{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:59:10Z","timestamp":1785441550493,"version":"3.56.0"},"reference-count":180,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["81072398"],"award-info":[{"award-number":["81072398"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"DOI":"10.1007\/s12026-026-09811-0","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:51:29Z","timestamp":1785379889000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune cells in liver transplantation: Dual roles, mechanistic insights, and targeted therapeutic strategies"],"prefix":"10.1007","volume":"74","author":[{"given":"Yuanzhen","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningjing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-7364","authenticated-orcid":false,"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"9811_CR1","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1002\/lt.25320","volume":"24","author":"AS Bodzin","year":"2018","unstructured":"Bodzin AS, Baker TB. Liver transplantation today: where we are now and where we are going. Liver Transpl. 2018;24:1470\u20135.","journal-title":"Liver Transpl"},{"key":"9811_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04169-w","volume":"16","author":"Y Tian","year":"2025","unstructured":"Tian Y, et al. Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through mir-17-5p-regulated kupffer cell pyroptosis. Stem Cell Res Ther. 2025;16:57.","journal-title":"Stem Cell Res Ther"},{"key":"9811_CR3","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S2468-1253(23)00363-1","volume":"9","author":"F Artru","year":"2024","unstructured":"Artru F, Trovato F, Morrison M, Bernal W, McPhail M. Liver transplantation for acute-on-chronic liver failure. Lancet Gastroenterol Hepatol. 2024;9:564\u201376.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"9811_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0416-y","volume":"7","author":"Y Tian","year":"2016","unstructured":"Tian Y, et al. Mesenchymal stem cells improve mouse non-heart-beating liver graft survival by inhibiting kupffer cell apoptosis via TLR4-ERK1\/2-fas\/FasL-caspase3 pathway regulation. Stem Cell Res Ther. 2016;7:157.","journal-title":"Stem Cell Res Ther"},{"key":"9811_CR5","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.transproceed.2018.11.010","volume":"51","author":"S Vivalda","year":"2019","unstructured":"Vivalda S, et al. Vascular and biliary complications following deceased donor liver transplantation: a meta-analysis. Transplant Proc. 2019;51:823\u201332.","journal-title":"Transplant Proc"},{"key":"9811_CR6","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/nm.2927","volume":"18","author":"TE Starzl","year":"2012","unstructured":"Starzl TE. The long reach of liver transplantation. Nat Med. 2012;18:1489\u201392.","journal-title":"Nat Med"},{"key":"9811_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.719954","volume":"12","author":"A Hann","year":"2021","unstructured":"Hann A, Oo YH, Perera MTPR. Regulatory T-cell therapy in liver transplantation and chronic liver disease. Front Immunol. 2021;12:719954.","journal-title":"Front Immunol"},{"key":"9811_CR8","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/lt.23826","volume":"20","author":"T Taner","year":"2014","unstructured":"Taner T, Stegall MD, Heimbach JK. Antibody-mediated rejection in liver transplantation: current controversies and future directions. Liver Transpl. 2014;20:514\u201327.","journal-title":"Liver Transpl"},{"key":"9811_CR9","doi-asserted-by":"crossref","unstructured":"Demetris, A. J. et al. Functional immune anatomy of the liver-as an allograft. Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg. 16, 1653\u20131680 (2016).","DOI":"10.1111\/ajt.13749"},{"key":"9811_CR10","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/MOT.0000000000000709","volume":"24","author":"K Nakamura","year":"2019","unstructured":"Nakamura K, Kageyama S, Kupiec-Weglinski JW. Innate immunity in ischemia-reperfusion injury and graft rejection. Curr Opin Organ Transplant. 2019;24:687\u201393.","journal-title":"Curr Opin Organ Transplant"},{"key":"9811_CR11","doi-asserted-by":"crossref","unstructured":"Zhuang, Q. et al. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat. Commun. 7, 12623 (2016).","DOI":"10.1038\/ncomms12623"},{"key":"9811_CR12","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/MOT.0000000000000708","volume":"24","author":"RG Gill","year":"2019","unstructured":"Gill RG, Lin CM. Linking innate immunity and chronic antibody-mediated allograft rejection. Curr Opin Organ Transplant. 2019;24:694\u20138.","journal-title":"Curr Opin Organ Transplant"},{"key":"9811_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103227","volume":"160","author":"W Zhang","year":"2021","unstructured":"Zhang W, Liu Z, Xu X. Navigating immune cell immunometabolism after liver transplantation. Crit Rev Oncol Hematol. 2021;160:103227.","journal-title":"Crit Rev Oncol Hematol"},{"key":"9811_CR14","doi-asserted-by":"crossref","unstructured":"Stolp, J., Zaitsu, M. & Wood, K. J. Immune tolerance and rejection in organ transplantation. Methods Mol. Biol. Clifton NJ 1899, 159\u2013180 (2019).","DOI":"10.1007\/978-1-4939-8938-6_12"},{"key":"9811_CR15","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1097\/TP.0000000000005220","volume":"109","author":"SK Lee","year":"2025","unstructured":"Lee SK, et al. The critical role of regulatory T cells in immune tolerance and rejection following liver transplantation: interactions with the gut microbiome. Transplantation. 2025;109:784\u201393.","journal-title":"Transplantation"},{"key":"9811_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbrc.2019.02.147","volume":"512","author":"H Huang","year":"2019","unstructured":"Huang H, Deng Z. Adoptive transfer of regulatory T cells stimulated by allogeneic hepatic stellate cells mitigates liver injury in mice with concanavalin a-induced autoimmune hepatitis. Biochem Biophys Res Commun. 2019;512:14\u201321.","journal-title":"Biochem Biophys Res Commun"},{"key":"9811_CR17","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","volume":"133","author":"S Sakaguchi","year":"2008","unstructured":"Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133:775\u201387.","journal-title":"Cell"},{"key":"9811_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01260","volume":"11","author":"M Comi","year":"2020","unstructured":"Comi M, et al. Generation of powerful human tolerogenic dendritic cells by lentiviral-mediated IL-10 gene transfer. Front Immunol. 2020;11:1260.","journal-title":"Front Immunol"},{"key":"9811_CR19","doi-asserted-by":"crossref","unstructured":"Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888\u20131902.e21 (2019).","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"9811_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1670683","volume":"16","author":"L Mou","year":"2025","unstructured":"Mou L, Pu Z. The single-cell revolution in transplantation: high-resolution mapping of graft rejection, tolerance, and injury. Front Immunol. 