{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:11:44Z","timestamp":1792721504206,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s12028-017-0477-5","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T11:42:18Z","timestamp":1510659738000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The Ictal\u2013Interictal Continuum: To Treat or Not to Treat (and How)?"],"prefix":"10.1007","volume":"29","author":[{"given":"Clio","family":"Rubinos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra S.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"477_CR1","first-page":"222","volume":"49","author":"J Rademecker","year":"1949","unstructured":"Rademecker J. Aspects electroencephalographiques dans trois cas d\u2019encephalite subaigue. Acta Neurol Psychiatr Belg. 1949;49:222\u201332.","journal-title":"Acta Neurol Psychiatr Belg"},{"key":"477_CR2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/brain\/73.3.392","volume":"73","author":"W Cobb","year":"1950","unstructured":"Cobb W, Hill D. Electroencephalogram in subacute progressive encephalitis. Brain. 1950;73:392\u2013404.","journal-title":"Brain"},{"key":"477_CR3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0013-4694(64)90149-X","volume":"17","author":"G Chatrian","year":"1964","unstructured":"Chatrian G, Shaw C, Leffman H. The significance of periodic lateralized epileptiform discharges in EEG: an electrographic, clinical and pathological study. Electroencephalogr Clin Neurophysiol. 1964;17:177\u201393.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"477_CR4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0013-4694(91)90013-T","volume":"78","author":"J Reiher","year":"1991","unstructured":"Reiher J, Rivest J, Grand\u2019Maison F, et al. Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures. Electroencephalogr Clin Neurophysiol. 1991;78:12\u20137.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2","key":"477_CR5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00004691-199004000-00007","volume":"7","author":"RP Brenner","year":"1990","unstructured":"Brenner RP, Schaul N. Periodic EEG patterns: classification, clinical correlation, and pathophysiology. J Clin Neurophysiol. 1990;7(2):249\u201367.","journal-title":"J Clin Neurophysiol"},{"issue":"2","key":"477_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.0013-9580.2004.38103.x","volume":"45","author":"LJ Hirsch","year":"2004","unstructured":"Hirsch LJ, Claassen J, Mayer SA, Emerson RG. Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill. Epilepsia. 2004;45(2):109\u201323.","journal-title":"Epilepsia"},{"issue":"10","key":"477_CR7","first-page":"1288","volume":"70","author":"N Gaspard","year":"2013","unstructured":"Gaspard N, Manganas L, Rampal N, et al. Similarity of lateralized rhythmic delta activity to periodic lateralized epileptiform discharges in critically ill patients. JAMA Neurol. 2013;70(10):1288\u201395.","journal-title":"JAMA Neurol"},{"issue":"2","key":"477_CR8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.WNP.0000158699.78529.AF","volume":"22","author":"DJ Chong","year":"2005","unstructured":"Chong DJ, Hirsch LJ. Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns. J Clin Neurophysiol. 2005;22(2):79\u201391.","journal-title":"J Clin Neurophysiol"},{"issue":"3","key":"477_CR9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3988\/jcn.2006.2.3.179","volume":"2","author":"Y-S Kim","year":"2006","unstructured":"Kim Y-S, Choi S-Y, Kwag H-J, Kim J-M. Classification and serial evolution of PLEDs. J Clin Neurol. 2006;2(3):179\u201385.","journal-title":"J Clin Neurol"},{"issue":"1","key":"477_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNP.0b013e3182784729","volume":"30","author":"LJ Hirsch","year":"2013","unstructured":"Hirsch LJ, LaRoche SM, Gaspard N, et al. American Clinical Neurophysiology Society\u2019s Standardized Critical Care EEG Terminology: 2012 version. J Clin Neurophysiol. 2013;30(1):1\u201327.","journal-title":"J Clin Neurophysiol"},{"issue":"10","key":"477_CR11","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/01.WNL.0000125184.88797.62","volume":"62","author":"J Claassen","year":"2004","unstructured":"Claassen J, Mayer SA, Kowalski RG, et al. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62(10):1743\u20138.","journal-title":"Neurology"},{"key":"477_CR12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yebeh.2014.05.014","volume":"36","author":"I Sen-Gupta","year":"2015","unstructured":"Sen-Gupta I, Schuele SU, Macken MP, et al. \u201cIctal\u201d lateralized periodic discharges. Epilepsy Behav. 2015;36:165\u201370.","journal-title":"Epilepsy Behav"},{"issue":"2","key":"477_CR13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00134-013-3149-8","volume":"40","author":"P Kurtz","year":"2014","unstructured":"Kurtz P, Gaspard N, Wahl AS, et al. Continuous electroencephalography in a surgical intensive care unit. Intensive Care Med. 2014;40(2):228\u201334.","journal-title":"Intensive Care Med"},{"issue":"2","key":"477_CR14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/00004691-200203000-00009","volume":"19","author":"I Garc\u00eda-Morales","year":"2002","unstructured":"Garc\u00eda-Morales I, Garc\u00eda MT, Gal\u00e1n-D\u00e1vila L, et al. Periodic lateralized epileptiform discharges: etiology, clinical aspects, seizures, and evolution in 130 patients. J Clin Neurophysiol. 2002;19(2):172\u20137.","journal-title":"J Clin Neurophysiol"},{"issue":"1","key":"477_CR15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/155005948301400105","volume":"14","author":"DE Jacome","year":"1983","unstructured":"Jacome DE. Periodic EEG patterns in cerebral fat embolism. Clin Electroencephalogr. 1983;14(1):27\u201334.","journal-title":"Clin Electroencephalogr"},{"issue":"1","key":"477_CR16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0013-4694(95)00211-1","volume":"98","author":"DR Chabolla","year":"1996","unstructured":"Chabolla DR, Moore JL, Westmoreland BF. Periodic lateralized epileptiform discharges in multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1996;98(1):5\u20138.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2","key":"477_CR17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0883073807307984","volume":"23","author":"EC Reyes de los","year":"2008","unstructured":"de los Reyes EC, McJunkin JE, Glauser TA, et al. Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcome. J Child Neurol. 2008;23(2):167\u201372.","journal-title":"J Child Neurol"},{"key":"477_CR18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.eplepsyres.2017.02.004","volume":"131","author":"H-T Li","year":"2017","unstructured":"Li H-T, Wu T, Lin W-R, et al. Clinical correlation and prognostic implication of periodic EEG patterns: a cohort study. Epilepsy Res. 2017;131:44\u201350.","journal-title":"Epilepsy Res"},{"key":"477_CR19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S0317167100007332","volume":"34","author":"W Fitzpatrick","year":"2007","unstructured":"Fitzpatrick W, Lowry N. PLEDS: clinical correlates. Can J Neurol Sci. 2007;34:443\u201350.","journal-title":"Can J Neurol Sci"},{"issue":"8","key":"477_CR20","first-page":"985","volume":"66","author":"DSJ Orta","year":"2009","unstructured":"Orta DSJ, Chiappa KH, Quiroz AZ, et al. Prognostic implications of periodic epileptiform discharges. Arch Neurol. 2009;66(8):985\u201391.","journal-title":"Arch Neurol"},{"issue":"19","key":"477_CR21","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1212\/WNL.0b013e3182735cd7","volume":"79","author":"B Foreman","year":"2012","unstructured":"Foreman B, Claassen J, Khaled KA, et al. Generalized periodic discharges in the critically ill: a case-control study of 200 patients. Neurology. 2012;79(19):1951\u201360.","journal-title":"Neurology"},{"issue":"1","key":"477_CR22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00004691-199901000-00005","volume":"16","author":"AM Husain","year":"1999","unstructured":"Husain AM, Mebust KA, Radtke RA. Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol. 1999;16(1):51\u20138.","journal-title":"J Clin Neurophysiol"},{"issue":"6","key":"477_CR23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/WNP.0000000000000206","volume":"32","author":"RK Sainju","year":"2015","unstructured":"Sainju RK, Manganas LN, Gilmore EJ, et al. Clinical correlates and prognostic significance of lateralized periodic discharges in patients without acute or progressive brain injury. J Clin Neurophysiol. 2015;32(6):495\u2013500.","journal-title":"J Clin Neurophysiol"},{"key":"477_CR24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1385\/NCC:4:2:103","volume":"4","author":"J Claassen","year":"2006","unstructured":"Claassen J, Hirsch LJ, Frontera JA, et al. Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrage. Neurocrit Care. 2006;4:103\u201312.","journal-title":"Neurocrit Care"},{"key":"477_CR25","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1212\/01.wnl.0000281664.02615.6c","volume":"69","author":"J Claassen","year":"2007","unstructured":"Claassen J, Jette N, Chun F, et al. Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology. 2007;69:1356\u201365.","journal-title":"Neurology"},{"issue":"2","key":"477_CR26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1213\/ane.0b013e3181a9d8b5","volume":"109","author":"D Friedman","year":"2009","unstructured":"Friedman D, Claassen J, Hirsch LJ. Continuous electroencephalogram monitoring in the intensive care unit. Anesth Analg. 2009;109(2):506\u201323.","journal-title":"Anesth Analg"},{"issue":"6","key":"477_CR27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.seizure.2012.04.011","volume":"21","author":"MP Kate","year":"2012","unstructured":"Kate MP, Dash GK, Radhakrishnan A. Long-term outcome and prognosis of patients with emergent periodic lateralized epileptiform discharges (ePLEDs). Seizure. 2012;21(6):450\u20136.","journal-title":"Seizure"},{"issue":"5","key":"477_CR28","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1528-1157.1987.tb03684.x","volume":"28","author":"JM Walsh","year":"1987","unstructured":"Walsh JM, Brenner RP. Periodic lateralized epileptiform discharges\u2014long-term outcome in adults. Epilepsia. 1987;28(5):533\u20136.","journal-title":"Epilepsia"},{"issue":"4","key":"477_CR29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.24606","volume":"79","author":"P Vespa","year":"2016","unstructured":"Vespa P, Tubi M, Claassen J, et al. Metabolic crisis occurs with seizures and periodic discharges after brain trauma. Ann Neurol. 2016;79(4):579\u201390.","journal-title":"Ann Neurol"},{"issue":"3","key":"477_CR30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/WNL.0000000000002281","volume":"86","author":"GM Marchis De","year":"2016","unstructured":"De Marchis GM, Pugin D, Meyers E, et al. Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome. Neurology. 2016;86(3):253\u201360.","journal-title":"Neurology"},{"issue":"4","key":"477_CR31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/00004691-199707000-00005","volume":"14","author":"R Jaitly","year":"1997","unstructured":"Jaitly R, Sgro JA, Towne AR, et al. Prognostic value of EEG monitoring after status epilepticus: a prospective adult study. J Clin Neurophysiol. 1997;14(4):326\u201334.","journal-title":"J Clin Neurophysiol"},{"issue":"2","key":"477_CR32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1528-1157.1999.tb02069.x","volume":"40","author":"M Nei","year":"1999","unstructured":"Nei M, Lee JM, Shanker VL, Sperling MR. The EEG and prognosis in status epilepticus. Epilepsia. 1999;40(2):157\u201363.","journal-title":"Epilepsia"},{"key":"477_CR33","first-page":"312","volume":"67","author":"W Stormvanleeuwn","year":"1964","unstructured":"Stormvanleeuwn W. Electroencephalographical and neurophysiological aspects of subacute sclerosing leuco-encephalitis. Psychiatr Neurol Neurochir. 1964;67:312\u201322.","journal-title":"Psychiatr Neurol Neurochir"},{"issue":"4","key":"477_CR34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/brain\/91.4.779","volume":"91","author":"P Gloor","year":"1968","unstructured":"Gloor P, Kalabay O, Giard N. The electroencephalogram in diffuse encephalopathies: electroencephalographic correlates of grey and white matter lesions. Brain. 1968;91(4):779\u2013802.","journal-title":"Brain"},{"issue":"3","key":"477_CR35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1528-1157.1968.tb04624.x","volume":"9","author":"P Gloor","year":"1968","unstructured":"Gloor P. Generalized cortico-reticular epilepsies some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia. 1968;9(3):249\u201363.","journal-title":"Epilepsia"},{"issue":"1","key":"477_CR36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archneur.1980.00500500045005","volume":"37","author":"Y Kuroiwa","year":"1980","unstructured":"Kuroiwa Y, Celesia GG. Clinical significance of periodic EEG patterns. Arch Neurol. 