{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:02:08Z","timestamp":1784876528911,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 82360976"],"award-info":[{"award-number":["Grant No. 82360976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"DOI":"10.1007\/s12026-026-09807-w","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:54Z","timestamp":1784874414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated transcriptomic analysis of peripheral blood CD4\u2009+\u2009T cells identifies immune-associated hub genes in rheumatoid arthritis: discovery and external validation"],"prefix":"10.1007","volume":"74","author":[{"given":"Haiyang","family":"Kou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"9807_CR1","doi-asserted-by":"publisher","first-page":"156616","DOI":"10.1016\/j.cyto.2024.156616","volume":"179","author":"P Monu, Agnihotri","year":"2024","unstructured":"Monu, Agnihotri P, Saquib M, Biswas S. Targeting TNF-\u03b1-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin\u2019s mediated therapeutic approach. Cytokine. 2024;179:156616.","journal-title":"Cytokine"},{"issue":"1","key":"9807_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.102020","volume":"39","author":"DP Misra","year":"2025","unstructured":"Misra DP. Clinical manifestations of rheumatoid arthritis, including comorbidities, complications, and long-term follow-up. Best Pract Res Clin Rheumatol. 2025;39(1):102020.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"9","key":"9807_CR3","first-page":"1533","volume":"43","author":"G Noto","year":"2025","unstructured":"Noto G, Salvetti F, Demaj A, Altieri P, Chericoni E, Ferrigno E, et al. Pathogenesis of rheumatoid arthritis: one year in review 2025. Clin Exp Rheumatol. 2025;43(9):1533\u201340.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"9807_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.101968","volume":"38","author":"SD Sharma","year":"2024","unstructured":"Sharma SD, Leung SH, Viatte S. Genetics of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2024;38(4):101968.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"9807_CR5","doi-asserted-by":"crossref","unstructured":"Argyriou A, Wadsworth MH 2nd, Lendvai A, Christensen SM, Hensvold AH, Gerstner C, et al. Single cell sequencing identifies clonally expanded synovial CD4(+) T(PH) cells expressing GPR56 in rheumatoid arthritis. Nat Commun. 2022;13(1):4046.","DOI":"10.1038\/s41467-022-31519-6"},{"issue":"10","key":"9807_CR6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00018-022-04563-0","volume":"79","author":"S Yan","year":"2022","unstructured":"Yan S, Kotschenreuther K, Deng S, Kofler DM. Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential. Cell Mol Life Sci. 2022;79(10):533.","journal-title":"Cell Mol Life Sci"},{"issue":"825","key":"9807_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adh1178","volume":"17","author":"H Cai","year":"2024","unstructured":"Cai H, Zhang J, Xu H, Sun W, Wu W, Dong C, et al. ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis. Sci Signal. 2024;17(825):eadh1178.","journal-title":"Sci Signal"},{"key":"9807_CR8","doi-asserted-by":"crossref","unstructured":"Xue M, Wang H, Campos F, Jackson CJ, March L. Rheumatoid Arthritis: Biomarkers and the Latest Breakthroughs. Int J Mol Sci. 2025;26(21).","DOI":"10.3390\/ijms262110594"},{"issue":"6","key":"9807_CR9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s00296-025-05908-1","volume":"45","author":"O Zimba","year":"2025","unstructured":"Zimba O, Baimukhamedov C, Kocyigit BF. Late-onset rheumatoid arthritis: clinical features, diagnostic challenges, and treatment approaches. Rheumatol Int. 2025;45(6):152.","journal-title":"Rheumatol Int"},{"issue":"4","key":"9807_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3899\/jrheum.2023-0334","volume":"51","author":"LJ O\u2019Neil","year":"2024","unstructured":"O\u2019Neil LJ, Alp\u00edzar-Rodr\u00edguez D, Deane KD. Rheumatoid Arthritis: The Continuum of Disease and Strategies for Prediction, Early Intervention, and Prevention. J Rhuematol. 