{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:27:11Z","timestamp":1788830831363,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-291"],"award-info":[{"award-number":["2024SF-YBXM-291"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12026-025-09593-x","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T13:14:47Z","timestamp":1736601287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning"],"prefix":"10.1007","volume":"73","author":[{"given":"Jun","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"issue":"11","key":"9593_CR1","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1080\/15384047.2019.1640032","volume":"20","author":"LE Davis","year":"2019","unstructured":"Davis LE, Shalin SC, Tackett AJ. Current state of melanoma diagnosis and treatment. Cancer Biol Ther. 2019;20(11):1366\u201379. https:\/\/doi.org\/10.1080\/15384047.2019.1640032.","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"9593_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349. https:\/\/doi.org\/10.3322\/caac.21820.","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"9593_CR3","doi-asserted-by":"publisher","first-page":"adv00502","DOI":"10.2340\/00015555-3832","volume":"101","author":"SS Ertekin","year":"2021","unstructured":"Ertekin SS, Podlipnik S, Riquelme-Mc Loughlin C, Barreiro-Capurro A, Arance A, Carrera C, et al. Initial stage of cutaneous primary melanoma plays a key role in the pattern and timing of disease recurrence. Acta Derm Venereol. 2021;101(7):adv00502. https:\/\/doi.org\/10.2340\/00015555-3832.","journal-title":"Acta Derm Venereol"},{"issue":"17","key":"9593_CR4","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.3390\/cancers13174431","volume":"13","author":"C Zhou","year":"2021","unstructured":"Zhou C, Louwman M, Wakkee M, van der Veldt A, Gr\u00fcnhagen D, Verhoef C, et al. Primary melanoma characteristics of metastatic disease: a nationwide cancer registry study. Cancers (Basel). 2021;13(17):4431. https:\/\/doi.org\/10.3390\/cancers13174431.","journal-title":"Cancers (Basel)"},{"issue":"5","key":"9593_CR5","doi-asserted-by":"publisher","first-page":"102962","DOI":"10.1016\/j.esmoop.2024.102962","volume":"9","author":"TA Sussman","year":"2024","unstructured":"Sussman TA, Ott PA. Adjuvant immunotherapy for melanoma patients: progress and opportunities. ESMO Open. 2024;9(5):102962. https:\/\/doi.org\/10.1016\/j.esmoop.2024.102962.","journal-title":"ESMO Open"},{"issue":"3","key":"9593_CR6","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.3390\/ijms24032413","volume":"24","author":"IY Filin","year":"2023","unstructured":"Filin IY, Mayasin YP, Kharisova CB, Gorodilova AV, Kitaeva KV, Chulpanova DS, et al. Cell immunotherapy against melanoma: clinical trials review. Int J Mol Sci. 2023;24(3):2413. https:\/\/doi.org\/10.3390\/ijms24032413.","journal-title":"Int J Mol Sci"},{"issue":"17","key":"9593_CR7","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1200\/jco.22.02575","volume":"41","author":"GV Long","year":"2023","unstructured":"Long GV, Menzies AM, Scolyer RA. Neoadjuvant checkpoint immunotherapy and melanoma: the time is now. J Clin Oncol. 2023;41(17):3236\u201348. https:\/\/doi.org\/10.1200\/jco.22.02575.","journal-title":"J Clin Oncol"},{"issue":"1","key":"9593_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.det.2022.07.007","volume":"41","author":"J Lazaroff","year":"2023","unstructured":"Lazaroff J, Bolotin D. Targeted therapy and immunotherapy in melanoma. Dermatol Clin. 2023;41(1):65\u201377. https:\/\/doi.org\/10.1016\/j.det.2022.07.007.","journal-title":"Dermatol Clin"},{"issue":"2","key":"9593_CR9","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y, Li Z, Zhang S, Zhang T, Liu Y, Zhang L. Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics. 2023;13(2):736\u201366. https:\/\/doi.org\/10.7150\/thno.79876.","journal-title":"Theranostics"},{"issue":"12","key":"9593_CR10","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","volume":"5","author":"A Picca","year":"2023","unstructured":"Picca A, Faitg J, Auwerx J, Ferrucci L, D\u2019Amico D. Mitophagy in human health, ageing and disease. Nat Metab. 