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The novel oral Janus kinase (JAK) inhibitor baricitinib has demonstrated high efficacy in RA. However, the effect of baricitinib on fibroblast-like synoviocytes (FLSs), a key component of invasive synovitis, has not been still elucidated. This study investigated whether GLS\/TP production could be regulated by JAK\/signal transducers and activators of transcription (STAT) signaling in FLSs derived from patients with RA. FLSs were cultured and stimulated by interferon (IFN)\u03b3 in the presence of baricitinib. Expression levels of GLS\/TP were determined using reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and immunocytochemistry. Phosphorylation of STAT proteins was investigated by Western blot. In cultured FLSs, GLS\/TP mRNA and protein levels were significantly induced by treatment with IFN\u03b3 and these inductions were suppressed by baricitinib treatment. Baricitinib inhibited IFN\u03b3-induced STAT1 phosphorylation, while JAK\/STAT activation played a pivotal role in IFN\u03b3-mediated GLS\/TP upregulation in RA. These results suggested that baricitinib suppressed IFN\u03b3-induced GLS\/TP expression by inhibiting JAK\/STAT signaling, resulting in the attenuation of neovascularization, synovial inflammation, and cartilage destruction.<\/jats:p>","DOI":"10.1007\/s12026-022-09261-4","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T22:02:36Z","timestamp":1641852156000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin\/thymidine phosphorylase in human fibroblast-like synoviocytes"],"prefix":"10.1007","volume":"70","author":[{"given":"Yuji","family":"Joyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yonezu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Senda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanshiro","family":"Yasuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Shiraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineyoshi","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-7731","authenticated-orcid":false,"given":"Yuko","family":"Waguri-Nagaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"9261_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","volume":"46","author":"GS Firestein","year":"2017","unstructured":"Firestein GS, McInnes IB. 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