{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:25:47Z","timestamp":1770240347450,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR42063\/MED\/29\/1562\/2021"],"award-info":[{"award-number":["BT\/PR42063\/MED\/29\/1562\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR42063\/MED\/29\/1562\/2021"],"award-info":[{"award-number":["BT\/PR42063\/MED\/29\/1562\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Science and Technology (DST), Govt. of Odisha","award":["4823\/ST, Bhubaneswar (ST-SCST-MISC-0026-2020"],"award-info":[{"award-number":["4823\/ST, Bhubaneswar (ST-SCST-MISC-0026-2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12026-025-09657-y","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T15:37:20Z","timestamp":1750952240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory activity of 4-(Benzyloxy)phenol facilitates intracellular mycobacterial clearance through p53 mediated IL-35 signaling dependent JAK1\/STAT3 pathway in human macrophages"],"prefix":"10.1007","volume":"73","author":[{"given":"Lincoln","family":"Naik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salina","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousumi","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dev Kiran","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramathesh Kumar","family":"Dandsena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafeez Ali","family":"Quaderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abtar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"9657_CR1","doi-asserted-by":"publisher","first-page":"107325","DOI":"10.1016\/j.ijid.2024.107325","volume":"150","author":"D Goletti","year":"2025","unstructured":"Goletti D, Meintjes G, Andrade BB, Zumla A, Shan Lee S. Insights from the 2024 WHO global tuberculosis report - more comprehensive action, innovation, and investments required for achieving WHO End TB goals. Int J Infect Dis. 2025;150:107325.","journal-title":"Int J Infect Dis"},{"key":"9657_CR2","first-page":"9","volume":"12","author":"A Singh","year":"2020","unstructured":"Singh A, Prasad R, Balasubramanian V, Gupta N. Drug-resistant tuberculosis and HIV infection: current perspectives. HIV\/AIDS (Auckland, NZ). 2020;12:9.","journal-title":"HIV\/AIDS (Auckland, NZ)"},{"issue":"1","key":"9657_CR3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/infdis\/jiz430","volume":"221","author":"AL Katelaris","year":"2020","unstructured":"Katelaris AL, Jackson C, Southern J, Gupta RK, Drobniewski F, Lalvani A, Lipman M, Mangtani P, Abubakar I. Effectiveness of BCG vaccination against Mycobacterium tuberculosis infection in adults: a cross-sectional analysis of a UK-based cohort. J Infect Dis. 2020;221(1):146\u201355.","journal-title":"J Infect Dis"},{"issue":"1","key":"9657_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","volume":"6","author":"D Li","year":"2021","unstructured":"Li D, Wu M. Pattern recognition receptors in health and diseases. Signal Transduct Target Ther. 2021;6(1):291.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"9657_CR5","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41598-023-27895-8","volume":"13","author":"P Sampath","year":"2023","unstructured":"Sampath P, Rajamanickam A, Thiruvengadam K, Natarajan AP, Hissar S, Dhanapal M, Thangavelu B, Jayabal L, Ramesh PM, Ranganathan UD. Cytokine upsurge among drug-resistant tuberculosis endorse the signatures of hyper inflammation and disease severity. Sci Rep. 2023;13(1):785.","journal-title":"Sci Rep"},{"issue":"1","key":"9657_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1600-065X.2008.00702.x","volume":"226","author":"AM Cooper","year":"2008","unstructured":"Cooper AM, Khader SA. The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol Rev. 2008;226(1):191\u2013204.","journal-title":"Immunol Rev"},{"issue":"1","key":"9657_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04146.x","volume":"161","author":"J Harris","year":"2010","unstructured":"Harris J, Keane J. How tumour necrosis factor blockers interfere with tuberculosis immunity. Clin Exp Immunol. 