{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:57:07Z","timestamp":1779188227664,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1-3","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12026-015-8722-5","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T21:13:21Z","timestamp":1445202801000},"page":"216-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes"],"prefix":"10.1007","volume":"63","author":[{"given":"Barbara","family":"Sherry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preetesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Yan","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan E.","family":"Kolitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanti R.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquie","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Hawtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Chiorazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"8722_CR1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","volume":"352","author":"N Chiorazzi","year":"2005","unstructured":"Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med. 2005;352:804\u201315.","journal-title":"N Engl J Med"},{"key":"8722_CR2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.semcancer.2010.10.012","volume":"20","author":"U Klein","year":"2010","unstructured":"Klein U, Dalla-Favera R. New insights into the pathogenesis of chronic lymphocytic leukemia. Semin Cancer Biol. 2010;20:377\u201383.","journal-title":"Semin Cancer Biol"},{"key":"8722_CR3","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1182\/blood-2009-06-225326","volume":"114","author":"JA Burger","year":"2009","unstructured":"Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114:3367\u201375.","journal-title":"Blood"},{"key":"8722_CR4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0065-230X(00)79005-1","volume":"79","author":"P Ghia","year":"2000","unstructured":"Ghia P, Caligaris-Cappio F. The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms. Adv Cancer Res. 2000;79:157\u201373.","journal-title":"Adv Cancer Res"},{"key":"8722_CR5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/j.seminhematol.2014.05.001","volume":"51","author":"SS Chen","year":"2014","unstructured":"Chen SS, Chiorazzi N. Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia. Semin Hematol. 2014;51:188\u2013205.","journal-title":"Semin Hematol"},{"key":"8722_CR6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1046\/j.1365-2141.2001.02672.x","volume":"112","author":"S Scrivener","year":"2001","unstructured":"Scrivener S, Kaminski ER, Demaine A, Prentice AG. Analysis of the expression of critical activation\/interaction markers on peripheral blood T cells in B-cell chronic lymphocytic leukaemia: evidence of immune dysregulation. Br J Haematol. 2001;112:959\u201364.","journal-title":"Br J Haematol"},{"key":"8722_CR7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1182\/blood-2015-03-567388","volume":"126","author":"F Forconi","year":"2015","unstructured":"Forconi F, Moss P. Perturbation of the normal immune system in patients with CLL. Blood. 2015;126:573\u201381.","journal-title":"Blood"},{"key":"8722_CR8","first-page":"2427","volume":"118","author":"AG Ramsay","year":"2008","unstructured":"Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 2008;118:2427\u201337.","journal-title":"J Clin Invest"},{"key":"8722_CR9","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/sj.leu.2403907","volume":"19","author":"M Motta","year":"2005","unstructured":"Motta M, Rassenti L, Shelvin BJ, et al. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Leukemia. 2005;19:1788\u201393.","journal-title":"Leukemia"},{"key":"8722_CR10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/nm0997-984","volume":"3","author":"M Cantwell","year":"1997","unstructured":"Cantwell M, Hua T, Pappas J, Kipps TJ. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nat Med. 1997;3:984\u20139.","journal-title":"Nat Med"},{"key":"8722_CR11","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1182\/blood-2010-07-299321","volume":"117","author":"P Christopoulos","year":"2011","unstructured":"Christopoulos P, Pfeifer D, Bartholome K, et al. Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL. Blood. 2011;117:3836\u201346.","journal-title":"Blood"},{"key":"8722_CR12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajh.2830160109","volume":"16","author":"A Mittelman","year":"1984","unstructured":"Mittelman A, Denny T, Gebhard D, et al. Analysis of T-cell subsets in B-cell chronic lymphocytic leukemia: a correlation with the stage of disease. Am J Hematol. 1984;16:67\u201373.","journal-title":"Am J Hematol"},{"key":"8722_CR13","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2217\/fon.14.298","volume":"11","author":"M Yousefi","year":"2015","unstructured":"Yousefi M, Movassaghpour AA, Shamsasenjan K, et al. The skewed balance between Tregs and Th17 in chronic lymphocytic leukemia. Future Oncol. 