2023;5(12):2047\u201361. https:\/\/doi.org\/10.1038\/s42255-023-00930-8.","journal-title":"Nat Metab"},{"issue":"1","key":"9593_CR11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","volume":"8","author":"S Wang","year":"2023","unstructured":"Wang S, Long H, Hou L, Feng B, Ma Z, Wu Y, et al. The mitophagy pathway and its implications in human diseases. Signal Transduct Target Ther. 2023;8(1):304. https:\/\/doi.org\/10.1038\/s41392-023-01503-7.","journal-title":"Signal Transduct Target Ther"},{"key":"9593_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","volume":"66","author":"DP Panigrahi","year":"2020","unstructured":"Panigrahi DP, Praharaj PP, Bhol CS, Mahapatra KK, Patra S, Behera BP, et al. The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics. Semin Cancer Biol. 2020;66:45\u201358. https:\/\/doi.org\/10.1016\/j.semcancer.2019.07.015.","journal-title":"Semin Cancer Biol"},{"issue":"12","key":"9593_CR13","doi-asserted-by":"publisher","first-page":"e13327","DOI":"10.1111\/cpr.13327","volume":"55","author":"C Song","year":"2022","unstructured":"Song C, Pan S, Zhang J, Li N, Geng Q. Mitophagy: a novel perspective for insighting into cancer and cancer treatment. Cell Prolif. 2022;55(12):e13327. https:\/\/doi.org\/10.1111\/cpr.13327.","journal-title":"Cell Prolif"},{"issue":"8","key":"9593_CR14","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1080\/15548627.2021.2007027","volume":"18","author":"J Yao","year":"2022","unstructured":"Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, et al. CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma. Autophagy. 2022;18(8):1879\u201397. https:\/\/doi.org\/10.1080\/15548627.2021.2007027.","journal-title":"Autophagy"},{"issue":"10","key":"9593_CR15","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1080\/15548627.2020.1850609","volume":"17","author":"R Deng","year":"2021","unstructured":"Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, et al. MAPK1\/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy. 2021;17(10):3011\u201329. https:\/\/doi.org\/10.1080\/15548627.2020.1850609.","journal-title":"Autophagy"},{"issue":"1","key":"9593_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41392-022-01253-y","volume":"7","author":"Y Meng","year":"2022","unstructured":"Meng Y, Qiu L, Zeng X, Hu X, Zhang Y, Wan X, et al. Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy. Signal Transduct Target Ther. 2022;7(1):388. https:\/\/doi.org\/10.1038\/s41392-022-01253-y.","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"9593_CR17","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1016\/j.jid.2021.03.031","volume":"141","author":"H Wang","year":"2021","unstructured":"Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, et al. The XBP1-MARCH5-MFN2 axis confers endoplasmic reticulum stress resistance by coordinating mitochondrial fission and mitophagy in melanoma. J Invest Dermatol. 2021;141(12):2932-43.e12. https:\/\/doi.org\/10.1016\/j.jid.2021.03.031.","journal-title":"J Invest Dermatol"},{"issue":"10","key":"9593_CR18","doi-asserted-by":"publisher","first-page":"e106214","DOI":"10.15252\/embj.2020106214","volume":"40","author":"M Vara-P\u00e9rez","year":"2021","unstructured":"Vara-P\u00e9rez M, Rossi M, Van den Haute C, Maes H, Sassano ML, Venkataramani V, et al. BNIP3 promotes HIF-1\u03b1-driven melanoma growth by curbing intracellular iron homeostasis. EMBO J. 2021;40(10):e106214. https:\/\/doi.org\/10.15252\/embj.2020106214.","journal-title":"EMBO J"},{"key":"9593_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/15548627.2024.2395142","volume":"21","author":"J Sun","year":"2024","unstructured":"Sun J, Ding J, Yue H, Xu B, Sodhi A, Xue K, et al. Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming. Autophagy. 2024;21:191\u2013209. https:\/\/doi.org\/10.1080\/15548627.2024.2395142.","journal-title":"Autophagy"},{"issue":"40","key":"9593_CR20","doi-asserted-by":"publisher","first-page":"11192","DOI":"10.1039\/d3sc03600f","volume":"14","author":"Z Liu","year":"2023","unstructured":"Liu Z, Qin G, Yang J, Wang W, Zhang W, Lu B, et al. Targeting mitochondrial degradation by chimeric autophagy-tethering compounds. Chem Sci. 2023;14(40):11192\u2013202. https:\/\/doi.org\/10.1039\/d3sc03600f.","journal-title":"Chem Sci"},{"issue":"4","key":"9593_CR21","doi-asserted-by":"publisher","first-page":"1947169","DOI":"10.1080\/23723556.2021.1947169","volume":"8","author":"M Vara-P\u00e9rez","year":"2021","unstructured":"Vara-P\u00e9rez M, Agostinis P. BNIP3 in melanoma: isn\u02bct it IRONic? Mol Cell Oncol. 