{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:43:49Z","timestamp":1793396629771,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"DOI":"10.1007\/s12026-025-09741-3","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:58:42Z","timestamp":1771289922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated levels of advanced glycation end-products AGE10 in patients with reactive arthritis caused by Chlamydia trachomatis and Epstein-Barr virus infection"],"prefix":"10.1007","volume":"74","author":[{"given":"Iryna","family":"Kril","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svitlana","family":"Zubchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Havrylyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lomikovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4264-8174","authenticated-orcid":false,"given":"Aleksandra","family":"Kuzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Jasku\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentyna","family":"Chopyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Gamian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"9741_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107806","author":"D Sellegounder","year":"2021","unstructured":"Sellegounder D, Zafari P, Rajabinejad M, Taghadosi M, Kapahi P, Elsevier B.V. Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis. Int Immunopharmacol. 2021. https:\/\/doi.org\/10.1016\/j.intimp.2021.107806.","journal-title":"Int Immunopharmacol"},{"key":"9741_CR2","doi-asserted-by":"publisher","unstructured":"Prasad K, Mishra M, Thieme Medical Publishers, Inc. AGE-RAGE stress, stressors, and antistressors in health and disease. Int J Angiol. 2018;27:1\u201312. https:\/\/doi.org\/10.1055\/S-0037-1613678.","DOI":"10.1055\/S-0037-1613678"},{"key":"9741_CR3","doi-asserted-by":"publisher","unstructured":"Twarda-Clapa A, Olczak A, Bia\u0142kowska AM, Kozio\u0142kiewicz M, MDPI. Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to AGEs. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11081312.","DOI":"10.3390\/cells11081312"},{"key":"9741_CR4","doi-asserted-by":"publisher","unstructured":"Monu, Agnihotri P, Biswas S. AGE\/Non-AGE glycation: an important event in rheumatoid arthritis Pathophysiology. Inflammation [Internet]. Springer; 2022;45:477\u201396. https:\/\/doi.org\/10.1007\/S10753-021-01589-7.","DOI":"10.1007\/S10753-021-01589-7"},{"key":"9741_CR5","doi-asserted-by":"publisher","unstructured":"Miranda ER, Fuller KNZ, Perkins RK, Beisswenger PJ, Farabi SS, Quinn L, et al. Divergent changes in plasma ages and sRAGE isoforms following an overnight fast in T1DM. Nutrients. 2019. https:\/\/doi.org\/10.3390\/NU11020386.","DOI":"10.3390\/NU11020386"},{"key":"9741_CR6","doi-asserted-by":"crossref","unstructured":"Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep [Internet]. Spandidos Publications. 2021;14:46. http:\/\/www.spandidos-publications.com\/10.3892\/br.2021.1422. Accessed 26 Mar 2021.","DOI":"10.3892\/br.2021.1422"},{"key":"9741_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4363927","author":"S Zubchenko","year":"2022","unstructured":"Zubchenko S, Kril I, Potemkina H, Havrylyuk A, Kuzan A, Gamian A, et al. Low level of advanced glycation end products in serum of patients with allergic rhinitis and chronic Epstein-Barr virus infection at different stages of virus persistence. J Immunol Res. 2022. https:\/\/doi.org\/10.1155\/2022\/4363927.","journal-title":"J Immunol Res"},{"key":"9741_CR8","doi-asserted-by":"publisher","unstructured":"Kay AM, Simpson CL, Stewart JA, Hindawi Publishing Corporation. The role of AGE\/RAGE signaling in diabetes-mediated vascular calcification. J Diabetes Res. 2016. https:\/\/doi.org\/10.1155\/2016\/6809703.","DOI":"10.1155\/2016\/6809703"},{"key":"9741_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/AR3538","author":"L de Groot","year":"2011","unstructured":"de Groot L, Hinkema H, Westra J, Smit AJ, Kallenberg CGM, Bijl M, et al. Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease. Arthritis Res Ther [Internet] Arthritis Res Ther. 2011. https:\/\/doi.org\/10.1186\/AR3538. [cited 2022 Jun 7];13.","journal-title":"Arthritis Res Ther [Internet] Arthritis Res Ther"},{"key":"9741_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24129881","author":"K Zgutka","year":"2023","unstructured":"Zgutka K, Tkacz M, Tomasiak P, Tarnowski M, Multidisciplinary Digital Publishing Institute (MDPI). A role for advanced glycation end products in molecular ageing. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/IJMS24129881.","journal-title":"Int J Mol Sci"},{"key":"9741_CR11","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1093\/RHEUMATOLOGY\/KEI047","volume":"44","author":"J Zochling","year":"2005","unstructured":"Zochling J, Brandt J, Braun J, Rheumatology (Oxford). The current concept of spondyloarthritis with special emphasis on undifferentiated spondyloarthritis. Rheumatology. 2005;44:1483\u201391. https:\/\/doi.org\/10.1093\/RHEUMATOLOGY\/KEI047.","journal-title":"Rheumatology"},{"key":"9741_CR12","doi-asserted-by":"publisher","unstructured":"Zeidler H, Hudson AP, Springer. Reactive arthritis update: spotlight on new and rare infectious agents implicated as pathogens. Curr Rheumatol Rep. 2021. https:\/\/doi.org\/10.1007\/S11926-021-01018-6.","DOI":"10.1007\/S11926-021-01018-6"},{"key":"9741_CR13","doi-asserted-by":"publisher","unstructured":"Bastidas RJ, Elwell CA, Engel JN, Valdivia RH, Cold Spring Harb Perspect Med. Chlamydial intracellular survival strategies. Cold Spring Harb Perspect Med. 2013. https:\/\/doi.org\/10.1101\/CSHPERSPECT.A010256.","DOI":"10.1101\/CSHPERSPECT.A010256"},{"key":"9741_CR14","doi-asserted-by":"publisher","unstructured":"Inman RD. Reactive arthritis. rheumatology: sixth Edition [Internet]. Mosby; 2015;2(2):928\u201340. https:\/\/doi.org\/10.1016\/B978-0-323-09138-1.00112-1","DOI":"10.1016\/B978-0-323-09138-1.00112-1"},{"key":"9741_CR15","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20191927","author":"H Zeng","year":"2020","unstructured":"Zeng H, Luo B, Zhang Y, Xie Z, Ye Z, Portland Press Ltd. Treatment of reactive arthritis with biological agents: a review. Biosci Rep. 2020. https:\/\/doi.org\/10.1042\/BSR20191927.","journal-title":"Biosci Rep"},{"key":"9741_CR16","doi-asserted-by":"publisher","unstructured":"Chen B, Li J, He C, Li D, Tong W, Zou Y, et al. Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review). Mol Med Rep [Internet] Spandidos Publications. 2017;15:1943\u201351. https:\/\/doi.org\/10.3892\/MMR.2017.6248.","DOI":"10.3892\/MMR.2017.6248"},{"key":"9741_CR17","doi-asserted-by":"publisher","unstructured":"Su QY, Zhang Y, Qiao D, Song X, Shi Y, Wang Z, et al. Gut microbiota dysbiosis in ankylosing spondylitis: a systematic review and meta-analysis. Front Cell Infect Microbiol [Internet] Front Media SA. 2024;14.\u00a0https:\/\/doi.org\/10.3389\/FCIMB.2024.1376525\/PDF.","DOI":"10.3389\/FCIMB.2024.1376525\/PDF"},{"key":"9741_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.12865\/CHSJ.41.02.03","volume":"41","author":"S Banicioiu-Covei","year":"2015","unstructured":"Banicioiu-Covei S, Vreju FA, Ciurea P, Curr Health Sci J. Predictive factors for the evolution of reactive arthritis to ankylosing spondylitis. Curr Health Sci J [Internet]. 