{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:27:03Z","timestamp":1773260823875,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T00:00:00Z","timestamp":1216684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1007\/s12026-008-8024-2","type":"journal-article","created":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T18:27:06Z","timestamp":1216664826000},"page":"1-12","source":"Crossref","is-referenced-by-count":32,"title":["Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report"],"prefix":"10.1007","volume":"45","author":[{"given":"Joel N. H.","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derin B.","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquin","family":"Zuniga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Encinales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond J.","family":"Yunis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,7,22]]},"reference":[{"key":"8024_CR1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.clim.2005.03.015","volume":"116","author":"FC Lin","year":"2005","unstructured":"Lin FC, Chen YC, Chen FJ, Chang SC. Cytokines and fibrinolytic enzymes in tuberculous and parapneumonic effusions. Clin Immunol. 2005;116:166\u201373.","journal-title":"Clin Immunol"},{"key":"8024_CR2","doi-asserted-by":"crossref","unstructured":"Diagnostic Standards and Classification of Tuberculosis in Adults and Children. This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. This statement was endorsed by the Council of the Infectious Disease Society of America, September 1999. Am J Respir Crit Care Med. 2000;161:1376\u201395.","DOI":"10.1164\/ajrccm.161.4.16141"},{"key":"8024_CR3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1165\/ajrcmb.27.2.4779","volume":"27","author":"A Rosendahl","year":"2002","unstructured":"Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin CH, Sideras P. Activation of bone morphogenetic protein\/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol. 2002;27:160\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"8024_CR4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1521-6616(03)00210-9","volume":"110","author":"J Chan","year":"2004","unstructured":"Chan J, Flynn J. The immunological aspects of latency in tuberculosis. Clin Immunol. 2004;110:2\u201312.","journal-title":"Clin Immunol"},{"key":"8024_CR5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/sj.jidsymp.5650027","volume":"12","author":"PL Lin","year":"2007","unstructured":"Lin PL, Plessner HL, Voitenok NN, Flynn JL. Tumor necrosis factor and tuberculosis. J Investig Dermatol Symp Proc. 2007;12:22\u20135.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"8024_CR6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.2007.00545.x","volume":"219","author":"WR Berrington","year":"2007","unstructured":"Berrington WR, Hawn TR. Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter? Immunol Rev. 2007;219:167\u201386.","journal-title":"Immunol Rev"},{"issue":"Suppl 2","key":"8024_CR7","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1086\/344266","volume":"186","author":"RM Ransohoff","year":"2002","unstructured":"Ransohoff RM. The chemokine system in neuroinflammation: an update. J Infect Dis. 2002;186 Suppl 2:S152\u20136.","journal-title":"J Infect Dis"},{"key":"8024_CR8","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.4049\/jimmunol.178.11.7222","volume":"178","author":"PJ Maglione","year":"2007","unstructured":"Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol. 2007;178:7222\u201334.","journal-title":"J Immunol"},{"key":"8024_CR9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-3083.2003.01304.x","volume":"58","author":"SJ Mogga","year":"2003","unstructured":"Mogga SJ, Mustafa T, Sviland L, Nilsen R. In situ expression of CD40, CD40L (CD154), IL\u201312, TNF-alpha, IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary tuberculosis. Scand J Immunol. 2003;58:327\u201334.","journal-title":"Scand J Immunol"},{"key":"8024_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2362.1998.00248.x","volume":"28","author":"C Cocito","year":"1998","unstructured":"Cocito C, Maes H. Immunological relatedness of the protective mechanisms against tuberculosis and cancer. Eur J Clin Invest. 