2025;16:1670683.","journal-title":"Front Immunol"},{"key":"9811_CR21","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nri2858","volume":"10","author":"AW Thomson","year":"2010","unstructured":"Thomson AW, Knolle PA. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol. 2010;10:753\u201366.","journal-title":"Nat Rev Immunol"},{"key":"9811_CR22","doi-asserted-by":"crossref","unstructured":"Racanelli, V. & Rehermann, B. The liver as an immunological organ. Hepatol. Baltim. Md 43, S54-62 (2006).","DOI":"10.1002\/hep.21060"},{"key":"9811_CR23","doi-asserted-by":"crossref","unstructured":"Crispe, I. N. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51\u201362 (2003).","DOI":"10.1038\/nri981"},{"key":"9811_CR24","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41575-018-0020-y","volume":"15","author":"S Shetty","year":"2018","unstructured":"Shetty S, Lalor PF, Adams DH. Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol. 2018;15:555\u201367.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"9811_CR25","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s12072-025-10778-7","volume":"19","author":"Z Pan","year":"2025","unstructured":"Pan Z, Ye Y-S, Liu C, Li W. Role of liver-resident NK cells in liver immunity. Hepatol Int. 2025;19:315\u201324.","journal-title":"Hepatol Int"},{"key":"9811_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00946","volume":"10","author":"J Mikulak","year":"2019","unstructured":"Mikulak J, Bruni E, Oriolo F, Di Vito C, Mavilio D. Hepatic natural killer cells: organ-specific sentinels of liver immune homeostasis and physiopathology. Front Immunol. 2019;10:946.","journal-title":"Front Immunol"},{"key":"9811_CR27","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/cmi.2015.96","volume":"13","author":"H Peng","year":"2016","unstructured":"Peng H, Wisse E, Tian Z. Liver natural killer cells: subsets and roles in liver immunity. Cell Mol Immunol. 2016;13:328\u201336.","journal-title":"Cell Mol Immunol"},{"key":"9811_CR28","doi-asserted-by":"crossref","unstructured":"Calne, R. Y. et al. Induction of immunological tolerance by porcine liver allografts. Nature 223, 472\u2013476 (1969).","DOI":"10.1038\/223472a0"},{"key":"9811_CR29","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/215744a0","volume":"215","author":"HM Cantor","year":"1967","unstructured":"Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature. 1967;215:744\u20135.","journal-title":"Nature"},{"key":"9811_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01615","volume":"11","author":"N Tanimine","year":"2020","unstructured":"Tanimine N, et al. Strategies for deliberate induction of immune tolerance in liver transplantation: from preclinical models to clinical application. Front Immunol. 2020;11:1615.","journal-title":"Front Immunol"},{"key":"9811_CR31","doi-asserted-by":"crossref","unstructured":"Yan, H. et al. TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8\u2009+\u2009T cells. Immunology 161, 325\u2013344 (2020).","DOI":"10.1111\/imm.13251"},{"key":"9811_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02525","volume":"10","author":"M Zheng","year":"2019","unstructured":"Zheng M, Tian Z. Liver-mediated adaptive immune tolerance. Front Immunol. 2019;10:2525.","journal-title":"Front Immunol"},{"key":"9811_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.655697","volume":"12","author":"J Giraud","year":"2021","unstructured":"Giraud J, Chalopin D, Blanc J-F, Saleh M. Hepatocellular carcinoma immune landscape and the potential of immunotherapies. Front Immunol. 2021;12:655697.","journal-title":"Front Immunol"},{"key":"9811_CR34","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.4049\/jimmunol.153.12.5453","volume":"153","author":"CR Roland","year":"1994","unstructured":"Roland CR, Walp L, Stack RM, Flye MW. Outcome of kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFN-gamma. J Immunol. 1994;153:5453\u201364.","journal-title":"J Immunol"},{"key":"9811_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1659404","volume":"16","author":"W Qiao","year":"2025","unstructured":"Qiao W, Li L, Jin R, Hu C. Integrating single-cell RNA sequencing with spatial transcriptomics reveal the fibrosis-related genes in hepatocellular carcinoma. Front Immunol. 2025;16:1659404.","journal-title":"Front Immunol"},{"key":"9811_CR36","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaf160","volume":"26","author":"L Gao","year":"2025","unstructured":"Gao L, et al. Deep scSTAR: leveraging deep learning for the extraction and enhancement of phenotype-associated features from single-cell RNA sequencing and spatial transcriptomics data. Brief Bioinform. 2025;26:bbaf160.","journal-title":"Brief Bioinform"},{"key":"9811_CR37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/hep.20756","volume":"42","author":"C Wiegard","year":"2005","unstructured":"Wiegard C, et al. Murine liver antigen presenting cells control suppressor activity of CD4\u2009+\u2009CD25+ regulatory T cells. Hepatology. 2005;42:193\u20139.","journal-title":"Hepatology"},{"key":"9811_CR38","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1365-2567.2009.03179.x","volume":"129","author":"J Wu","year":"2010","unstructured":"Wu J, et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010;129:363\u201374.","journal-title":"Immunology"},{"key":"9811_CR39","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1002\/hep.27254","volume":"60","author":"IN Crispe","year":"2014","unstructured":"Crispe IN. Immune tolerance in liver disease. Hepatology. 2014;60:2109\u201317.","journal-title":"Hepatology"},{"key":"9811_CR40","doi-asserted-by":"crossref","unstructured":"Li, L. et al. Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin \u03b14. J. Clin. Invest. 132, e156994 (2022).","DOI":"10.1172\/JCI156994"},{"key":"9811_CR41","doi-asserted-by":"crossref","unstructured":"Hughes, A. D. et al. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. J. Clin. Invest. 130, 287\u2013294 (2020).","DOI":"10.1172\/JCI125773"},{"key":"9811_CR42","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1097\/00007890-199510150-00027","volume":"60","author":"K Matsuno","year":"1995","unstructured":"Matsuno K, Kudo S, Ezaki T, Miyakawa K. Isolation of dendritic cells in the rat liver lymph. Transplantation. 