2021;8(4):1947169. https:\/\/doi.org\/10.1080\/23723556.2021.1947169.","journal-title":"Mol Cell Oncol"},{"issue":"7","key":"9593_CR22","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM 3rd, et al. Comprehensive integration of single-cell data. Cell. 2019;177(7):1888-902.e21. https:\/\/doi.org\/10.1016\/j.cell.2019.05.031.","journal-title":"Cell"},{"key":"9593_CR23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559. https:\/\/doi.org\/10.1186\/1471-2105-9-559.","journal-title":"BMC Bioinform"},{"issue":"23","key":"9593_CR24","doi-asserted-by":"publisher","first-page":"6575","DOI":"10.1158\/0008-5472.Can-18-0689","volume":"78","author":"L Xu","year":"2018","unstructured":"Xu L, Deng C, Pang B, Zhang X, Liu W, Liao G, et al. TIP: a web server for resolving tumor immunophenotype profiling. Cancer Res. 2018;78(23):6575\u201380. https:\/\/doi.org\/10.1158\/0008-5472.Can-18-0689.","journal-title":"Cancer Res"},{"issue":"1","key":"9593_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/annonc\/mdy495","volume":"30","author":"TA Chan","year":"2019","unstructured":"Chan TA, Yarchoan M, Jaffee E, Swanton C, Quezada SA, Stenzinger A, et al. Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic. Ann Oncol. 2019;30(1):44\u201356. https:\/\/doi.org\/10.1093\/annonc\/mdy495.","journal-title":"Ann Oncol"},{"issue":"1","key":"9593_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","volume":"39","author":"DS Chen","year":"2013","unstructured":"Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1\u201310. https:\/\/doi.org\/10.1016\/j.immuni.2013.07.012.","journal-title":"Immunity"},{"issue":"3","key":"9593_CR27","doi-asserted-by":"publisher","first-page":"e2716","DOI":"10.1038\/cddis.2017.133","volume":"8","author":"F Basit","year":"2017","unstructured":"Basit F, van Oppen LM, Sch\u00f6ckel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JC, et al. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017;8(3):e2716. https:\/\/doi.org\/10.1038\/cddis.2017.133.","journal-title":"Cell Death Dis"},{"issue":"6","key":"9593_CR28","doi-asserted-by":"publisher","first-page":"e28244","DOI":"10.1016\/j.heliyon.2024.e28244","volume":"10","author":"Y Li","year":"2024","unstructured":"Li Y, Jiang B, Chen B, Zou Y, Wang Y, Liu Q, et al. Integrative analysis of bulk and single-cell RNA-seq reveals the molecular characterization of the immune microenvironment and oxidative stress signature in melanoma. Heliyon. 2024;10(6):e28244. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e28244.","journal-title":"Heliyon"},{"issue":"20","key":"9593_CR29","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.3390\/math11204315","volume":"11","author":"S Seth","year":"2023","unstructured":"Seth S, Mallik S, Islam A, Bhadra T, Roy A, Singh PK, et al. Identifying genetic signatures from single-cell RNA sequencing data by matrix imputation and reduced set gene clustering. Mathematics. 2023;11(20):4315.","journal-title":"Mathematics"},{"key":"9593_CR30","doi-asserted-by":"publisher","first-page":"104969","DOI":"10.1016\/j.ebiom.2024.104969","volume":"100","author":"SY Lim","year":"2024","unstructured":"Lim SY, Rizos H. Single-cell RNA sequencing in melanoma: what have we learned so far? EBioMedicine. 2024;100:104969. https:\/\/doi.org\/10.1016\/j.ebiom.2024.104969.","journal-title":"EBioMedicine"},{"issue":"12","key":"9593_CR31","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.3390\/cancers14123030","volume":"14","author":"MF Ng","year":"2022","unstructured":"Ng MF, Simmons JL, Boyle GM. Heterogeneity in melanoma. Cancers (Basel). 2022;14(12):3030. https:\/\/doi.org\/10.3390\/cancers14123030.","journal-title":"Cancers (Basel)"},{"issue":"9","key":"9593_CR32","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1038\/jid.2015.145","volume":"135","author":"N Mukherjee","year":"2015","unstructured":"Mukherjee N, Schwan JV, Fujita M, Norris DA, Shellman YG. Alternative treatments for melanoma: targeting BCL-2 family members to de-bulk and kill cancer stem cells. J Invest Dermatol. 