{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T20:49:07Z","timestamp":1773521347331,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"DOI":"10.1007\/s12026-026-09755-5","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:10:03Z","timestamp":1773472203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Knockdown of LncRNA NIFK-AS1 inhibits the activation of CD4\u2009+\u2009T cells in systemic lupus erythematosus by regulating the let-7f-5p\/STAT3 axis"],"prefix":"10.1007","volume":"74","author":[{"given":"Yi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"issue":"10","key":"9755_CR1","doi-asserted-by":"publisher","first-page":"e30330","DOI":"10.7759\/cureus.30330","volume":"14","author":"MA Ameer","year":"2022","unstructured":"Ameer MA, Chaudhry H, Mushtaq J, Khan OS, Babar M, Hashim T, et al. An overview of systemic lupus erythematosus (SLE) Pathogenesis, Classification, and management. Cureus. 2022;14(10):e30330. https:\/\/doi.org\/10.7759\/cureus.30330.","journal-title":"Cureus"},{"issue":"4","key":"9755_CR2","first-page":"383","volume":"107","author":"NV Lam","year":"2023","unstructured":"Lam NV, Brown JA, Sharma R. Systemic lupus erythematosus: diagnosis and treatment. Am Family Phys. 2023;107(4):383\u201395.","journal-title":"Am Family Phys"},{"key":"9755_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","volume":"96","author":"A Fava","year":"2019","unstructured":"Fava A, Petri M. Systemic lupus erythematosus: diagnosis and clinical management. J Autoimmun. 2019;96:1\u201313. https:\/\/doi.org\/10.1016\/j.jaut.2018.11.001.","journal-title":"J Autoimmun"},{"issue":"9","key":"9755_CR4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nm.4148","volume":"22","author":"J He","year":"2016","unstructured":"He J, Zhang X, Wei Y, Sun X, Chen Y, Deng J, et al. Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus. Nat Med. 2016;22(9):991\u20133. https:\/\/doi.org\/10.1038\/nm.4148.","journal-title":"Nat Med"},{"key":"9755_CR5","doi-asserted-by":"publisher","first-page":"e18761429249908","DOI":"10.2174\/0118761429249908231221080806","volume":"17","author":"AR Nikpoor","year":"2024","unstructured":"Nikpoor AR, Mahmoudi M, Shapouri-Moghaddam A, Rezaieyazdi Z, Mollazadeh S, Tabasi N, et al. Curcumin and Berberine arrest maturation and activation of dendritic cells derived from lupus erythematosus patients. Curr Mol Pharmacol. 2024;17:e18761429249908. https:\/\/doi.org\/10.2174\/0118761429249908231221080806.","journal-title":"Curr Mol Pharmacol"},{"issue":"11","key":"9755_CR6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.2174\/0109298665335550241011080252","volume":"31","author":"S Tripathi","year":"2024","unstructured":"Tripathi S, Sharma Y, Kumar D. Exploring the therapeutic potential of noncoding RNAs in alzheimer\u2019s disease. Protein Pept Lett. 2024;31(11):862\u201383. https:\/\/doi.org\/10.2174\/0109298665335550241011080252.","journal-title":"Protein Pept Lett"},{"issue":"1","key":"9755_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1080\/08916934.2019.1693545","volume":"53","author":"F Muhammad Yusoff","year":"2020","unstructured":"Muhammad Yusoff F, Wong KK, Mohd Redzwan N. Th1, Th2, and Th17 cytokines in systemic lupus erythematosus. Autoimmunity. 2020;53(1):8\u201320. https:\/\/doi.org\/10.1080\/08916934.2019.1693545.","journal-title":"Autoimmunity"},{"issue":"1","key":"9755_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.rdc.2017.09.011","volume":"44","author":"BN Brewer","year":"2018","unstructured":"Brewer BN, Kamen DL. Gastrointestinal and hepatic disease in systemic lupus erythematosus. Rheum Dis Clin North Am. 2018;44(1):165\u201375. https:\/\/doi.org\/10.1016\/j.rdc.2017.09.011.","journal-title":"Rheum Dis Clin North Am"},{"issue":"4","key":"9755_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.2174\/0113892029345945241125064704","volume":"26","author":"X Wang","year":"2025","unstructured":"Wang X, Zeng S, Liu Y, Shi Y, Qu F, Li L, et al. Role of long noncoding RNA Dio3os in glycolipid metabolism. Curr Genom. 