{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:54Z","timestamp":1791412074104,"version":"4.3.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["109451"],"award-info":[{"award-number":["109451"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s12026-016-8880-0","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T03:23:55Z","timestamp":1479871435000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The role of B7 family costimulatory molecules and indoleamine 2,3-dioxygenase in primary Sj\u00f6gren\u2019s syndrome and systemic sclerosis"],"prefix":"10.1007","volume":"65","author":[{"given":"N\u00f3ra","family":"Leg\u00e1ny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Berta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Balog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Toldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"8880_CR1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1440-1711.1999.00835.x","volume":"77","author":"NL Harris","year":"1999","unstructured":"Harris NL, Ronchese F. The role of B7 costimulation in T-cell immunity. Immunol Cell Biol. 1999;77:304\u201311.","journal-title":"Immunol Cell Biol"},{"key":"8880_CR2","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1073\/pnas.90.14.6586","volume":"90","author":"CD Gimmi","year":"1993","unstructured":"Gimmi CD, Freeman GJ, Gribben JG, et al. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A. 1993;90:6586\u201390.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8880_CR3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.immunol.19.1.565","volume":"19","author":"CA Chambers","year":"2001","unstructured":"Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol. 2001;19:565\u201394.","journal-title":"Annu Rev Immunol"},{"key":"8880_CR4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.20021752","volume":"197","author":"S Wang","year":"2003","unstructured":"Wang S, Bajorath J, Flies DB, et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med. 2003;197:1083\u201391.","journal-title":"J Exp Med"},{"key":"8880_CR5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(00)80089-8","volume":"11","author":"H Nishimura","year":"1999","unstructured":"Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999;11:141\u201351.","journal-title":"Immunity"},{"key":"8880_CR6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1074-7613(00)00011-X","volume":"13","author":"AJ Coyle","year":"2000","unstructured":"Coyle AJ, Lehar S, Lloyd C, et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity. 2000;13:95\u2013105.","journal-title":"Immunity"},{"key":"8880_CR7","first-page":"37","volume":"1","author":"S Wang","year":"2004","unstructured":"Wang S, Chen L. T lymphocyte co-signaling pathways of the B7-CD28 family. Cell Mol Immunol. 2004;1:37\u201342.","journal-title":"Cell Mol Immunol"},{"key":"8880_CR8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1600-0897.2010.00841.x","volume":"63","author":"MG Petroff","year":"2010","unstructured":"Petroff MG, Perchellet A. B7 family molecules regulators of the maternal immune system in pregnancy. Am J Reprod Immunol. 2010;63:506\u201319.","journal-title":"Am J Reprod Immunol"},{"key":"8880_CR9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ni846","volume":"3","author":"U Grohmann","year":"2002","unstructured":"Grohmann U, Orabona C, Fallarino F, et al. CTLA-4-Ig regulates tryphtophan catabolism in vivo. Nat Immunol. 2002;3:1097\u2013101.","journal-title":"Nat Immunol"},{"key":"8880_CR10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00702-011-0681-y","volume":"119","author":"Y M\u00e1ndi","year":"2012","unstructured":"M\u00e1ndi Y, V\u00e9csei L. The kynurenine system and immunoregulation. J Neural Transm (Vienna). 2012;119:197\u2013209.","journal-title":"J Neural Transm (Vienna)"},{"key":"8880_CR11","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.2174\/092986712803833353","volume":"19","author":"P Filippini","year":"2012","unstructured":"Filippini P, Del Papa N, Sambataro D, et al. Emerging conception inhibitors of indoleamine 2,3-dioxygenase in rheumatic disease. Curr Med Chem. 2012;19:5381\u2013593.","journal-title":"Curr Med Chem"},{"key":"8880_CR12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/00002281-200309000-00007","volume":"15","author":"A Hansen","year":"2003","unstructured":"Hansen A, Lipsky PE, D\u00f6rner T. New concepts in the pathogenesis of Sj\u00f6gren syndrome: many questions, fewer answers. Curr Opin Rheumol. 2003;15:563\u201370.","journal-title":"Curr Opin Rheumol"},{"key":"8880_CR13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","volume":"117","author":"J Varga","year":"2007","unstructured":"Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557\u201367.","journal-title":"J Clin Invest"},{"key":"8880_CR14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tips.2015.06.005","volume":"36","author":"JM Chinai","year":"2015","unstructured":"Chinai JM, Janakiram M, Chen F, et al. New immunotherapies targeting the PD-1 pathway. Trends Pharmacol Sci. 2015;36:587\u201395.","journal-title":"Trends Pharmacol Sci"},{"key":"8880_CR15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/03009742.2013.812238","volume":"43","author":"FV Paoli de","year":"2014","unstructured":"de Paoli FV, Nielsen BD, Rasmussen F, et al. Abatacept induces clinical improvement in patients with severe systemic sclerosis. Scand J Rheumatol. 