{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:27:20Z","timestamp":1772040440832,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Science and Technology project of Fujian Provincial Department","award":["2019J01166"],"award-info":[{"award-number":["2019J01166"]}]},{"name":"Innovative medical research project of Fujian Province","award":["2018-CX-33"],"award-info":[{"award-number":["2018-CX-33"]}]},{"name":"High-level talent program of science and technology project of Quanzhou city","award":["2018C044R"],"award-info":[{"award-number":["2018C044R"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12026-021-09241-0","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:03:41Z","timestamp":1642809821000},"page":"331-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microarray profiling and functional analysis reveal the regulatory role of differentially expressed plasma circular RNAs in Hashimoto\u2019s thyroiditis"],"prefix":"10.1007","volume":"70","author":[{"given":"Xuefeng","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meirong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengrong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-7029","authenticated-orcid":false,"given":"Huibin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"issue":"3","key":"9241_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.23736\/S0391-1977.17.02757-2","volume":"43","author":"RM Ruggeri","year":"2018","unstructured":"Ruggeri RM, Giuffrida G, Campenn\u00ec A. Autoimmune endocrine diseases. Minerva Endocrinol. 2018;43(3):305\u201322. https:\/\/doi.org\/10.23736\/S0391-1977.17.02757-2.","journal-title":"Minerva Endocrinol"},{"key":"9241_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","volume":"571","author":"G Cavalli","year":"2019","unstructured":"Cavalli G, Heard E. Advances in epigenetics link genetics to the environment and disease. Nature. 2019;571:489\u201399. https:\/\/doi.org\/10.1038\/s41586-019-1411-0.","journal-title":"Nature."},{"issue":"7","key":"9241_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1186\/s13059-014-0409-z","volume":"15","author":"JU Guo","year":"2014","unstructured":"Guo JU, Agarwal V, Guo H, et al. Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 2014;15(7):409. https:\/\/doi.org\/10.1186\/s13059-014-0409-z.","journal-title":"Genome Biol"},{"issue":"8","key":"9241_CR4","doi-asserted-by":"publisher","first-page":"bqaa053","DOI":"10.1210\/endocr\/bqaa053","volume":"161","author":"L Yin","year":"2020","unstructured":"Yin L, Zeng C, Yao J, et al. Emerging roles for noncoding RNAs in autoimmune thyroid disease. Endocrinology. 2020;161(8):bqaa053. https:\/\/doi.org\/10.1210\/endocr\/bqaa053.","journal-title":"Endocrinology"},{"key":"9241_CR5","doi-asserted-by":"publisher","first-page":"8029","DOI":"10.3892\/mmr.2017.7638","volume":"16","author":"F Zheng","year":"2017","unstructured":"Zheng F, Yu X, Huang J, et al. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Mol Med Rep. 2017;16:8029\u201336. https:\/\/doi.org\/10.3892\/mmr.2017.7638.","journal-title":"Mol Med Rep"},{"key":"9241_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/imm.12940","volume":"155","author":"LJ Li","year":"2018","unstructured":"Li LJ, Zhu ZW, Zhao W, et al. Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus. Immunology. 2018;155:137\u201349. https:\/\/doi.org\/10.1111\/imm.12940.","journal-title":"Immunology"},{"key":"9241_CR7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.omtn.2017.12.006","volume":"10","author":"J Luan","year":"2018","unstructured":"Luan J, Jiao C, Kong W, et al. circHLA-C plays an important role in lupus nephritis by sponging miR-150. Mol Ther Nucleic Acids. 2018;10:245\u201353. https:\/\/doi.org\/10.1016\/j.omtn.2017.12.006.","journal-title":"Mol Ther Nucleic Acids"},{"key":"9241_CR8","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1093\/hmg\/ddaa219","volume":"29","author":"L Iparraguirre","year":"2020","unstructured":"Iparraguirre L, Alberro A, Sep\u00falveda L, et al. RNA-Seq profiling of leukocytes reveals a sex-dependent global circular RNA upregulation in multiple sclerosis and 6 candidate biomarkers. Hum Mol Genet. 