{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:13:33Z","timestamp":1773213213037,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s12026-018-9057-9","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T22:08:21Z","timestamp":1546812501000},"page":"649-654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered expression of regulatory molecules in the skin of psoriasis"],"prefix":"10.1007","volume":"66","author":[{"given":"A. D.","family":"Sabag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dias-Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bejar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sheffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahava","family":"Vadasz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"9057_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3899\/jrheum.150638","volume":"93","author":"P Gisondi","year":"2015","unstructured":"Gisondi P, Di Mercurio M, Idolazzi L, Girolomoni G. Concept of remission in chronic plaque psoriasis. J Rheumatol Suppl. 2015;93:57\u201360.","journal-title":"J Rheumatol Suppl"},{"key":"9057_CR2","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.clindermatol.2007.08.012","volume":"25","author":"K Ghoreschi","year":"2007","unstructured":"Ghoreschi K, Weigert C, Rocken M. Immunopathogenesis and role of T cells in psoriasis. Clin Dermatol. 2007;25:574\u201380.","journal-title":"Clin Dermatol"},{"key":"9057_CR3","first-page":"7","volume":"6","author":"N Ayala-Fontanez","year":"2016","unstructured":"Ayala-Fontanez N, Soler DC, McCormick TS. Current knowledge on psoriasis and autoimmune diseases. Psoriasis (Auckl). 2016;6:7\u201332.","journal-title":"Psoriasis (Auckl)"},{"key":"9057_CR4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1189\/JLB.0109046","volume":"86","author":"C Ortega","year":"2009","unstructured":"Ortega C, Fernandez-A S, Carrillo JM, Romero P, Molina IJ, Moreno JC, et al. IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J Leukoc Biol. 2009;86:435\u201343.","journal-title":"J Leukoc Biol"},{"key":"9057_CR5","doi-asserted-by":"publisher","first-page":"e14108","DOI":"10.1371\/journal.pone.0014108","volume":"5","author":"PC Res","year":"2010","unstructured":"Res PC, Piskin G, de Boer OJ, van der Loos CM, Teeling P, Bos JD, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One. 2010;5:e14108.","journal-title":"PLoS One"},{"key":"9057_CR6","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1038\/jid.2014.261","volume":"134","author":"MBM Teunissen","year":"2014","unstructured":"Teunissen MBM, Yeremenko NG, Baeten DLP, Chielie S, Spuls PI, de Rie MA, et al. The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional cells. J Invest Dermatol. 2014;134:2898\u20137.","journal-title":"J Invest Dermatol"},{"key":"9057_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/jid.2008.194","volume":"129","author":"LC Zaba","year":"2009","unstructured":"Zaba LC, Fuentes-Duculan J, Eungdamrong NJ, Abello MV, Novitskaya I, Pierson KC, et al. Psoriasis is characterized by accumulation of immunostimulatory and Th1\/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol. 2009;129:79\u201388.","journal-title":"J Invest Dermatol"},{"key":"9057_CR8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.autrev.2014.11.012","volume":"14","author":"M Diani","year":"2015","unstructured":"Diani M, Altomare G, Reali E. T cell responses in psoriasis and psoriatic arthritis. Autoimmun Rev. 2015;14:286\u201392.","journal-title":"Autoimmun Rev"},{"key":"9057_CR9","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cellimm.2014.06.007","volume":"290","author":"L Luan","year":"2014","unstructured":"Luan L, Ding Y, Han S, Zhang Z, Liu X. An increased proportion of circulating Th22 and Tc22 cells in psoriasis. Cell Immunol. 2014;290:196\u2013200.","journal-title":"Cell Immunol"},{"key":"9057_CR10","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/sji.12404","volume":"83","author":"L Zhang","year":"2016","unstructured":"Zhang L, Li Y, Yang X, Wei J, Zhou S, Zhao Z, et al. Charaterization of Th17 and FoxP3+ Treg cells in pediatric psoriasis patients. Scand J Immunol. 2016;83:174\u201380.","journal-title":"Scand J Immunol"},{"key":"9057_CR11","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1038\/jid.2011.139","volume":"131","author":"HJ Bovenschen","year":"2011","unstructured":"Bovenschen HJ, van de Kerkhof PC, van Erp PE, Woestenenk R, Joosten I, Koenen HJ. FoxP3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin. J Invest Dermatol. 2011;131:1853\u201360.","journal-title":"J Invest Dermatol"},{"key":"9057_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jdermsci.2015.11.007","volume":"81","author":"L Yang","year":"2016","unstructured":"Yang L, Li B, Dang E, Jin L, Fan X, Wang G. Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3. J Dermatol Sci. 2016;81:85\u201392.","journal-title":"J Dermatol Sci"},{"key":"9057_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.4820","volume":"241","author":"M Gatzka","year":"2017","unstructured":"Gatzka M. Skin under Thf influence: how regulatory T cells work against macrophages in psoriasis. J Pathol. 2017;241:3\u20135.","journal-title":"J Pathol"},{"key":"9057_CR14","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1172\/JCI72932","volume":"124","author":"R Sanchez Rodrigues","year":"2014","unstructured":"Sanchez Rodrigues R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, et al. Memory regulatory T cells reside in human skin. J Clin Invest. 2014;124:1027\u201336.","journal-title":"J Clin Invest"},{"key":"9057_CR15","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nm.3554","volume":"20","author":"RX Wang","year":"2014","unstructured":"Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV, et al. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med. 2014;20:633\u201341.","journal-title":"Nat Med"},{"key":"9057_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12016-013-8360-4","volume":"47","author":"Z Vadasz","year":"2014","unstructured":"Vadasz Z, Toubi E. Semaphorins: their dual role in regulating immune-mediated diseases. Clin Rev Allergy Immunol. 2014;47:17\u201325.","journal-title":"Clin Rev Allergy Immunol"},{"key":"9057_CR17","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.4049\/jimmunol.0903527","volume":"185","author":"A Catalano","year":"2010","unstructured":"Catalano A. The neuroimmune semaphoring-3A reduces inflammation and progression of experimental autoimmune arthritis. J Immunol. 2010;185:6373\u201383.","journal-title":"J Immunol"},{"key":"9057_CR18","doi-asserted-by":"publisher","first-page":"e0125860","DOI":"10.1371\/journal.pone.0125860","volume":"10","author":"Z Vadasz","year":"2015","unstructured":"Vadasz Z, Rainis T, Nakhleh A, Hai T, Bejar J, Halasz K, et al. The involvement of immune semaphorins in the pathogenesis of inflammatory bowel diseases. PLoS One. 2015;10:e0125860.","journal-title":"PLoS One"},{"key":"9057_CR19","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1177\/0961203312456753","volume":"21","author":"Z Vadasz","year":"2012","unstructured":"Vadasz Z|, Toubi E. Semaphorin 3A- a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus. Lupus 2012; 21: 1266\u20131270.","journal-title":"Lupus"},{"key":"9057_CR20","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3389\/fimmu.2018.00634","volume":"9","author":"J Bejar","year":"2018","unstructured":"Bejar J, Kessler O, Sabag AD, Sabo E, Itzhak OB, Neufeld G, et al. Semaphorin3A: a potential therapeutic tool for lupus nephritis. Front Immunol. 2018;9:634. \n                    https:\/\/doi.org\/10.3389\/fimmu.2018.00634\n                    \n                  .","journal-title":"Front Immunol"},{"key":"9057_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/1346-8138.12317","volume":"41","author":"M Tominaga","year":"2014","unstructured":"Tominaga M, Takamori K. Itch and nerve fibers with special references to atopic dermatitis: therapeutic implications. J Dermatol. 2014;41:205\u201312.","journal-title":"J Dermatol"},{"key":"9057_CR22","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/imm.12791","volume":"152","author":"N Ali","year":"2017","unstructured":"Ali N, Rosenblum MD. Regulatory T cells in skin. Immunology. 2017;152:372\u201381.","journal-title":"Immunology"},{"key":"9057_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/bjd.16336","volume":"179","author":"IS Kotb","year":"2018","unstructured":"Kotb IS, Lewis BJ, Barker RN, Ormerod AD. Differential effects of phototherapy, adalimumab and betamethasone-calcipotriol on effector and regulatory T cells in psoriasis. Br J Dermatol. 2018;179:127\u201335. \n                    https:\/\/doi.org\/10.1111\/bjd.16336\n                    \n                  .","journal-title":"Br J Dermatol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-018-9057-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-018-9057-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-018-9057-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T19:25:03Z","timestamp":1578338703000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-018-9057-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["9057"],"URL":"https:\/\/doi.org\/10.1007\/s12026-018-9057-9","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"7 January 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declair that they do not have any conflict of interest regarding this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}