{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:01:56Z","timestamp":1761919316493},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"1-3","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1007\/s12026-009-8135-4","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T16:27:15Z","timestamp":1263918435000},"page":"14-24","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Immune evasive mechanisms contributing to persistent Leishmania donovani infection"],"prefix":"10.1007","volume":"47","author":[{"given":"Simona","family":"St\u00e4ger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trupti","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Bankoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"8135_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0167-5699(99)01549-2","volume":"21","author":"CR Engwerda","year":"2000","unstructured":"Engwerda CR, Kaye PM. Organ-specific immune responses associated with infectious disease. Immunol Today. 2000;21:73\u20138.","journal-title":"Immunol Today"},{"key":"8135_CR2","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.140.11.3971","volume":"140","author":"JJ Stern","year":"1988","unstructured":"Stern JJ, Oca MJ, Rubin BY, Anderson SL, Murray HW. Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis. J Immunol. 1988;140:3971\u20137.","journal-title":"J Immunol"},{"key":"8135_CR3","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<687::AID-IMMU687>3.0.CO;2-N","volume":"28","author":"PM Gorak","year":"1998","unstructured":"Gorak PM, Engwerda CR, Kaye PM. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur J Immunol. 1998;28:687\u201395.","journal-title":"Eur J Immunol"},{"key":"8135_CR4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<669::AID-IMMU669>3.0.CO;2-N","volume":"28","author":"CR Engwerda","year":"1998","unstructured":"Engwerda CR, Murphy ML, Cotterell SE, Smelt SC, Kaye PM. Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani. Eur J Immunol. 1998;28:669\u201380.","journal-title":"Eur J Immunol"},{"key":"8135_CR5","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.158.8.3813","volume":"158","author":"SC Smelt","year":"1997","unstructured":"Smelt SC, Engwerda CR, McCrossen M, Kaye PM. Destruction of follicular dendritic cells during chronic visceral leishmaniasis. J Immunol. 1997;158:3813\u201321.","journal-title":"J Immunol"},{"key":"8135_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/eji.1830220211","volume":"22","author":"PM Kaye","year":"1992","unstructured":"Kaye PM, Cooke A, Lund T, Wattie M, Blackwell JM. Altered course of visceral leishmaniasis in mice expressing transgenic I-E molecules. Eur J Immunol. 1992;22:357\u201364.","journal-title":"Eur J Immunol"},{"key":"8135_CR7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4049\/jimmunol.153.2.768","volume":"153","author":"MC Tumang","year":"1994","unstructured":"Tumang MC, Keogh C, Moldawer LL, Helfgott DC, Teitelbaum R, Hariprashad J, et al. Role and effect of TNF-alpha in experimental visceral leishmaniasis. J Immunol. 1994;153:768\u201375.","journal-title":"J Immunol"},{"key":"8135_CR8","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/ni861","volume":"3","author":"M Ato","year":"2002","unstructured":"Ato M, Stager S, Engwerda CR, Kaye PM. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat Immunol. 2002;3:1185\u201391.","journal-title":"Nat Immunol"},{"key":"8135_CR9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9440(10)64199-5","volume":"161","author":"CR Engwerda","year":"2002","unstructured":"Engwerda CR, Ato M, Cotterell SE, Mynott TL, Tschannerl A, Gorak-Stolinska PM, et al. A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovani infection. Am J Pathol. 2002;161:429\u201337.","journal-title":"Am J Pathol"},{"key":"8135_CR10","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1002\/eji.200635937","volume":"36","author":"S Stager","year":"2006","unstructured":"Stager S, Maroof A, Zubairi S, Sanos SL, Kopf M, Kaye PM. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. Eur J Immunol. 2006;36:1764\u201371.","journal-title":"Eur J Immunol"},{"key":"8135_CR11","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1084\/jem.20061141","volume":"204","author":"S Nylen","year":"2007","unstructured":"Nylen S, Maurya R, Eidsmo L, Manandhar KD, Sundar S, Sacks D. Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+ CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis. J Exp Med. 2007;204:805\u201317.","journal-title":"J Exp Med"},{"key":"8135_CR12","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nature01152","volume":"420","author":"Y Belkaid","year":"2002","unstructured":"Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+ CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 2002;420:502\u20137.","journal-title":"Nature"},{"key":"8135_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1084\/jem.20061886","volume":"204","author":"CF Anderson","year":"2007","unstructured":"Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4(+)CD25(\u2212)Foxp3(\u2212) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med. 2007;204:285\u201397.","journal-title":"J Exp Med"},{"key":"8135_CR14","doi-asserted-by":"crossref","first-page":"e1000431","DOI":"10.1371\/journal.ppat.1000431","volume":"5","author":"T Joshi","year":"2009","unstructured":"Joshi T, Rodriguez S, Perovic V, Cockburn IA, Stager S. B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. PLoS Pathog 2009;5:e1000431.","journal-title":"PLoS Pathog"},{"key":"8135_CR15","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/ni1102-1041","volume":"3","author":"D Sacks","year":"2002","unstructured":"Sacks D, Sher A. Evasion of innate immunity by parasitic protozoa. Nat Immunol. 2002;3:1041\u20137.","journal-title":"Nat Immunol"},{"key":"8135_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O\u2019Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683\u2013765.","journal-title":"Annu Rev Immunol"},{"key":"8135_CR17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S1473-3099(06)70577-1","volume":"6","author":"JL Mege","year":"2006","unstructured":"Mege JL, Meghari S, Honstettre A, Capo C, Raoult D. The two faces of interleukin 10 in human infectious diseases. Lancet Infect Dis. 2006;6:557\u201369.","journal-title":"Lancet Infect Dis"},{"key":"8135_CR18","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","volume":"180","author":"KN Couper","year":"2008","unstructured":"Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008;180:5771\u20137.","journal-title":"J Immunol"},{"key":"8135_CR19","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.4049\/jimmunol.171.10.5430","volume":"171","author":"FM Omer","year":"2003","unstructured":"Omer FM, de Souza JB, Riley EM. Differential induction of TGF-beta regulates proinflammatory cytokine production and determines the outcome of lethal and nonlethal Plasmodium yoelii infections. J Immunol. 2003;171:5430\u20136.","journal-title":"J Immunol"},{"key":"8135_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.exppara.2006.09.015","volume":"115","author":"Y Wu","year":"2007","unstructured":"Wu Y, Wang QH, Zheng L, Feng H, Liu J, Ma SH, et al. Plasmodium yoelii: distinct CD4(+)CD25(+) regulatory T cell responses during the early stages of infection in susceptible and resistant mice. Exp Parasitol. 2007;115:301\u20134.","journal-title":"Exp Parasitol"},{"key":"8135_CR21","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.4049\/jimmunol.174.5.2934","volume":"174","author":"CF Anderson","year":"2005","unstructured":"Anderson CF, Mendez S, Sacks DL. Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL\/6 mice. J Immunol. 2005;174:2934\u201341.","journal-title":"J Immunol"},{"key":"8135_CR22","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","volume":"194","author":"Y Belkaid","year":"2001","unstructured":"Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, et al. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med. 2001;194:1497\u2013506.","journal-title":"J Exp Med"},{"key":"8135_CR23","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/nm1492","volume":"12","author":"DG Brooks","year":"2006","unstructured":"Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med. 2006;12:1301\u20139.","journal-title":"Nat Med"},{"key":"8135_CR24","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1084\/jem.20061462","volume":"203","author":"M Ejrnaes","year":"2006","unstructured":"Ejrnaes M, Filippi CM, Martinic MM, Ling EM, Togher LM, Crotty S, et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med. 2006;203:2461\u201372.","journal-title":"J Exp Med"},{"key":"8135_CR25","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.4049\/jimmunol.178.12.8028","volume":"178","author":"S Roque","year":"2007","unstructured":"Roque S, Nobrega C, Appelberg R, Correia-Neves M. IL-10 underlies distinct susceptibility of BALB\/c and C57BL\/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy. J Immunol. 2007;178:8028\u201335.","journal-title":"J Immunol"},{"key":"8135_CR26","doi-asserted-by":"publisher","first-page":"6284","DOI":"10.1128\/IAI.70.11.6284-6293.2002","volume":"70","author":"HW Murray","year":"2002","unstructured":"Murray HW, Lu CM, Mauze S, Freeman S, Moreira AL, Kaplan G, et al. Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect Immun. 