2015;41:104\u20138. https:\/\/doi.org\/10.12865\/CHSJ.41.02.03.","journal-title":"Curr Health Sci J [Internet]"},{"key":"9741_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.12865\/CHSJ.45.04.01","volume":"45","author":"S B\u0103nicioiu-Covei","year":"2019","unstructured":"B\u0103nicioiu-Covei S, Vreju AF, Rosu A, Ciurea PL. The Importance of HLA-B27 in the Evolution of Reactive Arthritis. Curr Health Sci J [Internet]. 2019;45:345\u201352. https:\/\/doi.org\/10.12865\/CHSJ.45.04.01.","journal-title":"Curr Health Sci J [Internet]"},{"key":"9741_CR20","unstructured":"Tiwari V, Bergman MJ. Viral Arthritis. StatPearls [Internet]. StatPearls Publishing; 2023.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK531507\/. Accessed 30 Aug 2025."},{"key":"9741_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.587380","author":"G Houen","year":"2021","unstructured":"Houen G, Trier NH, Frontiers Media S.A. Epstein-Barr Virus and Systemic Autoimmune Diseases. Front Immunol. 2021. https:\/\/doi.org\/10.3389\/FIMMU.2020.587380.","journal-title":"Front Immunol"},{"key":"9741_CR22","doi-asserted-by":"publisher","first-page":"286","DOI":"10.14348\/molcells.2016.0066","volume":"39","author":"BS M\u00f6hl","year":"2016","unstructured":"M\u00f6hl BS, Chen J, Sathiyamoorthy K, Jardetzky TS, Longnecker R, Korean Society for Molecular and Cellular Biology. Structural and mechanistic insights into the tropism of Epstein-Barr virus. Mol Cells. 2016;39:286\u201391. https:\/\/doi.org\/10.14348\/molcells.2016.0066.","journal-title":"Mol Cells"},{"key":"9741_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82585-7","author":"M Staniszewska","year":"2021","unstructured":"Staniszewska M, Bronowicka-Szyde\u0142ko A, Gostomska-Pampuch K, Szkudlarek J, Barty\u015b A, Bieg T, et al. The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues. Sci Rep. 2021. https:\/\/doi.org\/10.1038\/s41598-021-82585-7.","journal-title":"Sci Rep"},{"key":"9741_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/JCM10194499","author":"A Bronowicka-Szyde\u0142ko","year":"2021","unstructured":"Bronowicka-Szyde\u0142ko A, Krzystek-Korpacka M, Gacka M, Pietkiewicz J, Jakobsche-Policht U, Gamian A. Association of Novel Advanced Glycation End-Product (AGE10) with Complications of Diabetes as Measured by Enzyme-Linked Immunosorbent Assay. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/JCM10194499.","journal-title":"J Clin Med"},{"key":"9741_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/BS.ACC.2015.07.005","volume":"72","author":"SW Vetter","year":"2015","unstructured":"Vetter SW, Elsevier. Glycated Serum Albumin and AGE Receptors. Adv Clin Chem. 2015;72:205\u201375. https:\/\/doi.org\/10.1016\/BS.ACC.2015.07.005.","journal-title":"Adv Clin Chem"},{"issue":"5","key":"9741_CR26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0956462415618837","volume":"27","author":"E Lanjouw","year":"2016","unstructured":"Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K, Unemo M, et al. 2015 European guideline on the management of Chlamydia trachomatis infections. Int J STD AIDS. 2016;27(5):333\u201348. https:\/\/doi.org\/10.1177\/0956462415618837.","journal-title":"Int J STD AIDS"},{"key":"9741_CR27","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/S10067-014-2661-8","volume":"33","author":"A Deodhar","year":"2014","unstructured":"Deodhar A, Springer-Verlag London Ltd. Axial spondyloarthritis criteria and modified NY criteria: issues and controversies. Clin Rheumatol. 2014;33:741\u20137. https:\/\/doi.org\/10.1007\/S10067-014-2661-8.