2025;26(4):260\u201372. https:\/\/doi.org\/10.2174\/0113892029345945241125064704.","journal-title":"Curr Genom"},{"issue":"1","key":"9755_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/0109298665248028231122064831","volume":"31","author":"Z Xu","year":"2024","unstructured":"Xu Z, Yu Y, Ni H, Sun W, Kuang Y. LINC01836 promotes colorectal cancer progression and functions as CeRNA to target SLC17A9 by sponging miR-1226-3p. Protein Pept Lett. 2024;31(1):43\u201360. https:\/\/doi.org\/10.2174\/0109298665248028231122064831.","journal-title":"Protein Pept Lett"},{"issue":"6","key":"9755_CR11","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1007\/s13577-021-00587-z","volume":"34","author":"YT Chen","year":"2021","unstructured":"Chen YT, Xiang D, Zhao XY, Chu XY. Upregulation of LncRNA NIFK-AS1 in hepatocellular carcinoma by m(6)A methylation promotes disease progression and Sorafenib resistance. Hum Cell. 2021;34(6):1800\u201311. https:\/\/doi.org\/10.1007\/s13577-021-00587-z.","journal-title":"Hum Cell"},{"issue":"4","key":"9755_CR12","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.21037\/jgo-22-705","volume":"13","author":"H Song","year":"2022","unstructured":"Song H, Li W, Guo S, He Z, Liu S, Duo Y. A novel biomarker NIFK-AS1 promotes hepatocellular carcinoma cell cycle progression through interaction with SRSF10. J Gastrointest Oncol. 2022;13(4):1927\u201341. https:\/\/doi.org\/10.21037\/jgo-22-705.","journal-title":"J Gastrointest Oncol"},{"key":"9755_CR13","doi-asserted-by":"publisher","first-page":"1105690","DOI":"10.3389\/fnagi.2023.1105690","volume":"15","author":"Y Tan","year":"2023","unstructured":"Tan Y, Tang W, Xiao W, Huang R, Li X, Peng W, et al. lncRNA-associated CeRNA network revealing the potential regulatory roles of ferroptosis and immune infiltration in alzheimer\u2019s disease. Front Aging Neurosci. 2023;15:1105690. https:\/\/doi.org\/10.3389\/fnagi.2023.1105690.","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"9755_CR14","first-page":"778","volume":"13","author":"X Sun","year":"2023","unstructured":"Sun X, Song J, Lu C, Sun X, Yue H, Bao H, et al. Characterization of cuproptosis-related LncRNA landscape for predicting the prognosis and aiding immunotherapy in lung adenocarcinoma patients. Am J Cancer Res. 2023;13(3):778\u2013801.","journal-title":"Am J Cancer Res"},{"key":"9755_CR15","doi-asserted-by":"publisher","first-page":"148713","DOI":"10.1016\/j.gene.2024.148713","volume":"927","author":"XC Peng","year":"2024","unstructured":"Peng XC, Ma LL, Miao JY, Xu SQ, Shuai ZW. Differential LncRNA profiles of blood plasma-derived exosomes from systemic lupus erythematosus. Gene. 2024;927:148713. https:\/\/doi.org\/10.1016\/j.gene.2024.148713.","journal-title":"Gene"},{"key":"9755_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ncrna.2025.02.004","volume":"12","author":"YJ Liu","year":"2025","unstructured":"Liu YJ, Miao HB, Lin S, Chen Z. Exosomes derived let-7f-5p is a potential biomarker of SLE with anti-inflammatory function. Non-coding RNA Res. 2025;12:116\u201331. https:\/\/doi.org\/10.1016\/j.ncrna.2025.02.004.","journal-title":"Non-coding RNA Res"},{"key":"9755_CR17","doi-asserted-by":"publisher","first-page":"109313","DOI":"10.1016\/j.biopha.2019.109313","volume":"118","author":"W Tan","year":"2019","unstructured":"Tan W, Gu Z, Leng J, Zou X, Chen H, Min F, et al. Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Biomed pharmacotherapy = Biomedecine Pharmacotherapie. 2019;118:109313. https:\/\/doi.org\/10.1016\/j.biopha.2019.109313.","journal-title":"Biomed pharmacotherapy = Biomedecine Pharmacotherapie"},{"issue":"9","key":"9755_CR18","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1136\/annrheumdis-2018-214819","volume":"78","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European league against Rheumatism\/American college of rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151\u20139. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214819.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"9755_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jaut.2010.02.002","volume":"35","author":"M Zhao","year":"2010","unstructured":"Zhao M, Sun Y, Gao F, Wu X, Tang J, Yin H, et al. Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4\u2009+\u2009T cells. J Autoimmun. 2010;35(1):58\u201369. https:\/\/doi.org\/10.1016\/j.jaut.2010.02.002.","journal-title":"J Autoimmun"},{"issue":"46","key":"9755_CR20","doi-asserted-by":"publisher","first-page":"e45739","DOI":"10.1097\/md.0000000000045739","volume":"104","author":"RH Ma","year":"2025","unstructured":"Ma RH, Luo XB, Liu YP, Li Q. Clonorchis sinensis infection are associated with calcium phosphate gallbladder stones: A single-center retrospective observational study in China. Medicine. 