2014;43:342\u20135.","journal-title":"Scand J Rheumatol"},{"key":"8880_CR16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/annrheumdis-2013-204653","volume":"73","author":"PM Meiners","year":"2014","unstructured":"Meiners PM, Vissink A, Kroese FG, et al. Abatacept treatment reduces disease activity in early primary Sj\u00f6gren\u2019s syndrome. Ann Rheum Dis. 2014;73:1393\u20136.","journal-title":"Ann Rheum Dis"},{"key":"8880_CR17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","volume":"61","author":"C Vitali","year":"2002","unstructured":"Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554\u20138.","journal-title":"Ann Rheum Dis"},{"key":"8880_CR18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/acr.21591","volume":"64","author":"SC Shiboski","year":"2012","unstructured":"Shiboski SC, Shiboski CH, Criswell L, et al. American College of Rheumatology classification criteria for Sj\u00f6gren\u2019s syndrome: a data-driven expert consensus approach in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance cohort. Arthritis Care Res. 2012;64:475\u201387.","journal-title":"Arthritis Care Res"},{"key":"8880_CR19","doi-asserted-by":"crossref","first-page":"e000022","DOI":"10.1136\/rmdopen-2014-000022","volume":"1","author":"R Seror","year":"2015","unstructured":"Seror R, Bowman SJ, Brito-Zeron P, et al. EULAR Sj\u00f6gren\u2019s syndrome disease activity index (ESSDAI): a user guide. RMD Open. 2015;1:e000022.","journal-title":"RMD Open"},{"key":"8880_CR20","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F Hoogen van den","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European league against rheumatism collaborative initiative. Arthritis Rheum. 2013;65:2737\u201347.","journal-title":"Arthritis Rheum"},{"key":"8880_CR21","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202\u20135.","journal-title":"J Rheumatol"},{"key":"8880_CR22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1182\/blood-2012-10-385591","volume":"121","author":"P Greaves","year":"2013","unstructured":"Greaves P, Gribben JG. The role of B7 family molecules in hematologic malignancy. Blood. 2013;121:734\u201344.","journal-title":"Blood"},{"key":"8880_CR23","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nri1131","volume":"3","author":"CE Rudd","year":"2003","unstructured":"Rudd CE, Schneider H. Unifying concepts inCD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol. 2003;3:544\u201356.","journal-title":"Nat Rev Immunol"},{"key":"8880_CR24","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.270.5238.985","volume":"270","author":"P Waterhouse","year":"1995","unstructured":"Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science. 1995;270:985\u20138.","journal-title":"Science"},{"key":"8880_CR25","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.4049\/jimmunol.0800758","volume":"182","author":"JM Odegard","year":"2009","unstructured":"Odegard JM, Di Placido LD, Greenwald L, et al. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. J Immunol. 2009;182:4076\u201384.","journal-title":"J Immunol"},{"key":"8880_CR26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2013.11.003","volume":"51","author":"YZ Gong","year":"2014","unstructured":"Gong YZ, Nititham J, Taylor K, et al. Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sj\u00f6gren\u2019s syndrome. J Autoimmunity. 2014;51:57\u201366.","journal-title":"J Autoimmunity"},{"key":"8880_CR27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.immuni.2015.02.015","volume":"42","author":"LL Teichmann","year":"2015","unstructured":"Teichmann LL, Cullen JL, Kashgarian M, et al. Local triggering of the ICOS coreceptor by CD11c\u00a0+\u00a0myeloid cells drives organ inflammation in lupus. Immunity. 2015;42:552\u201365.","journal-title":"Immunity"},{"key":"8880_CR28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fimmu.2016.00304","volume":"7","author":"DJ Wikenheiser","year":"2016","unstructured":"Wikenheiser DJ, Stumhofer JS. ICOS Co-stimulation: friend or foe? Front Immunol. 2016;7:304.","journal-title":"Front Immunol"},{"key":"8880_CR29","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s10147-016-0958-0","volume":"21","author":"S Chikuma","year":"2016","unstructured":"Chikuma S. Basics of PD-1 in self-tolerance, infection, and cancer immunity. Int J Clin Oncol. 2016;21:448\u201355.","journal-title":"Int J Clin Oncol"},{"key":"8880_CR30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/IJTR.S11737","volume":"21","author":"RO Williams","year":"2013","unstructured":"Williams RO. Exploitation of the IDO pathway in the therapy of rheumatoid arthritis. Int J Tryptophan Res. 2013;21:67\u201373.","journal-title":"Int J Tryptophan Res"},{"key":"8880_CR31","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/ar4245","volume":"15","author":"J Furuzawa-Carballeda","year":"2013","unstructured":"Furuzawa-Carballeda J, Hern\u00e1ndez-Molina G, Lima G, et al. Peripheral regulatory cells immunophenotyping in primary Sj\u00f6gren\u2019s syndrome: a cross-sectional study. Arthritis Res Ther. 2013;15:R68.","journal-title":"Arthritis Res Ther"},{"key":"8880_CR32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2249.2005.02889.x","volume":"142","author":"M Petrovaara","year":"2005","unstructured":"Petrovaara M. RaitalaA, Uusitalo H, et al. Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sj\u00f6gren\u2019s syndrome. Clin Exp Immunol. 2005;142:155\u201361.","journal-title":"Clin Exp Immunol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-016-8880-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8880-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8880-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T10:09:29Z","timestamp":1589710169000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-016-8880-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["8880"],"URL":"https:\/\/doi.org\/10.1007\/s12026-016-8880-0","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}