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"9741_CR28","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/RHEUMATOLOGY\/39.2.148","volume":"39","author":"G Eberl","year":"2000","unstructured":"Eberl G, Studnicka-Benke A, Hitzelhammer H, Gschnait F, Smolen JS, Rheumatology (Oxford). Development of a disease activity index for the assessment of reactive arthritis (DAREA). Rheumatology. 2000;39(2):148\u201355. https:\/\/doi.org\/10.1093\/RHEUMATOLOGY\/39.2.148.","journal-title":"Rheumatology"},{"key":"9741_CR29","first-page":"71","volume":"53","author":"M Staniszewska","year":"2005","unstructured":"Staniszewska M, Jarosz S, Jon M, Gamian A. Advanced glycation end-products prepared in solution under high pressure contain epitopes distinct from those formed in the dry reaction at high temperature. Arch Immunol Ther Exp. 2005;53:71\u20138.","journal-title":"Arch Immunol Ther Exp"},{"key":"9741_CR30","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/1533317506291075","volume":"21","author":"J Leszek","year":"2006","unstructured":"Leszek J, Ma\u0142yszczak K, Barty\u015b A, Staniszewska M, Gamian A, SAGE Publications Inc. Analysis of serum of patients with Alzheimer\u2019s disease for the level of advanced glycation end products. American Journal of Alzheimer\u2019s Disease & Other Dementias\u00ae. 2006;21:360\u20135. https:\/\/doi.org\/10.1177\/1533317506291075.","journal-title":"American Journal of Alzheimer's Disease & Other Dementias\u00ae"},{"issue":"1","key":"9741_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-021-92630-0","volume":"11","author":"D Indyk","year":"2021","unstructured":"Indyk D, Bronowicka-Szyde\u0142ko A, Gamian A, Kuzan A. Advanced glycation end products and their receptors in serum of patients with type 2 diabetes. Sci Rep. 2021;11(1):13264. https:\/\/doi.org\/10.1038\/S41598-021-92630-0.","journal-title":"Sci Rep"},{"key":"9741_CR32","doi-asserted-by":"publisher","unstructured":"Kuzan A, Kr\u00f3lewicz E, Nowakowska K, Stach K, Kaliszewski K, Domos\u0142awski P, et al. Contribution of glycation and oxidative stress to thyroid gland pathology\u2014a pilot study. Biomolecules. 2021. https:\/\/doi.org\/10.3390\/biom11040557.","DOI":"10.3390\/biom11040557"},{"key":"9741_CR33","doi-asserted-by":"publisher","unstructured":"\u0141ysenko L, Mierzcha\u0142a M, Gamian A, Durek G, K\u00fcbler A, Koz\u0142owski R et al. The effect of packed red blood cell storage on arachidonic acid and advanced glycation end-product formation. Arch Immunol ther exp (Warsz) [Internet]. Arch Immunol Ther Exp (Warsz); 2006;54:357\u201362. https:\/\/doi.org\/10.1007\/S00005-006-0042-Y","DOI":"10.1007\/S00005-006-0042-Y"},{"key":"9741_CR34","unstructured":"Leszek J, Ferens-Sieczkowska M, K-PI. Fluorescent advanced glycation end products in the sera of Alzheimer\u2019s disease patients. In: Baloyannis SJ, editor. Perspectives in Neurosciences: in memory of professor Agapitos Diacoyannis. Thessaloniki: Greece Society for Amelioration of the Quality of Life for Chronic Neurologic Patients; 2005. p. 373\u201381."},{"key":"9741_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0009-8981(00)00389-2","volume":"303","author":"Z Turk","year":"2001","unstructured":"Turk Z, Ljubic S, Turk N, Benko B. Detection of autoantibodies against advanced glycation endproducts and AGE-immune complexes in serum of patients with diabetes mellitus. Clin Chim Acta. 2001;303:105\u201315. https:\/\/doi.org\/10.1016\/S0009-8981(00)00389-2.","journal-title":"Clin Chim Acta"},{"key":"9741_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2119\/2006.00090.NAKAMURA","volume":"13","author":"K Nakamura","year":"2007","unstructured":"Nakamura K, Yamagishi SI, Adachi H, Kurita-Nakamura Y, Matsui T, Yoshida T, et al. Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes. Mol Med. 2007;13:185\u20139. https:\/\/doi.org\/10.2119\/2006.00090.NAKAMURA.","journal-title":"Mol Med"},{"key":"9741_CR37","unstructured":"Reactive Arthritis. Background, Pathophysiology, Etiology [Internet]. [cited 2025 Aug 30]. https:\/\/emedicine.medscape.com\/article\/331347-overview. Accessed 30 Aug 2025."},{"key":"9741_CR38","doi-asserted-by":"publisher","unstructured":"Fugl A, Andersen CL, BioMed Central Ltd. Epstein-Barr virus and its association with disease - a review of relevance to general practice. BMC Fam Pract. 2019. https:\/\/doi.org\/10.1186\/S12875-019-0954-3.","DOI":"10.1186\/S12875-019-0954-3"},{"issue":"5","key":"9741_CR39","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/S41588-018-0102-3","volume":"50","author":"JB Harley","year":"2018","unstructured":"Harley JB, Chen X, Pujato M, Miller D, Maddox A, Forney C, et al. Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. Nat Genet. 2018;50(5):699\u2013707. https:\/\/doi.org\/10.1038\/S41588-018-0102-3.","journal-title":"Nat Genet"},{"key":"9741_CR40","doi-asserted-by":"publisher","unstructured":"Bar-Or A, Pender MP, Khanna R, Steinman L, Hartung HP, Maniar T, et al. Epstein\u2013Barr virus in multiple sclerosis: theory and emerging immunotherapies. Trends Mol Med. 2020;26(3):296\u2013310. https:\/\/doi.org\/10.1016\/j.molmed.2019.11.003.","DOI":"10.1016\/j.molmed.2019.11.003"},{"key":"9741_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-019-55850-Z","author":"A Afrasiabi","year":"2020","unstructured":"Afrasiabi A, Parnell GP, Swaminathan S, Stewart GJ, Booth DR. The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis. Sci Rep. 2020. https:\/\/doi.org\/10.1038\/S41598-019-55850-Z.","journal-title":"Sci Rep"},{"key":"9741_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/MICROORGANISMS8101459","volume":"8","author":"M Bo","year":"2020","unstructured":"Bo M, Jasemi S, Uras G, Erre GL, Passiu G, Sechi LA, et al. Role of infections in the pathogenesis of rheumatoid arthritis: focus on mycobacteria. Microorganisms. 2020;8:1\u201319. https:\/\/doi.org\/10.3390\/MICROORGANISMS8101459.","journal-title":"Microorganisms"},{"key":"9741_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ART.40350","volume":"70","author":"PA Nigrovic","year":"2018","unstructured":"Nigrovic PA, Raychaudhuri S, Thompson SD, John Wiley and Sons Inc. Review: genetics and the classification of arthritis in adults and children. Arthritis Rheumatol. 2018;70:7\u201317. https:\/\/doi.org\/10.1002\/ART.40350.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"9741_CR44","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1177\/1740774518761367","volume":"15","author":"PA Nigrovic","year":"2018","unstructured":"Nigrovic PA, Beukelman T, Tomlinson G, Feldman BM, Schanberg LE, Kimura Y, et al. Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: first-line options for systemic juvenile idiopathic arthritis treatment (FROST). Clin Trials. 2018;15(3):268\u201377. https:\/\/doi.org\/10.1177\/1740774518761367.","journal-title":"Clin Trials"},{"key":"9741_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/V14071474","author":"K Otsuka","year":"2022","unstructured":"Otsuka K, Sato M, Tsunematsu T, Ishimaru N. Virus infections play crucial roles in the pathogenesis of Sj\u00f6gren\u2019s syndrome. Viruses. 