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The aim of this study was to assess the potential role of polymorphic variations in the genes coding for three NK and \u03b3\u03b4 T cell receptors: NCR3, FC\u03b3R3A, and DNAM-1 (rs1052248, rs396991, and rs763361, respectively) in the disease susceptibility and the efficacy of treatment with TNF inhibitors. The study included 461 patients with RA, 168 patients with AS, and 235 voluntary blood donors as controls. The\n                    <jats:italic>NCR3<\/jats:italic>\n                    rs1052248\n                    <jats:italic>AA<\/jats:italic>\n                    homozygosity prevailed in RA in patients lacking rheumatoid factor (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.044) as well as in those who manifested the disease at a younger age (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and had higher CRP levels after 12\u00a0weeks of anti-TNF therapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021). The\n                    <jats:italic>FC\u03b3R3A<\/jats:italic>\n                    rs396991 polymorphism was associated with pain visual analogue scale (VAS) values before the initiation of anti-TNF treatment. Lower VAS values were observed in the\n                    <jats:italic>GG<\/jats:italic>\n                    homozygous RA patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) and in AS patients with the\n                    <jats:italic>TT<\/jats:italic>\n                    genotype (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). Moreover, AS heterozygous patients with the\n                    <jats:italic>TG<\/jats:italic>\n                    genotype presented higher CRP levels in the 12th week of anti-TNF treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021). The findings suggest that the\n                    <jats:italic>NCR3<\/jats:italic>\n                    rs1052248\n                    <jats:italic>AA<\/jats:italic>\n                    homozygosity may have an adverse effect on RA, while the\n                    <jats:italic>T<\/jats:italic>\n                    allele potentially plays a protective role in the development of AS. Moreover, the rs1052248\n                    <jats:italic>T<\/jats:italic>\n                    allele and\n                    <jats:italic>TT<\/jats:italic>\n                    genotype appear to have a favorable impact on the response to anti-TNF therapy in RA patients.\n                  <\/jats:p>","DOI":"10.1007\/s12026-024-09488-3","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T18:02:12Z","timestamp":1715104932000},"page":"614-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic variability of three common NK and \u03b3\u03b4 T cell receptor genes (FC\u03b33R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis"],"prefix":"10.1007","volume":"72","author":[{"given":"Sylwia","family":"Bia\u0142y","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Iwaszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"\u015awierkot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kolossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wieli\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Jeka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0376","authenticated-orcid":false,"given":"Katarzyna","family":"Bogunia-Kubik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"issue":"2","key":"9488_CR1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/cells9020462","volume":"9","author":"I Bank","year":"2020","unstructured":"Bank I. 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