{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:57:30Z","timestamp":1781647050117,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Forensic Sci Med Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infective endocarditis is extremely rare in neonates and early infants but is associated with substantial morbidity and mortality. We report a sudden unexpected death in a 5-week-old male infant who was born at term in good condition. At one week of age, he presented with Enterococcus faecalis sepsis confirmed by blood culture. Ultrasound revealed a previously undiagnosed congenital renal duplex anomaly. Intravenous ampicillin-based beta-lactam antibiotics were administered after which the baby demonstrated clinical improvement. The baby was discharged after 2 weeks and was given antibiotic prophylaxis to be administered at home; blood culture was negative before discharge. At 5 weeks of age, he presented at the Accident and Emergency department in cardiac arrest. Despite aggressive resuscitation, the baby died. At autopsy, there was cardiomegaly and the aortic valves showed multiple friable vegetations (measuring approximately 2\u20133\u00a0mm), in keeping with infective endocarditis. Renal duplex anomaly was confirmed. Culture from heart blood, aortic vegetations and urine revealed a pure growth of Enterococcus faecalis. This case highlights the importance of early echocardiographic evaluation and renal anomaly surveillance in neonate with Enterococcus sepsis to prevent diagnostic delay and improve clinical outcomes.<\/jats:p>","DOI":"10.1007\/s12024-026-01209-6","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:39:14Z","timestamp":1775450354000},"page":"337-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enterococcus endocarditis in an infant with congenital renal duplex anomaly: A case report"],"prefix":"10.1007","volume":"22","author":[{"given":"Eteesha","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-9501","authenticated-orcid":false,"given":"Srinivas","family":"Annavarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"1209_CR1","volume-title":"Pediatric Infectious Diseases: Principles and Practice","author":"RS Baltimore","year":"1995","unstructured":"Baltimore RS. Infective endocarditis. In: Jenson HB, Baltimore RS, editors. Pediatric Infectious Diseases: Principles and Practice. Norwalk: Appleton & Lange; 1995."},{"issue":"3","key":"1209_CR2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0095-5108(18)30696-1","volume":"15","author":"DD Millard","year":"1988","unstructured":"Millard DD, Shulman ST. The changing spectrum of neonatal endocarditis. Clin Perinatol. 1988;15(3):587\u2013608. https:\/\/doi.org\/10.1016\/S0095-5108(18)30696-1.","journal-title":"Clin Perinatol"},{"issue":"3","key":"1209_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1542\/peds.71.3.392","volume":"71","author":"DG Oelberg","year":"1983","unstructured":"Oelberg DG, Fisher DJ, Gross DM, Denson SE, Adcock EW III. Endocarditis in high-risk neonates. Pediatrics. 1983;71(3):392\u20137. 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Clin Pediatr (Phila). 1998;37(12):741\u20136. https:\/\/doi.org\/10.1177\/000992289803701205.","journal-title":"Clin Pediatr (Phila)"},{"issue":"3","key":"1209_CR8","doi-asserted-by":"publisher","first-page":"e20200134","DOI":"10.1542\/peds.2020-0134","volume":"146","author":"BJ McMullan","year":"2020","unstructured":"McMullan BJ, Campbell AJ, Blyth CC, McNeil JC, Montgomery CP, Tong SYC, Bowen AC. Clinical management of Staphylococcus aureus bacteremia in neonates, children, and adolescents. Pediatrics. 2020;146(3):e20200134. https:\/\/doi.org\/10.1542\/peds.2020-0134.","journal-title":"Pediatrics"},{"issue":"6","key":"1209_CR9","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.arcped.2011.03.019","volume":"18","author":"K Crouzet","year":"2011","unstructured":"Crouzet K, Martinovici D, Hadeed K, Dulac Y, Acar P, S\u00e9gu\u00e9la PE. Maternal Group B streptococcal bacteriuria and neonatal infective endocarditis: a case report. 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Eur Heart J. 2023;44(39):3948\u20134042. https:\/\/doi.org\/10.1093\/eurheartj\/ehad193.","journal-title":"Eur Heart J"}],"container-title":["Forensic Science, Medicine and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12024-026-01209-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12024-026-01209-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12024-026-01209-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:30:31Z","timestamp":1781645431000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12024-026-01209-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["1209"],"URL":"https:\/\/doi.org\/10.1007\/s12024-026-01209-6","relation":{},"ISSN":["1556-2891"],"issn-type":[{"value":"1556-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"19 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Parental informed consent was obtained for autopsy and publication. Institutional ethical approval standards were fully adhered to.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"This manuscript reports an anonymised clinical case and does not include any identifiable patient information. Parental informed consent was obtained for autopsy and publication for dissemination of knowledge.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"Authors have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors have reviewed and edited the output and take full responsibility for the content of this publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}]}}