{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:53:53Z","timestamp":1790420033816,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23N8094538"],"award-info":[{"award-number":["K23N8094538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005339","name":"American Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000913","name":"James S. McDonnell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s12028-017-0391-x","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T03:52:49Z","timestamp":1490154769000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reverse Locked-In Syndrome"],"prefix":"10.1007","volume":"27","author":[{"given":"Pooja","family":"Raibagkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram V.","family":"Chavali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan V.","family":"Nitka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry H.-Y.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Edlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"391_CR1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1161\/01.STR.21.8.1135","volume":"21","author":"A Ferbert","year":"1990","unstructured":"Ferbert A, Bruckmann H, Drummen R. Clinical features of proven basilar artery occlusion. Stroke. 1990;21:1135\u201342.","journal-title":"Stroke"},{"key":"391_CR2","first-page":"1","volume":"10","author":"F Plum","year":"1972","unstructured":"Plum F, Posner JB. The diagnosis of stupor and coma. Contemp Neurol Ser. 1972;10:1\u2013286.","journal-title":"Contemp Neurol Ser"},{"key":"391_CR3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1081\/CEH-120015337","volume":"24","author":"T Brandt","year":"2002","unstructured":"Brandt T. Diagnosis and thrombolytic therapy of acute basilar artery occlusion: a review. Clin Exp Hypertens. 2002;24:611\u201322.","journal-title":"Clin Exp Hypertens"},{"key":"391_CR4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1385\/NCC:1:3:319","volume":"1","author":"TA Baird","year":"2004","unstructured":"Baird TA, Muir KW, Bone I. Basilar artery occlusion. Neurocrit Care. 2004;1:319\u201329.","journal-title":"Neurocrit Care"},{"key":"391_CR5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1001\/archneur.1974.00490320064009","volume":"30","author":"JS Karp","year":"1974","unstructured":"Karp JS, Hurtig HI. \u201cLocked-in\u201d state with bilateral midbrain infarcts. Arch Neurol. 1974;30:176\u20138.","journal-title":"Arch Neurol"},{"key":"391_CR6","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1212\/01.wnl.0000229160.49552.b0","volume":"67","author":"T Zakaria","year":"2006","unstructured":"Zakaria T, Flaherty ML. Locked-in syndrome resulting from bilateral cerebral peduncle infarctions. Neurology. 2006;67:1889.","journal-title":"Neurology"},{"key":"391_CR7","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1080\/02699050110119781","volume":"16","author":"J Leon-Carrion","year":"2002","unstructured":"Leon-Carrion J, van Eeckhout P, Dominguez-Morales Mdel R, Perez-Santamaria FJ. The locked-in syndrome: a syndrome looking for a therapy. Brain Injury. 2002;16:571\u201382.","journal-title":"Brain Injury"},{"key":"391_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/3-211-27577-0_39","volume":"93","author":"J Leon-Carrion","year":"2005","unstructured":"Leon-Carrion J, Van Eeckhout P, Dominguez-Morales MR. The locked-in syndrome: a challenge for therapy. Acta Neurochir Suppl. 2005;93:213\u20135.","journal-title":"Acta Neurochir Suppl"},{"key":"391_CR9","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","volume":"372","author":"M Goyal","year":"2015","unstructured":"Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019\u201330.","journal-title":"N Engl J Med"},{"key":"391_CR10","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","volume":"372","author":"JL Saver","year":"2015","unstructured":"Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372:2285\u201395.","journal-title":"N Engl J Med"},{"key":"391_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1411587","volume":"372","author":"OA Berkhemer","year":"2015","unstructured":"Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11\u201320.","journal-title":"N Engl J Med"},{"key":"391_CR12","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","volume":"372","author":"BC Campbell","year":"2015","unstructured":"Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009\u201318.","journal-title":"N Engl J Med"},{"key":"391_CR13","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","volume":"372","author":"TG Jovin","year":"2015","unstructured":"Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8\u00a0hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372:2296\u2013306.","journal-title":"N Engl J Med"},{"key":"391_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/NEN.0b013e3182588293","volume":"71","author":"BL Edlow","year":"2012","unstructured":"Edlow BL, Takahashi E, Wu O, et al. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol. 2012;71:531\u201346.","journal-title":"J Neuropathol Exp Neurol"},{"key":"391_CR15","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12028-013-9870-x","volume":"19","author":"BL Edlow","year":"2013","unstructured":"Edlow BL, Giacino JT, Hirschberg RE, Gerrard J, Wu O, Hochberg LR. Unexpected recovery of function after severe traumatic brain injury: the limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013;19:364\u201375.","journal-title":"Neurocrit Care"},{"key":"391_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1089\/brain.2015.0378","volume":"6","author":"BL Edlow","year":"2016","unstructured":"Edlow BL, McNab JA, Witzel T, Kinney HC. The structural connectome of the human central homeostatic network. Brain Connect. 