2015;135(9):2155\u201361. https:\/\/doi.org\/10.1038\/jid.2015.145.","journal-title":"J Invest Dermatol"},{"issue":"3","key":"9593_CR33","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11864-021-00818-3","volume":"22","author":"T Ito","year":"2021","unstructured":"Ito T, Tanaka Y, Murata M, Kaku-Ito Y, Furue K, Furue M. BRAF heterogeneity in melanoma. Curr Treat Options Oncol. 2021;22(3):20. https:\/\/doi.org\/10.1007\/s11864-021-00818-3.","journal-title":"Curr Treat Options Oncol"},{"issue":"1","key":"9593_CR34","doi-asserted-by":"publisher","first-page":"108701","DOI":"10.1016\/j.isci.2023.108701","volume":"27","author":"Z Fan","year":"2024","unstructured":"Fan Z, Liu Y, Li C, Jiang Y, Wang N, Wang M, et al. T proliferating cells derived autophagy signature associated with prognosis and immunotherapy resistance in a pan-cancer analysis. iScience. 2024;27(1):108701. https:\/\/doi.org\/10.1016\/j.isci.2023.108701.","journal-title":"iScience"},{"issue":"1","key":"9593_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12943-024-01936-w","volume":"23","author":"J Kim","year":"2024","unstructured":"Kim J, Kim TJ, Chae S, Ha H, Park Y, Park S, et al. Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma. Mol Cancer. 2024;23(1):45. https:\/\/doi.org\/10.1186\/s12943-024-01936-w.","journal-title":"Mol Cancer"},{"issue":"20","key":"9593_CR36","doi-asserted-by":"publisher","first-page":"12123","DOI":"10.3390\/ijms232012123","volume":"23","author":"C Liu","year":"2022","unstructured":"Liu C, Wu Z, Wang L, Yang Q, Huang J, Huang J. A mitophagy-related gene signature for subtype identification and prognosis prediction of hepatocellular carcinoma. Int J Mol Sci. 2022;23(20):12123. https:\/\/doi.org\/10.3390\/ijms232012123.","journal-title":"Int J Mol Sci"},{"key":"9593_CR37","doi-asserted-by":"publisher","first-page":"100210","DOI":"10.1016\/j.ctarc.2020.100210","volume":"25","author":"G Cheng","year":"2020","unstructured":"Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, et al. Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. Cancer Treat Res Commun. 2020;25:100210. https:\/\/doi.org\/10.1016\/j.ctarc.2020.100210.","journal-title":"Cancer Treat Res Commun"},{"issue":"1","key":"9593_CR38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.semcancer.2008.12.001","volume":"19","author":"S Grandemange","year":"2009","unstructured":"Grandemange S, Herzig S, Martinou JC. Mitochondrial dynamics and cancer. Semin Cancer Biol. 2009;19(1):50\u20136. https:\/\/doi.org\/10.1016\/j.semcancer.2008.12.001.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"9593_CR39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"W Chen","year":"2023","unstructured":"Chen W, Zhao H, Li Y. Mitochondrial dynamics in health and disease: mechanisms and potential targets. Signal Transduct Target Ther. 2023;8(1):333. https:\/\/doi.org\/10.1038\/s41392-023-01547-9.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"9593_CR40","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1158\/2159-8290.Cd-13-0440","volume":"4","author":"TJ Parmenter","year":"2014","unstructured":"Parmenter TJ, Kleinschmidt M, Kinross KM, Bond ST, Li J, Kaadige MR, et al. Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov. 2014;4(4):423\u201333. https:\/\/doi.org\/10.1158\/2159-8290.Cd-13-0440.","journal-title":"Cancer Discov"},{"issue":"1","key":"9593_CR41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbrc.2019.05.111","volume":"515","author":"X Yang","year":"2019","unstructured":"Yang X, Zhao H, Yang J, Ma Y, Liu Z, Li C, et al. MiR-150-5p regulates melanoma proliferation, invasion and metastasis via SIX1-mediated Warburg Effect. Biochem Biophys Res Commun. 2019;515(1):85\u201391. https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.111.","journal-title":"Biochem Biophys Res Commun"},{"key":"9593_CR42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.omto.2019.11.001","volume":"16","author":"X Yang","year":"2020","unstructured":"Yang X, Zhu X, Yan Z, Li C, Zhao H, Ma L, et al. miR-489-3p\/SIX1 axis regulates melanoma proliferation and glycolytic potential. Mol Ther Oncolytics. 