1995;60:765\u20138.","journal-title":"Transplantation"},{"key":"9811_CR43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20240519","volume":"221","author":"M Esposito","year":"2024","unstructured":"Esposito M, Amory JK, Kang Y. The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes. J Exp Med. 2024;221:e20240519.","journal-title":"J Exp Med"},{"key":"9811_CR44","doi-asserted-by":"crossref","unstructured":"Meital, L. T. et al. Endotoxin Tolerance in Abdominal Aortic Aneurysm Macrophages, In Vitro: A Case-Control Study. Antioxidants 9, 896 (2020).","DOI":"10.3390\/antiox9090896"},{"key":"9811_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002241","volume":"3","author":"M Giuliani","year":"2008","unstructured":"Giuliani M, et al. Generation of a novel regulatory NK cell subset from peripheral blood CD34\u2009+\u2009progenitors promoted by membrane-bound IL-15. PLoS One. 2008;3:e2241.","journal-title":"PLoS One"},{"key":"9811_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2025.09.014","author":"Q Shen","year":"2025","unstructured":"Shen Q, et al. Macrophages mediate acute kidney allograft rejection via a toll-like receptor 4-dependent mechanism. Kidney Int. 2025. https:\/\/doi.org\/10.1016\/j.kint.2025.09.014.","journal-title":"Kidney Int"},{"key":"9811_CR47","doi-asserted-by":"crossref","unstructured":"Bergler, T. et al. Infiltration of macrophages correlates with severity of allograft rejection and outcome in human kidney transplantation. PLOS ONE 11, e0156900 (2016).","DOI":"10.1371\/journal.pone.0156900"},{"key":"9811_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","volume":"18","author":"Y Wen","year":"2021","unstructured":"Wen Y, Lambrecht J, Ju C, Tacke F. Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities. Cell Mol Immunol. 2021;18:45\u201356.","journal-title":"Cell Mol Immunol"},{"key":"9811_CR49","doi-asserted-by":"crossref","unstructured":"Nusse, Y. & Kubes, P. Liver macrophages: Development, dynamics, and functions. Cell. Mol. Immunol. 22, 1178\u20131189 (2025).","DOI":"10.1038\/s41423-025-01298-3"},{"key":"9811_CR50","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.biopha.2017.03.022","volume":"89","author":"X Li","year":"2017","unstructured":"Li X, Wu Y, Zhang W, Gong J, Cheng Y. Pre-conditioning with tanshinone IIA attenuates the ischemia\/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat kupffer cells. Biomed Pharmacother. 2017;89:1392\u2013400.","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"9811_CR51","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1097\/TXD.0000000000000608","volume":"2","author":"M Hidaka","year":"2016","unstructured":"Hidaka M, et al. The kupffer cell number affects the outcome of living donor liver transplantation from elderly donors. Transplant Direct. 2016;2:e94.","journal-title":"Transplant Direct"},{"key":"9811_CR52","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/hep.24488","volume":"54","author":"B Shao","year":"2011","unstructured":"Shao B, et al. Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin. Hepatology. 2011;54:1051\u201362.","journal-title":"Hepatology"},{"key":"9811_CR53","doi-asserted-by":"crossref","unstructured":"Heymann, F. et al. Liver inflammation abrogates immunological tolerance induced by kupffer cells. Hepatol. Baltim. Md 62, 279\u2013291 (2015).","DOI":"10.1002\/hep.27793"},{"key":"9811_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6862439","volume":"2017","author":"J-S Byun","year":"2017","unstructured":"Byun J-S, Yi H-S. Hepatic immune microenvironment in alcoholic and nonalcoholic liver disease. BioMed Res Int. 2017;2017:6862439.","journal-title":"BioMed Res Int"},{"key":"9811_CR55","doi-asserted-by":"publisher","first-page":"237","DOI":"10.35946\/arcr.v37.2.08","volume":"37","author":"LE Nagy","year":"2015","unstructured":"Nagy LE. The role of innate immunity in alcoholic liver disease. Alcohol Res Curr Rev. 2015;37:237\u201350.","journal-title":"Alcohol Res Curr Rev"},{"key":"9811_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01193","volume":"11","author":"L Ye","year":"2020","unstructured":"Ye L, et al. Effect of hepatic macrophage polarization and apoptosis on liver ischemia and reperfusion injury during liver transplantation. Front Immunol. 2020;11:1193.","journal-title":"Front Immunol"},{"key":"9811_CR57","doi-asserted-by":"crossref","unstructured":"Datta, G., Fuller, B. J. & Davidson, B. R. Molecular mechanisms of liver ischemia reperfusion injury: Insights from transgenic knockout models. World J. Gastroenterol. 19, 1683\u20131698 (2013).","DOI":"10.3748\/wjg.v19.i11.1683"},{"key":"9811_CR58","doi-asserted-by":"crossref","unstructured":"Bhogal, R. H., Sutaria, R. & Afford, S. C. Hepatic liver ischemia\/reperfusion injury: Processes in inflammatory networks\u2013a review. Liver Transplant. Off. Publ. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc. 17, 95:96 (2011).","DOI":"10.1002\/lt.22205"},{"key":"9811_CR59","doi-asserted-by":"crossref","unstructured":"Horn, P. & Tacke, F. Liver macrophage diversity in health and disease. Results Probl. Cell Differ. 74, 175\u2013209 (2024).","DOI":"10.1007\/978-3-031-65944-7_7"},{"key":"9811_CR60","doi-asserted-by":"crossref","unstructured":"Chen, S. et al. Myeloid MAS-driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers. Sci. Transl. Med. 17, eadr2725 (2025).","DOI":"10.1126\/scitranslmed.adr2725"},{"key":"9811_CR61","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1126\/science.aal3535","volume":"356","author":"WKE Ip","year":"2017","unstructured":"Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513\u20139.","journal-title":"Science"},{"key":"9811_CR62","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi J, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660\u20135.","journal-title":"Nature"},{"key":"9811_CR63","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","volume":"23","author":"L Vande Walle","year":"2024","unstructured":"Vande Walle L, Lamkanfi M. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2024;23:43\u201366.","journal-title":"Nat Rev Drug Discov"},{"key":"9811_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1338125","volume":"15","author":"L Ni","year":"2024","unstructured":"Ni L, Chen D, Zhao Y, Ye R, Fang P. Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases. Front Immunol. 2024;15:1338125.","journal-title":"Front Immunol"},{"key":"9811_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02351-0","volume":"8","author":"W Guo","year":"2017","unstructured":"Guo W, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168.","journal-title":"Nat Commun"},{"key":"9811_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280565","volume":"18","author":"A Sriwarom","year":"2023","unstructured":"Sriwarom A, Chiewchengchol D, Saithong S, Worasilchai N, Chindamporn A. Neutrophil extracellular traps and phagocytosis in Pythium insidiosum. PLoS One. 2023;18:e0280565.","journal-title":"PLoS One"},{"key":"9811_CR67","doi-asserted-by":"crossref","unstructured":"Reis, A. P. C. et al. The dermatophyte trichophyton rubrum induces neutrophil extracellular traps release by human neutrophils. J. Fungi Basel Switz. 