2016;6:187\u2013200.","journal-title":"Brain Connect"},{"key":"391_CR17","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1161\/01.STR.0000202582.29510.6b","volume":"37","author":"PJ Lindsberg","year":"2006","unstructured":"Lindsberg PJ, Mattle HP. Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis. Stroke. 2006;37:922\u20138.","journal-title":"Stroke"},{"key":"391_CR18","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0090-3019(86)90135-7","volume":"26","author":"S Marinkovic","year":"1986","unstructured":"Marinkovic S, Milisavljevic M, Kovacevic M. Interpeduncular perforating branches of the posterior cerebral artery. Microsurgical anatomy of their extracerebral and intracerebral segments. Surg Neurol. 1986;26:349\u201359.","journal-title":"Surg Neurol"},{"key":"391_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/brain\/69.2.73","volume":"69","author":"CS Kubik","year":"1946","unstructured":"Kubik CS, Adams RD. Occlusion of the basilar artery; a clinical and pathological study. Brain. 1946;69:73\u2013121.","journal-title":"Brain"},{"key":"391_CR20","doi-asserted-by":"crossref","unstructured":"Duvernoy HM. Human brain stem vessels: including the pineal gland and information on brain stem infarction. 2nd completely rev. and expanded ed. Berlin: Springer; 1999.","DOI":"10.1007\/978-3-662-07813-6"},{"key":"391_CR21","first-page":"117","volume":"98","author":"E Facon","year":"1958","unstructured":"Facon E, Steriade M, Wertheim N. Prolonged hypersomnia caused by bilateral lesions of the medial activator system; thrombotic syndrome of the bifurcation of the basilar trunk. Rev Neurol (Paris). 1958;98:117\u201333.","journal-title":"Rev Neurol (Paris)"},{"key":"391_CR22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/BF01997791","volume":"17","author":"C Finocchi","year":"1996","unstructured":"Finocchi C, Del Sette M, Croce R, Giberti L, Serrati C, Gandolfo C. Bilateral ophthalmoplegia: an unusual sign of the top of the basilar artery syndrome. Ital J Neurol Sci. 1996;17:301\u20134.","journal-title":"Ital J Neurol Sci"},{"key":"391_CR23","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/STROKEAHA.107.504761","volume":"39","author":"MJ Thurtell","year":"2008","unstructured":"Thurtell MJ, Halmagyi GM. Complete ophthalmoplegia: an unusual sign of bilateral paramedian midbrain-thalamic infarction. Stroke. 2008;39:1355\u20137.","journal-title":"Stroke"},{"key":"391_CR24","first-page":"31","volume":"5","author":"FP Inocencio","year":"1985","unstructured":"Inocencio FP, Ballecer R. Tuberculosis granuloma in the midbrain causing wall-eyed bilateral internuclear ophthalmoplegia (Webino). J Clin Neuroophthalmol. 1985;5:31\u20135.","journal-title":"J Clin Neuroophthalmol"},{"key":"391_CR25","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1212\/01.wnl.0000299904.48116.cf","volume":"70","author":"JS Kim","year":"2008","unstructured":"Kim JS, Jeong SH, Oh YM, Yang YS, Kim SY. Teaching NeuroImage: wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) from midbrain infarction. Neurology. 2008;70:e35.","journal-title":"Neurology"},{"key":"391_CR26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1212\/WNL.55.3.352","volume":"55","author":"P Pullicino","year":"2000","unstructured":"Pullicino P, Lincoff N, Truax BT. Abnormal vergence with upper brainstem infarcts: pseudoabducens palsy. Neurology. 2000;55:352\u20138.","journal-title":"Neurology"},{"key":"391_CR27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1212\/WNL.30.1.72","volume":"30","author":"LR Caplan","year":"1980","unstructured":"Caplan LR. \u201cTop of the basilar\u201d syndrome. Neurology. 1980;30:72\u20139.","journal-title":"Neurology"},{"key":"391_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/brain\/103.1.23","volume":"103","author":"MB Bender","year":"1980","unstructured":"Bender MB. Brain control of conjugate horizontal and vertical eye movements: a survey of the structural and functional correlates. Brain. 1980;103:23\u201369.","journal-title":"Brain"},{"key":"391_CR29","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1161\/01.STR.0000087786.38997.9E","volume":"34","author":"JD Schmahmann","year":"2003","unstructured":"Schmahmann JD. Vascular syndromes of the thalamus. Stroke. 2003;34:2264\u201378.","journal-title":"Stroke"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12028-017-0391-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-017-0391-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-017-0391-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T19:16:06Z","timestamp":1692731766000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12028-017-0391-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["391"],"URL":"https:\/\/doi.org\/10.1007\/s12028-017-0391-x","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]},"assertion":[{"value":"21 March 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Sherry H.-Y. Chou: National Institutes of Health\/National Institute of Neurological Disorders and Stroke (K23-NS073806), University of Pittsburgh Physicians Research Grant, serves as the site principal investigator for Newton II clinical trial funded by Edge Therapeutics. Pooja Raibagkar, Ram V. Chavali, Tamara B. Kaplan, Jennifer A. Kim, Meaghan V. Nitka, Brian L. Edlow: nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}