erkol Z, Bulut ER, Arslan MN. Postmortem findings after anaphylactic reactions to drugs in Turkey. Am J Forensic Med Pathol. 2009;30:346\u20139.","journal-title":"Am J Forensic Med Pathol"},{"key":"134_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.forsciint.2008.12.007","volume":"186","author":"Y Shen","year":"2009","unstructured":"Shen Y, Li L, Grant J, Rubio A, Zhao Z, Zhang X. Anaphylactic deaths in Maryland (United States) and Shanghai (China): a review of forensic autopsy cases from 2004 to 2006. Forensic Sci Int. 2009;186:1\u20135.","journal-title":"Forensic Sci Int"},{"key":"134_CR22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1710-1492-10-38","volume":"10","author":"YS Xu","year":"2014","unstructured":"Xu YS, Kastner M, Laurie Harada L, Xu A, Salter J, Waserman S. Anaphylaxis-related deaths in Ontario: a retrospective review of cases from 1986 to 2011. Allergy Asthma Clin Immunol. 2014;10:38.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"134_CR23","first-page":"37","volume":"37","author":"E Navarro Escayola","year":"2011","unstructured":"Navarro Escayola E, Villena C, Carlos J. Protocolo de actuaci\u00f3n en muerte s\u00fabita por anafilaxia. Rev Esp Med Legal. 2011;37:37\u201345.","journal-title":"Rev Esp Med Legal"},{"issue":"Suppl 1","key":"134_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1258\/msl.2010.010059","volume":"51","author":"S Luongo","year":"2011","unstructured":"Luongo S, Frontalini C, Pesaresi M, Valsecchi M, Tagliabracci A. Histopathological markers for the diagnosis of anaphylactic death. Med Sci Law. 2011;51(Suppl 1):30.","journal-title":"Med Sci Law"},{"key":"134_CR25","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1136\/jclinpath-2013-201769","volume":"67","author":"A McLean-Tooke","year":"2014","unstructured":"McLean-Tooke A, Goulding M, Bundell C, White J, Hollingsworth P. Postmortem serum tryptase levels in anaphylactic and non-anaphylactic deaths. J Clin Pathol. 2014;67:134\u20138.","journal-title":"J Clin Pathol"},{"key":"134_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0379-0738(98)00040-1","volume":"93","author":"E Edston","year":"1998","unstructured":"Edston E, van Hage-Hamsten M. Beta-Tryptase measurements post-mortem in anaphylactic deaths and in controls. Forensic Sci Int. 1998;93:135\u201342.","journal-title":"Forensic Sci Int"},{"key":"134_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.forsciint.2011.05.020","volume":"212","author":"DE Mayer","year":"2011","unstructured":"Mayer DE, Krauskopf A, Hemmer W, Moritz K, Jarisch R, Reiter C. Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis. Forensic Sci Int. 2011;212:96\u2013101.","journal-title":"Forensic Sci Int"},{"key":"134_CR28","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1111\/j.1365-2222.1995.tb00029.x","volume":"25","author":"HJ Schwartz","year":"1995","unstructured":"Schwartz HJ, Yunginger JW, Schwartz LB. Is unrecognized anaphylaxis a cause of sudden unexpected death? Clin Exp Allergy. 1995;25:866\u201370.","journal-title":"Clin Exp Allergy"},{"key":"134_CR29","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.jaci.2014.08.018","volume":"134","author":"EM Jerschow","year":"2014","unstructured":"Jerschow EM, Lin RY, Scaperottu MM, McGinn A. Fatal anaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations. J Allergy Clin Immunol. 2014;134:1318\u20132.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR30","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.anai.2017.07.014","volume":"119","author":"MS Motosue","year":"2017","unstructured":"Motosue MS, Bellolio MF, Van Houten HK, Shah ND, Campbell RL. Risk factors for severe anaphylaxis in the United States. Ann Allergy Asthma Immunol. 2017;119:356\u201361 e2.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"134_CR31","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.jaci.2013.06.015","volume":"132","author":"SGA Brown","year":"2014","unstructured":"Brown SGA, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, et al. Anaphylaxis: clinical patterns, mediator release, and severity. J Allergy Clin Immunol. 2014;132:1141\u20139 e5.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR32","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.jaci.2007.07.040","volume":"120","author":"LM Poulos","year":"2007","unstructured":"Poulos LM, Waters A, Correll PK, Loblay RH, Marks GB. Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005. J Allergy Clin Immunol. 2007;120:878\u201384.","journal-title":"J Allergy Clin Immunol"},{"key":"134_CR33","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.jaci.2011.09.030","volume":"129","author":"RL Campbell","year":"2012","unstructured":"Campbell RL, Hagan JB, Manivannan V, et al. Evaluation of national institute of allergy and infectious diseases\/food allergy and anaphylaxis network criteria for the diagnosis of anaphylaxis in emergency department subjects. J Allergy Clin Immunol. 2012;129:748\u201352.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Forensic Science, Medicine and Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12024-019-00134-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12024-019-00134-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12024-019-00134-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T23:39:03Z","timestamp":1594337943000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12024-019-00134-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["134"],"URL":"https:\/\/doi.org\/10.1007\/s12024-019-00134-1","relation":{},"ISSN":["1547-769X","1556-2891"],"issn-type":[{"value":"1547-769X","type":"print"},{"value":"1556-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]},"assertion":[{"value":"4 June 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committees and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.The study was approved by the Research Committee and the Clinical Research Ethics Committee of University Hospital Fundaci\u00f3n Alcorc\u00f3n (number 17\/103).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Given the retrospective design of the study, formal consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}