2015;11:1567\u201382.","journal-title":"Future Oncol"},{"key":"8722_CR14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/1042819021000029993","volume":"44","author":"S Scrivener","year":"2003","unstructured":"Scrivener S, Goddard RV, Kaminski ER, Prentice AG. Abnormal T-cell function in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma. 2003;44:383\u20139.","journal-title":"Leuk Lymphoma"},{"key":"8722_CR15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ajh.23170","volume":"87","author":"G D\u2019Arena","year":"2012","unstructured":"D\u2019Arena G, D\u2019Auria F, Simeon V, et al. A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia. Am J Hematol. 2012;87:628\u201331.","journal-title":"Am J Hematol"},{"key":"8722_CR16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3109\/10428194.2012.728287","volume":"54","author":"DP Lad","year":"2013","unstructured":"Lad DP, Varma S, Varma N, et al. Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias. Leuk Lymphoma. 2013;54:1012\u20139.","journal-title":"Leuk Lymphoma"},{"key":"8722_CR17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.intimp.2015.03.047","volume":"28","author":"ME Wallace","year":"2015","unstructured":"Wallace ME, Alcantara MB, Minoda Y, Kannourakis G, Berzins SP. An emerging role for immune regulatory subsets in chronic lymphocytic leukaemia. Int Immunopharmacol. 2015;28:897\u2013900.","journal-title":"Int Immunopharmacol"},{"key":"8722_CR18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3324\/haematol.2011.047316","volume":"97","author":"P Jain","year":"2012","unstructured":"Jain P, Javdan M, Feger FK, et al. Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance. Haematologica. 2012;97:599\u2013607.","journal-title":"Haematologica"},{"key":"8722_CR19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.5414\/CN106548","volume":"75","author":"K Miyazaki","year":"2011","unstructured":"Miyazaki K, Miyazawa T, Sugimoto K, et al. An adolescent with marked hyperimmuno-globulinemia E showing minimal change nephrotic syndrome and a STAT3 gene mutation. Clin Nephrol. 2011;75:369\u201373.","journal-title":"Clin Nephrol"},{"key":"8722_CR20","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1002\/art.34601","volume":"64","author":"JH Ju","year":"2012","unstructured":"Ju JH, Heo YJ, Cho ML, et al. Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells. Arthr Rheum. 2012;64:3543\u201352.","journal-title":"Arthr Rheum"},{"key":"8722_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00262-011-1151-y","volume":"61","author":"GW Middleton","year":"2012","unstructured":"Middleton GW, Annels NE, Pandha HS. Are we ready to start studies of Th17 cell manipulation as a therapy for cancer? Cancer Immunol Immunother. 2012;61:1\u20137.","journal-title":"Cancer Immunol Immunother"},{"key":"8722_CR22","doi-asserted-by":"crossref","unstructured":"Bailey SR, Nelson MH, Himes RA et al. Th17 cells in cancer: the ultimate identity crisis. Front Immunol. 2014;5:276. doi: 10.3389\/fimmu.2014.00276 . eCollection@2014.:276.","DOI":"10.3389\/fimmu.2014.00276"},{"key":"8722_CR23","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00262-011-1054-y","volume":"60","author":"MM Ankathatti","year":"2011","unstructured":"Ankathatti MM, Deng Y, Mulligan SJ, Xiang J. Th17 and Th17-stimulated CD8(+) T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity. Cancer Immunol Immunother. 2011;60:1473\u201384.","journal-title":"Cancer Immunol Immunother"},{"key":"8722_CR24","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1038\/onc.2010.367","volume":"29","author":"E Maniati","year":"2010","unstructured":"Maniati E, Soper R, Hagemann T. Up for Mischief? IL-17\/Th17 in the tumour microenvironment. Oncogene. 2010;29:5653\u201362.","journal-title":"Oncogene"},{"key":"8722_CR25","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.4049\/jimmunol.0901017","volume":"183","author":"G Murugaiyan","year":"2009","unstructured":"Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J Immunol. 2009;183:4169\u201375.","journal-title":"J Immunol"},{"key":"8722_CR26","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1182\/blood-2011-03-342436","volume":"118","author":"XJ Yan","year":"2011","unstructured":"Yan XJ, Dozmorov I, Li W, et al. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Blood. 2011;118:5201\u201310.","journal-title":"Blood"},{"key":"8722_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","volume":"34","author":"Y Iwakura","year":"2011","unstructured":"Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity. 2011;34:149\u201362.","journal-title":"Immunity"},{"key":"8722_CR28","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.4049\/jimmunol.180.8.5625","volume":"180","author":"PF Cheung","year":"2008","unstructured":"Cheung PF, Wong CK, Lam CW. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation. J Immunol. 2008;180:5625\u201335.","journal-title":"J Immunol"},{"key":"8722_CR29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","volume":"30","author":"H Ishigame","year":"2009","unstructured":"Ishigame H, Kakuta S, Nagai T, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009;30:108\u201319.","journal-title":"Immunity"},{"key":"8722_CR30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10753-011-9419-0","volume":"35","author":"H Fujie","year":"2012","unstructured":"Fujie H, Niu K, Ohba M, et al. A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells. Inflammation. 