2010;161(1):1\u20139.","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"9657_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-065X.2008.00698.x","volume":"226","author":"SY Zhang","year":"2008","unstructured":"Zhang SY, Boisson-Dupuis S, Chapgier A, Yang K, Bustamante J, Puel A, Picard C, Abel L, Jouanguy E, Casanova JL. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-\u03b1\/\u03b2, IFN-\u03b3, and IFN-\u03bb in host defense. Immunol Rev. 2008;226(1):29\u201340.","journal-title":"Immunol Rev"},{"key":"9657_CR9","doi-asserted-by":"publisher","first-page":"101672","DOI":"10.1016\/j.smim.2022.101672","volume":"65","author":"D Tiwari","year":"2023","unstructured":"Tiwari D, Martineau AR. Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies. Seminars in Immunology. 2023;65:101672.","journal-title":"Seminars in Immunology"},{"issue":"1","key":"9657_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/ni.3048","volume":"16","author":"IM Orme","year":"2015","unstructured":"Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol. 2015;16(1):57\u201363.","journal-title":"Nat Immunol"},{"key":"9657_CR11","doi-asserted-by":"publisher","first-page":"623941","DOI":"10.3389\/fimmu.2021.623941","volume":"12","author":"A Nienaber","year":"2021","unstructured":"Nienaber A, Hayford FE, Variava E, Martinson N, Malan L. The manipulation of the lipid mediator metabolism as adjunct host-directed therapy in tuberculosis. Front Immunol. 2021;12:623941.","journal-title":"Front Immunol"},{"key":"9657_CR12","doi-asserted-by":"publisher","first-page":"107231","DOI":"10.1016\/j.intimp.2020.107231","volume":"90","author":"Q Xie","year":"2021","unstructured":"Xie Q, Xu W-D, Pan M, Lan Y-Y, Liu X-Y, Su L-C, Huang A-F. Association of IL-35 expression and gene polymorphisms in rheumatoid arthritis. Int Immunopharmacol. 2021;90:107231.","journal-title":"Int Immunopharmacol"},{"key":"9657_CR13","doi-asserted-by":"publisher","first-page":"1267624","DOI":"10.3389\/fimmu.2024.1267624","volume":"15","author":"L Gao","year":"2024","unstructured":"Gao L, Xiong Y-J, Liang Y-X, Huang P-F, Liu S, Xiao Y, Huang Q, Wang H, Wu H-M. The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis. Front Immunol. 2024;15:1267624.","journal-title":"Front Immunol"},{"issue":"7169","key":"9657_CR14","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature06306","volume":"450","author":"LW Collison","year":"2007","unstructured":"Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DAA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450(7169):566\u20139.","journal-title":"Nature"},{"issue":"1","key":"9657_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/imm.13044","volume":"157","author":"J Zhang","year":"2019","unstructured":"Zhang J, Zhang Y, Wang Q, Li C, Deng H, Si C, Xiong H. Interleukin-35 in immune-related diseases: protection or destruction. Immunology. 2019;157(1):13\u201320.","journal-title":"Immunology"},{"issue":"11","key":"9657_CR16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1089\/jir.2021.0147","volume":"41","author":"C Ye","year":"2021","unstructured":"Ye C, Yano H, Workman CJ, Vignali DAA. Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases. J Interferon Cytokine Res. 2021;41(11):391\u2013406.","journal-title":"J Interferon Cytokine Res"},{"issue":"47","key":"9657_CR17","doi-asserted-by":"publisher","first-page":"e40375","DOI":"10.1097\/MD.0000000000040375","volume":"103","author":"L Wang","year":"2024","unstructured":"Wang L, Qi Y, Nan Y, Qi S. Role of IFN-\u03b3, IL-33, and IL-35 concentrations in tuberculous pleural effusion in diagnosis and analysis of the effectiveness of combined tests. Medicine. 2024;103(47):e40375.","journal-title":"Medicine"},{"key":"9657_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.molimm.2019.05.004","volume":"112","author":"Y-C Dai","year":"2019","unstructured":"Dai Y-C, Wang W-D, Zhang J-A, Chen C, Luo H-L, Xu H, Peng Y, Luo H, Yang X-R, Chen X. MTB driven B cells producing IL-35 and secreting high level of IL-10 in the patients with active pulmonary tuberculosis. Mol Immunol. 