{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:44Z","timestamp":1788386084524,"version":"build-2803163510"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s12026-018-9004-9","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T22:38:10Z","timestamp":1529102290000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers)"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-4924","authenticated-orcid":false,"given":"Pio","family":"Conti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Caraffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Ronconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara M.","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros K.","family":"Kritas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiberto","family":"Mastrangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tettamanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theoharis C.","family":"Theoharides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,16]]},"reference":[{"issue":"4","key":"9004_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1212\/WNL.0000000000002898","volume":"87","author":"Z Goodarzi","year":"2016","unstructured":"Goodarzi Z, Mrklas KJ, Roberts DJ, Jette N, Pringsheim T, Holroyd-Leduc J. Detecting depression in Parkinson disease: a systematic review and meta-analysis. Neurology. 2016;87(4):426\u201337.","journal-title":"Neurology"},{"key":"9004_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.coph.2016.06.001","volume":"29","author":"S Hayley","year":"2016","unstructured":"Hayley S, Audet MC, Anisman H. Inflammation and the microbiome: implications for depressive disorders. Curr Opin Pharmacol. 2016;29:42\u20136.","journal-title":"Curr Opin Pharmacol"},{"key":"9004_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.msard.2015.11.005","volume":"5","author":"P Conti","year":"2016","unstructured":"Conti P, Kempuraj D. Important role of mast cells in multiple sclerosis. Mult Scler Relat Disord. 2016;5:77\u201380.","journal-title":"Mult Scler Relat Disord"},{"issue":"7","key":"9004_CR4","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1177\/0333102416638520","volume":"36","author":"Y Yang","year":"2016","unstructured":"Yang Y, Ligthart L, Terwindt GM, Boomsma DI, Rodriguez-Acevedo AJ, Nyholt DR. Genetic epidemiology of migraine and depression. Cephalalgia. 2016;36(7):679\u201391.","journal-title":"Cephalalgia"},{"issue":"3","key":"9004_CR5","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jaac.2013.11.013","volume":"53","author":"RH Mitchell","year":"2014","unstructured":"Mitchell RH, Goldstein BI. Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry. 2014;53(3):274\u201396.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"9","key":"9004_CR6","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nm.3303","volume":"19","author":"S Bittner","year":"2013","unstructured":"Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Maati HM, Bobak N, et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 2013;19(9):1161\u20135.","journal-title":"Nat Med"},{"issue":"7","key":"9004_CR7","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1152\/jn.00991.2014","volume":"113","author":"J Zhao","year":"2015","unstructured":"Zhao J, Levy D. Modulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment. J Neurophysiol. 2015;113(7):2778\u201385.","journal-title":"J Neurophysiol"},{"issue":"Suppl 2","key":"9004_CR8","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1007\/s10072-006-0577-z","volume":"27","author":"T Dalkara","year":"2006","unstructured":"Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci. 2006;27(Suppl 2):S86\u201390.","journal-title":"Neurol Sci"},{"issue":"Suppl 1","key":"9004_CR9","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1016\/j.pain.2013.07.021","volume":"154","author":"R Noseda","year":"2013","unstructured":"Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013;154(Suppl 1):S44\u201353.","journal-title":"Pain"},{"issue":"1","key":"9004_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2174\/187152711794488674","volume":"10","author":"D Berardis De","year":"2011","unstructured":"De Berardis D, Di Iorio G, Acciavatti T, Conti C, Serroni N, Olivieri L, et al. The emerging role of melatonin agonists in the treatment of major depression: focus on agomelatine. CNS Neurol Disord Drug Targets. 