{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:38:02Z","timestamp":1791567482437,"version":"4.3.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-040A"],"award-info":[{"award-number":["TJYXZDXK-040A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s12026-023-09359-3","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T08:03:43Z","timestamp":1673510623000},"page":"497-504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune myositis and autoimmune hemolytic anemia in two sisters with DOCK8-deficient hyper-IgE syndrome"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-6774","authenticated-orcid":false,"given":"Jing","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-0965","authenticated-orcid":false,"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-4167","authenticated-orcid":false,"given":"Yuci","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-4974","authenticated-orcid":false,"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-6297","authenticated-orcid":false,"given":"Chongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"issue":"1384\u20131394","key":"9359_CR1","doi-asserted-by":"publisher","first-page":"e1382","DOI":"10.1016\/j.jaci.2016.04.023","volume":"138","author":"S Keles","year":"2016","unstructured":"Keles S, Charbonnier LM, Kabaleeswaran V, et al. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. J Allergy Clin Immunol. 2016;138(1384\u20131394):e1382. https:\/\/doi.org\/10.1016\/j.jaci.2016.04.023.","journal-title":"J Allergy Clin Immunol"},{"key":"9359_CR2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/imcb.12209","volume":"97","author":"T Al-Shaikhly","year":"2019","unstructured":"Al-Shaikhly T, Ochs HD. Hyper IgE syndromes: clinical and molecular characteristics. Immunol Cell Biol. 2019;97:368\u201379. https:\/\/doi.org\/10.1111\/imcb.12209.","journal-title":"Immunol Cell Biol"},{"key":"9359_CR3","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1182\/blood-2012-01-407098","volume":"119","author":"Y Harada","year":"2012","unstructured":"Harada Y, Tanaka Y, Terasawa M, et al. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012;119:4451\u201361. https:\/\/doi.org\/10.1182\/blood-2012-01-407098.","journal-title":"Blood"},{"key":"9359_CR4","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1084\/jem.20110345","volume":"208","author":"KL Randall","year":"2011","unstructured":"Randall KL, Chan SS, Ma CS, et al. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med. 2011;208:2305\u201320. https:\/\/doi.org\/10.1084\/jem.20110345.","journal-title":"J Exp Med"},{"key":"9359_CR5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700751","author":"CJ Kearney","year":"2017","unstructured":"Kearney CJ, Vervoort SJ, Ramsbottom KM, et al. DOCK8 drives Src-dependent NK cell effector function. J Immunol. 2017. https:\/\/doi.org\/10.4049\/jimmunol.1700751.","journal-title":"J Immunol"},{"key":"9359_CR6","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jaci.2016.07.016","volume":"139","author":"SG Tangye","year":"2017","unstructured":"Tangye SG, Pillay B, Randall KL, et al. Dedicator of cytokinesis 8-deficient CD4(+) T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells. J Allergy Clin Immunol. 2017;139:933\u201349. https:\/\/doi.org\/10.1016\/j.jaci.2016.07.016.","journal-title":"J Allergy Clin Immunol"},{"key":"9359_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.iac.2018.08.007","volume":"39","author":"JRE Bergerson","year":"2019","unstructured":"Bergerson JRE, Freeman AF. An update on syndromes with a hyper-IgE phenotype. Immunol Allergy Clin North Am. 2019;39:49\u201361. https:\/\/doi.org\/10.1016\/j.iac.2018.08.007.","journal-title":"Immunol Allergy Clin North Am"},{"key":"9359_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10875-014-0126-0","volume":"35","author":"SE Aydin","year":"2015","unstructured":"Aydin SE, Kilic SS, Aytekin C, et al. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol. 2015;35:189\u201398. https:\/\/doi.org\/10.1007\/s10875-014-0126-0.","journal-title":"J Clin Immunol"},{"key":"9359_CR9","doi-asserted-by":"publisher","first-page":"e1458","DOI":"10.1542\/peds.2013-1383","volume":"134","author":"Z Jouhadi","year":"2014","unstructured":"Jouhadi Z, Khadir K, Ailal F, et al. Ten-year follow-up of a DOCK8-deficient child with features of systemic lupus erythematosus. Pediatrics. 