2020;29:3361\u201372. https:\/\/doi.org\/10.1093\/hmg\/ddaa219.","journal-title":"Hum Mol Genet"},{"key":"9241_CR9","doi-asserted-by":"publisher","first-page":"588","DOI":"10.7150\/thno.29678","volume":"9","author":"X Chen","year":"2019","unstructured":"Chen X, Yang T, Wang W, et al. Circular RNAs in immune responses and immune diseases. Theranostics. 2019;9:588\u2013607. https:\/\/doi.org\/10.7150\/thno.29678.","journal-title":"Theranostics"},{"key":"9241_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.05.004","volume":"17","author":"S Xiong","year":"2019","unstructured":"Xiong S, Peng H, Ding X, et al. Circular RNA expression profiling and the potential role of hsa_circ_0089172 in Hashimoto\u2019s thyroiditis via sponging miR125a-3p. Mol Ther Nucleic Acids. 2019;17:38\u201348. https:\/\/doi.org\/10.1016\/j.omtn.2019.05.004.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"19","key":"9241_CR11","doi-asserted-by":"publisher","first-page":"jcs214551","DOI":"10.1242\/jcs.214551","volume":"131","author":"CM de Winde","year":"2018","unstructured":"de Winde CM, Matthews AL, van Deventer S, et al. C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37. J Cell Sci. 2018;131(19):jcs214551. https:\/\/doi.org\/10.1242\/jcs.214551.","journal-title":"J Cell Sci"},{"issue":"1","key":"9241_CR12","doi-asserted-by":"publisher","first-page":"101366","DOI":"10.1016\/j.beem.2019.101366","volume":"34","author":"SM Ferrari","year":"2020","unstructured":"Ferrari SM, Fallahi P, Elia G, et al. Novel therapies for thyroid autoimmune diseases: an update. Best Pract Res Clin Endocrinol Metab. 2020;34(1):101366. https:\/\/doi.org\/10.1016\/j.beem.2019.101366.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"9241_CR13","doi-asserted-by":"publisher","first-page":"dgz289","DOI":"10.1210\/clinem\/dgz289","volume":"105","author":"P Fallahi","year":"2020","unstructured":"Fallahi P, Ferrari SM, Ragusa F, et al. Th1 chemokines in autoimmune endocrine disorders. J Clin Endocrinol Metab. 2020;105(4):dgz289. https:\/\/doi.org\/10.1210\/clinem\/dgz289.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"9241_CR14","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1210\/jc.2018-00541","volume":"103","author":"LC Faustino","year":"2018","unstructured":"Faustino LC, Lombardi A, Madrigal-Matute J, et al. Interferon-\u03b1 triggers autoimmune thyroid diseases via lysosomal-dependent degradation of thyroglobulin. J Clin Endocrinol Metab. 2018;103(10):3678\u201387. https:\/\/doi.org\/10.1210\/jc.2018-00541.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9241_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2014.09.001","volume":"159","author":"XO Zhang","year":"2014","unstructured":"Zhang XO, Wang HB, Zhang Y, et al. Complementary sequence-mediated exon circularization. Cell. 2014;159(1):134\u201347. https:\/\/doi.org\/10.1016\/j.cell.2014.09.001.","journal-title":"Cell."},{"issue":"12","key":"9241_CR16","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1096\/fj.13-231381","volume":"27","author":"S Ock","year":"2013","unstructured":"Ock S, Ahn J, Lee SH, et al. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J. 2013;27(12):4899\u2013908. https:\/\/doi.org\/10.1096\/fj.13-231381.","journal-title":"FASEB J"},{"issue":"5","key":"9241_CR17","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ajhg.2011.04.015","volume":"88","author":"A Teumer","year":"2011","unstructured":"Teumer A, Rawal R, Homuth G, et al. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. Am J Hum Genet. 2011;88(5):664\u201373. https:\/\/doi.org\/10.1016\/j.ajhg.2011.04.015.