2011;10(1):119\u201332.","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"3","key":"9004_CR11","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.neubiorev.2013.01.021","volume":"37","author":"W Swardfager","year":"2013","unstructured":"Swardfager W, Winer DA, Herrmann N, Winer S, Lanct\u00f4t KL. Interleukin-17 in post-stroke neurodegeneration. Neurosci Biobehav Rev. 2013;37(3):436\u201347.","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"9004_CR12","first-page":"837","volume":"31","author":"I Robuffo","year":"2017","unstructured":"Robuffo I, Toniato E, Tettamanti L, Mastrangelo F, Ronconi G, Frydas I, Caraffa A, Kritas SK, Conti P. Mast cell in innate immunity mediated by proiflammatory and antiinflammatory IL-1 family members. J Biol Regul Homeostst Agents. 2017;31(4):837\u201342.","journal-title":"J Biol Regul Homeostst Agents"},{"issue":"2","key":"9004_CR13","first-page":"263","volume":"31","author":"P Conti","year":"2017","unstructured":"Conti P, Caraffa Al, Kritas SK, Ronconi G, Lessiani G, Toniato E, Theoharides TC. Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. J Biol Regul Homeost Agents. 2017;31(2):263\u20137.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"9004_CR14","first-page":"543","volume":"31","author":"E Toniato","year":"2017","unstructured":"Toniato E, Frydas I, Robuffo I, Ronconi G, Caraffa AI, Kritas SK, Conti P. Activation and inhibition of adaptive immune response mediated by mast cells. J Biol RegulHomeost Agents. 2017;31(3):543\u20138.","journal-title":"J Biol RegulHomeost Agents"},{"issue":"2","key":"9004_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0165-2478(03)00002-6","volume":"86","author":"P Conti","year":"2003","unstructured":"Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, et al. IL-10, an inflammatory\/inhibitory cytokine, but not always. Immunol Lett. 2003;86(2):123\u20139.","journal-title":"Immunol Lett"},{"key":"9004_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/7854_2016_26","volume":"31","author":"CL Raison","year":"2016","unstructured":"Raison CL. The promise and limitations of anti-inflammatory agents for the treatment of major depressive disorder. Curr Top Behav Neurosci. 2016;31:287\u2013302.","journal-title":"Curr Top Behav Neurosci"},{"issue":"4","key":"9004_CR17","first-page":"957","volume":"31","author":"A Kasperska-Zaiac","year":"2017","unstructured":"Kasperska-Zaiac A, Grzanka A, Damasiewicz-Bodzek A, Bieniek K, Skrzypulec-Frankel A, Stencel-Gabriel K, Sikora-Zydek A. Elevated plasma IL-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria. J Biol Regul Homeost Agents. 2017;31(4):957\u201361.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"9004_CR18","doi-asserted-by":"publisher","first-page":"380","DOI":"10.5114\/ceji.2015.54603","volume":"40","author":"P Conti","year":"2015","unstructured":"Conti P, Shaik-Dasthagirisaeb Y. Atherosclerosis: a chronic inflammatory disease mediated by mast cells. Cent Eur J Immunol. 2015;40(3):380\u20136.","journal-title":"Cent Eur J Immunol"},{"issue":"5","key":"9004_CR19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","volume":"18","author":"SJ Galli","year":"2012","unstructured":"Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med. 2012;18(5):693\u2013704.","journal-title":"Nat Med"},{"issue":"4","key":"9004_CR20","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/0394632016644447","volume":"29","author":"S Nakayama","year":"2016","unstructured":"Nakayama S, Yokote T, Hiraoka N, Nishiwaki U, Hanafusa T, Nishimura Y, et al. Role of mast cells in fibrosis of classical Hodgkin lymphoma. Int J Immunopathol Pharmacol. 2016;29(4):603\u201311.","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"9004_CR21","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1177\/0394632015626150","volume":"29","author":"N Eskandari","year":"2016","unstructured":"Eskandari N, Tashrifi F, Bastan R, Andalib A, Yousefi Z, Peachell PT. Cyclic nucleotide phosphodiesterase isoforms in human basophils and mast cells. Int J Immunopathol Pharmacol. 2016;29(4):654\u201365.","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"6","key":"9004_CR22","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1586\/1744666X.2014.906302","volume":"10","author":"AI Petra","year":"2014","unstructured":"Petra AI, Panagiotidou S, Stewart JM, Conti P, Theoharides TC. Spectrum of mast cell activation disorders. Expert Rev Clin Immunol. 2014;10(6):729\u201339.","journal-title":"Expert Rev Clin Immunol"},{"issue":"1\u20132","key":"9004_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2008.09.014","volume":"205","author":"TC Theoharides","year":"2008","unstructured":"Theoharides TC, Rozniecki JJ, Sahagian G, et al. Impact of stress and mast cells on brain metastases. J Neuroimmunol. 