{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:12:33Z","timestamp":1790118753526,"version":"4.0.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s12026-013-8482-z","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T07:26:24Z","timestamp":1388647584000},"page":"40-50","source":"Crossref","is-referenced-by-count":10,"title":["Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens"],"prefix":"10.1007","volume":"58","author":[{"given":"Jesper Dyrendom","family":"Svalgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"S\u00e6rmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Buschard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re","family":"Engkilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"key":"8482_CR1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1084\/jem.166.6.1654","volume":"166","author":"SE Macatonia","year":"1987","unstructured":"Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med. 1987;166:1654\u201367.","journal-title":"J Exp Med"},{"key":"8482_CR2","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.162.5.2472","volume":"162","author":"H Saeki","year":"1999","unstructured":"Saeki H, Moore AM, Brown MJ, Hwang ST. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol. 1999;162:2472\u20135.","journal-title":"J Immunol"},{"key":"8482_CR3","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.4049\/jimmunol.171.11.6225","volume":"171","author":"M Szczepanik","year":"2003","unstructured":"Szczepanik M, Akahira-Azuma M, Bryniarski K, Tsuji RF, Kawikova I, Ptak W, Kiener C, Campos RA, Askenase PW. B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity. J Immunol. 2003;171:6225\u201335.","journal-title":"J Immunol"},{"key":"8482_CR4","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.4049\/jimmunol.168.6.3079","volume":"168","author":"H Akiba","year":"2002","unstructured":"Akiba H, Kehren J, Ducluzeau MT, Krasteva M, Horand F, Kaiserlian D, Kaneko F, Nicolas JF. Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8\u00a0+\u00a0T cytotoxic 1 cells inducing keratinocyte apoptosis. J Immunol. 2002;168:3079\u201387.","journal-title":"J Immunol"},{"key":"8482_CR5","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/eji.1830251103","volume":"25","author":"H Bour","year":"1995","unstructured":"Bour H, Peyron E, Gaucherand M, Garrigue JL, Desvignes C, Kaiserlian D, Revillard JP, Nicolas JF. Major histocompatibility complex class I-restricted CD8\u00a0+\u00a0T cells and class II-restricted CD4\u00a0+\u00a0T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. Eur J Immunol. 1995;25:3006\u201310.","journal-title":"Eur J Immunol"},{"key":"8482_CR6","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.4049\/jimmunol.145.11.3706","volume":"145","author":"RS Kalish","year":"1990","unstructured":"Kalish RS, Johnson KL. Enrichment and function of urushiol (poison ivy)-specific T lymphocytes in lesions of allergic contact dermatitis to urushiol. J Immunol. 1990;145:3706\u201313.","journal-title":"J Immunol"},{"key":"8482_CR7","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.4049\/jimmunol.177.10.6852","volume":"177","author":"D He","year":"2006","unstructured":"He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. CD8\u00a0+\u00a0IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol. 2006;177:6852\u20138.","journal-title":"J Immunol"},{"key":"8482_CR8","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4049\/jimmunol.0804108","volume":"183","author":"D He","year":"2009","unstructured":"He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. IL-17 and IFN-gamma mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses. J Immunol. 2009;183:1463\u201370.","journal-title":"J Immunol"},{"key":"8482_CR9","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.4049\/jimmunol.0802830","volume":"182","author":"DD Kish","year":"2009","unstructured":"Kish DD, Li X, Fairchild RL. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J Immunol. 2009;182:5949\u201359.","journal-title":"J Immunol"},{"key":"8482_CR10","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jaci.2004.10.019","volume":"114","author":"M Kawaguchi","year":"2004","unstructured":"Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol. 2004;114:1265\u201373.","journal-title":"J Allergy Clin Immunol"},{"key":"8482_CR11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","volume":"21","author":"JK Kolls","year":"2004","unstructured":"Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21:467\u201376.","journal-title":"Immunity"},{"key":"8482_CR12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/intimm\/dxg028","volume":"15","author":"S Nakae","year":"2003","unstructured":"Nakae S, Komiyama Y, Narumi S, Sudo K, Horai R, Tagawa Y, Sekikawa K, Matsushima K, Asano M, Iwakura Y. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response. Int Immunol. 