2014;134:e1458-1463. https:\/\/doi.org\/10.1542\/peds.2013-1383.","journal-title":"Pediatrics"},{"key":"9359_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3904\/kjim.1999.14.1.95","volume":"14","author":"JK Min","year":"1999","unstructured":"Min JK, Cho ML, Kim SC, et al. Hyperimmunoglobulin E-recurrent infection syndrome in a patient with juvenile dermatomyositis. Korean J Intern Med. 1999;14:95\u20138. https:\/\/doi.org\/10.3904\/kjim.1999.14.1.95.","journal-title":"Korean J Intern Med"},{"issue":"Suppl 1","key":"9359_CR11","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1007\/s10067-010-1439-x","volume":"32","author":"B Saikia","year":"2013","unstructured":"Saikia B, Aneja H, Jain J, et al. Hyperimmunoglobulin E syndrome with juvenile dermatomyositis and calcinosis. Clin Rheumatol. 2013;32(Suppl 1):S51-53. https:\/\/doi.org\/10.1007\/s10067-010-1439-x.","journal-title":"Clin Rheumatol"},{"key":"9359_CR12","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1097\/01.bor.0000434664.37880.ac","volume":"25","author":"SL Tansley","year":"2013","unstructured":"Tansley SL, Betteridge ZE, McHugh NJ. The diagnostic utility of autoantibodies in adult and juvenile myositis. Curr Opin Rheumatol. 2013;25:772\u20137. https:\/\/doi.org\/10.1097\/01.bor.0000434664.37880.ac.","journal-title":"Curr Opin Rheumatol"},{"key":"9359_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jim.2012.07.019","volume":"384","author":"E Tarricone","year":"2012","unstructured":"Tarricone E, Ghirardello A, Rampudda M, et al. Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. J Immunol Methods. 2012;384:128\u201334. https:\/\/doi.org\/10.1016\/j.jim.2012.07.019.","journal-title":"J Immunol Methods"},{"key":"9359_CR14","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1136\/annrheumdis-2018-215004","volume":"78","author":"S Sabbagh","year":"2019","unstructured":"Sabbagh S, Pinal-Fernandez I, Kishi T, et al. Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis. Ann Rheum Dis. 2019;78:988\u201395. https:\/\/doi.org\/10.1136\/annrheumdis-2018-215004.","journal-title":"Ann Rheum Dis"},{"key":"9359_CR15","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1016\/j.bbmt.2019.04.028","volume":"25","author":"A Gokarn","year":"2019","unstructured":"Gokarn A, Toshniwal A, Pathak A, et al. Use of leflunomide for treatment of cytomegalovirus infection in recipients of allogeneic stem cell transplant. Biol Blood Marrow Transplant. 2019;25:1832\u20136. https:\/\/doi.org\/10.1016\/j.bbmt.2019.04.028.","journal-title":"Biol Blood Marrow Transplant"},{"key":"9359_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.antiviral.2004.03.007","volume":"65","author":"DL Evers","year":"2005","unstructured":"Evers DL, Wang X, Huong SM, et al. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. Antiviral Res. 2005;65:1\u201312. https:\/\/doi.org\/10.1016\/j.antiviral.2004.03.007.","journal-title":"Antiviral Res"},{"key":"9359_CR17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00296-010-1786-6","volume":"32","author":"AO Orden","year":"2012","unstructured":"Orden AO, Chuluyan JC, Colombini AC, et al. Leflunomide use in a cytomegalovirus infection of a patient with dermatomyositis. Rheumatol Int. 2012;32:273\u20135. https:\/\/doi.org\/10.1007\/s00296-010-1786-6.","journal-title":"Rheumatol Int"},{"key":"9359_CR18","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1136\/ard.2007.073221","volume":"67","author":"VS Sangle","year":"2008","unstructured":"Sangle VS, Sangle SR, D\u2019Cruz DP. Leflunomide as a remission-maintaining therapy in difficult-to-treat dermatomyositis. Ann Rheum Dis. 2008;67:723. https:\/\/doi.org\/10.1136\/ard.2007.073221.","journal-title":"Ann Rheum Dis"},{"key":"9359_CR19","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s10875-017-0451-1","volume":"37","author":"FJ Alroqi","year":"2017","unstructured":"Alroqi FJ, Charbonnier LM, Keles S, et al. DOCK8 deficiency presenting as an IPEX-like disorder. J Clin Immunol. 2017;37:811\u20139. https:\/\/doi.org\/10.1007\/s10875-017-0451-1.","journal-title":"J Clin Immunol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-023-09359-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-023-09359-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-023-09359-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:21:42Z","timestamp":1684203702000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-023-09359-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["9359"],"URL":"https:\/\/doi.org\/10.1007\/s12026-023-09359-3","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]},"assertion":[{"value":"29 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Tianjin Children\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent had been obtained from legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}