2024;51(4):337\u201349.","journal-title":"J Rhuematol"},{"issue":"7","key":"9807_CR11","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/art.43124","volume":"77","author":"M Lacaud","year":"2025","unstructured":"Lacaud M, Bouzidi HG, Petit M, Breckler M, Lemeiter D, Sigaux J, et al. Cytotoxic response of CD4(+) T cells orchestrated by SLAMF4 in rheumatoid arthritis. Arthritis Rheumatol. 2025;77(7):827\u201341.","journal-title":"Arthritis Rheumatol"},{"key":"9807_CR12","doi-asserted-by":"crossref","unstructured":"Turcinov S, Sharma RK, De Vries C, C\u00eerciumaru A, Gerstner C, Mathsson-Alm L et al. Arthritis progressors have a decreased frequency of circulating autoreactive T cells during the at-risk phase of rheumatoid arthritis. RMD open. 2024;10(4).","DOI":"10.1136\/rmdopen-2024-004510"},{"key":"9807_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.","journal-title":"BMC Bioinformatics"},{"key":"9807_CR14","doi-asserted-by":"crossref","unstructured":"Mucha P, Ruczy\u0144ski J, Prochera K, Rekowski P. Lasso Peptides-A New Weapon Against Superbugs. Int J Mol Sci. 2025;26(17).","DOI":"10.3390\/ijms26178184"},{"key":"9807_CR15","doi-asserted-by":"crossref","unstructured":"Hu J, Szymczak S. A review on longitudinal data analysis with random forest. Brief Bioinform. 2023;24(2).","DOI":"10.1093\/bib\/bbad002"},{"issue":"43","key":"9807_CR16","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545\u201350.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9807_CR17","doi-asserted-by":"crossref","unstructured":"Chen G, Ram\u00edrez JC, Deng N, Qiu X, Wu C, Zheng WJ et al. Restructured GEO: restructuring Gene Expression Omnibus metadata for genome dynamics analysis. Database: the journal of biological databases and curation. 2019;2019.","DOI":"10.1093\/database\/bay145"},{"key":"9807_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.951582","volume":"13","author":"S Feng","year":"2022","unstructured":"Feng S, Xu Y, Dai Z, Yin H, Zhang K, Shen Y. Integrative analysis from multicenter studies identifies a WGCNA-derived cancer-associated fibroblast signature for ovarian cancer. Front Immunol. 2022;13:951582.","journal-title":"Front Immunol"},{"key":"9807_CR19","doi-asserted-by":"publisher","first-page":"802393","DOI":"10.3389\/fgene.2022.802393","volume":"13","author":"KY Chloe Li","year":"2022","unstructured":"Chloe Li KY, Cook AC, Lovering RC. GOing Forward With the Cardiac Conduction System Using Gene Ontology. Front Genet. 2022;13:802393.","journal-title":"Front Genet"},{"issue":"1","key":"9807_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"9807_CR21","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51(D1):D638\u201346.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"9807_CR22","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1002\/art.42954","volume":"76","author":"T Wu","year":"2024","unstructured":"Wu T, Su D, Zhang L, Liu T, Wang Q, Yan C, et al. Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue-Resident Memory T Cells in Patients with Rheumatoid Arthritis. Arthritis Rheumatol (Hoboken NJ). 2024;76(12):1743\u201357.","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"9807_CR23","doi-asserted-by":"publisher","first-page":"103818","DOI":"10.1016\/j.redox.2025.103818","volume":"86","author":"Z Bai","year":"2025","unstructured":"Bai Z, Ren J, Liu J, Zhang C, Huang H, Zhao X, et al. DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4(+)PD-1(+)T cells. Redox Biol. 2025;86:103818.","journal-title":"Redox Biol"},{"key":"9807_CR24","doi-asserted-by":"crossref","unstructured":"Zerrouk N, Aghakhani S, Singh V, Aug\u00e9 F, Niarakis A. A Mechanistic Cellular Atlas of the Rheumatic Joint. 2022;2\u20132022.","DOI":"10.3389\/fsysb.2022.925791"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09807-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-026-09807-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09807-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:56Z","timestamp":1784874416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-026-09807-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9807"],"URL":"https:\/\/doi.org\/10.1007\/s12026-026-09807-w","relation":{},"ISSN":["1559-0755"],"issn-type":[{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"3 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. All analyses were based on previously published studies.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"74"}}