2003;15:251\u201360.","journal-title":"Int Immunol"},{"key":"8482_CR13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","volume":"194","author":"P Ye","year":"2001","unstructured":"Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001;194:519\u201327.","journal-title":"J Exp Med"},{"key":"8482_CR14","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.4049\/jimmunol.1002337","volume":"186","author":"DD Kish","year":"2011","unstructured":"Kish DD, Volokh N, Baldwin WM III, Fairchild RL. Hapten application to the skin induces an inflammatory program directing hapten-primed effector CD8 T cell interaction with hapten-presenting endothelial cells. J Immunol. 2011;186:2117\u201326.","journal-title":"J Immunol"},{"key":"8482_CR15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1146\/annurev.immunol.22.012703.104608","volume":"22","author":"M Brigl","year":"2004","unstructured":"Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004;22:817\u201390.","journal-title":"Annu Rev Immunol"},{"key":"8482_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri854","volume":"2","author":"M Kronenberg","year":"2002","unstructured":"Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol. 2002;2:557\u201368.","journal-title":"Nat Rev Immunol"},{"key":"8482_CR17","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI200423594","volume":"114","author":"DI Godfrey","year":"2004","unstructured":"Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest. 2004;114:1379\u201388.","journal-title":"J Clin Invest"},{"key":"8482_CR18","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20030630","volume":"198","author":"DB Stetson","year":"2003","unstructured":"Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003;198:1069\u201376.","journal-title":"J Exp Med"},{"key":"8482_CR19","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.4049\/jimmunol.175.11.7170","volume":"175","author":"A Itakura","year":"2005","unstructured":"Itakura A, Szczepanik M, Campos RA, Paliwal V, Majewska M, Matsuda H, Takatsu K, Askenase PW. An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1\u00a0day they produce IgM antibodies that initiate elicitation of contact sensitivity. J Immunol. 2005;175:7170\u20138.","journal-title":"J Immunol"},{"key":"8482_CR20","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1084\/jem.20021562","volume":"198","author":"RA Campos","year":"2003","unstructured":"Campos RA, Szczepanik M, Itakura A, Akahira-Azuma M, Sidobre S, Kronenberg M, Askenase PW. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med. 2003;198:1785\u201396.","journal-title":"J Exp Med"},{"key":"8482_CR21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/taap.1999.8734","volume":"159","author":"GF Gerberick","year":"1999","unstructured":"Gerberick GF, Cruse LW, Miller CM, Ridder GM. Selective modulation of B-cell activation markers CD86 and I-Ak on murine draining lymph node cells following allergen or irritant treatment. Toxicol Appl Pharmacol. 1999;159:142\u201351.","journal-title":"Toxicol Appl Pharmacol"},{"key":"8482_CR22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2310\/6620.2009.08089","volume":"20","author":"M Krasteva","year":"2009","unstructured":"Krasteva M, Bons B, Ryan C, Gerberick GF. Consumer allergy to oxidative hair coloring products: epidemiologic data in the literature. Dermatitis. 2009;20:123\u201341.","journal-title":"Dermatitis"},{"key":"8482_CR23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0536.2008.01395.x","volume":"59","author":"JP Thyssen","year":"2008","unstructured":"Thyssen JP, Carlsen BC, Sosted H, Menne T, Johansen JD. Frequency of p-phenylenediamine sensitization among Danish eczema patients tested between 1985 and 2007. Contact Dermat. 2008;59:184\u20135.","journal-title":"Contact Dermat"},{"key":"8482_CR24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1440-0960.2009.00556.x","volume":"50","author":"DL Damian","year":"2009","unstructured":"Damian DL, Shannon KF, Saw RP, Thompson JF. Topical diphencyprone immunotherapy for cutaneous metastatic melanoma. Australas J Dermatol. 2009;50:266\u201371.","journal-title":"Australas J Dermatol"},{"key":"8482_CR25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10227-001-0050-9","volume":"6","author":"JA Upitis","year":"2002","unstructured":"Upitis JA, Krol A. The use of diphenylcyclopropenone in the treatment of recalcitrant warts. J Cutan Med Surg. 2002;6:214\u20137.","journal-title":"J Cutan Med Surg"},{"key":"8482_CR26","first-page":"365","volume":"132","author":"S Rozen","year":"2000","unstructured":"Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol. 2000;132:365\u201386.","journal-title":"Methods Mol Biol"},{"key":"8482_CR27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/10799900252952181","volume":"22","author":"H Watanabe","year":"2002","unstructured":"Watanabe H, Unger M, Tuvel B, Wang B, Sauder DN. Contact hypersensitivity: the mechanism of immune responses and T cell balance. J Interferon Cytokine Res. 2002;22:407\u201312.","journal-title":"J Interferon Cytokine Res"},{"key":"8482_CR28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s00125-006-0162-2","volume":"49","author":"K Engkilde","year":"2006","unstructured":"Engkilde K, Menne T, Johansen JD. Inverse relationship between allergic contact dermatitis and type 1 diabetes mellitus: a retrospective clinic-based study. Diabetologia. 