1998;28:1\u201312.","journal-title":"Eur J Clin Invest"},{"key":"8024_CR11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/path.2185","volume":"212","author":"S Aly","year":"2007","unstructured":"Aly S, Laskay T, Mages J, Malzan A, Lang R, Ehlers S. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol. 2007;212:295\u2013305.","journal-title":"J Pathol"},{"key":"8024_CR12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.cellbio.20.010403.114015","volume":"20","author":"I Vergne","year":"2004","unstructured":"Vergne I, Chua J, Singh SB, Deretic V: Cell biology of Mycobacterium tuberculosis phagosome. Annu Rev Cell Dev Biol. 2004;20:367\u201394.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"8024_CR13","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1462-5822.2004.00449.x","volume":"6","author":"V Deretic","year":"2004","unstructured":"Deretic V, Vergne I, Chua J, Master S, Singh SB, Fazio JA, Kyei G. Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV. Cell Microbiol. 2004;6:999\u20131009.","journal-title":"Cell Microbiol"},{"key":"8024_CR14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1371\/journal.ppat.0010033","volume":"1","author":"GR Stewart","year":"2005","unstructured":"Stewart GR, Patel J, Robertson BD, Rae A, Young DB. Mycobacterial mutants with defective control of phagosomal acidification. PLoS Pathog. 2005;1:269\u201378.","journal-title":"PLoS Pathog"},{"key":"8024_CR15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1046\/j.1365-2249.1999.00783.x","volume":"115","author":"A Verbon","year":"1999","unstructured":"Verbon A, Juffermans N, Van Deventer SJ, Speelman P, Van Deutekom H, Van Der Poll T. Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment. Clin Exp Immunol. 1999;115:110\u20133.","journal-title":"Clin Exp Immunol"},{"key":"8024_CR16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1164\/ajrccm.159.1.9803066","volume":"159","author":"M Casarini","year":"1999","unstructured":"Casarini M, Ameglio F, Alemanno L, Zangrilli P, Mattia P, Paone G, et al. Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis. Am J Respir Crit Care Med. 1999;159:143\u20138.","journal-title":"Am J Respir Crit Care Med"},{"key":"8024_CR17","first-page":"994","volume":"7","author":"M Morosini","year":"2003","unstructured":"Morosini M, Meloni F, Marone Bianco A, Paschetto E, Uccelli M, Pozzi E, et al. The assessment of IFN-gamma and its regulatory cytokines in the plasma and bronchoalveolar lavage fluid of patients with active pulmonary tuberculosis. Int J Tuberc Lung Dis. 2003;7:994\u20131000.","journal-title":"Int J Tuberc Lung Dis"},{"key":"8024_CR18","first-page":"479","volume":"9","author":"ZT Handzel","year":"2007","unstructured":"Handzel ZT, Barak V, Altman Y, Bibi H, Lidgi M, Iancovici-Kidon M, et al. Increased Th1 and Th2 type cytokine production in patients with active tuberculosis. Isr Med Assoc J. 2007;9:479\u201383.","journal-title":"Isr Med Assoc J"},{"key":"8024_CR19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2249.2008.03638.x","volume":"152","author":"JN Stern","year":"2008","unstructured":"Stern JN, Keskin DB, Barteneva N, Zuniga J, Yunis EJ, Ahmed AR. Possible role of natural killer cells in pemphigus vulgaris\u2014preliminary observations. Clin Exp Immunol. 2008;152:472\u201381.","journal-title":"Clin Exp Immunol"},{"key":"8024_CR20","doi-asserted-by":"crossref","first-page":"11743","DOI":"10.1073\/pnas.0403832101","volume":"101","author":"JN Stern","year":"2004","unstructured":"Stern JN, Illes Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, et al. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci USA. 2004;101:11743\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8024_CR21","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1073\/pnas.0403833101","volume":"101","author":"Z Illes","year":"2004","unstructured":"Illes Z, Stern JN, Reddy J, Waldner H, Mycko MP, Brosnan CF, et al. Modified amino acid copolymers suppress myelin basic protein 85\u201399-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci USA. 2004;101:11749\u201354.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8024_CR22","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1002\/eji.200526121","volume":"35","author":"Z Illes","year":"2005","unstructured":"Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, et al. Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005;35:3683\u201393.","journal-title":"Eur J Immunol"},{"key":"8024_CR23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cyto.2007.12.007","volume":"41","author":"DB Keskin","year":"2008","unstructured":"Keskin DB, Stern JN, Fridkis-Hareli M, Razzaque Ahmed A. Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine. 2008;41:315\u201321.","journal-title":"Cytokine"},{"key":"8024_CR24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.immunol.19.1.93","volume":"19","author":"JL Flynn","year":"2001","unstructured":"Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol. 2001;19:93\u2013129.","journal-title":"Annu Rev Immunol"},{"key":"8024_CR25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2007.07.022","volume":"27","author":"J Harris","year":"2007","unstructured":"Harris J, De Haro SA, Master SS, Keane J, Roberts EA, Delgado M, et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity. 2007;27:505\u201317.","journal-title":"Immunity"},{"key":"8024_CR26","first-page":"1021","volume":"11","author":"T Mori","year":"2007","unstructured":"Mori T, Harada N, Higuchi K, Sekiya Y, Uchimura K, Shimao T. Waning of the specific interferon-gamma response after years of tuberculosis infection. Int J Tuberc Lung Dis. 2007;11:1021\u20135.","journal-title":"Int J Tuberc Lung Dis"},{"key":"8024_CR27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/147323000403200313","volume":"32","author":"M Berktas","year":"2004","unstructured":"Berktas M, Guducuoglu H, Bozkurt H, Onbasi KT, Kurtoglu MG, Andic S. Change in serum concentrations of interleukin-2 and interferon-gamma during treatment of tuberculosis. J Int Med Res. 2004;32:324\u201330.","journal-title":"J Int Med Res"},{"key":"8024_CR28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-695X.2007.00256.x","volume":"50","author":"P Natarajan","year":"2007","unstructured":"Natarajan P, Narayanan S. Mycobacterium tuberculosis H37Rv induces monocytic release of interleukin-6 via activation of mitogen-activated protein kinases: inhibition by N-acetyl-L-cysteine. FEMS Immunol Med Microbiol. 2007;50:309\u201318.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"8024_CR29","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4049\/jimmunol.179.3.1549","volume":"179","author":"R Romieu-Mourez","year":"2007","unstructured":"Romieu-Mourez R, Francois M, Boivin MN, Stagg J, Galipeau J. Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density. J Immunol. 2007;179:1549\u201358.","journal-title":"J Immunol"},{"key":"8024_CR30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.vetimm.2006.04.012","volume":"113","author":"KG Meade","year":"2006","unstructured":"Meade KG, Gormley E, Park SD, Fitzsimons T, Rosa GJ, Costello E, et al. Gene expression profiling of peripheral blood mononuclear cells (PBMC) from Mycobacterium bovis infected cattle after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD). Vet Immunol Immunopathol. 2006;113:73\u201389.","journal-title":"Vet Immunol Immunopathol"},{"key":"8024_CR31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.vetimm.2007.05.009","volume":"119","author":"TC Thacker","year":"2007","unstructured":"Thacker TC, Palmer MV, Waters WR. Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle. Vet Immunol Immunopathol. 2007;119:204\u201313.","journal-title":"Vet Immunol Immunopathol"},{"key":"8024_CR32","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1128\/IAI.68.5.2962-2970.2000","volume":"68","author":"MJ Maeurer","year":"2000","unstructured":"Maeurer MJ, Trinder P, Hommel G, Walter W, Freitag K, Atkins D, et al. Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect Immun. 2000;68:2962\u201370.","journal-title":"Infect Immun"},{"key":"8024_CR33","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1016\/j.vaccine.2005.12.066","volume":"24","author":"M Romano","year":"2006","unstructured":"Romano M, D\u2019Souza S, Adnet PY, Laali R, Jurion F, Palfliet K, et al. Priming but not boosting with plasmid DNA encoding mycolyl-transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv. Vaccine. 