{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:23Z","timestamp":1792783403648,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Anhui Province Nature Science Foundation in University","award":["No. KJ2013A158"],"award-info":[{"award-number":["No. KJ2013A158"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.81330081"],"award-info":[{"award-number":["No.81330081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81173075"],"award-info":[{"award-number":["No. 81173075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.81302845"],"award-info":[{"award-number":["No.81302845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Training programme of Academic and technical leaders in universities of Anhui province","award":["No. 34"],"award-info":[{"award-number":["No. 34"]}]},{"name":"the Grants for Scientific Research of BSKY","award":["No.XJ201211"],"award-info":[{"award-number":["No.XJ201211"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s12026-016-8788-8","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T20:46:26Z","timestamp":1453409186000},"page":"857-868","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of 6\u2032-acetylpaeoniflorin on dinitrochlorobenzene-induced allergic contact dermatitis in BALB\/c mice"],"prefix":"10.1007","volume":"64","author":[{"given":"Peng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Asenso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"issue":"1","key":"8788_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2012.01.009","volume":"210","author":"QQ Tang","year":"2012","unstructured":"Tang QQ, Zou P, Jin HF, Fu J, Yang JT, Shang LQ, Wei XT. Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro. Toxicol Lett. 2012;210(1):1\u20138.","journal-title":"Toxicol Lett"},{"issue":"4","key":"8788_CR2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/1535370213477975","volume":"238","author":"JK Choi","year":"2013","unstructured":"Choi JK, Kim SH. Rutin suppresses atopic dermatitis and allergic contact dermatitis. Exp Biol Med. 2013;238(4):410\u20137.","journal-title":"Exp Biol Med"},{"issue":"1\u20133","key":"8788_CR3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2009.12.007","volume":"629","author":"XY Yuan","year":"2010","unstructured":"Yuan XY, Liu W, Zhang P, Wang RY, Guo JY. Effects and mechanisms of aloperine on 2,4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB\/c mice. Eur J Pharmacol. 2010;629(1\u20133):147\u201352.","journal-title":"Eur J Pharmacol"},{"key":"8788_CR4","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.cca.2010.08.030","volume":"411","author":"N Akhtar","year":"2010","unstructured":"Akhtar N, Satyam A, Anand V, Verma KK, Khatri R, Sharma A. Dysregulation of T(H) type cytokines in the patients of Parthenium induced contact dermatitis. Clin Chim Acta. 2010;411:2024\u20138.","journal-title":"Clin Chim Acta"},{"issue":"11","key":"8788_CR5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","volume":"6","author":"LE Harrington","year":"2005","unstructured":"Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4\u00a0+\u00a0effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123\u201332.","journal-title":"Nat Immunol"},{"issue":"1","key":"8788_CR6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4049\/jimmunol.162.1.277","volume":"162","author":"BH Wang","year":"1999","unstructured":"Wang BH, Zhuang LH, Fujisawa H, Shinder GA, Feliciani C, Shivji GM, Suzuki H, Amerio P, Toto P, Sauder DN. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J Immunol. 1999;162(1):277\u201383.","journal-title":"J Immunol"},{"issue":"2","key":"8788_CR7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jep.2014.04.009","volume":"154","author":"YY Choi","year":"2014","unstructured":"Choi YY, Kim MH, Lee JY, Hong J, Kim SH, Yang WM. Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice. J Ethnopharmacol. 2014;154(2):380\u20135.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"8788_CR8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jep.2008.09.028","volume":"121","author":"Y Chang","year":"2009","unstructured":"Chang Y, Wei W, Zhang L, Xu HM. Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis. J Ethnopharmacol. 2009;121(1):43\u20138.","journal-title":"J Ethnopharmacol"},{"issue":"10","key":"8788_CR9","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.intimp.2005.03.010","volume":"5","author":"YQ Zheng","year":"2005","unstructured":"Zheng YQ, Wei W. Total glucosides of paeony suppresses adjuvant arthritis in rats and intervenes cytokine-signaling between different types of synoviocytes. Int Immunopharmacol. 2005;5(10):1560\u201373.","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"8788_CR10","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3109\/13880209.2014.880490","volume":"52","author":"QS Wang","year":"2014","unstructured":"Wang QS, Gao T, Cui YL, Gao LN, Jiang HL. Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol. 2014;52(9):1189\u201395.","journal-title":"Pharm Biol"},{"issue":"3","key":"8788_CR11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2012.07.012","volume":"14","author":"Z Zhou","year":"2012","unstructured":"Zhou Z, Lin J, Huo R, Huang W, Zhang J, Wang L, Sun Y, Shen B, Li N. Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4\/5 signaling in vivo. Int Immunopharmacol. 2012;14(3):275\u201382.","journal-title":"Int Immunopharmacol"},{"key":"8788_CR12","first-page":"487","volume":"9","author":"WQ Min","year":"2005","unstructured":"Min WQ, Wei Q, Li HY, Zhang ZC, Wu LJ, Yuan GH, Dou CR, Shi GY. A clinical study of total glucosides paeony in the treatment of rheumatoid arthritis: a multi-center trial. Chin J Rheumatol. 2005;9:487\u201391.","journal-title":"Chin J Rheumatol"},{"issue":"12","key":"8788_CR13","first-page":"1646","volume":"30","author":"C Wang","year":"2014","unstructured":"Wang C, Wei W. Research progress of pharmacokinetic study on paeoniflorin. Chin Pharmacol Bull. 2014;30(12):1646\u201350.","journal-title":"Chin Pharmacol Bull"},{"issue":"8","key":"8788_CR14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s10529-013-1192-8","volume":"35","author":"KN Nam","year":"2013","unstructured":"Nam KN, Yae CG, Hong JW, Cho DH, Lee JH, Lee EH. Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response. Biotechnol Lett. 2013;35(8):1183\u20139.","journal-title":"Biotechnol Lett"},{"issue":"1","key":"8788_CR15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2012.02.034","volume":"141","author":"PP Li","year":"2012","unstructured":"Li PP, Liu DD, Liu YJ, Song SS, Wang QT, Chang Y, Wu YJ, Chen JY, Zhao WD, Zhang LL, Wei W. BAFF\/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3\u00a0K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012;141(1):290\u2013300.","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"8788_CR16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2014.12.032","volume":"24","author":"Y Sun","year":"2015","unstructured":"Sun Y, Zhang J, Huo RF, Zhai TH, Li HD, Wu PR, Zhu XJ, Zhou Z, Shen BH, Li NL. Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation. Int Immunopharmacol. 2015;24(2):392\u20139.","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"8788_CR17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00011-013-0662-8","volume":"62","author":"C Wang","year":"2013","unstructured":"Wang C, Yuan J, Wu HX, Chang Y, Wang QT, Wu YJ, Liu LH, Wei W. Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines. Inflamm Res. 2013;62(12):1035\u201344.","journal-title":"Inflamm Res"},{"issue":"12A","key":"8788_CR18","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.2042-7158.1995.tb03293.x","volume":"47","author":"S Takeda","year":"1995","unstructured":"Takeda S, Isono T, Wakui Y, Matsuzaki Y, Sasaki H, Amagaya S, Maruno M. Absorption and excretion of paeoniflorin in rats. J Pharm Pharmacol. 1995;47(12A):1036\u201340.","journal-title":"J Pharm Pharmacol"},{"issue":"12","key":"8788_CR19","first-page":"997","volume":"67","author":"C Wang","year":"2012","unstructured":"Wang C, Yuan J, Yang ZY, Nie XX, Song LH, Wei W. Pharmacokinetics of paeoniflorin microemulsion after repeated dosing in rats with adjuvant arthritis. Pharmazie. 2012;67(12):997\u20131001.","journal-title":"Pharmazie"},{"issue":"12","key":"8788_CR20","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1007\/s11095-006-9100-8","volume":"23","author":"ZQ Liu","year":"2006","unstructured":"Liu ZQ, Jiang ZH, Liu L, Hu M. Mechanisms responsible for poor oral bioavailability of paeoniflorin: role of intestinal disposition and interactions with sinomenine. Pharm Res. 2006;23(12):2768\u201380.","journal-title":"Pharm Res"},{"issue":"7","key":"8788_CR21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1248\/cpb.51.759","volume":"51","author":"T Ogawa","year":"2003","unstructured":"Ogawa T, Araki M, Miyamae T, Okayama T, Hagiwara M, Sakurada S, Morikawa T. Synthesis and antinociceptive activity of orally active opioid peptides: improvement of oral bioavailability by esterification. Chem Pharm Bull. 2003;51(7):759\u201371.","journal-title":"Chem Pharm Bull"},{"issue":"15","key":"8788_CR22","first-page":"2097","volume":"44","author":"XW Yang","year":"2013","unstructured":"Yang XW, Guo J, Xu W. Absorption and transport characteristic of paeoniflorin and its derivatives in model of Caco-2 cell monolayers. Chin Tradit Herb Drugs. 2013;44(15):2097\u2013104.","journal-title":"Chin Tradit Herb Drugs"},{"key":"8788_CR23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.foodchem.2014.12.092","volume":"177","author":"IC Vlachogianni","year":"2015","unstructured":"Vlachogianni IC, Fragopoulou E, Kostakis IK, Antonopoulou S. In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives. Food Chem. 2015;177:165\u201373.","journal-title":"Food Chem"},{"key":"8788_CR24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1749-6632.2010.05871.x","volume":"1215","author":"D Delmas","year":"2011","unstructured":"Delmas D, Aires V, Limagne E, Dutartre P, Mazu\u00e9 F, Ghiringhelli F, Latruffe N. Transport, stability, and biological activity of resveratrol. Ann N Y Acad Sci. 2011;1215:48\u201359.","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"8788_CR25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.intimp.2014.12.026","volume":"24","author":"C Wang","year":"2015","unstructured":"Wang C, Yuan J, Wu HX, Chang Y, Wang QT, Wu YJ, Zhou P, Yang XD, Yu J, Wei W. Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-\/anti-inflammatory cytokines. Int Immunopharmacol. 2015;24(2):325\u201334.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"8788_CR26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/toxsci\/kfh049","volume":"78","author":"DR Germolec","year":"2004","unstructured":"Germolec DR, Nyska A, Kashon M, Kuper CF, Portier C, Kommineni C, Johnson KA, Luster MI. Extended histopathology in immunotoxicity testing: interlaboratory validation studies. Toxicol Sci. 2004;78(1):107\u201315.","journal-title":"Toxicol Sci"},{"key":"8788_CR27","first-page":"1495","volume":"25","author":"LL Zhang","year":"2004","unstructured":"Zhang LL, Wei W, Yan SX, Hu XY, Sun WY, et al. Therapeutic effects of glucosides of Cheanomeles speciosa on collagen-induced arthritis in mice. Acta Pharmacol Sin. 2004;25:1495\u2013501.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"8788_CR28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.intimp.2007.10.002","volume":"8","author":"K Liu","year":"2008","unstructured":"Liu K, Xu Q. Roxithromycin inhibits the effector phase of delayed-type hypersensitivity. Int Immunopharmacol. 2008;8(1):126\u201331.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"8788_CR29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.intimp.2015.02.031","volume":"25","author":"DM Shi","year":"2015","unstructured":"Shi DM, Li XF, Li DM, Zhao QJ, Shen YN, Yan HX, Fu HJ, Zheng HL, Lu GX, Qiu Y, Liu WD. Oral administration of paeoniflorin attenuates allergic contact dermatitis by inhibiting dendritic cell migration and Th1 and Th17 differentiation in a mouse model. Int Immunopharmacol. 2015;25(2):432\u20139.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"8788_CR30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/all.12351","volume":"69","author":"D Simon","year":"2014","unstructured":"Simon D, Aeberhard C, Erdemoglu Y, Simon HU. Th17 cells and tissue remodeling in atopic and contact dermatitis. Allergy. 2014;69(1):125\u201331.","journal-title":"Allergy"},{"issue":"4","key":"8788_CR31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0536.2009.01693.x","volume":"63","author":"N Akhtar","year":"2010","unstructured":"Akhtar N, Verma KK, Sharma A. Study of pro- and anti-inflammatory cytokine profile in the patients with parthenium dermatitis. Contact Dermat. 2010;63(4):203\u20138.","journal-title":"Contact Dermat"},{"key":"8788_CR32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.fct.2014.11.010","volume":"75","author":"AP Aleksandrov","year":"2015","unstructured":"Aleksandrov AP, Mirkov I, Demenesku J, Ninkov M, Zolotarevski L, Kataranovski D, Kataranovski M. Strain differences in contact hypersensitivity reaction to dinitrochlorobenzene (DNCB) in rats. Food Chem Toxicol. 2015;75:94\u2013103.","journal-title":"Food Chem Toxicol"},{"issue":"10","key":"8788_CR33","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.4049\/jimmunol.177.10.6852","volume":"177","author":"DG He","year":"2006","unstructured":"He DG, Wu LZ, Kim HK, Li H, Elmets CA, Xu H. CD8\u00a0+\u00a0IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol. 2006;177(10):6852\u20138.","journal-title":"J Immunol"},{"issue":"2","key":"8788_CR34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.0105-1873.2005.00635.x","volume":"53","author":"H Moed","year":"2005","unstructured":"Moed H, Von Blomberg BME, Bruynzeel DP, Scheper RJ, Gibbs S, Rustemeyer T. Regulation of nickel-induced T-cell responsiveness by CD4\u00a0+\u00a0CD25\u00a0+\u00a0cells in contact allergic patients and healthy individuals. Contact Dermat. 2005;53(2):71\u20134.","journal-title":"Contact Dermat"},{"issue":"3","key":"8788_CR35","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1365-2249.2006.03018.x","volume":"143","author":"JT Minang","year":"2006","unstructured":"Minang JT, Arestr\u00f6m I, Zuber B, J\u00f6nsson G, Troye-Blomberg M, Ahlborg N. Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Clin Exp Immunol. 2006;143(3):494\u2013502.","journal-title":"Clin Exp Immunol"},{"key":"8788_CR36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.intimp.2010.11.012","volume":"11","author":"WJ Cao","year":"2011","unstructured":"Cao WJ, Zhang W, Liu JJ, Wang Y, Peng XM, Lu DX, Qi RB, Wang YP, Wang HD. Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-a and IL-1b release and augmentation of IL-10 production. Int Immunopharmacol. 2011;11:172\u20138.","journal-title":"Int Immunopharmacol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8788-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-016-8788-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8788-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T11:37:34Z","timestamp":1692185854000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-016-8788-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,22]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["8788"],"URL":"https:\/\/doi.org\/10.1007\/s12026-016-8788-8","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,22]]}}}