2002;70:6284\u201393.","journal-title":"Infect Immun"},{"key":"8135_CR27","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","volume":"31","author":"ML Murphy","year":"2001","unstructured":"Murphy ML, Wille U, Villegas EN, Hunter CA, Farrell JP. IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol. 2001;31:2848\u201356.","journal-title":"Eur J Immunol"},{"key":"8135_CR28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.immuni.2008.06.012","volume":"29","author":"A Maroof","year":"2008","unstructured":"Maroof A, Beattie L, Zubairi S, Svensson M, Stager S, Kaye PM. Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function. Immunity. 2008;29:295\u2013305.","journal-title":"Immunity"},{"key":"8135_CR29","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1084\/jem.20041470","volume":"201","author":"SA Miles","year":"2005","unstructured":"Miles SA, Conrad SM, Alves RG, Jeronimo SM, Mosser DM. A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J Exp Med. 2005;201:747\u201354.","journal-title":"J Exp Med"},{"key":"8135_CR30","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.immuni.2004.10.012","volume":"21","author":"M Svensson","year":"2004","unstructured":"Svensson M, Maroof A, Ato M, Kaye PM. Stromal cells direct local differentiation of regulatory dendritic cells. Immunity. 2004;21:805\u201316.","journal-title":"Immunity"},{"key":"8135_CR31","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1084\/jem.20062175","volume":"204","author":"D Jankovic","year":"2007","unstructured":"Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, et al. Conventional T-bet(+)Foxp3(\u2212) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med. 2007;204:273\u201383.","journal-title":"J Exp Med"},{"key":"8135_CR32","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.4049\/jimmunol.165.12.7064","volume":"165","author":"S Stager","year":"2000","unstructured":"Stager S, Smith DF, Kaye PM. Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. J Immunol. 2000;165:7064\u201371.","journal-title":"J Immunol"},{"key":"8135_CR33","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.4049\/jimmunol.174.10.6340","volume":"174","author":"UM Padigel","year":"2005","unstructured":"Padigel UM, Farrell JP. Control of infection with Leishmania major in susceptible BALB\/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol. 2005;174:6340\u20135.","journal-title":"J Immunol"},{"key":"8135_CR34","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1128\/IAI.00316-07","volume":"76","author":"BN Thomas","year":"2008","unstructured":"Thomas BN, Buxbaum LU. FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions. Infect Immun. 2008;76:623\u201331.","journal-title":"Infect Immun"},{"key":"8135_CR35","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.4049\/jimmunol.164.7.3681","volume":"164","author":"SC Smelt","year":"2000","unstructured":"Smelt SC, Cotterell SE, Engwerda CR, Kaye PM. B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. J Immunol. 2000;164:3681\u20138.","journal-title":"J Immunol"},{"key":"8135_CR36","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1365-2249.1994.tb06527.x","volume":"95","author":"F Peyron","year":"1994","unstructured":"Peyron F, Burdin N, Ringwald P, Vuillez JP, Rousset F, Banchereau J. High levels of circulating IL-10 in human malaria. Clin Exp Immunol. 1994;95:300\u20133.","journal-title":"Clin Exp Immunol"},{"key":"8135_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1126\/science.1925582","volume":"254","author":"M Yamamura","year":"1991","unstructured":"Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science. 1991;254:277\u20139.","journal-title":"Science"},{"key":"8135_CR38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1365-2249.1999.00865.x","volume":"116","author":"E Stylianou","year":"1999","unstructured":"Stylianou E, Aukrust P, Kvale D, Muller F, Froland SS. IL-10 in HIV infection: increasing serum IL-10 levels with disease progression\u2013down-regulatory effect of potent anti-retroviral therapy. Clin Exp Immunol. 1999;116:115\u201320.","journal-title":"Clin Exp Immunol"},{"key":"8135_CR39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1172\/JCI116570","volume":"92","author":"HW Ghalib","year":"1993","unstructured":"Ghalib HW, Piuvezam MR, Skeiky YA, Siddig M, Hashim FA, el-Hassan AM, et al. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest. 1993;92:324\u20139.","journal-title":"J Clin Invest"},{"key":"8135_CR40","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.1073\/pnas.95.16.9465","volume":"95","author":"J Eskdale","year":"1998","unstructured":"Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA. 1998;95:9465\u201370.