2008;205(1\u20132):1\u20137.","journal-title":"J Neuroimmunol"},{"issue":"1","key":"9004_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMra073096","volume":"358","author":"RH Belmaker","year":"2008","unstructured":"Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008;358(1):55\u201368.","journal-title":"N Engl J Med"},{"issue":"5","key":"9004_CR25","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1136\/gut.45.5.705","volume":"45","author":"A Tailor","year":"1999","unstructured":"Tailor A, Tomlinson A, Salas A, Pan\u00e9s J, Granger DN, Flower RJ, et al. Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. Gut. 1999;45(5):705\u201312.","journal-title":"Gut"},{"issue":"1","key":"9004_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbadis.2011.06.004","volume":"1822","author":"S Buhner","year":"2012","unstructured":"Buhner S, Schemann M. Mast cell-nerve axis with a focus on the human gut. Biochim Biophys Acta. 2012;1822(1):85\u201392.","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"9004_CR27","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.tips.2008.06.002","volume":"29","author":"TC Theoharides","year":"2008","unstructured":"Theoharides TC, Doyle R, Francis K, Conti P, Kalogeromitros D. Novel therapeutic targets for autism. Trends Pharmacol Sci. 2008;29(8):375\u201382.","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"9004_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.immuni.2013.10.005","volume":"39","author":"T Marichal","year":"2013","unstructured":"Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, et al. A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity. 2013;39(5):963\u201375.","journal-title":"Immunity"},{"issue":"5","key":"9004_CR29","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1182\/blood.V90.5.1807","volume":"90","author":"SY Tam","year":"1997","unstructured":"Tam SY, Tsai M, Yamaguchi M, Yano K, Butterfield JH, Galli SJ. Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells. Blood. 1997;90(5):1807\u201320.","journal-title":"Blood"},{"key":"9004_CR30","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","volume":"23","author":"SJ Galli","year":"2005","unstructured":"Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M. Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: recent advances. Annu Rev Immunol. 2005;23:749\u201386. Review","journal-title":"Annu Rev Immunol"},{"issue":"7","key":"9004_CR31","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.4049\/jimmunol.0803832","volume":"183","author":"AE John","year":"2009","unstructured":"John AE, Zhu YM, Brightling CE, Pang L, Knox AJ. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C\/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J Immunol. 2009;183(7):4682\u201392.","journal-title":"J Immunol"},{"issue":"20","key":"9004_CR32","doi-asserted-by":"publisher","first-page":"E4002","DOI":"10.1073\/pnas.1524845114","volume":"114","author":"A Taracanova","year":"2017","unstructured":"Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. SP and IL-33 markedly enhance TNF synsthesis and secretion from human mast cells mediated by the ineraction of their receptors. Proc Natl Acad Sci USA. 2017;114(20):E4002\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1 Suppl 1","key":"9004_CR33","first-page":"49","volume":"32","author":"E Savi","year":"2018","unstructured":"Savi E, Peveri S, Cavsaliere C, Masieri S, Montagni M. Laboratory tests for allergic diagnosis. J Biol Regul Homeost Agents. 2018;32(1 Suppl 1):49\u201360.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"1 Suppl 1","key":"9004_CR34","first-page":"61","volume":"32","author":"C Incorvala","year":"2018","unstructured":"Incorvala C, Cavaliere C, Frati F, Masieri S. Allergic rhinitis. J Biol Regul Homeost Agents. 2018;32(1 Suppl 1):61\u20136.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"11","key":"9004_CR35","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1248\/yakushi.14-00198","volume":"134","author":"Y Taketomi","year":"2014","unstructured":"Taketomi Y. Emerging roles of phospholipase A2s in mast cell biology. Yakugaku Zasshi. 2014;134(11):1179\u201389. Review","journal-title":"Yakugaku Zasshi"},{"issue":"11","key":"9004_CR36","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.tips.2004.09.007","volume":"25","author":"TC Theoharides","year":"2004","unstructured":"Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P. Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci. 2004;25(11):563\u20138.","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"9004_CR37","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1067\/mai.2001.117460","volume":"108","author":"BM Haselden","year":"2001","unstructured":"Haselden BM, Larch\u00e9 M, Meng Q, Shirley K, Dworski R, Kaplan AP, et al. Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or T(H)2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid. J Allergy Clin Immunol. 2001;108(3):394\u2013401.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"9004_CR38","doi-asserted-by":"publisher","first-page":"G850","DOI":"10.1152\/ajpgi.00277.2007","volume":"293","author":"S Yu","year":"2007","unstructured":"Yu S, Kollarik M, Ouyang A, Myers AC, Undem BJ. Mast cell-mediated long-lasting increases in excitability of vagal C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2007;293(4):G850\u20136.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"9004_CR39","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s11916-012-0255-1","volume":"16","author":"D Levy","year":"2012","unstructured":"Levy D. Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr Pain Headache Rep. 2012;16(3):270\u20137.","journal-title":"Curr Pain Headache Rep"},{"issue":"Suppl 1","key":"9004_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1471-4159.2009.05853.x","volume":"109","author":"RM Dietz","year":"2009","unstructured":"Dietz RM, Weiss JH, Shuttleworth CW. Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem. 2009;109(Suppl 1):145\u201352.","journal-title":"J Neurochem"},{"issue":"9","key":"9004_CR41","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.tics.2012.07.009","volume":"16","author":"MP Paulus","year":"2012","unstructured":"Paulus MP, Yu AJ. Emotion and decision-making: affect-driven belief systems in anxiety and depression. Trends Cogn Sci. 2012;16(9):476\u201383.","journal-title":"Trends Cogn Sci"},{"issue":"3","key":"9004_CR42","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.4049\/jimmunol.128.3.1211","volume":"128","author":"D Ba","year":"1982","unstructured":"Ba D, Takeichi N, Kodama T, Kobayashi H. Restoration of T cell depression and suppression of blood pressure in spontaneously hypertensive rats (SHR) by thymus grafts or thymus extracts. J Immunol. 1982;128(3):1211\u20136.","journal-title":"J Immunol"},{"issue":"Suppl 12","key":"9004_CR43","first-page":"S258","volume":"10","author":"JE Hall","year":"1999","unstructured":"Hall JE, Brands MW, Henegar JR. Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney. J Am Soc Nephrol. 1999;10(Suppl 12):S258\u201365.","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"9004_CR44","first-page":"29","volume":"32","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Song T, Zhang L, Wei N. Immunomodulatory effects of T helper 17 cells and regulatory T cells on cerebral ischemia. J Biol Regul Homeost Agents. 2018;32(1):29\u201335.","journal-title":"J Biol Regul Homeost Agents"},{"key":"9004_CR45","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/1742-2094-11-132","volume":"11","author":"J Cazareth","year":"2014","unstructured":"Cazareth J, Guyon A, Heurteaux C, Chabry J, Petit-Paitel A. Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2\/CCL2 signaling. J Neuroinflammation. 2014;11:132.","journal-title":"J Neuroinflammation"},{"issue":"2","key":"9004_CR46","first-page":"341","volume":"32","author":"Y Liu","year":"2018","unstructured":"Liu Y, Yan H, Shao F, Li QH, Cui M. Correlation between chidhood eczema and specific IgG antibody level. J Biol Regul Homeost Agents. 2018;32(2):341\u20134.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"9004_CR47","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1523\/JNEUROSCI.13-03-01167.1993","volume":"13","author":"MA Moskowitz","year":"1993","unstructured":"Moskowitz MA, Nozaki K, Kraig RP. Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms. J Neurosci. 1993;13(3):1167\u201377.","journal-title":"J Neurosci"},{"issue":"6","key":"9004_CR48","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.yjmcc.2010.02.020","volume":"48","author":"R Fallach","year":"2010","unstructured":"Fallach R, Shainberg A, Avlas O, Fainblut M, Chepurko Y, Porat E, et al. Cardiomyocyte toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia. J Mol Cell Cardiol. 2010;48(6):1236\u201344.