2020;16:30\u201340. https:\/\/doi.org\/10.1016\/j.omto.2019.11.001.","journal-title":"Mol Ther Oncolytics"},{"issue":"3","key":"9593_CR43","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1002\/jcb.26917","volume":"120","author":"H Zhang","year":"2019","unstructured":"Zhang H, Feng C, Zhang M, Zeng A, Si L, Yu N, et al. miR-625-5p\/PKM2 negatively regulates melanoma glycolysis state. J Cell Biochem. 2019;120(3):2964\u201372. https:\/\/doi.org\/10.1002\/jcb.26917.","journal-title":"J Cell Biochem"},{"key":"9593_CR44","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3389\/fonc.2020.00722","volume":"10","author":"A Avagliano","year":"2020","unstructured":"Avagliano A, Fiume G, Pelagalli A, Sanit\u00e0 G, Ruocco MR, Montagnani S, et al. Metabolic plasticity of melanoma cells and their crosstalk with tumor microenvironment. Front Oncol. 2020;10:722. https:\/\/doi.org\/10.3389\/fonc.2020.00722.","journal-title":"Front Oncol"},{"issue":"4","key":"9593_CR45","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.bbrc.2018.05.069","volume":"501","author":"Y Liu","year":"2018","unstructured":"Liu Y, Huo Y, Wang D, Tai Y, Li J, Pang D, et al. MiR-216a-5p\/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect. Biochem Biophys Res Commun. 2018;501(4):885\u201392. https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.069.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"9593_CR46","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1007\/s12094-023-03096-7","volume":"25","author":"C Chen","year":"2023","unstructured":"Chen C, Zhang X. Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth. Clin Transl Oncol. 2023;25(7):2183\u201391. https:\/\/doi.org\/10.1007\/s12094-023-03096-7.","journal-title":"Clin Transl Oncol"},{"key":"9593_CR47","doi-asserted-by":"publisher","first-page":"602555","DOI":"10.3389\/fonc.2020.602555","volume":"10","author":"JA Zhang","year":"2020","unstructured":"Zhang JA, Zhou XY, Huang D, Luan C, Gu H, Ju M, et al. Development of an immune-related gene signature for prognosis in melanoma. Front Oncol. 2020;10:602555. https:\/\/doi.org\/10.3389\/fonc.2020.602555.","journal-title":"Front Oncol"},{"key":"9593_CR48","doi-asserted-by":"publisher","first-page":"663495","DOI":"10.3389\/fimmu.2021.663495","volume":"12","author":"D Liu","year":"2021","unstructured":"Liu D, Yang X, Wu X. Tumor immune microenvironment characterization identifies prognosis and immunotherapy-related gene signatures in melanoma. Front Immunol. 2021;12:663495. https:\/\/doi.org\/10.3389\/fimmu.2021.663495.","journal-title":"Front Immunol"},{"issue":"10","key":"9593_CR49","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.immuni.2023.09.005","volume":"56","author":"JR Giles","year":"2023","unstructured":"Giles JR, Globig AM, Kaech SM, Wherry EJ. CD8(+) T cells in the cancer-immunity cycle. Immunity. 2023;56(10):2231\u201353. https:\/\/doi.org\/10.1016\/j.immuni.2023.09.005.","journal-title":"Immunity"},{"issue":"2","key":"9593_CR50","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","volume":"124","author":"H Raskov","year":"2021","unstructured":"Raskov H, Orhan A, Christensen JP, G\u00f6genur I. Cytotoxic CD8(+) T cells in cancer and cancer immunotherapy. Br J Cancer. 2021;124(2):359\u201367. https:\/\/doi.org\/10.1038\/s41416-020-01048-4.","journal-title":"Br J Cancer"},{"issue":"22","key":"9593_CR51","doi-asserted-by":"publisher","first-page":"8444","DOI":"10.1002\/cam4.3466","volume":"9","author":"L Huang","year":"2020","unstructured":"Huang L, Chen H, Xu Y, Chen J, Liu Z, Xu Q. Correlation of tumor-infiltrating immune cells of melanoma with overall survival by immunogenomic analysis. Cancer Med. 2020;9(22):8444\u201356. https:\/\/doi.org\/10.1002\/cam4.3466.","journal-title":"Cancer Med"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-025-09593-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:28:18Z","timestamp":1770190098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-025-09593-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["9593"],"URL":"https:\/\/doi.org\/10.1007\/s12026-025-09593-x","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]},"assertion":[{"value":"15 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"30"}}