2025;104(46):e45739. https:\/\/doi.org\/10.1097\/md.0000000000045739.","journal-title":"Medicine"},{"issue":"4","key":"9755_CR21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jaut.2007.07.018","volume":"29","author":"KS Lang","year":"2007","unstructured":"Lang KS, Burow A, Kurrer M, Lang PA, Recher M. The role of the innate immune response in autoimmune disease. J Autoimmun. 2007;29(4):206\u201312. https:\/\/doi.org\/10.1016\/j.jaut.2007.07.018.","journal-title":"J Autoimmun"},{"key":"9755_CR22","doi-asserted-by":"publisher","first-page":"1325262","DOI":"10.1155\/sci\/1325262","volume":"2025","author":"P Wang","year":"2025","unstructured":"Wang P, Xu S, Guo Q, Zhao Y. Discovery of PAK2 as a key regulator of cancer stem cell in head and neck squamous cell carcinoma using Multi-Omic techniques. Stem Cells Int. 2025;2025:1325262. https:\/\/doi.org\/10.1155\/sci\/1325262.","journal-title":"Stem Cells Int"},{"key":"9755_CR23","doi-asserted-by":"publisher","first-page":"5308441","DOI":"10.1155\/humu\/5308441","volume":"2025","author":"T Yin","year":"2025","unstructured":"Yin T, Guo Q, Wen Z, Guo Y, Li C, Qu Z. Multiomic landscape uncovers TRMT112 as a central driver of HPV-Positive head and neck squamous cell carcinoma. Hum Mutat. 2025;2025:5308441. https:\/\/doi.org\/10.1155\/humu\/5308441.","journal-title":"Hum Mutat"},{"key":"9755_CR24","doi-asserted-by":"publisher","first-page":"834731","DOI":"10.3389\/fgene.2022.834731","volume":"13","author":"S Xu","year":"2022","unstructured":"Xu S, Liu Y, Ma H, Fang S, Wei S, Li X, et al. A novel signature integrated of Immunoglobulin, glycosylation and Anti-Viral genes to predict prognosis for breast cancer. Front Genet. 2022;13:834731. https:\/\/doi.org\/10.3389\/fgene.2022.834731.","journal-title":"Front Genet"},{"issue":"14","key":"9755_CR25","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1177\/09612033241294032","volume":"33","author":"Q Ma","year":"2024","unstructured":"Ma Q, Li L, Xing Y. LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression. Lupus. 2024;33(14):1538\u201346. https:\/\/doi.org\/10.1177\/09612033241294032.","journal-title":"Lupus"},{"issue":"7","key":"9755_CR26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/apm.13410","volume":"132","author":"L Jiang","year":"2024","unstructured":"Jiang L, Qi A, Yang H, Wang S, Wang F, Bai X et al. LncRNA SNHG1 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression. APMIS: acta pathologica, microbiologica, et immunologica scandinavica. 2024;132(7):507\u201314. https:\/\/doi.org\/10.1111\/apm.13410","journal-title":"APMIS: acta pathologica, microbiologica, et immunologica scandinavica"},{"issue":"3","key":"9755_CR27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/1756-185x.13786","volume":"23","author":"HY Cao","year":"2020","unstructured":"Cao HY, Li D, Wang YP, Lu HX, Sun J, Li HB. Clinical significance of reduced expression of LncRNA TUG1 in the peripheral blood of systemic lupus erythematosus patients. Int J Rheum Dis. 2020;23(3):428\u201334. https:\/\/doi.org\/10.1111\/1756-185x.13786.","journal-title":"Int J Rheum Dis"},{"issue":"7","key":"9755_CR28","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1177\/09612033241243175","volume":"33","author":"H Yang","year":"2024","unstructured":"Yang H, Wang S, Wang F, Bai X, Ren J. Serum long non-coding ribonucleic acid H19 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression. Lupus. 2024;33(7):675\u201384. https:\/\/doi.org\/10.1177\/09612033241243175.","journal-title":"Lupus"},{"key":"9755_CR29","doi-asserted-by":"publisher","first-page":"1007918","DOI":"10.3389\/fonc.2022.1007918","volume":"12","author":"G Cui","year":"2022","unstructured":"Cui G, Liu J, Wang C, Gu R, Wang M, Sun Z, et al. Comprehensive analysis of the prognostic signature and tumor microenvironment infiltration characteristics of cuproptosis-related LncRNAs for patients with colon adenocarcinoma. Front Oncol. 