2022. https:\/\/doi.org\/10.3390\/V14071474.","journal-title":"Viruses"},{"key":"9741_CR46","doi-asserted-by":"publisher","unstructured":"Strzelczyk J, Szumska M, Damasiewicz-Bodzek A, Krywult A, D\u0142ugaszek M, Czubili\u0144ska J et al. Determination of advanced glycation end-products and antibodies against them (anti-CML and anti-CEL) in the serum of graves\u2019 orbitopathy patients before and after Methylprednisolone treatment. Endokrynol pol [Internet]. Endokrynol Pol; 2016;67. https:\/\/doi.org\/10.5603\/EP.A2016.0047","DOI":"10.5603\/EP.A2016.0047"},{"key":"9741_CR47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3892\/ETM.2017.5378","volume":"15","author":"S Kan","year":"2018","unstructured":"Kan S, Wu J, Sun C, Hao J, Wu Z. Correlation between RAGE gene promoter methylation and diabetic retinal inflammation. Exp Ther Med. 2018;15:242\u20136. https:\/\/doi.org\/10.3892\/ETM.2017.5378.","journal-title":"Exp Ther Med"},{"key":"9741_CR48","doi-asserted-by":"publisher","unstructured":"Tronko MD, Pushkarev VM, Kovzun EI, Sokolova LK, Pushkarev VV. Epigenetics, cell cycle and stem cell metabolism. Formation of insulin-producing cells.\u00a0Int. J. Endocrinol\u00a0(Ukraine). Zaslavsky Publishing House. 2022;18(3):169\u201379. https:\/\/doi.org\/10.22141\/2224-0721.18.3.2022.1165.","DOI":"10.22141\/2224-0721.18.3.2022.1165"},{"key":"9741_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2021.757318","author":"J Li","year":"2021","unstructured":"Li J, Li L, Wang Y, Huang G, Li X, Xie Z, et al. Insights into the role of DNA methylation in immune cell development and autoimmune disease. Front Cell Dev Biol. 2021. https:\/\/doi.org\/10.3389\/FCELL.2021.757318.","journal-title":"Front Cell Dev Biol"},{"key":"9741_CR50","unstructured":"Cheeti A, Chakraborty RK, Ramphul K. Reactive Arthritis. StatPearls [Internet]. StatPearls Publishing; 2023.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499831\/. Accessed 30 Aug 2025."},{"key":"9741_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/S13098-022-00873-2","author":"T Jiang","year":"2022","unstructured":"Jiang T, Zhang Y, Dai F, Liu C, Hu H, Zhang Q, et al. Advanced glycation end products and diabetes and other metabolic indicators. Diabetol Metab Syndr. 2022. https:\/\/doi.org\/10.1186\/S13098-022-00873-2.","journal-title":"Diabetol Metab Syndr"},{"key":"9741_CR52","doi-asserted-by":"publisher","unstructured":"Nowak A, Przywara-Chowaniec B, Tyrpie\u0144-Golder K, Nowalany-Kozielska E, Termedia Publishing House Ltd. Systemic lupus erythematosus and glycation process. Cent Eur J Immunol. 2020;45:93\u20138. https:\/\/doi.org\/10.5114\/CEJI.2018.77875.","DOI":"10.5114\/CEJI.2018.77875"},{"key":"9741_CR53","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.tem.2019.08.005","volume":"30","author":"C Zeng","year":"2019","unstructured":"Zeng C, Li Y, Ma J, Niu L, Tay FR, Elsevier Inc. Clinical\/Translational aspects of advanced glycation end-products. Trends Endocrinol Metab. 2019;30:959\u201373. https:\/\/doi.org\/10.1016\/j.tem.2019.08.005.","journal-title":"Trends Endocrinol Metab"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09741-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-025-09741-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-025-09741-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:02:31Z","timestamp":1771333351000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-025-09741-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9741"],"URL":"https:\/\/doi.org\/10.1007\/s12026-025-09741-3","relation":{},"ISSN":["1559-0755"],"issn-type":[{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The research was approved by the Ethics Committee at the Danylo Halytsky Lviv National Medical University (protocol #6, 2017\/03\/08).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}