2019;112:175\u201381.","journal-title":"Mol Immunol"},{"key":"9657_CR19","doi-asserted-by":"crossref","unstructured":"A. Mishra, A. Behura, A. Kumar, A. Ghosh, L. Naik, S. Mawatwal, S.S. Mohanty, A. Mishra, S. Saha, S.K. Bhutia, Soybean lectin induces autophagy through P2RX7 dependent activation of NF-\u03baB-ROS pathway to kill intracellular mycobacteria. Biochimica et Biophysica Acta (BBA)-General Subjects 1865(2) (2021) 129806","DOI":"10.1016\/j.bbagen.2020.129806"},{"key":"9657_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2018.07.033","volume":"111","author":"S Mawatwal","year":"2018","unstructured":"Mawatwal S, Behura A, Mishra A, Singh R, Dhiman R. Calcimycin induced IL-12 production inhibits intracellular mycobacterial growth by enhancing autophagy. Cytokine. 2018;111:1\u201312.","journal-title":"Cytokine"},{"key":"9657_CR21","doi-asserted-by":"crossref","unstructured":"A. Mishra, A. Kumar, L. Naik, S. Patel, M. Das, A. Behura, D.K. Nayak, A. Mishra, S.K. Bhutia, R.J.C. Singh, Soybean lectin-triggered IL-6 secretion induces autophagy to kill intracellular mycobacteria through P2RX7 dependent activation of the JAK2\/STAT3\/Mcl-1 pathway, 171 (2023) 156366.","DOI":"10.1016\/j.cyto.2023.156366"},{"key":"9657_CR22","doi-asserted-by":"crossref","unstructured":"Kumar A, Naik L, Patel S, Das M, Nayak DK, Mishra A, Mishra A, Singh R, Behura A, Dhiman R. Ac-93253 inhibits intracellular growth of mycobacteria in human macrophages by inducing apoptosis in mitochondrial-dependent manner. Biochimica et Biophysica Acta (BBA) - General Subjects. 2023;1867(9):130425.","DOI":"10.1016\/j.bbagen.2023.130425"},{"key":"9657_CR23","doi-asserted-by":"crossref","unstructured":"S. Mawatwal, A. Behura, A. Ghosh, S. Kidwai, A. Mishra, A. Deep, S. Agarwal, S. Saha, R. Singh, R. Dhiman, Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochimica Et Biophysica Acta (BBA)-General Subjects 1861(12) (2017) 3190\u20133200","DOI":"10.1016\/j.bbagen.2017.09.010"},{"key":"9657_CR24","doi-asserted-by":"publisher","first-page":"127976","DOI":"10.1016\/j.micres.2024.127976","volume":"290","author":"S Patel","year":"2025","unstructured":"Patel S, Naik L, Das M, Nayak DK, Dandsena PK, Mishra A, Kumar A, Dirisala VR, Mishra A, Das S. Furamidine-induced autophagy exerts an anti-mycobacterial effect in a SIRT1-pAMPK-FOXO3a-dependent manner by elevation of intracellular Ca2+ level expression. Microbiol Res. 2025;290:127976.","journal-title":"Microbiol Res"},{"key":"9657_CR25","doi-asserted-by":"publisher","first-page":"127664","DOI":"10.1016\/j.micres.2024.127664","volume":"282","author":"L Naik","year":"2024","unstructured":"Naik L, Patel S, Kumar A, Ghosh A, Mishra A, Das M, Nayak DK, Saha S, Mishra A, Singh R, Behura A, Dhiman R. 4-(Benzyloxy)phenol-induced p53 exhibits antimycobacterial response triggering phagosome-lysosome fusion through ROS-dependent intracellular Ca2+ pathway in THP-1 cells. Microbiol Res. 2024;282:127664.","journal-title":"Microbiol Res"},{"issue":"12","key":"9657_CR26","doi-asserted-by":"publisher","first-page":"6661","DOI":"10.4049\/jimmunol.1100315","volume":"186","author":"V Chaturvedi","year":"2011","unstructured":"Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA. Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol. 2011;186(12):6661\u20136.","journal-title":"J Immunol"},{"issue":"3","key":"9657_CR27","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/ni.2227","volume":"13","author":"LW Collison","year":"2012","unstructured":"Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, Garcia KC, Hunter CA, Drake CG. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012;13(3):290\u20139.","journal-title":"Nat Immunol"},{"issue":"2","key":"9657_CR28","first-page":"623","volume":"8","author":"B Kong","year":"2016","unstructured":"Kong B, Liu G-B, Zhang J-A, Fu X-X, Xiang W-Y, Gao Y-C, Lu Y-B, Wu X-J, Qiu F, Wang W-D. Elevated serum IL-35 and increased expression of IL-35-p35 or-EBI3 in CD4+ CD25+ T cells in patients with active tuberculosis. Am J Translational Res. 2016;8(2):623.","journal-title":"Am J Translational Res"},{"issue":"1","key":"9657_CR29","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1515\/biol-2022-0025","volume":"17","author":"F Yu","year":"2022","unstructured":"Yu F, Zhu X, Li Q, Xu W, Gao Y, Wen Y, Zhang Q, Dou J. Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice. Open Life Sci. 2022;17(1):312\u201320.","journal-title":"Open Life Sci"},{"key":"9657_CR30","doi-asserted-by":"publisher","first-page":"117663","DOI":"10.1016\/j.lfs.2020.117663","volume":"252","author":"Y Dong","year":"2020","unstructured":"Dong Y, Li X, Yu Y, Lv F, Chen Y. JAK\/STAT signaling is involved in IL-35-induced inhibition of hepatitis B virus antigen-specific cytotoxic T cell exhaustion in chronic hepatitis B. Life Sci. 2020;252:117663.","journal-title":"Life Sci"},{"issue":"12","key":"9657_CR31","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.humimm.2018.10.009","volume":"79","author":"Z Zhu","year":"2018","unstructured":"Zhu Z, Zhang Y, Ye J, Wang X, Fu X, Yin Y, Wen J, Wu X, Xia Z. IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases. Hum Immunol. 2018;79(12):869\u201375.","journal-title":"Hum Immunol"},{"issue":"45","key":"9657_CR32","doi-asserted-by":"publisher","first-page":"73003","DOI":"10.18632\/oncotarget.12193","volume":"7","author":"Y Ma","year":"2016","unstructured":"Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, Zheng Y, Wang W, Deng L, Shen L. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1\/STAT3. Oncotarget. 2016;7(45):73003.","journal-title":"Oncotarget"},{"issue":"1","key":"9657_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41420-023-01366-5","volume":"9","author":"M Xie","year":"2023","unstructured":"Xie M, Zhu Y, Zhou Y, Wang Q, Gu E, Chu Y, Wang L. Interleukin-35-producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification. Cell Death Discovery. 2023;9(1):67.","journal-title":"Cell Death Discovery"},{"issue":"24","key":"9657_CR34","doi-asserted-by":"publisher","first-page":"15709","DOI":"10.3390\/ijms232415709","volume":"23","author":"W Zysk","year":"2022","unstructured":"Zysk W, Gle\u0144 J, Trzeciak M. Current insight into the role of IL-35 and its potential involvement in the pathogenesis and therapy of atopic dermatitis. Int J Mol Sci. 2022;23(24):15709.","journal-title":"Int J Mol Sci"},{"key":"9657_CR35","doi-asserted-by":"publisher","first-page":"669394","DOI":"10.3389\/fcimb.2021.669394","volume":"11","author":"F Wang","year":"2021","unstructured":"Wang F, Huang G, Shen L, Peng Y, Sha W, Chen ZW, Shen H. Genetics and functional mechanisms of STAT3 polymorphisms in human tuberculosis. Front Cell Infect Microbiol. 2021;11:669394.","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"9657_CR36","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1111\/jcmm.17168","volume":"26","author":"L Puigdevall","year":"2022","unstructured":"Puigdevall L, Michiels C, Stewardson C, Dumoutier L. JAK\/STAT: why choose a classical or an alternative pathway when you can have both? J Cell Mol Med. 2022;26(7):1865\u201375.","journal-title":"J Cell Mol Med"},{"issue":"5","key":"9657_CR37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/0968-0004(94)90026-4","volume":"19","author":"JN Ihle","year":"1994","unstructured":"Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci. 1994;19(5):222\u20137.","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"9657_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.191.2.287","volume":"191","author":"ZA Malik","year":"2000","unstructured":"Malik ZA, Denning GM, Kusner DJ. Inhibition of Ca2+ signaling by Mycobacterium tuberculosis is associated with reduced phagosome\u2013lysosome fusion and increased survival within human macrophages. J Exp Med. 2000;191(2):287\u2013302.","journal-title":"J Exp Med"},{"issue":"14","key":"9657_CR39","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1002\/elps.1150181409","volume":"18","author":"V Deretic","year":"1997","unstructured":"Deretic V, Via LE, Fratti RA, Deretic D. Mycobacterial phagosome maturation, rab proteins, and intracellular trafficking. Electrophoresis. 