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A week before his last hospitalization, he was treated with antibiotics for respiratory infection. A day before his death, he vomited and was visibly irritable. He collapsed during rehabilitation treatment and became unresponsive. He did not sustain any injuries. The patient presented to the hospital with tachycardia, elevated cardiac enzymes, and respiratory insufficiency. Computed tomography of the brain revealed irregular hypodense areas in the supratentorial region and the lungs showed ground glass opacity. He required mechanical ventilation and high doses of vasopressors. The patient died 12\u00a0h after admission due to circulatory collapse. Postmortem histologic examination revealed skeletal muscle and myocardial degeneration, and multiorgan fat embolism involving the lungs, heart, kidneys and brain. Death was attributed to cardiovascular collapse due to heart failure associated with a genetically determined muscle disease with unexplained fat embolism syndrome.<\/jats:p>","DOI":"10.1007\/s12024-026-01278-7","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:40:40Z","timestamp":1779770440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unexplained multiorgan fat embolism syndrome in a 10-year-old child with LAMA2-related congenital muscular dystrophy"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9804-018X","authenticated-orcid":false,"given":"Silvia","family":"Farka\u0161ov\u00e1 Iannaccone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"N\u00e9methov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u017ebeta","family":"Ginelliov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Farka\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"1278_CR1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000792","author":"RJ Butterfield","year":"2019","unstructured":"Butterfield RJ. 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