2006;24:3353\u201364.","journal-title":"Vaccine"},{"key":"8024_CR34","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/infdis\/174.3.574","volume":"174","author":"T Tantawichien","year":"1996","unstructured":"Tantawichien T, Young LS, Bermudez LE. Interleukin-7 induces anti-Mycobacterium avium activity in human monocyte-derived macrophages. J Infect Dis. 1996;174:574\u201382.","journal-title":"J Infect Dis"},{"key":"8024_CR35","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1128\/IAI.74.5.2686-2696.2006","volume":"74","author":"SB Jung","year":"2006","unstructured":"Jung SB, Yang CS, Lee JS, Shin AR, Jung SS, Son JW, et al. The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. Infect Immun. 2006;74:2686\u201396.","journal-title":"Infect Immun"},{"key":"8024_CR36","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.0022-202X.2005.23963.x","volume":"125","author":"R Hosokawa","year":"2005","unstructured":"Hosokawa R, Urata MM, Ito Y, Bringas P Jr, Chai Y. Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Invest Dermatol. 2005;125:1302\u20139.","journal-title":"J Invest Dermatol"},{"key":"8024_CR37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1164\/rccm.2201023","volume":"166","author":"HS Choi","year":"2002","unstructured":"Choi HS, Rai PR, Chu HW, Cool C, Chan ED. Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis. Am J Respir Crit Care Med. 2002;166:178\u201386.","journal-title":"Am J Respir Crit Care Med"},{"key":"8024_CR38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1164\/ajrccm.161.1.9902113","volume":"161","author":"HP Kuo","year":"2000","unstructured":"Kuo HP, Wang CH, Huang KS, Lin HC, Yu CT, Liu CY, et al. Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis. Am J Respir Crit Care Med. 2000;161:192\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"8024_CR39","first-page":"283","volume":"5","author":"CH Wang","year":"2001","unstructured":"Wang CH, Lin HC, Liu CY, Huang KH, Huang TT, Yu CT, et al. Upregulation of inducible nitric oxide synthase and cytokine secretion in peripheral blood monocytes from pulmonary tuberculosis patients. Int J Tuberc Lung Dis. 2001;5:283\u201391.","journal-title":"Int J Tuberc Lung Dis"},{"key":"8024_CR40","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4049\/jimmunol.163.3.1570","volume":"163","author":"C Sciorati","year":"1999","unstructured":"Sciorati C, Rovere P, Ferrarini M, Paolucci C, Heltai S, Vaiani R, et al. Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J Immunol. 1999;163:1570\u20136.","journal-title":"J Immunol"},{"key":"8024_CR41","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","volume":"177","author":"E Lockhart","year":"2006","unstructured":"Lockhart E, Green AM, Flynn JL. IL\u201317 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006;177:4662\u20139.","journal-title":"J Immunol"},{"key":"8024_CR42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","volume":"8","author":"SA Khader","year":"2007","unstructured":"Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007;8:369\u201377.","journal-title":"Nat Immunol"},{"key":"8024_CR43","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/eji.200737409","volume":"37","author":"T Zelante","year":"2007","unstructured":"Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol. 2007;37:2695\u2013706.","journal-title":"Eur J Immunol"},{"key":"8024_CR44","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","volume":"178","author":"M Umemura","year":"2007","unstructured":"Umemura M, Yahagi A, Hamada S, Begum MD, Watanabe H, Kawakami K, et al. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J Immunol. 2007;178:3786\u201396.","journal-title":"J Immunol"},{"key":"8024_CR45","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","unstructured":"Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007;8:639\u201346.","journal-title":"Nat Immunol"},{"key":"8024_CR46","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","volume":"12","author":"JM Brenchley","year":"2006","unstructured":"Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365\u201371.","journal-title":"Nat Med"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-008-8024-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-008-8024-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-008-8024-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:53:04Z","timestamp":1684482784000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-008-8024-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,22]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["8024"],"URL":"https:\/\/doi.org\/10.1007\/s12026-008-8024-2","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,22]]}}}