8, 147 (2022).","DOI":"10.3390\/jof8020147"},{"key":"9811_CR68","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cytogfr.2024.12.001","volume":"81","author":"H Manoj","year":"2025","unstructured":"Manoj H, et al. Cytokine signalling in formation of neutrophil extracellular traps: implications for health and diseases. Cytokine Growth Factor Rev. 2025;81:27\u201339.","journal-title":"Cytokine Growth Factor Rev"},{"key":"9811_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.823511","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu Y, et al. Neutrophil extracellular traps regulate HMGB1 translocation and kupffer cell M1 polarization during acute liver transplantation rejection. Front Immunol. 2022;13:823511.","journal-title":"Front Immunol"},{"key":"9811_CR70","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.1073\/pnas.1909546117","volume":"117","author":"HR Thiam","year":"2020","unstructured":"Thiam HR, et al. NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture. Proc Natl Acad Sci U S A. 2020;117:7326\u201337.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9811_CR71","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/hep.27841","volume":"62","author":"H Huang","year":"2015","unstructured":"Huang H, et al. Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 2015;62:600\u201314.","journal-title":"Hepatology"},{"key":"9811_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2021.101434","volume":"68","author":"Y Liu","year":"2021","unstructured":"Liu Y, Qin X, Lei Z, Chai H, Wu Z. Diphenyleneiodonium ameliorates acute liver rejection during transplantation by inhibiting neutrophil extracellular traps formation in vivo. Transpl Immunol. 2021;68:101434.","journal-title":"Transpl Immunol"},{"key":"9811_CR73","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1038\/onc.2016.406","volume":"36","author":"L Erpenbeck","year":"2017","unstructured":"Erpenbeck L, Sch\u00f6n MP. Neutrophil extracellular traps: protagonists of cancer progression? Oncogene. 2017;36:2483\u201390.","journal-title":"Oncogene"},{"key":"9811_CR74","first-page":"305","volume":"119","author":"AB Imaeda","year":"2009","unstructured":"Imaeda AB, et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 2009;119:305\u201314.","journal-title":"J Clin Invest"},{"key":"9811_CR75","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s40472-019-0230-4","volume":"6","author":"K Nakamura","year":"2019","unstructured":"Nakamura K, Kageyama S, Kupiec-Weglinski JW. The evolving role of neutrophils in liver transplant ischemia-reperfusion injury. Curr Transplant Rep. 2019;6:78\u201389.","journal-title":"Curr Transplant Rep"},{"key":"9811_CR76","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/labinvest.2017.90","volume":"98","author":"T Oliveira","year":"2018","unstructured":"Oliveira T, Marques PE, Proost P, Teixeira MMM. Neutrophils: a cornerstone of liver ischemia and reperfusion injury. Lab Invest. 2018;98:51\u201362.","journal-title":"Lab Invest"},{"key":"9811_CR77","doi-asserted-by":"publisher","first-page":"621","DOI":"10.2119\/molmed.2016.00054","volume":"22","author":"AB Al-Khafaji","year":"2016","unstructured":"Al-Khafaji AB, et al. Superoxide induces neutrophil extracellular trap formation in a TLR-4 and NOX-dependent mechanism. Mol Med. 2016;22:621\u201331.","journal-title":"Mol Med"},{"key":"9811_CR78","doi-asserted-by":"crossref","unstructured":"Liu, Y. et al. Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia\/reperfusion injury in rat liver transplantation. Exp. Cell Res. 406, 112719 (2021).","DOI":"10.1016\/j.yexcr.2021.112719"},{"key":"9811_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.010","author":"HO Yazdani","year":"2017","unstructured":"Yazdani HO, et al. IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation. J Hepatol. 2017. https:\/\/doi.org\/10.1016\/j.jhep.2017.09.010.","journal-title":"J Hepatol"},{"key":"9811_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111874","volume":"131","author":"M Xie","year":"2024","unstructured":"Xie M, et al. Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction. Int Immunopharmacol. 2024;131:111874.","journal-title":"Int Immunopharmacol"},{"key":"9811_CR81","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1054753","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu Y, Yan P, Bin Y, Qin X, Wu Z. Neutrophil extracellular traps and complications of liver transplantation. Front Immunol. 2022;13:1054753.","journal-title":"Front Immunol"},{"key":"9811_CR82","doi-asserted-by":"crossref","unstructured":"Albrengues, J. et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science\u00a0361, eaao4227 (2018).","DOI":"10.1126\/science.aao4227"},{"key":"9811_CR83","doi-asserted-by":"crossref","unstructured":"Leal, A. C. et al. Tumor-derived exosomes induce the formation of neutrophil extracellular traps: Implications for the establishment of cancer-associated thrombosis. Sci. Rep. 7, 6438 (2017).","DOI":"10.1038\/s41598-017-06893-7"},{"key":"9811_CR84","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1158\/0008-5472.CAN-15-1591","volume":"76","author":"S Tohme","year":"2016","unstructured":"Tohme S, et al. Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress. Cancer Res. 2016;1367\u201380.","journal-title":"Cancer Res"},{"key":"9811_CR85","doi-asserted-by":"crossref","unstructured":"Steinman, R. M. & Cohn, Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142\u20131162 (1973).","DOI":"10.1084\/jem.137.5.1142"},{"key":"9811_CR86","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.bbadis.2013.01.005","volume":"1832","author":"AH Rahman","year":"2013","unstructured":"Rahman AH, Aloman C. Dendritic cells and liver fibrosis. Biochim Biophys Acta. 2013;998\u20131004.","journal-title":"Biochim Biophys Acta"},{"key":"9811_CR87","doi-asserted-by":"crossref","unstructured":"Eckert, C., Klein, N., Kornek, M. & Lukacs-Kornek, V. The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation. Front. Immunol. 6, 179 (2015).","DOI":"10.3389\/fimmu.2015.00179"},{"key":"9811_CR88","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/imr.13050","volume":"306","author":"B Bo\u0161njak","year":"2022","unstructured":"Bo\u0161njak B, Do KTH, F\u00f6rster R, Hammerschmidt SI. Imaging dendritic cell functions. Immunol Rev. 2022;306:137\u201363.","journal-title":"Immunol Rev"},{"key":"9811_CR89","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41575-020-0334-4","volume":"17","author":"AW Thomson","year":"2020","unstructured":"Thomson AW, Vionnet J, Sanchez-Fueyo A. Understanding, predicting and achieving liver transplant tolerance: from bench to bedside. Nat Rev Gastroenterol Hepatol. 2020;17:719\u201339.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"9811_CR90","doi-asserted-by":"crossref","unstructured":"Bamboat, Z. M. et al. Human liver dendritic cells promote T cell hyporesponsiveness. J. Immunol. Baltim. Md 1950 182, 1901\u20131911 (2009).","DOI":"10.4049\/jimmunol.0803404"},{"key":"9811_CR91","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.4049\/jimmunol.174.4.2037","volume":"174","author":"A De Creus","year":"2005","unstructured":"De Creus A, et al. Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol. 2005;174:2037\u201345.","journal-title":"J Immunol"},{"key":"9811_CR92","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1055\/s-0038-1646949","volume":"38","author":"L Dou","year":"2018","unstructured":"Dou L, Ono Y, Chen Y-F, Thomson AW, Chen X-P. Hepatic dendritic cells, the tolerogenic liver environment, and liver disease. Semin Liver Dis. 2018;38:170\u201380.","journal-title":"Semin Liver Dis"},{"key":"9811_CR93","doi-asserted-by":"crossref","unstructured":"Wirtz, T. H., Brandt, E. F. & Berres, M.-L. Liver DCs in health and disease. Int. Rev. Cell Mol. Biol. 348, 263\u2013299 (2019).","DOI":"10.1016\/bs.ircmb.2019.08.001"},{"key":"9811_CR94","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","volume":"23","author":"Y-J Liu","year":"2005","unstructured":"Liu Y-J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 2005;23:275\u2013306.","journal-title":"Annu Rev Immunol"},{"key":"9811_CR95","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.4049\/jimmunol.1303073","volume":"192","author":"S Bhatt","year":"2014","unstructured":"Bhatt S, et al. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function. J Immunol. 2014;192:5098\u2013108.","journal-title":"J Immunol"},{"key":"9811_CR96","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.4049\/jimmunol.1200819","volume":"189","author":"TL Sumpter","year":"2012","unstructured":"Sumpter TL, et al. Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. J Immunol. 2012;189:3848\u201358.","journal-title":"J Immunol"},{"key":"9811_CR97","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.4049\/jimmunol.168.8.3771","volume":"168","author":"AL Mellor","year":"2002","unstructured":"Mellor AL, Keskin DB, Johnson T, Chandler P, Munn DH. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol. 2002;168:3771\u20136.","journal-title":"J Immunol"},{"key":"9811_CR98","unstructured":"Favre, D. et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci. Transl. Med. 2, 32ra36 (2010)."},{"key":"9811_CR99","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.4049\/jimmunol.172.2.1009","volume":"172","author":"VG Pillarisetty","year":"2004","unstructured":"Pillarisetty VG, Shah AB, Miller G, Bleier JI, DeMatteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol. 2004;172:1009\u201317.","journal-title":"J Immunol"},{"key":"9811_CR100","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.4049\/jimmunol.164.3.1346","volume":"164","author":"A Khanna","year":"2000","unstructured":"Khanna A, et al. Effects of liver-derived dendritic cell progenitors on Th1- and TH2-like cytokine responses in vitro and in vivo. J Immunol. 2000;164:1346\u201354.","journal-title":"J Immunol"},{"key":"9811_CR101","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705465","volume":"12","author":"R Nakano","year":"2021","unstructured":"Nakano R, et al. Dendritic cell-mediated regulation of liver ischemia-reperfusion injury and liver transplant rejection. Front Immunol. 2021;12:705465.","journal-title":"Front Immunol"},{"key":"9811_CR102","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1111\/ajt.12229","volume":"13","author":"NM Rogers","year":"2013","unstructured":"Rogers NM, Isenberg JS, Thomson AW. Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance? Am J Transplant. 2013;13:1125\u201333.","journal-title":"Am J Transplant"},{"key":"9811_CR103","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1111\/ajt.16412","volume":"21","author":"R Nakano","year":"2021","unstructured":"Nakano R, et al. Donor plasmacytoid dendritic cells modulate effector and regulatory T cell responses in mouse spontaneous liver transplant tolerance. Am J Transplant. 2021;21:2040\u201355.","journal-title":"Am J Transplant"},{"key":"9811_CR104","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1111\/ajt.12757","volume":"14","author":"O Yoshida","year":"2014","unstructured":"Yoshida O, et al. DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance. Am J Transplant. 2014;14:1791\u2013805.","journal-title":"Am J Transplant"},{"key":"9811_CR105","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.4049\/jimmunol.1000527","volume":"186","author":"TL Sumpter","year":"2011","unstructured":"Sumpter TL, et al. DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability. J Immunol. 2011;186:1970\u201380.","journal-title":"J Immunol"},{"key":"9811_CR106","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.jhep.2008.07.028","volume":"49","author":"D Tokita","year":"2008","unstructured":"Tokita D, et al. Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol. 2008;49:1008\u201318.","journal-title":"J Hepatol"},{"key":"9811_CR107","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/hep.21457","volume":"45","author":"TP Kingham","year":"2007","unstructured":"Kingham TP, et al. Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after flt-3 ligand expansion. Hepatology. 2007;45:445\u201354.","journal-title":"Hepatology"},{"key":"9811_CR108","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/ni.1658","volume":"9","author":"H Hadeiba","year":"2008","unstructured":"Hadeiba H, et al. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253\u201360.","journal-title":"Nat Immunol"},{"key":"9811_CR109","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/ni.2695","volume":"14","author":"ID Mascanfroni","year":"2013","unstructured":"Mascanfroni ID, et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013;14:1054\u201363.","journal-title":"Nat Immunol"},{"key":"9811_CR110","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.4049\/jimmunol.1103382","volume":"188","author":"BM Matta","year":"2012","unstructured":"Matta BM, Raimondi G, Rosborough BR, Sumpter TL, Thomson AW. IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. J Immunol. 2012;188:5227\u201337.","journal-title":"J Immunol"},{"key":"9811_CR111","doi-asserted-by":"crossref","unstructured":"Vivier, E. et al. Innate or adaptive immunity? The example of natural killer cells. Science 331, 44\u201349 (2011).","DOI":"10.1126\/science.1198687"},{"key":"9811_CR112","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061332","volume":"10","author":"SG Kalathil","year":"2021","unstructured":"Kalathil SG, Thanavala Y. Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches. Cells. 2021;10:1332.","journal-title":"Cells"},{"key":"9811_CR113","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41577-021-00558-3","volume":"22","author":"NK Bj\u00f6rkstr\u00f6m","year":"2022","unstructured":"Bj\u00f6rkstr\u00f6m NK, Strunz B, Ljunggren H-G. Natural killer cells in antiviral immunity. Nat Rev Immunol. 