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"9004_CR49","first-page":"97","volume":"32","author":"Y Chen","year":"2018","unstructured":"Chen Y, Liu ZH, Lin ZH, Shi XZ. Eyes in pituitary disorders. J Biol Regul Homeost Agents. 2018;32(1):97\u20139.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"2","key":"9004_CR50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s12640-015-9533-0","volume":"28","author":"P Conti","year":"2015","unstructured":"Conti P, Shaik-Dasthagirisaheb YB. Mast cell serotonin immunoregulatory effects impacting on neuronal function: implications for neurodegenerative and psychiatric disorders. Neurotox Res. 2015;28(2):147\u201353.","journal-title":"Neurotox Res"},{"issue":"8","key":"9004_CR51","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1139\/y87-240","volume":"65","author":"JF Cloix","year":"1987","unstructured":"Cloix JF, Crabos M, Grichois ML, Meyer P. An endogenous digitalis-like compound extracted from human urine: biochemical and chemical studies. Can J Physiol Pharmacol. 1987;65(8):1522\u20137.","journal-title":"Can J Physiol Pharmacol"},{"key":"9004_CR52","doi-asserted-by":"publisher","first-page":"572","DOI":"10.2741\/2083","volume":"12","author":"S Kalantaridou","year":"2007","unstructured":"Kalantaridou S, Makrigiannakis A, Zoumakis E, Chrousos GP. Peripheral corticotropin-releasing hormone is produced in the immune and reproductive systems: actions, potential roles and clinical implications. Front Biosci. 2007;12:572\u201380.","journal-title":"Front Biosci"},{"issue":"5","key":"9004_CR53","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2174\/1568007023339049","volume":"1","author":"J Kehne","year":"2002","unstructured":"Kehne J, De Lombaert S. Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders. Curr Drug Targets CNS Neurol Disord. 2002;1(5):467\u201393.","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"9004_CR54","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbi.2015.08.011","volume":"51","author":"K Ramirez","year":"2016","unstructured":"Ramirez K, Niraula A, Sheridan JF. GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations. Brain Behav Immun. 2016;51:154\u201368.","journal-title":"Brain Behav Immun"},{"issue":"10","key":"9004_CR55","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","volume":"38","author":"R Yirmiya","year":"2015","unstructured":"Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease. Trends Neurosci. 2015;38(10):637\u201358.","journal-title":"Trends Neurosci"},{"issue":"Pt B","key":"9004_CR56","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.biocel.2016.03.012","volume":"77","author":"S Dogra","year":"2016","unstructured":"Dogra S, Sona C, Kumar A, Yadav PN. Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders. Int J Biochem Cell Biol. 2016;77(Pt B):226\u201339.","journal-title":"Int J Biochem Cell Biol"},{"issue":"12","key":"9004_CR57","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1210\/endo.137.12.8940412","volume":"137","author":"EL Webster","year":"1996","unstructured":"Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996;137(12):5747\u201350.","journal-title":"Endocrinology"},{"issue":"3","key":"9004_CR58","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.neuroscience.2010.02.060","volume":"167","author":"F Du","year":"2010","unstructured":"Du F, Yin L, Shi M, Cheng H, Xu X, Liu Z, et al. Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotropin releasing hormone type 1 receptor. Neuroscience. 2010;167(3):909\u201319.","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"9004_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1385\/NMM:7:1-2:003","volume":"7","author":"B Martin","year":"2005","unstructured":"Martin B, Lopez de Maturana R, Brenneman R, Walent T, Mattson MP, Maudsley S. Class II G protein-coupled receptors and their ligands in neuronal function and protection. NeuroMolecular Med. 2005;7(1\u20132):3\u201336.","journal-title":"NeuroMolecular Med"},{"issue":"3\u20134","key":"9004_CR60","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.yfrne.2005.09.001","volume":"26","author":"AG Watts","year":"2005","unstructured":"Watts AG. Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback. Front Neuroendocrinol. 2005;26(3\u20134):109\u201330.","journal-title":"Front Neuroendocrinol"},{"issue":"1","key":"9004_CR61","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","volume":"1822","author":"TC Theoharides","year":"2012","unstructured":"Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, et al. Mast cells and inflammation. Biochim Biophys Acta. 2012;1822(1):21\u201333.