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8135_CR41","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.4049\/jimmunol.166.6.3915","volume":"166","author":"AW Gibson","year":"2001","unstructured":"Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol. 2001;166:3915\u201322.","journal-title":"J Immunol"},{"key":"8135_CR42","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.0105-2896.2004.00216.x","volume":"202","author":"AP Vicari","year":"2004","unstructured":"Vicari AP, Trinchieri G. Interleukin-10 in viral diseases and cancer: exiting the labyrinth? Immunol Rev. 2004;202:223\u201336.","journal-title":"Immunol Rev"},{"key":"8135_CR43","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.it.2007.07.004","volume":"28","author":"S Nylen","year":"2007","unstructured":"Nylen S, Sacks D. Interleukin-10 and the pathogenesis of human visceral leishmaniasis. Trends Immunol. 2007;28:378\u201384.","journal-title":"Trends Immunol"},{"key":"8135_CR44","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.4049\/jimmunol.180.9.6139","volume":"180","author":"A Salhi","year":"2008","unstructured":"Salhi A, Rodrigues V Jr, Santoro F, Dessein H, Romano A, Castellano LR, et al. Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol. 2008;180:6139\u201348.","journal-title":"J Immunol"},{"key":"8135_CR45","doi-asserted-by":"crossref","unstructured":"Ranatunga D, Hedrich CM, Wang F, McVicar DW, Nowak N, Joshi T, Feigenbaum L, Grant LR, Stager S, Bream JH. A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. Proc Natl Acad Sci USA. 2009.","DOI":"10.1073\/pnas.0904955106"},{"key":"8135_CR46","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/sj.gene.6363920","volume":"3","author":"E Reuss","year":"2002","unstructured":"Reuss E, Fimmers R, Kruger A, Becker C, Rittner C, Hohler T. Differential regulation of interleukin-10 production by genetic and environmental factors\u2014a twin study. Genes Immun. 2002;3:407\u201313.","journal-title":"Genes Immun"},{"key":"8135_CR47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0171-2985(96)80043-X","volume":"195","author":"K Erb","year":"1996","unstructured":"Erb K, Blank C, Ritter U, Bluethmann H, Moll H. Leishmania major infection in major histocompatibility complex class II-deficient mice: CD8+ T cells do not mediate a protective immune response. Immunobiology. 1996;195:243\u201360.","journal-title":"Immunobiology"},{"key":"8135_CR48","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/IAI.66.8.3968-3970.1998","volume":"66","author":"M Huber","year":"1998","unstructured":"Huber M, Timms E, Mak TW, Rollinghoff M, Lohoff M. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun. 1998;66:3968\u201370.","journal-title":"Infect Immun"},{"key":"8135_CR49","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.4049\/jimmunol.168.8.3992","volume":"168","author":"Y Belkaid","year":"2002","unstructured":"Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, et al. CD8+ T cells are required for primary immunity in C57BL\/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol. 2002;168:3992\u20134000.","journal-title":"J Immunol"},{"key":"8135_CR50","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1084\/jem.20040172","volume":"199","author":"JE Uzonna","year":"2004","unstructured":"Uzonna JE, Joyce KL, Scott P. Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells. J Exp Med. 2004;199:1559\u201366.","journal-title":"J Exp Med"},{"key":"8135_CR51","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1128\/IAI.71.1.401-410.2003","volume":"71","author":"S Ahmed","year":"2003","unstructured":"Ahmed S, Colmenares M, Soong L, Goldsmith-Pestana K, Munstermann L, Molina R, et al. Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis. Infect Immun. 2003;71:401\u201310.","journal-title":"Infect Immun"},{"key":"8135_CR52","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.0141-9838.2004.00672.x","volume":"25","author":"P Tsagozis","year":"2003","unstructured":"Tsagozis P, Karagouni E, Dotsika E. CD8(+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis. Parasite Immunol. 2003;25:569\u201379.","journal-title":"Parasite Immunol"},{"key":"8135_CR53","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.parint.2005.02.005","volume":"54","author":"P Tsagozis","year":"2005","unstructured":"Tsagozis P, Karagouni E, Dotsika E. Function of CD8+ T lymphocytes in a self-curing mouse model of visceral leishmaniasis. Parasitol Int. 2005;54:139\u201346.","journal-title":"Parasitol Int"},{"key":"8135_CR54","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1128\/IAI.67.11.5559-5566.1999","volume":"67","author":"C Mary","year":"1999","unstructured":"Mary C, Auriault V, Faugere B, Dessein AJ. Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells. Infect Immun. 1999;67:5559\u201366.","journal-title":"Infect Immun"},{"key":"8135_CR55","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1016\/S0264-410X(02)00189-5","volume":"20","author":"S Rafati","year":"2002","unstructured":"Rafati S, Kariminia A, Seyde-Eslami S, Narimani M, Taheri T, Lebbatard M. Recombinant cysteine proteinases-based vaccines against Leishmania major in BALB\/c mice: the partial protection relies on interferon gamma producing CD8(+) T lymphocyte activation. Vaccine. 