2006;49:644\u20137.","journal-title":"Diabetologia"},{"key":"8482_CR29","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/00365520600999334","volume":"42","author":"K Engkilde","year":"2007","unstructured":"Engkilde K, Menne T, Johansen JD. Inflammatory bowel disease in relation to contact allergy: a patient-based study. Scand J Gastroenterol. 2007;42:572\u20136.","journal-title":"Scand J Gastroenterol"},{"key":"8482_CR30","doi-asserted-by":"crossref","first-page":"e000084","DOI":"10.1136\/bmjopen-2011-000084","volume":"1","author":"K Engkilde","year":"2011","unstructured":"Engkilde K, Thyssen JP, Menne T, Johansen JD. Association between cancer and contact allergy: a linkage study. BMJ Open. 2011;1:e000084.","journal-title":"BMJ Open"},{"key":"8482_CR31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2340\/00015555-1205","volume":"92","author":"K Engkilde","year":"2012","unstructured":"Engkilde K, Thyssen JP, Bangsgaard N, Menne T, Johansen JD. Inverse association between rheumatoid arthritis and contact allergy. Acta Derm Venereol. 2012;92:175\u20136.","journal-title":"Acta Derm Venereol"},{"key":"8482_CR32","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/eji.201040913","volume":"41","author":"CT Mayer","year":"2011","unstructured":"Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T. CD8\u00a0+\u00a0Foxp3\u00a0+\u00a0T cells share developmental and phenotypic features with classical CD4\u00a0+\u00a0Foxp3\u00a0+\u00a0regulatory T cells but lack potent suppressive activity. Eur J Immunol. 2011;41:716\u201325.","journal-title":"Eur J Immunol"},{"key":"8482_CR33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/jid.2012.404","volume":"133","author":"A Goubier","year":"2013","unstructured":"Goubier A, Vocanson M, Macari C, Poyet G, Herbelin A, Nicolas JF, Dubois B, Kaiserlian D. Invariant NKT Cells Suppress CD8(+) T-Cell-Mediated Allergic Contact Dermatitis Independently of Regulatory CD4(+) T Cells. J Invest Dermatol. 2013;133:980\u20137.","journal-title":"J Invest Dermatol"},{"key":"8482_CR34","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.4049\/jimmunol.1003880","volume":"187","author":"SA Long","year":"2011","unstructured":"Long SA, Rieck M, Tatum M, Bollyky PL, Wu RP, Muller I, Ho JC, Shilling HG, Buckner JH. Low-dose antigen promotes induction of FOXP3 in human CD4\u00a0+\u00a0T cells. J Immunol. 2011;187:3511\u201320.","journal-title":"J Immunol"},{"key":"8482_CR35","doi-asserted-by":"crossref","first-page":"e10591","DOI":"10.1371\/journal.pone.0010591","volume":"5","author":"K Engkilde","year":"2010","unstructured":"Engkilde K, Buschard K, Hansen AK, Menne T, Johansen JD. Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis. PLoS ONE. 2010;5:e10591.","journal-title":"PLoS ONE"},{"key":"8482_CR36","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1084\/jem.20050953","volume":"202","author":"NY Crowe","year":"2005","unstructured":"Crowe NY, Coquet JM, Berzins SP, Kyparissoudis K, Keating R, Pellicci DG, Hayakawa Y, Godfrey DI, Smyth MJ. Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med. 2005;202:1279\u201388.","journal-title":"J Exp Med"},{"key":"8482_CR37","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-3083.2011.02522.x","volume":"73","author":"PW Askenase","year":"2011","unstructured":"Askenase PW, Majewska-Szczepanik M, Kerfoot S, Szczepanik M. Participation of iNKT cells in the early and late components of Tc1-mediated DNFB contact sensitivity: cooperative role of gammadelta-T cells. Scand J Immunol. 2011;73:465\u201377.","journal-title":"Scand J Immunol"},{"key":"8482_CR38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-3083.2011.02540.x","volume":"74","author":"N Dey","year":"2011","unstructured":"Dey N, Szczepanik M, Lau K, Majewska-Szczepanik M, Askenase PW. Stimulatory lipids accumulate in the mouse liver within 30\u00a0min of contact sensitization to facilitate the activation of Naive iNKT cells in a CD1d-dependent fashion. Scand J Immunol. 2011;74:52\u201361.","journal-title":"Scand J Immunol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-013-8482-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-013-8482-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-013-8482-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T11:32:09Z","timestamp":1688902329000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-013-8482-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["8482"],"URL":"https:\/\/doi.org\/10.1007\/s12026-013-8482-z","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}