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"9004_CR62","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.imlet.2004.12.003","volume":"98","author":"Y Yang","year":"2005","unstructured":"Yang Y, Hahm E, Kim Y, Kang J, Lee W, Han I, et al. Regulation of IL-18 expression by CRH in mouse microglial cells. Immunol Lett. 2005;98(2):291\u20136.","journal-title":"Immunol Lett"},{"issue":"1","key":"9004_CR63","first-page":"83","volume":"32","author":"RF Hoseini","year":"2018","unstructured":"Hoseini RF, Jabbari F, Rezaee A, Rafatpanah H, Yousefzadeh H, Ariaee N, et al. House dust mite sublingual-swallow immunotherapy in perennial rhinitis: a double-blind, placebo-controlled Iranian study. J Biol Regul Homeost Agents. 2018;32(1):83\u20138.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"9004_CR64","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0022-3565(24)38092-9","volume":"288","author":"LK Singh","year":"1999","unstructured":"Singh LK, Boucher W, Pang X, Letourneau R, Seretakis D, Green M, et al. Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J Pharmacol Exp Ther. 1999;288(3):1349\u201356.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"9004_CR65","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1517\/14712598.6.2.109","volume":"6","author":"SH Ramkissoon","year":"2006","unstructured":"Ramkissoon SH, Patel HJ, Taborga M, Rameshwar P. G protein-coupled receptors in haematopoietic disruption. Expert Opin Biol Ther. 2006;6(2):109\u201320.","journal-title":"Expert Opin Biol Ther"},{"issue":"10","key":"9004_CR66","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1136\/gut.2005.064261","volume":"54","author":"JE Mawdsley","year":"2005","unstructured":"Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut. 2005;54(10):1481\u201391.","journal-title":"Gut"},{"issue":"6","key":"9004_CR67","first-page":"432","volume":"48","author":"A Norcini Pala","year":"2013","unstructured":"Norcini Pala A. HIV, depression and compliance: the mediating role of cytokines. A review of the international literature. Riv Psichiatr. 2013;48(6):432\u201340.","journal-title":"Riv Psichiatr"},{"issue":"2 Suppl 1","key":"9004_CR68","first-page":"189","volume":"31","author":"FJ Silvestre","year":"2017","unstructured":"Silvestre FJ, Lauritano D, Carinci F, Silvestre-Rangil J, Martinez-Herrera M, Del Olmo A. Neuroinflammation: Alzheimers disease and periodontal disease: is there an association between the two processes? J Biol Regul Homeost Agents. 2017;31(2 Suppl 1):189\u201396.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"9004_CR69","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1017\/S1041610215001155","volume":"28","author":"R Schaakxs","year":"2016","unstructured":"Schaakxs R, Wielaard I, Verhoeven JE, Beekman AT, Penninx BW, Comijs HC. Early and recent psychosocial stress and telomere length in older adults. Int Psychogeriatr. 2016;28(3):405\u201313.","journal-title":"Int Psychogeriatr"},{"issue":"23","key":"9004_CR70","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.2174\/13816128113196660738","volume":"20","author":"G Anderson","year":"2014","unstructured":"Anderson G, Maes M. Oxidative\/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications. Curr Pharm Des. 2014;20(23):3812\u201347.","journal-title":"Curr Pharm Des"},{"issue":"2","key":"9004_CR71","first-page":"579","volume":"30","author":"N Matin","year":"2016","unstructured":"Matin N, Tabatabaie O, Falsaperla R, Pavone P, Serra A, Cocuzza S, et al. Efficacy and safety of omalizumab in paediatric age: an update of literature data. J Biol Regul Homeost Agents. 2016;30(2):579\u201384.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"1","key":"9004_CR72","first-page":"13","volume":"32","author":"L Tettamanti","year":"2018","unstructured":"Tettamanti L, Caraffa A, Mastrangelo F, Ronconi G, Kritas S, Frydas I, et al. Different signals induce mast cell inflammatory activity: inhibitory effect of vitamin E. J Biol Regul Homeost Agents. 2018;32(1):13\u20139.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"6","key":"9004_CR73","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/00005072-199706000-00001","volume":"56","author":"KC Dines","year":"1997","unstructured":"Dines KC, Powell HC. Mast cell interactions with the nervous system: relationship to mechanisms of disease. J Neuropathol Exp Neurol. 