2002;20:2439\u201347.","journal-title":"Vaccine"},{"key":"8135_CR56","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1084\/jem.20020147","volume":"195","author":"EG Rhee","year":"2002","unstructured":"Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, et al. Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection. J Exp Med. 2002;195:1565\u201373.","journal-title":"J Exp Med"},{"key":"8135_CR57","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/nm933","volume":"9","author":"S Stager","year":"2003","unstructured":"Stager S, Alexander J, Kirby AC, Botto M, Rooijen NV, Smith DF, et al. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med. 2003;9:1287\u201392.","journal-title":"Nat Med"},{"key":"8135_CR58","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.165.2.915","volume":"165","author":"S Gurunathan","year":"2000","unstructured":"Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, et al. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000;165:915\u201324.","journal-title":"J Immunol"},{"key":"8135_CR59","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/4000","volume":"4","author":"S Gurunathan","year":"1998","unstructured":"Gurunathan S, Prussin C, Sacks DL, Seder RA. Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection. Nat Med. 1998;4:1409\u201315.","journal-title":"Nat Med"},{"key":"8135_CR60","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S1074-7613(00)80469-0","volume":"8","author":"EA Butz","year":"1998","unstructured":"Butz EA, Bevan MJ. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity. 1998;8:167\u201375.","journal-title":"Immunity"},{"key":"8135_CR61","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","volume":"8","author":"K Murali-Krishna","year":"1998","unstructured":"Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, Miller JD, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 1998;8:177\u201387.","journal-title":"Immunity"},{"key":"8135_CR62","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.immuni.2008.04.010","volume":"28","author":"JJ Obar","year":"2008","unstructured":"Obar JJ, Khanna KM, Lefrancois L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity. 2008;28:859\u201369.","journal-title":"Immunity"},{"key":"8135_CR63","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1084\/jem.20001021","volume":"195","author":"JN Blattman","year":"2002","unstructured":"Blattman JN, Antia R, Sourdive DJ, Wang X, Kaech SM, Murali-Krishna K, et al. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med. 2002;195:657\u201364.","journal-title":"J Exp Med"},{"key":"8135_CR64","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1084\/jem.188.1.61","volume":"188","author":"DH Busch","year":"1998","unstructured":"Busch DH, Pilip I, Pamer EG. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J Exp Med. 1998;188:61\u201370.","journal-title":"J Exp Med"},{"key":"8135_CR65","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.4049\/jimmunol.175.5.3214","volume":"175","author":"D Chakraborty","year":"2005","unstructured":"Chakraborty D, Banerjee S, Sen A, Banerjee KK, Das P, Roy S. Leishmania donovani affects antigen presentation of macrophage by disrupting lipid rafts. J Immunol. 2005;175:3214\u201324.","journal-title":"J Immunol"},{"key":"8135_CR66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1046\/j.1462-5822.1999.00002.x","volume":"1","author":"S Scianimanico","year":"1999","unstructured":"Scianimanico S, Desrosiers M, Dermine JF, Meresse S, Descoteaux A, Desjardins M. Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes. Cell Microbiol. 1999;1:19\u201332.","journal-title":"Cell Microbiol"},{"key":"8135_CR67","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1084\/jem.185.12.2061","volume":"185","author":"M Desjardins","year":"1997","unstructured":"Desjardins M, Descoteaux A. Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan. J Exp Med. 1997;185:2061\u20138.","journal-title":"J Exp Med"},{"key":"8135_CR68","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1002\/eji.1830270430","volume":"27","author":"MR Garcia","year":"1997","unstructured":"Garcia MR, Graham S, Harris RA, Beverley SM, Kaye PM. Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation. Eur J Immunol. 1997;27:1005\u201313.","journal-title":"Eur J Immunol"},{"key":"8135_CR69","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.177.6.3525","volume":"177","author":"S Bertholet","year":"2006","unstructured":"Bertholet S, Goldszmid R, Morrot A, Debrabant A, Afrin F, Collazo-Custodio C, et al. Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol. 2006;177:3525\u201333.","journal-title":"J Immunol"},{"key":"8135_CR70","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.4049\/jimmunol.180.7.4355","volume":"180","author":"L Soong","year":"2008","unstructured":"Soong L. Modulation of dendritic cell function by Leishmania parasites. J Immunol. 2008;180:4355\u201360.","journal-title":"J Immunol"},{"key":"8135_CR71","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.4049\/jimmunol.181.9.6473","volume":"181","author":"LP Carvalho","year":"2008","unstructured":"Carvalho LP, Pearce EJ, Scott P. Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses. J Immunol. 2008;181:6473\u201380.","journal-title":"J Immunol"},{"key":"8135_CR72","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nri2251","volume":"8","author":"JT Harty","year":"2008","unstructured":"Harty JT, Badovinac VP. Shaping and reshaping CD8+ T-cell memory. Nat Rev Immunol. 2008;8:107\u201319.","journal-title":"Nat Rev Immunol"},{"key":"8135_CR73","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1128\/IAI.00643-07","volume":"76","author":"A Maroof","year":"2008","unstructured":"Maroof A, Kaye PM. Temporal regulation of interleukin-12p70 (IL-12p70) and IL-12-related cytokines in splenic dendritic cell subsets during Leishmania donovani infection. Infect Immun. 2008;76:239\u201349.","journal-title":"Infect Immun"},{"key":"8135_CR74","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1084\/jem.20021910","volume":"197","author":"JM Curtsinger","year":"2003","unstructured":"Curtsinger JM, Lins DC, Mescher MF. Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med. 2003;197:1141\u201351.","journal-title":"J Exp Med"},{"key":"8135_CR75","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ni978","volume":"4","author":"A Le Bon","year":"2003","unstructured":"Le Bon A, Etchart N, Rossmann C, Ashton M, Hou S, Gewert D, et al. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat Immunol. 2003;4:1009\u201315.","journal-title":"Nat Immunol"},{"key":"8135_CR76","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.180.2.1131","volume":"180","author":"A Shaulov","year":"2008","unstructured":"Shaulov A, Murali-Krishna K. CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu. J Immunol. 2008;180:1131\u20138.","journal-title":"J Immunol"},{"key":"8135_CR77","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","volume":"211","author":"MF Mescher","year":"2006","unstructured":"Mescher MF, Curtsinger JM, Agarwal P, Casey KA, Gerner M, Hammerbeck CD, et al. Signals required for programming effector and memory development by CD8+ T cells. Immunol Rev. 2006;211:81\u201392.","journal-title":"Immunol Rev"},{"key":"8135_CR78","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1242\/jcs.00860","volume":"117","author":"E Prina","year":"2004","unstructured":"Prina E, Abdi SZ, Lebastard M, Perret E, Winter N, Antoine JC. Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation. J Cell Sci. 2004;117:315\u201325.","journal-title":"J Cell Sci"},{"key":"8135_CR79","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ijpara.2007.08.010","volume":"38","author":"N Wanasen","year":"2008","unstructured":"Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008;38:417\u201329.","journal-title":"Int J Parasitol"},{"key":"8135_CR80","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.4049\/jimmunol.167.8.4534","volume":"167","author":"H Qi","year":"2001","unstructured":"Qi H, Popov V, Soong L. Leishmania amazonensis-dendritic cell interactions in vitro and the priming of parasite-specific CD4(+) T cells in vivo. J Immunol. 2001;167:4534\u201342.","journal-title":"J Immunol"},{"key":"8135_CR81","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.4049\/jimmunol.179.7.4520","volume":"179","author":"PS Biswas","year":"2007","unstructured":"Biswas PS, Pedicord V, Ploss A, Menet E, Leiner I, Pamer EG. Pathogen-specific CD8 T cell responses are directly inhibited by IL-10. J Immunol. 2007;179:4520\u20138.","journal-title":"J Immunol"},{"key":"8135_CR82","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.4049\/jimmunol.177.4.2565","volume":"177","author":"KE Foulds","year":"2006","unstructured":"Foulds KE, Rotte MJ, Seder RA. IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J Immunol. 2006;177:2565\u201374.","journal-title":"J Immunol"},{"key":"8135_CR83","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.4049\/jimmunol.174.9.5382","volume":"174","author":"SS Kang","year":"2005","unstructured":"Kang SS, Allen PM. Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses. J Immunol. 2005;174:5382\u20139.","journal-title":"J Immunol"},{"key":"8135_CR84","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.immuni.2009.04.020","volume":"31","author":"S Sanjabi","year":"2009","unstructured":"Sanjabi S, Mosaheb MM, Flavell RA. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity. 2009;31:131\u201344.","journal-title":"Immunity"},{"key":"8135_CR85","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.4049\/jimmunol.180.6.4090","volume":"180","author":"CF Anderson","year":"2008","unstructured":"Anderson CF, Lira R, Kamhawi S, Belkaid Y, Wynn TA, Sacks D. IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL\/6 mice. J Immunol. 2008;180:4090\u20137.","journal-title":"J Immunol"},{"key":"8135_CR86","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.4049\/jimmunol.164.4.2001","volume":"164","author":"NA Gomes","year":"2000","unstructured":"Gomes NA, Gattass CR, Barreto-De-Souza V, Wilson ME, DosReis GA. TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar. J Immunol. 2000;164:2001\u20138.","journal-title":"J Immunol"},{"key":"8135_CR87","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1002\/eji.200324021","volume":"34","author":"S Zubairi","year":"2004","unstructured":"Zubairi S, Sanos SL, Hill S, Kaye PM. Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani. Eur J Immunol. 2004;34:1433\u201340.","journal-title":"Eur J Immunol"},{"key":"8135_CR88","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1126\/science.1172815","volume":"324","author":"A Frohlich","year":"2009","unstructured":"Frohlich A, Kisielow J, Schmitz I, Freigang S, Shamshiev AT, Weber J, et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009;324:1576\u201380.","journal-title":"Science"},{"key":"8135_CR89","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1126\/science.1175194","volume":"324","author":"JS Yi","year":"2009","unstructured":"Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324:1572\u20136.","journal-title":"Science"},{"key":"8135_CR90","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1073\/pnas.0809818106","volume":"106","author":"SN Mueller","year":"2009","unstructured":"Mueller SN, Ahmed R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA. 2009;106:8623\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8135_CR91","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1084\/jem.20011723","volume":"195","author":"S Reignat","year":"2002","unstructured":"Reignat S, Webster GJ, Brown D, Ogg GS, King A, Seneviratne SL, et al. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med. 2002;195:1089\u2013101.","journal-title":"J Exp Med"},{"key":"8135_CR92","doi-asserted-by":"publisher","first-page":"5550","DOI":"10.1128\/JVI.75.12.5550-5558.2001","volume":"75","author":"NH Gruener","year":"2001","unstructured":"Gruener NH, Lechner F, Jung MC, Diepolder H, Gerlach T, Lauer G, et al. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J Virol. 2001;75:5550\u20138.","journal-title":"J Virol"},{"key":"8135_CR93","doi-asserted-by":"publisher","first-page":"10249","DOI":"10.1128\/JVI.74.21.10249-10255.2000","volume":"74","author":"PA Goepfert","year":"2000","unstructured":"Goepfert PA, Bansal A, Edwards BH, Ritter GD Jr, Tellez I, McPherson SA, et al. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J Virol. 2000;74:10249\u201355.","journal-title":"J Virol"},{"key":"8135_CR94","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1084\/jem.187.9.1383","volume":"187","author":"A Gallimore","year":"1998","unstructured":"Gallimore A, Glithero A, Godkin A, Tissot AC, Pluckthun A, Elliott T, et al. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med. 1998;187:1383\u201393.","journal-title":"J Exp Med"},{"key":"8135_CR95","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1182\/blood-2006-11-060087","volume":"110","author":"F Tsushima","year":"2007","unstructured":"Tsushima F, Yao S, Shin T, Flies A, Flies S, Xu H, et al. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 2007;110:180\u20135.","journal-title":"Blood"},{"key":"8135_CR96","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature04444","volume":"439","author":"DL Barber","year":"2006","unstructured":"Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439:682\u20137.","journal-title":"Nature"},{"key":"8135_CR97","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.4049\/jimmunol.180.7.4875","volume":"180","author":"JR Lukens","year":"2008","unstructured":"Lukens JR, Cruise MW, Lassen MG, Hahn YS. Blockade of PD-1\/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J Immunol. 2008;180:4875\u201384.","journal-title":"J Immunol"},{"key":"8135_CR98","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1182\/blood-2002-10-3065","volume":"101","author":"D Trabattoni","year":"2003","unstructured":"Trabattoni D, Saresella M, Biasin M, Boasso A, Piacentini L, Ferrante P, et al. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood. 2003;101:2514\u201320.","journal-title":"Blood"},{"key":"8135_CR99","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.4049\/jimmunol.178.10.6634","volume":"178","author":"L Chen","year":"2007","unstructured":"Chen L, Zhang Z, Chen W, Zhang Z, Li Y, Shi M, et al. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J Immunol. 2007;178:6634\u201341.","journal-title":"J Immunol"},{"key":"8135_CR100","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nm863","volume":"9","author":"TJ Curiel","year":"2003","unstructured":"Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med. 2003;9:562\u20137.","journal-title":"Nat Med"},{"key":"8135_CR101","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","volume":"192","author":"GJ Freeman","year":"2000","unstructured":"Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027\u201334.","journal-title":"J Exp Med"},{"key":"8135_CR102","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","volume":"8","author":"H Dong","year":"2002","unstructured":"Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793\u2013800.","journal-title":"Nat Med"},{"key":"8135_CR103","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.immuni.2009.06.019","volume":"31","author":"H Shin","year":"2009","unstructured":"Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, et al. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 2009;31:309\u201320.","journal-title":"Immunity"},{"key":"8135_CR104","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ni.1679","volume":"10","author":"SD Blackburn","year":"2009","unstructured":"Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10:29\u201337.","journal-title":"Nat Immunol"},{"key":"8135_CR105","doi-asserted-by":"crossref","first-page":"e1000313","DOI":"10.1371\/journal.ppat.1000313","volume":"5","author":"N Nakamoto","year":"2009","unstructured":"Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1\/CTLA-4 blockade. PLoS Pathog 2009;5:e1000313.","journal-title":"PLoS Pathog"},{"key":"8135_CR106","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.1158\/0008-5472.CAN-07-6598","volume":"68","author":"S Wei","year":"2008","unstructured":"Wei S, Shreiner AB, Takeshita N, Chen L, Zou W, Chang AE. Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1\/PD-1 axis and transforming growth factor beta. Cancer Res. 2008;68:5432\u20138.","journal-title":"Cancer Res"},{"key":"8135_CR107","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.immuni.2009.06.015","volume":"31","author":"R Tinoco","year":"2009","unstructured":"Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009;31:145\u201357.","journal-title":"Immunity"},{"key":"8135_CR108","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.4049\/jimmunol.161.11.6148","volume":"161","author":"ME Wilson","year":"1998","unstructured":"Wilson ME, Young BM, Davidson BL, Mente KA, McGowan SE. The importance of TGF-beta in murine visceral leishmaniasis. J Immunol. 1998;161:6148\u201355.","journal-title":"J Immunol"},{"key":"8135_CR109","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1172\/JCI116372","volume":"91","author":"CL Karp","year":"1993","unstructured":"Karp CL, el-Safi SH, Wynn TA, Satti MM, Kordofani AM, Hashim FA, et al. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest. 1993;91:1644\u20138.","journal-title":"J Clin Invest"},{"key":"8135_CR110","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.4049\/jimmunol.178.9.5429","volume":"178","author":"JM den Haan","year":"2007","unstructured":"den Haan JM, Kraal G, Bevan MJ. Cutting edge: Lipopolysaccharide induces IL-10-producing regulatory CD4+ T cells that suppress the CD8+ T cell response. J Immunol 2007;178:5429\u201333.","journal-title":"J Immunol"},{"key":"8135_CR111","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1128\/IAI.74.1.773-776.2006","volume":"74","author":"R Polley","year":"2006","unstructured":"Polley R, Stager S, Prickett S, Maroof A, Zubairi S, Smith DF, et al. Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen. Infect Immun. 2006;74:773\u20136.","journal-title":"Infect Immun"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-009-8135-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-009-8135-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-009-8135-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-009-8135-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T17:23:59Z","timestamp":1685381039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-009-8135-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,20]]},"references-count":111,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["8135"],"URL":"https:\/\/doi.org\/10.1007\/s12026-009-8135-4","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,20]]},"assertion":[{"value":"20 January 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}