2022;12:1007918. https:\/\/doi.org\/10.3389\/fonc.2022.1007918.","journal-title":"Front Oncol"},{"key":"9755_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.imlet.2020.08.001","volume":"227","author":"Q Liu","year":"2020","unstructured":"Liu Q, Deng Y, Li C, Xie H, Liu Q, Ming S, et al. LncRNA GAS5 suppresses CD4(+) T cell activation by upregulating E4BP4 via inhibiting miR-92a-3p in systemic lupus erythematosus. Immunol Lett. 2020;227:41\u20137. https:\/\/doi.org\/10.1016\/j.imlet.2020.08.001.","journal-title":"Immunol Lett"},{"key":"9755_CR31","doi-asserted-by":"publisher","first-page":"2513829","DOI":"10.1155\/2017\/2513829","volume":"2017","author":"M Vitales-Noyola","year":"2017","unstructured":"Vitales-Noyola M, Oceguera-Maldonado B, Ni\u00f1o-Moreno P, Baltazar-Ben\u00edtez N, Baranda L, Layseca-Espinosa E, et al. Patients with systemic lupus erythematosus show increased levels and defective function of CD69(+) T regulatory cells. Mediat Inflamm. 2017;2017:2513829. https:\/\/doi.org\/10.1155\/2017\/2513829.","journal-title":"Mediat Inflamm"},{"issue":"1","key":"9755_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/art.40682","volume":"71","author":"MP Karampetsou","year":"2019","unstructured":"Karampetsou MP, Comte D, Su\u00e1rez-Fueyo A, Katsuyama E, Yoshida N, Kono M, et al. Signaling lymphocytic activation molecule family member 1 engagement inhibits T cell-B cell interaction and diminishes Interleukin-6 production and plasmablast differentiation in systemic lupus erythematosus. Arthritis Rheumatol (Hoboken NJ). 2019;71(1):99\u2013108. https:\/\/doi.org\/10.1002\/art.40682.","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"issue":"3","key":"9755_CR33","doi-asserted-by":"publisher","first-page":"e70242","DOI":"10.1002\/ctm2.70242","volume":"15","author":"H Sun","year":"2025","unstructured":"Sun H, Miao J, Zhang K, Zhang P, Shen H, Wang J, et al. Id2 exacerbates the development of rheumatoid arthritis by increasing IFN-\u03b3 production in CD4(+) T cells. Clin Translational Med. 2025;15(3):e70242. https:\/\/doi.org\/10.1002\/ctm2.70242.","journal-title":"Clin Translational Med"},{"issue":"5","key":"9755_CR34","first-page":"875","volume":"17","author":"T Horiuchi","year":"2006","unstructured":"Horiuchi T, Morita C, Tsukamoto H, Mitoma H, Sawabe T, Harashima S, et al. Increased expression of membrane TNF-alpha on activated peripheral CD8\u2009+\u2009T cells in systemic lupus erythematosus. Int J Mol Med. 2006;17(5):875\u20139.","journal-title":"Int J Mol Med"},{"issue":"13","key":"9755_CR35","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.18632\/aging.102093","volume":"11","author":"ZH Li","year":"2019","unstructured":"Li ZH, Wang YF, He DD, Zhang XM, Zhou YL, Yue H, et al. Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis. Aging. 2019;11(13):4463\u201377. https:\/\/doi.org\/10.18632\/aging.102093.","journal-title":"Aging"},{"issue":"3","key":"9755_CR36","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/rheumatology\/kez354","volume":"59","author":"A De Groof","year":"2020","unstructured":"De Groof A, Ducreux J, Aleva F, Long AJ, Ferster A, van der Ven A, et al. STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE. Rheumatology (Oxford). 2020;59(3):668\u201377. https:\/\/doi.org\/10.1093\/rheumatology\/kez354.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"9755_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08916930601095148","volume":"40","author":"T Harada","year":"2007","unstructured":"Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, Tsokos GC. Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity. 2007;40(1):1\u20138. https:\/\/doi.org\/10.1080\/08916930601095148.","journal-title":"Autoimmunity"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09755-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-026-09755-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09755-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:01:51Z","timestamp":1773514911000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-026-09755-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9755"],"URL":"https:\/\/doi.org\/10.1007\/s12026-026-09755-5","relation":{},"ISSN":["1559-0755"],"issn-type":[{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,14]]},"assertion":[{"value":"3 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present investigation was granted approval by the ethics committee of Affiliated Hospital of PanZhiHua University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval statement"}},{"value":"Written consent was obtained from all individuals participating in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Permission to reproduce material from other sources"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}],"article-number":"27"}}