1997;56(6):627\u201340.","journal-title":"J Neuropathol Exp Neurol"},{"key":"9004_CR74","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1742-2094-10-46","volume":"10","author":"TC Theoharides","year":"2013","unstructured":"Theoharides TC, Asadi S, Patel AB. Focal brain inflammation and autism. J Neuroinflammation. 2013;10:46.","journal-title":"J Neuroinflammation"},{"issue":"Pt 1","key":"9004_CR75","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1017\/S0031182000065033","volume":"112","author":"S Milano","year":"1996","unstructured":"Milano S, Arcoleo F, Dieli M, D'Agostino R, De Nucci G, D'Agostino P, et al. Ex vivo evidence for PGE2 and LTB4 involvement in cutaneous leishmaniasis: relation with infection status and cytokine production. Parasitology. 1996;112(Pt 1):13\u20139.","journal-title":"Parasitology"},{"issue":"9","key":"9004_CR76","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1073\/pnas.1000803107","volume":"107","author":"TC Theoharides","year":"2010","unstructured":"Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, et al. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A. 2010;107(9):4448\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"9004_CR77","doi-asserted-by":"publisher","first-page":"e61574","DOI":"10.1371\/journal.pone.0061574","volume":"8","author":"N Liu","year":"2013","unstructured":"Liu N, Wang LH, Guo LL, Wang GQ, Zhou XP, Jiang Y, et al. Chronic restraint stress inhibits hair growth via substance P mediated by reactive oxygen species in mice. PLoS One. 2013;8(4):e61574.","journal-title":"PLoS One"},{"issue":"2","key":"9004_CR78","first-page":"541","volume":"30","author":"T Yan","year":"2016","unstructured":"Yan T. Role of anti-inflammatory cytokines in pathogenesis of pediatric mycoplasma pneumoniae pneumonia. J Biol Regul Homeost Agents. 2016;30(2):541\u20135.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"2","key":"9004_CR79","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/0394632015627464","volume":"29","author":"AA Abd El-Aal","year":"2016","unstructured":"Abd El-Aal AA, Hassan MA, Gawdat HI, Ali MA, Barakat M. Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies. Int J Immunopathol Pharmacol. 2016;29(2):188\u201394.","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"2","key":"9004_CR80","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/jnc.12382","volume":"127","author":"DK Kaushik","year":"2013","unstructured":"Kaushik DK, Thounaojam MC, Kumawat KL, Gupta M, Basu A. Interleukin-1\u03b2 orchestrates underlying inflammatory responses in microglia via Kr\u00fcppel-like factor 4. J Neurochem. 2013;127(2):233\u201344.","journal-title":"J Neurochem"},{"issue":"1","key":"9004_CR81","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12974-016-0628-1","volume":"13","author":"RF Franca","year":"2016","unstructured":"Franca RF, Costa RS, Silva JR, et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. J Neuroinflammation. 2016;13(1):159.","journal-title":"J Neuroinflammation"},{"issue":"6","key":"9004_CR82","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.smim.2013.10.001","volume":"25","author":"CA Dinarello","year":"2013","unstructured":"Dinarello CA. Overview of the interleukin-1 family of ligands and receptors. Semin Immunol. 2013;25(6):389\u201393.","journal-title":"Semin Immunol"},{"issue":"6123","key":"9004_CR83","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.1231897","volume":"339","author":"H Karatas","year":"2013","unstructured":"Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Kocak E, Sen ZD, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science. 2013;339(6123):1092\u20135.","journal-title":"Science"},{"issue":"8","key":"9004_CR84","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1038\/sj.bjp.0702246","volume":"125","author":"M Msghina","year":"1998","unstructured":"Msghina M, Gonon F, Stj\u00e4rne L. Paired pulse analysis of ATP and noradrenaline release from sympathetic nerves of rat tail artery and mouse vas deferens: effects of K+ channel blockers. Br J Pharmacol. 1998;125(8):1669\u201376.","journal-title":"Br J Pharmacol"},{"issue":"7","key":"9004_CR85","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3109\/09513590.2014.911280","volume":"30","author":"A Graziottin","year":"2014","unstructured":"Graziottin A, Skaper SD, Fusco M. Mast cells in chronic inflammation, pelvic pain and depression in women. Gynecol Endocrinol. 