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"9241_CR18","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/febs.15493","volume":"288","author":"K Hutter","year":"2021","unstructured":"Hutter K, R\u00fclicke T, Drach M, Andersen L, Villunger A, Herzog S. Differential roles of miR-15a\/16\u20131 and miR-497\/195 clusters in immune cell development and homeostasis. FEBS J. 2021;288(5):1533\u201345. https:\/\/doi.org\/10.1111\/febs.15493.","journal-title":"FEBS J"},{"key":"9241_CR19","doi-asserted-by":"publisher","first-page":"117202","DOI":"10.1016\/j.jns.2020.117202","volume":"420","author":"AV Varma-Doyle","year":"2021","unstructured":"Varma-Doyle AV, Lukiw WJ, Zhao Y, Lovera J, Devier D. A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways. J Neurol Sci. 2021;420:117202. https:\/\/doi.org\/10.1016\/j.jns.2020.117202.","journal-title":"J Neurol Sci"},{"key":"9241_CR20","doi-asserted-by":"publisher","first-page":"619392","DOI":"10.3389\/fimmu.2021.619392","volume":"12","author":"S Wang","year":"2021","unstructured":"Wang S, Xu J, Guo Y, et al. MicroRNA-497 reduction and increase of its family member microRNA-424 lead to dysregulation of multiple inflammation related genes in synovial fibroblasts with rheumatoid arthritis. Front Immunol. 2021;12:619392. https:\/\/doi.org\/10.3389\/fimmu.2021.619392.","journal-title":"Front Immunol."},{"issue":"2","key":"9241_CR21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.gene.2014.04.069","volume":"544","author":"MA Honardoost","year":"2014","unstructured":"Honardoost MA, Kiani-Esfahani A, Ghaedi K, Etemadifar M, Salehi M. miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis. Gene. 2014;544(2):128\u201333. https:\/\/doi.org\/10.1016\/j.gene.2014.04.069.","journal-title":"Gene"},{"issue":"12","key":"9241_CR22","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/eji.201747132","volume":"47","author":"M Friedrich","year":"2017","unstructured":"Friedrich M, Pracht K, Mashreghi MF, et al. The role of the miR-148\/-152 family in physiology and disease. Eur J Immunol. 2017;47(12):2026\u201338. https:\/\/doi.org\/10.1002\/eji.201747132.","journal-title":"Eur J Immunol."},{"key":"9241_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.toxlet.2018.12.010","volume":"317","author":"LX Pan","year":"2019","unstructured":"Pan LX, Li LY, Zhou H, et al. TMEM100 mediates inflammatory cytokines secretion in hepatic stellate cells and its mechanism research. Toxicol Lett. 2019;317:82\u201391. https:\/\/doi.org\/10.1016\/j.toxlet.2018.12.010.","journal-title":"Toxicol Lett"},{"issue":"3","key":"9241_CR24","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1080\/15476286.2019.1703069","volume":"17","author":"KC Liao","year":"2020","unstructured":"Liao KC, Chuo V, Fagg WS, et al. The RNA binding protein Quaking represses host interferon response by downregulating MAVS. RNA Biol. 2020;17(3):366\u201380. https:\/\/doi.org\/10.1080\/15476286.2019.1703069.","journal-title":"RNA Biol"},{"key":"9241_CR25","doi-asserted-by":"publisher","first-page":"110635","DOI":"10.1016\/j.mce.2019.110635","volume":"500","author":"N Giusti","year":"2020","unstructured":"Giusti N, Gillotay P, Trubiroha A, et al. Inhibition of the thyroid hormonogenic H 2 O 2 production by Duox\/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Mol Cell Endocrinol. 2020;500:110635. https:\/\/doi.org\/10.1016\/j.mce.2019.110635.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"9241_CR26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrm.2015.32","volume":"17","author":"LL Chen","year":"2016","unstructured":"Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 2016;17(4):205\u201311. https:\/\/doi.org\/10.1038\/nrm.2015.32.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"9241_CR27","doi-asserted-by":"publisher","first-page":"e1478","DOI":"10.1002\/wrna.1478","volume":"9","author":"JE Wilusz","year":"2018","unstructured":"Wilusz JE. A 360\u00b0 view of circular RNAs: from biogenesis to functions. Wiley Interdiscip Rev RNA. 2018;9(4):e1478. https:\/\/doi.org\/10.1002\/wrna.1478.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"2","key":"9241_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12026-015-8643-3","volume":"62","author":"H Peng","year":"2015","unstructured":"Peng H, Liu Y, Tian J, et al. Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto\u2019s thyroiditis. Immunol Res. 2015;62(2):129\u201336. https:\/\/doi.org\/10.1007\/s12026-015-8643-3.","journal-title":"Immunol Res"},{"issue":"1","key":"9241_CR29","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13148-019-0632-2","volume":"11","author":"R Mazzone","year":"2019","unstructured":"Mazzone R, Zwergel C, Artico M, et al. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenetics. 2019;11(1):34. https:\/\/doi.org\/10.1186\/s13148-019-0632-2.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"9241_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1194\/jlr.M052670","volume":"56","author":"MC Romay","year":"2015","unstructured":"Romay MC, Che N, Becker SN, et al. Regulation of NF-\u03baB signaling by oxidized glycerophospholipid and IL-1\u03b2 induced miRs-21\u20133p and -27a-5p in human aortic endothelial cells. J Lipid Res. 2015;56(1):38\u201350. https:\/\/doi.org\/10.1194\/jlr.M052670.","journal-title":"J Lipid Res"},{"issue":"10","key":"9241_CR31","doi-asserted-by":"publisher","first-page":"102649","DOI":"10.1016\/j.autrev.2020.102649","volume":"19","author":"M Ralli","year":"2020","unstructured":"Ralli M, Angeletti D, Fiore M, et al. Hashimoto\u2019s thyroiditis: an update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev. 2020;19(10):102649. https:\/\/doi.org\/10.1016\/j.autrev.2020.102649.","journal-title":"Autoimmun Rev"},{"key":"9241_CR32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ebiom.2019.10.061","volume":"50","author":"R Mart\u00ednez-Hern\u00e1ndez","year":"2019","unstructured":"Mart\u00ednez-Hern\u00e1ndez R, Serrano-Somavilla A, Ramos-Lev\u00ed A, et al. Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases. EBioMedicine. 2019;50:329\u201342. https:\/\/doi.org\/10.1016\/j.ebiom.2019.10.061.","journal-title":"EBioMedicine"},{"key":"9241_CR33","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.clim.2015.12.009","volume":"164","author":"XF Liu","year":"2016","unstructured":"Liu XF, Wang RQ, Hu B, et al. MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10. Clin Immunol. 2016;164:106\u201313. https:\/\/doi.org\/10.1016\/j.clim.2015.12.009.","journal-title":"Clin Immunol"},{"key":"9241_CR34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.bbrc.2021.03.090","volume":"554","author":"X Jia","year":"2021","unstructured":"Jia X, Wei Y, Miao X, et al. Deficiency of miR-15a\/16 upregulates NKG2D in CD8+\u00a0T cells to exacerbate dextran sulfate sodium-induced colitis. Biochem Biophys Res Commun. 2021;554:114\u201322. https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.090.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"9241_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/BF03345149","volume":"26","author":"M Rotondi","year":"2003","unstructured":"Rotondi M, Lazzeri E, Romagnani P, Serio M. Role for interferon-gamma inducible chemokines in endocrine autoimmunity: an expanding field. J Endocrinol Invest. 2003;26(2):177\u201380. https:\/\/doi.org\/10.1007\/BF03345149.","journal-title":"J Endocrinol Invest"},{"key":"9241_CR36","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1530\/EC-18-0019","volume":"7","author":"X Luo","year":"2018","unstructured":"Luo X, Zheng T, Mao C, et al. Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1\u03b2\/MAPK pathway in Hashimoto\u2019s thyroiditis. Endocr Connect. 2018;7:850\u20138. https:\/\/doi.org\/10.1530\/EC-18-0019.","journal-title":"Endocr Connect"},{"key":"9241_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.intimp.2017.08.012","volume":"51","author":"T Mohan","year":"2017","unstructured":"Mohan T, Deng L, Wang BZ. CCL28 chemokine: an anchoring point bridging innate and adaptive immunity. Int Immunopharmacol. 2017;51:165\u201370. https:\/\/doi.org\/10.1016\/j.intimp.2017.08.012.","journal-title":"Int Immunopharmacol."}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-021-09241-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-021-09241-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-021-09241-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:15:19Z","timestamp":1655252119000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-021-09241-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,22]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["9241"],"URL":"https:\/\/doi.org\/10.1007\/s12026-021-09241-0","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,22]]},"assertion":[{"value":"23 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}