2022;22:112\u201323.","journal-title":"Nat Rev Immunol"},{"key":"9811_CR114","doi-asserted-by":"crossref","unstructured":"Lysakova-Devine, T. & O\u2019Farrelly, C. Tissue-specific NK cell populations and their origin. J. Leukoc. Biol. 96, 981\u2013990 (2014).","DOI":"10.1189\/jlb.1RU0514-241R"},{"key":"9811_CR115","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","volume":"22","author":"MA Cooper","year":"2001","unstructured":"Cooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol. 2001;22:633\u201340.","journal-title":"Trends Immunol"},{"key":"9811_CR116","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/ajt.13565","volume":"16","author":"C Harmon","year":"2016","unstructured":"Harmon C, Sanchez-Fueyo A, O\u2019Farrelly C, Houlihan DD. Natural killer cells and liver transplantation: orchestrators of rejection or tolerance? Am J Transplant. 2016;16:751\u20137.","journal-title":"Am J Transplant"},{"key":"9811_CR117","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1002\/eji.201646559","volume":"46","author":"C Harmon","year":"2016","unstructured":"Harmon C, et al. Tissue-resident eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver. Eur J Immunol. 2016;46:2111\u201320.","journal-title":"Eur J Immunol"},{"key":"9811_CR118","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1111\/j.1600-6143.2011.03928.x","volume":"12","author":"L Li","year":"2012","unstructured":"Li L, et al. A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation. Am J Transplant. 2012;1218\u201328.","journal-title":"Am J Transplant"},{"key":"9811_CR119","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1002\/eji.202049033","volume":"51","author":"X Yuan","year":"2021","unstructured":"Yuan X, Rasul F, Nashan B, Sun C. Innate lymphoid cells and cancer: role in tumor progression and inhibition. Eur J Immunol. 2021;2188\u2013205.","journal-title":"Eur J Immunol"},{"key":"9811_CR120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060144","volume":"8","author":"AC Meehan","year":"2013","unstructured":"Meehan AC, et al. Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. PLoS One. 2013;e60144.","journal-title":"PLoS One"},{"key":"9811_CR121","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/tan.15061","volume":"102","author":"H Bae","year":"2023","unstructured":"Bae H, et al. Discovery of cellular and genetic signatures of immune tolerance in kidney transplant recipients through single cell RNA sequencing analysis. HLA. 2023;316\u201330.","journal-title":"HLA"},{"key":"9811_CR122","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.bbmt.2009.11.009","volume":"16","author":"J Pidala","year":"2010","unstructured":"Pidala J, et al. Biomarkers to discern transplantation tolerance after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;729\u201338.","journal-title":"Biol Blood Marrow Transplant"},{"key":"9811_CR123","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00167","volume":"11","author":"M Khan","year":"2020","unstructured":"Khan M, Arooj S, Wang H. NK cell-based immune checkpoint inhibition. Front Immunol. 2020;11:167.","journal-title":"Front Immunol"},{"key":"9811_CR124","doi-asserted-by":"crossref","unstructured":"Jamil, K. M. et al. STAT4-associated natural killer cell tolerance following liver transplantation. Gut 66, 352\u2013361 (2017).","DOI":"10.1136\/gutjnl-2015-309395"},{"key":"9811_CR125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.535012","volume":"12","author":"X Ni","year":"2021","unstructured":"Ni X, Wang Q, Gu J, Lu L. Clinical and basic research progress on treg-induced immune tolerance in liver transplantation. Front Immunol. 2021;12:535012.","journal-title":"Front Immunol"},{"key":"9811_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01044","volume":"11","author":"H Dai","year":"2020","unstructured":"Dai H, Zheng Y, Thomson AW, Rogers NM. Transplant tolerance induction: insights from the liver. Front Immunol. 2020;11:1044.","journal-title":"Front Immunol"},{"key":"9811_CR127","doi-asserted-by":"crossref","unstructured":"Teratani, T. et al. The liver-brain-gut neural arc maintains the treg cell niche in the gut. Nature 585, 591\u2013596 (2020).","DOI":"10.1038\/s41586-020-2425-3"},{"key":"9811_CR128","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.12659\/MSM.899725","volume":"23","author":"X Zhang","year":"2017","unstructured":"Zhang X, et al. Immune regulation of intrahepatic regulatory T cells in fibrotic livers of mice. Med Sci Monit. 2017;23:1009\u201316.","journal-title":"Med Sci Monit"},{"key":"9811_CR129","doi-asserted-by":"crossref","unstructured":"Kobayashi, N. et al. FOXP3\u2009+\u2009regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 13, 902\u2013911 (2007).","DOI":"10.1158\/1078-0432.CCR-06-2363"},{"key":"9811_CR130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00043","volume":"10","author":"M Romano","year":"2019","unstructured":"Romano M, Fanelli G, Albany CJ, Giganti G, Lombardi G. Past, present, and future of regulatory T cell therapy in transplantation and autoimmunity. Front Immunol. 2019;10:43.","journal-title":"Front Immunol"},{"key":"9811_CR131","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2016-0095","volume":"3","author":"F Famili","year":"2017","unstructured":"Famili F, Wiekmeijer A-S, Staal FJ. The development of T cells from stem cells in mice and humans. Future Sci OA. 2017;3:FSO186.","journal-title":"Future Sci OA"},{"key":"9811_CR132","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nri.2016.36","volume":"16","author":"T Tanoue","year":"2016","unstructured":"Tanoue T, Atarashi K, Honda K. Development and maintenance of intestinal regulatory T cells. Nat Rev Immunol. 2016;16:295\u2013309.","journal-title":"Nat Rev Immunol"},{"key":"9811_CR133","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2017.39","volume":"6","author":"M Luu","year":"2017","unstructured":"Luu M, Steinhoff U, Visekruna A. Functional heterogeneity of gut-resident regulatory T cells. Clin Transl Immunol. 2017;6:e156.","journal-title":"Clin Transl Immunol"},{"key":"9811_CR134","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00051","volume":"3","author":"A Schmidt","year":"2012","unstructured":"Schmidt A, Oberle N, Krammer PH. Molecular mechanisms of treg-mediated T cell suppression. Front Immunol. 2012;3:51.","journal-title":"Front Immunol"},{"key":"9811_CR135","doi-asserted-by":"crossref","unstructured":"Wu, K.-J. et al. Regulatory T cells (tregs) in liver fibrosis. Cell Death Discov. 9, 53 (2023).","DOI":"10.1038\/s41420-023-01347-8"},{"key":"9811_CR136","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1080\/1744666X.2017.1389646","volume":"13","author":"M Iman","year":"2017","unstructured":"Iman M, et al. Th17\/treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases. Expert Rev Clin Immunol. 2017;13:1173\u201388.","journal-title":"Expert Rev Clin Immunol"},{"key":"9811_CR137","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/tri.12909","volume":"30","author":"M Romano","year":"2017","unstructured":"Romano M, Tung SL, Smyth LA, Lombardi G. Treg therapy in transplantation: a general overview. Transplant Int. 2017;30:745\u201353.","journal-title":"Transplant Int"},{"key":"9811_CR138","doi-asserted-by":"crossref","unstructured":"Todo, S. et al. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation. Hepatol. Baltim. Md 64, 632\u2013643 (2016).","DOI":"10.1002\/hep.28459"},{"key":"9811_CR139","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1097\/TP.0b013e318188d3e6","volume":"86","author":"JA Pons","year":"2008","unstructured":"Pons JA, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation. 2008;86:1370\u20138.","journal-title":"Transplantation"},{"key":"9811_CR140","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.transproceed.2011.03.084","volume":"43","author":"Q He","year":"2011","unstructured":"He Q, Fan H, Li JQ, Qi HZ. Decreased circulating CD4\u2009+\u2009CD25highFoxp3+ T cells during acute rejection in liver transplant patients. Transplant Proc. 2011;43:1696\u2013700.","journal-title":"Transplant Proc"},{"key":"9811_CR141","doi-asserted-by":"crossref","unstructured":"Li, X. et al. Landscape of immune cells heterogeneity in liver transplantation by single-cell RNA sequencing analysis. Front. Immunol. 13, 890019 (2022).","DOI":"10.3389\/fimmu.2022.890019"},{"key":"9811_CR142","doi-asserted-by":"crossref","unstructured":"Sakaguchi, S. et al. Regulatory T cells and human disease. Annu. Rev. Immunol. 38, 541\u2013566 (2020).","DOI":"10.1146\/annurev-immunol-042718-041717"},{"key":"9811_CR143","doi-asserted-by":"publisher","first-page":"a015552","DOI":"10.1101\/cshperspect.a015552","volume":"3","author":"Q Tang","year":"2013","unstructured":"Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med. 2013;3:a015552.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"3","key":"9811_CR144","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/ni1572","volume":"9","author":"Q Tang","year":"2008","unstructured":"Tang Q, Bluestone JA. The Foxp3\u2009+\u2009regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008;9(3):239\u201344.","journal-title":"Nat Immunol"},{"key":"9811_CR145","doi-asserted-by":"crossref","unstructured":"Kendal, A. R. et al. Sustained suppression by Foxp3\u2009+\u2009regulatory T cells is vital for infectious transplantation tolerance. J. Exp. Med. 208, 2043\u20132053 (2011).","DOI":"10.1084\/jem.20110767"},{"key":"9811_CR146","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Fueyo, A. et al. Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation. Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg. 20, 1125\u20131136 (2020).","DOI":"10.1111\/ajt.15700"},{"key":"9811_CR147","doi-asserted-by":"publisher","DOI":"10.3389\/frtra.2023.1163539","volume":"2","author":"PA Vargas","year":"2023","unstructured":"Vargas PA, Yu C, Goldaracena N. Comprehensive review of the application of MP and the potential for graft modification. Front Transplant. 2023;2:1163539.","journal-title":"Front Transplant"},{"key":"9811_CR148","doi-asserted-by":"crossref","unstructured":"Hautz, T. et al. Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver. Nat. Commun. 14, 2285 (2023).","DOI":"10.1038\/s41467-023-37674-8"},{"key":"9811_CR149","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041046","volume":"9","author":"F Dengu","year":"2020","unstructured":"Dengu F, Abbas SH, Ebeling G, Nasralla D. Normothermic machine perfusion (NMP) of the liver as a platform for therapeutic interventions during ex-vivo liver preservation: a review. J Clin Med. 2020;9:1046.","journal-title":"J Clin Med"},{"key":"9811_CR150","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/00007890-200207150-00018","volume":"74","author":"T Okuda","year":"2002","unstructured":"Okuda T, et al. Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells. Transplant. 2002;74:103\u201311.","journal-title":"Transplant"},{"key":"9811_CR151","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.565616","volume":"11","author":"A Parente","year":"2020","unstructured":"Parente A, Osei-Bordom D-C, Ronca V, Perera MTPR, Mirza D. Organ restoration with normothermic machine perfusion and immune reaction. Front Immunol. 2020;11:565616.","journal-title":"Front Immunol"},{"key":"9811_CR152","doi-asserted-by":"crossref","unstructured":"Laing, R. W. et al. The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion. Front. Immunol. 11, 1226 (2020).","DOI":"10.3389\/fimmu.2020.01226"},{"key":"9811_CR153","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14010127","volume":"14","author":"DT Koch","year":"2024","unstructured":"Koch DT, et al. Impact of hypothermic oxygenated machine perfusion on immune cell clearance in liver transplantation: enhancing graft function and post-transplant outcomes. J Clin Med. 2024;14:127.","journal-title":"J Clin Med"},{"key":"9811_CR154","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/TP.0000000000005274","volume":"109","author":"C Aspord","year":"2025","unstructured":"Aspord C, et al. Hypothermic oxygenated machine perfusion and static cold storage drive distinct immunomodulation during liver transplantation: a pilot study. Transplantation. 2025;109:658\u201370.","journal-title":"Transplantation"},{"key":"9811_CR155","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247381","volume":"11","author":"F Horn\u00e9","year":"2022","unstructured":"Horn\u00e9 F, et al. Hypothermic oxygenated machine perfusion (HOPE) prior to liver transplantation mitigates post-reperfusion syndrome and perioperative electrolyte shifts. J Clin Med. 2022;11:7381.","journal-title":"J Clin Med"},{"key":"9811_CR156","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/LVT.0000000000000741","volume":"32","author":"SY Ohara","year":"2026","unstructured":"Ohara SY, et al. Overcoming hepatic artery variations: arterial reconstruction strategies to expand normothermic machine perfusion in liver transplantation. Liver Transpl. 2026;32:812\u201322.","journal-title":"Liver Transpl"},{"key":"9811_CR157","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.940437","volume":"24","author":"S-F Li","year":"2023","unstructured":"Li S-F, et al. Using IV-tubing \u2018bridge\u2019 from splenic artery to superior mesentery artery to create a single arterial cannulation for normothermic machine perfusion when donor liver has replaced right hepatic artery. Am J Case Rep. 2023;24:e940437.","journal-title":"Am J Case Rep"},{"key":"9811_CR158","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/MOT.0000000000001152","volume":"29","author":"PC Groen","year":"2024","unstructured":"Groen PC, van Leeuwen OB, de Jonge J, Porte RJ. Viability assessment of the liver during ex-situ machine perfusion prior to transplantation. Curr Opin Organ Transpl. 2024;29:239\u201347.","journal-title":"Curr Opin Organ Transpl"},{"key":"9811_CR159","doi-asserted-by":"crossref","unstructured":"Cirelli, R. et al. Transplantation of Severely Steatotic Liver Grafts After Machine Perfusion Remains a Risky Challenge. Clin. Transplant. 