2014;30(7):472\u20137.","journal-title":"Gynecol Endocrinol"},{"key":"9004_CR86","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.brainres.2009.09.077","volume":"1314","author":"JC Morales-Medina","year":"2010","unstructured":"Morales-Medina JC, Dumont Y, Quirion R. A possible role of neuropeptide Y in depression and stress. Brain Res. 2010;1314:194\u2013205.","journal-title":"Brain Res"},{"issue":"3","key":"9004_CR87","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s13105-012-0227-2","volume":"69","author":"M Thomson","year":"2013","unstructured":"Thomson M. The physiological roles of placental corticotropin releasing hormone in pregnancy and childbirth. J Physiol Biochem. 2013;69(3):559\u201373.","journal-title":"J Physiol Biochem"},{"issue":"8","key":"9004_CR88","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/0306-4530(95)00011-9","volume":"20","author":"EB Souza De","year":"1995","unstructured":"De Souza EB. Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology. 1995;20(8):789\u2013819.","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"9004_CR89","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3892\/etm.2015.2854","volume":"11","author":"GZ Hu","year":"2016","unstructured":"Hu GZ, Yang SJ, Hu WX, Wen Z, He D, Zeng LF, et al. Effect of cold stress on immunity in rats. Exp Ther Med. 2016;11(1):33\u201342.","journal-title":"Exp Ther Med"},{"key":"9004_CR90","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1721727X16677604","volume":"14","author":"NM F\u00e9lix","year":"2016","unstructured":"F\u00e9lix NM, Goy-Thollot I, Walton RS, Gil SA, Mateus LM, Matos AS, et al. Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats. Eur J Inflamm. 2016;14:147\u201361.","journal-title":"Eur J Inflamm."},{"key":"9004_CR91","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","volume":"11","author":"KW Moor","year":"1993","unstructured":"Moor KW, O\u2019Garra A, de Waal Malefyt R, et al. Interleukin-10. Annu Rev Immunol. 1993;11:165\u201390.","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"9004_CR92","first-page":"181","volume":"30","author":"QL Liu","year":"2016","unstructured":"Liu QL, Huang L, Zhao QJ, Li Q, He Z. Relationship between serum interleukin-17 level and inflammatory bowel disease. J Biol Regul Homeost Agents. 2016;30(1):181\u20138.","journal-title":"J Biol Regul Homeost Agents"},{"key":"9004_CR93","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1177\/1721727X15622960","volume":"14","author":"T dar","year":"2016","unstructured":"dar T, Edden Y, Shteingart S, Ben Ya\u2019acov A, et al. Portal hypertension is associated with modulation of regulatory T cells. Eur J Inflamm. 2016;14:40\u20137.","journal-title":"Eur J Inflamm."},{"issue":"9","key":"9004_CR94","doi-asserted-by":"publisher","first-page":"4830","DOI":"10.4049\/jimmunol.171.9.4830","volume":"171","author":"K Kandere-Grzybowska","year":"2003","unstructured":"Kandere-Grzybowska K, Letourneau R, Kempuraj D, Donelan J, Poplawski S, Boucher W, et al. IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J Immunol. 2003;171(9):4830\u20136.","journal-title":"J Immunol"},{"issue":"6","key":"9004_CR95","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.4049\/jimmunol.144.6.2216","volume":"144","author":"R Schindler","year":"1990","unstructured":"Schindler R, Ghezzi P, Dinarello CA. IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1. J Immunol. 1990;144(6):2216\u201322.","journal-title":"J Immunol"},{"issue":"6","key":"9004_CR96","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.smim.2013.10.004","volume":"25","author":"CA Dinarello","year":"2013","unstructured":"Dinarello CA, Bufler P. Interleukin-37. Semin Immunol. 2013;25(6):466\u20138. https:\/\/doi.org\/10.1016\/j.smim.2013.10.004 .","journal-title":"Semin Immunol"},{"issue":"4","key":"9004_CR97","first-page":"201","volume":"42","author":"JD Wood","year":"1999","unstructured":"Wood JD. Neurotransmission at the interface of sympathetic and enteric divisions of the autonomic nervous system. Chin J Physiol. 1999;42(4):201\u201310.","journal-title":"Chin J Physiol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-018-9004-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-018-9004-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-018-9004-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:32:37Z","timestamp":1751689957000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-018-9004-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["9004"],"URL":"https:\/\/doi.org\/10.1007\/s12026-018-9004-9","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"16 June 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}