1997;18(14):2542\u20137.","journal-title":"Electrophoresis"},{"issue":"1","key":"9657_CR40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","volume":"8","author":"H Wang","year":"2023","unstructured":"Wang H, Guo M, Wei H, Chen Y. Targeting p53 pathways: Mechanisms, structures and advances in therapy. Signal Transduct Target Ther. 2023;8(1):92.","journal-title":"Signal Transduct Target Ther"},{"key":"9657_CR41","doi-asserted-by":"publisher","first-page":"100392","DOI":"10.1016\/j.jctube.2023.100392","volume":"33","author":"H Hashim","year":"2023","unstructured":"Hashim H. Morbidity and mortality in tuberculosis associated immune reconstitution inflammatory syndrome in children living with HIV: A narrative review. J Clin Tuberculosis Other Mycobacterial Diseases. 2023;33:100392.","journal-title":"J Clin Tuberculosis Other Mycobacterial Diseases"},{"issue":"1","key":"9657_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s44263-023-00035-0","volume":"2","author":"MR Dauphinais","year":"2024","unstructured":"Dauphinais MR, Koura KG, Narasimhan PB, Mehta S, Finkelstein JL, Heysell SK, Sinha P. Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis. BMC Global and Public Health. 2024;2(1):4.","journal-title":"BMC Global and Public Health"},{"key":"9657_CR43","doi-asserted-by":"publisher","first-page":"1328193","DOI":"10.3389\/fimmu.2024.1328193","volume":"15","author":"O Goldmann","year":"2024","unstructured":"Goldmann O, Nwofor OV, Chen Q, Medina E. Mechanisms underlying immunosuppression by regulatory cells. Front Immunol. 2024;15:1328193.","journal-title":"Front Immunol"},{"key":"9657_CR44","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.3389\/fimmu.2019.02139","volume":"10","author":"P Cardona","year":"2019","unstructured":"Cardona P, Cardona P-J. Regulatory T cells in Mycobacterium tuberculosis infection. Front Immunol. 2019;10:2139.","journal-title":"Front Immunol"},{"issue":"1","key":"9657_CR45","doi-asserted-by":"publisher","first-page":"13212","DOI":"10.1038\/s41598-020-69984-y","volume":"10","author":"C Chen","year":"2020","unstructured":"Chen C, Xu H, Peng Y, Luo H, Huang G-X, Wu X-J, Dai Y-C, Luo H-L, Zhang J-A, Zheng B-Y. Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1\/Th17 and upregulation of Foxp3+ Treg. Sci Rep. 2020;10(1):13212.","journal-title":"Sci Rep"},{"issue":"6","key":"9657_CR46","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.4049\/jimmunol.167.6.3308","volume":"167","author":"DJ Kusner","year":"2001","unstructured":"Kusner DJ, Barton JA. ATP stimulates human macrophages to kill intracellular virulent Mycobacterium tuberculosis via calcium-dependent phagosome-lysosome fusion. J Immunol. 2001;167(6):3308\u201315.","journal-title":"J Immunol"},{"issue":"1","key":"9657_CR47","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1038\/s41598-019-38982-0","volume":"9","author":"H-S Park","year":"2019","unstructured":"Park H-S, Back YW, Shin K-W, Bae HS, Lee K-I, Choi H-G, Choi S, Lee H-H, Choi CH, Park J-K. Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential. Sci Rep. 2019;9(1):4246.","journal-title":"Sci Rep"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-025-09657-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:03:13Z","timestamp":1770192193000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-025-09657-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["9657"],"URL":"https:\/\/doi.org\/10.1007\/s12026-025-09657-y","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article contains no studies performed by authors with human participants or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"99"}}