39, e70260 (2025).","DOI":"10.1111\/ctr.70260"},{"key":"9811_CR160","doi-asserted-by":"crossref","unstructured":"Geiger, R. et al. L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity. Cell 167, 829\u2013842.e13 (2016).","DOI":"10.1016\/j.cell.2016.09.031"},{"key":"9811_CR161","doi-asserted-by":"crossref","unstructured":"O\u2019Neill, L. A. J., Kishton, R. J. & Rathmell, J. A guide to immunometabolism for immunologists. Nat. Rev. Immunol. 16, 553\u2013565 (2016).","DOI":"10.1038\/nri.2016.70"},{"key":"9811_CR162","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242454","volume":"342","author":"EL Pearce","year":"2013","unstructured":"Pearce EL, Poffenberger MC, Chang C-H, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science. 2013;342:1242454.","journal-title":"Science"},{"key":"9811_CR163","doi-asserted-by":"crossref","unstructured":"Shi, L. Z. et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and treg cells. J. Exp. Med. 208, 1367\u20131376 (2011).","DOI":"10.1084\/jem.20110278"},{"key":"9811_CR164","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.7150\/thno.82607","volume":"13","author":"S Du","year":"2023","unstructured":"Du S, et al. Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia\/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes. Theranostics. 2023;13:3856\u201371.","journal-title":"Theranostics"},{"key":"9811_CR165","doi-asserted-by":"publisher","DOI":"10.2174\/0118715303401342250514102731","volume":"26","author":"W Huang","year":"2026","unstructured":"Huang W, Meng W, Zhao J, Zhang B. Sterile inflammation and cell death pathways in liver ischemia-reperfusion injury: a review and perspective. Endocr Metab Immune Disord Drug Targets. 2026;26:e18715303401342.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"9811_CR166","doi-asserted-by":"crossref","unstructured":"Zhang, W. & Lang, R. Succinate metabolism: a promising therapeutic target for inflammation, ischemia\/reperfusion injury and cancer. Front. Cell Dev. Biol. 11, 1266973 (2023).","DOI":"10.3389\/fcell.2023.1266973"},{"key":"9811_CR167","doi-asserted-by":"crossref","unstructured":"Chen, K. et al. STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileus. Commun. Biol. 9, 358 (2026).","DOI":"10.1038\/s42003-026-09602-1"},{"key":"9811_CR168","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-pathmechdis-031521-024831","volume":"18","author":"T Martini","year":"2023","unstructured":"Martini T, Naef F, Tchorz JS. Spatiotemporal metabolic liver zonation and consequences on pathophysiology. Annu Rev Pathol. 2023;18:439\u201366.","journal-title":"Annu Rev Pathol"},{"key":"9811_CR169","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202522891","volume":"13","author":"F Zhang","year":"2026","unstructured":"Zhang F, et al. SAA\/FPR2 signaling between pericentral hepatocytes and macrophages exacerbates zonated liver transplant injury. Adv Sci. 2026;13:e22891.","journal-title":"Adv Sci"},{"key":"9811_CR170","doi-asserted-by":"publisher","first-page":"5277","DOI":"10.1016\/j.apsb.2025.07.042","volume":"15","author":"K Wang","year":"2025","unstructured":"Wang K, et al. Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation. Acta Pharm Sin B. 2025;15:5277\u201393.","journal-title":"Acta Pharm Sin B"},{"key":"9811_CR171","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70336","volume":"29","author":"C Sun","year":"2025","unstructured":"Sun C, Li L, Li D, Wang Z. Discovery of endothelial-monocyte crosstalk in ischemic-reperfusion injury following liver transplantation based on integration of single-cell RNA and transcriptome RNA sequencing. J Cell Mol Med. 2025;29:e70336.","journal-title":"J Cell Mol Med"},{"key":"9811_CR172","doi-asserted-by":"publisher","unstructured":"Luo T, et al. Substantially altered local and systemic immunity in ischemia-free versus conventional liver transplantation. Adv Sci. 2026;e02854. https:\/\/doi.org\/10.1002\/advs.202502854.","DOI":"10.1002\/advs.202502854"},{"key":"9811_CR173","doi-asserted-by":"crossref","unstructured":"Li, X. et al. Single cell RNA-sequencing delineates CD8\u2009+\u2009tissue resident memory T cells maintaining rejection in liver transplantation. Theranostics 14, 4844\u20134860 (2024).","DOI":"10.7150\/thno.96928"},{"key":"9811_CR174","doi-asserted-by":"crossref","unstructured":"Zhou, T. et al. Single-cell and spatial transcriptomics reveal transplant-associated T cells and myeloid cells in human liver transplantation. Front. Immunol. 17, 1745647 (2026).","DOI":"10.3389\/fimmu.2026.1745647"},{"key":"9811_CR175","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.990","volume":"11","author":"Y Fang","year":"2023","unstructured":"Fang Y, et al. ScRNA-seq revealed disruption in CD8\u2009+\u2009NKG2A+ natural killer T cells in patients after liver transplantation and immunosuppressive therapy. Immunity Inflamm Dis. 2023;11:e990.","journal-title":"Immunity Inflamm Dis"},{"key":"9811_CR176","doi-asserted-by":"crossref","unstructured":"Cai, H. et al. Single cell multi-omics revealing the important role of MR1 mediated MAIT cells in maintaining rejection for liver transplantation. Cell Prolif. e70194 (2026) doi:10.1111\/cpr.70194.","DOI":"10.1111\/cpr.70194"},{"key":"9811_CR177","doi-asserted-by":"crossref","unstructured":"Liu, Y. et al. Single-cell immune profiling of mouse liver aging reveals Cxcl2\u2009+\u2009macrophages recruit neutrophils to aggravate liver injury. Hepatology 79, 589\u2013605 (2024).","DOI":"10.1097\/HEP.0000000000000590"},{"key":"9811_CR178","doi-asserted-by":"crossref","unstructured":"Xue, F. et al. Correlation of Chimerism with Acute Graft-versus-Host Disease in Rats following Liver Transplantation. Int. J. Hepatol. 2011, 947150 (2011).","DOI":"10.4061\/2011\/947150"},{"key":"9811_CR179","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1642451","volume":"16","author":"SH Kim","year":"2025","unstructured":"Kim SH. Genomic identification of recipient-derived hepatocytes in liver transplantation: a hypothesis linking graft repopulation to immune tolerance. Front Immunol. 2025;16:1642451.","journal-title":"Front Immunol"},{"key":"9811_CR180","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.jhep.2025.04.037","volume":"83","author":"P Yang","year":"2025","unstructured":"Yang P, et al. Decoding the resistin-CAP1 pathway in intermediate monocytes mediating liver allograft rejection. J Hepatol. 2025;83:931\u201345.","journal-title":"J Hepatol"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09811-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12026-026-09811-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-026-09811-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:05:56Z","timestamp":1785438356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12026-026-09811-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":180,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9811"],"URL":"https:\/\/doi.org\/10.1007\/s12026-026-09811-0","relation":{},"ISSN":["1559-0755"],"issn-type":[{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"76"}}