2012;35:1119\u201331.","journal-title":"Inflammation"},{"key":"8722_CR31","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.4049\/jimmunol.181.4.2799","volume":"181","author":"JF Wright","year":"2008","unstructured":"Wright JF, Bennett F, Li B, et al. The human IL-17F\/IL-17A heterodimeric cytokine signals through the IL-17RA\/IL-17RC receptor complex. J Immunol. 2008;181:2799\u2013805.","journal-title":"J Immunol"},{"key":"8722_CR32","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","volume":"111","author":"M Hallek","year":"2008","unstructured":"Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446\u201356.","journal-title":"Blood"},{"key":"8722_CR33","doi-asserted-by":"crossref","unstructured":"Hawtin RE, Cesano A. Immune monitoring technology primer: Single Cell Network Profiling (SCNP). J.Immunother.Cancer. 2015;3:34. doi: 10.1186\/s40425-015-0075-z . eCollection@2015.:34-0075.","DOI":"10.1186\/s40425-015-0075-z"},{"key":"8722_CR34","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3324\/haematol.2012.071910","volume":"98","author":"A Cesano","year":"2013","unstructured":"Cesano A, Perbellini O, Evensen E, et al. Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies. Haematologica. 2013;98:626\u201334.","journal-title":"Haematologica"},{"key":"8722_CR35","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.4049\/jimmunol.1102514","volume":"188","author":"DM Longo","year":"2012","unstructured":"Longo DM, Louie B, Putta S, et al. Single-cell network profiling of peripheral blood mononuclear cells from healthy donors reveals age- and race-associated differences in immune signaling pathway activation. J Immunol. 2012;188:1717\u201325.","journal-title":"J Immunol"},{"key":"8722_CR36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/cmi.2012.10","volume":"9","author":"G Huang","year":"2012","unstructured":"Huang G, Wang Y, Chi H. Regulation of TH17 cell differentiation by innate immune signals. Cell Mol Immunol. 2012;9:287\u201395.","journal-title":"Cell Mol Immunol"},{"key":"8722_CR37","doi-asserted-by":"crossref","unstructured":"Schmitt N, Ueno H. Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol. 2015;34:130\u20136. doi: 10.1016\/j.coi.2015.03.007 . Epub@2015 Apr 11:130\u2013136.","DOI":"10.1016\/j.coi.2015.03.007"},{"key":"8722_CR38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imr.12036","volume":"252","author":"LA Zuniga","year":"2013","unstructured":"Zuniga LA, Jain R, Haines C, Cua DJ. Th17 cell development: from the cradle to the grave. Immunol Rev. 2013;252:78\u201388.","journal-title":"Immunol Rev"},{"key":"8722_CR39","first-page":"80","volume":"1","author":"JL McGovern","year":"2012","unstructured":"McGovern JL, Notley CA. Production of IL-17: What\u2019s STAT got to do with it? JAKSTAT. 2012;1:80\u20132.","journal-title":"JAKSTAT"},{"key":"8722_CR40","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1182\/blood-2011-05-352682","volume":"118","author":"J Wit de","year":"2011","unstructured":"de Wit J, Souwer Y, van Beelen AJ, et al. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood. 2011;118:6107\u201314.","journal-title":"Blood"},{"key":"8722_CR41","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.4049\/jimmunol.0903823","volume":"185","author":"MH Brown","year":"2010","unstructured":"Brown MH, Lacey E. A ligand for CD5 is CD5. J Immunol. 2010;185:6068\u201374.","journal-title":"J Immunol"},{"key":"8722_CR42","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","author":"II Ivanov","year":"2006","unstructured":"Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17\u00a0+\u00a0T helper cells. Cell. 2006;126:1121\u201333.","journal-title":"Cell"},{"key":"8722_CR43","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","volume":"117","author":"Y Herishanu","year":"2011","unstructured":"Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117:563\u201374.","journal-title":"Blood"},{"key":"8722_CR44","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/2159-8290.CD-14-0104","volume":"4","author":"F Damm","year":"2014","unstructured":"Damm F, Mylonas E, Cosson A, et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 2014;4:1088\u2013101.","journal-title":"Cancer Discov"},{"key":"8722_CR45","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2217\/fon.09.72","volume":"5","author":"C Pepper","year":"2009","unstructured":"Pepper C, Hewamana S, Brennan P, Fegan C. NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia. Future Oncol. 2009;5:1027\u201337.","journal-title":"Future Oncol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-015-8722-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-015-8722-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-015-8722-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:06:11Z","timestamp":1553612771000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-015-8722-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":45,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["8722"],"URL":"https:\/\/doi.org\/10.1007\/s12026-015-8722-5","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}