1980;37(1):15\u201320.","journal-title":"Arch Neurol"},{"issue":"4","key":"477_CR37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/WNP.0000000000000173","volume":"32","author":"GP Kalamangalam","year":"2015","unstructured":"Kalamangalam GP, Slater JD. Periodic lateralized epileptiform discharges and after discharges: common dynamic mechanisms. J Clin Neurophysiol. 2015;32(4):331\u201340.","journal-title":"J Clin Neurophysiol"},{"key":"477_CR38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yebeh.2015.04.007","volume":"49","author":"M Putten Van","year":"2015","unstructured":"Van Putten M, Hofmeijer J. Generalized periodic discharges: pathophysiology and clinical considerations. Epilepsy Behav. 2015;49:228\u201333.","journal-title":"Epilepsy Behav"},{"issue":"6","key":"477_CR39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1528-1167.2007.01481.x","volume":"49","author":"LJ Hirsch","year":"2008","unstructured":"Hirsch LJ, Pang T, Claassen J, et al. Focal motor seizures induced by alerting stimuli in critically ill patients. Epilepsia. 2008;49(6):968\u201373.","journal-title":"Epilepsia"},{"issue":"9","key":"477_CR40","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/epi.12653","volume":"55","author":"N Gaspard","year":"2014","unstructured":"Gaspard N, Hirsch LJ, LaRoche SM, Hahn CD, Westover MB for the Critical Care EEG Monitoring Research Consortium. Interrater agreement for critical care EEG terminology. Epilepsia. 2014;55(9):1366\u201373.","journal-title":"Epilepsia"},{"key":"477_CR41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/WNP.0000000000000370","volume":"34","author":"CR Newey","year":"2017","unstructured":"Newey CR, Sahota P, Hantus S. Electrographic features of lateralized periodic discharges stratify risk in the interictal\u2013ictal continuum. J Clin Neurophysiol. 2017;34:365\u20139.","journal-title":"J Clin Neurophysiol"},{"key":"477_CR42","first-page":"1","volume":"30329","author":"A Rodriguez Ruiz","year":"2016","unstructured":"Rodriguez Ruiz A, Vlachy J, Lee JW, et al. Association of periodic and rhythmic electroencephalographic patterns with seizures in critically ill patients. JAMA Neurol. 2016;30329:1\u20138.","journal-title":"JAMA Neurol"},{"issue":"4","key":"477_CR43","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jamaneurol.2013.6238","volume":"71","author":"JY Yoo","year":"2014","unstructured":"Yoo JY, Rampal N, Petroff OA, et al. Brief potentially ictal rhythmic discharges in critically ill adults. JAMA Neurol. 2014;71(4):454\u201362.","journal-title":"JAMA Neurol"},{"issue":"3","key":"477_CR44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ana.21721","volume":"66","author":"A Waziri","year":"2009","unstructured":"Waziri A, Claassen J, Morgan Stuart R, et al. Intracortical electroencephalography in acute brain injury. Ann Neurol. 2009;66(3):366\u201377.","journal-title":"Ann Neurol"},{"issue":"October","key":"477_CR45","first-page":"1","volume":"9","author":"Y H\u00f6ller","year":"2015","unstructured":"H\u00f6ller Y, Kutil R, Klaffenb\u00f6ck L, et al. High-frequency oscillations in epilepsy and surgical outcome. A meta-analysis. Front Hum Neurosci. 2015;9(October):1\u201314.","journal-title":"Front Hum Neurosci"},{"issue":"6","key":"477_CR46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/WNP.0b013e31818e8010","volume":"25","author":"CA Schevon","year":"2008","unstructured":"Schevon CA, Ng SK, Cappell J, et al. Microphysiology of epileptiform activity in human neocortex. J Clin Neurophysiol. 2008;25(6):321\u201330.","journal-title":"J Clin Neurophysiol"},{"issue":"8","key":"477_CR47","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.clinph.2006.11.312","volume":"118","author":"J Jirsch","year":"2007","unstructured":"Jirsch J, Hirsch LJ. Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clin Neurophysiol. 2007;118(8):1660\u201370.","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"477_CR48","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00004691-200107000-00006","volume":"18","author":"NB Fountain","year":"2001","unstructured":"Fountain NB, Waldman WA. Effects of benzodiazepines on triphasic waves: implications for nonconvulsive status epilepticus. J Clin Neurophysiol. 2001;18(4):345\u201352.","journal-title":"J Clin Neurophysiol"},{"issue":"6","key":"477_CR49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/NRL.0b013e31822f688c","volume":"17","author":"J Hopp","year":"2011","unstructured":"Hopp JL, Sanchez A, Krumholz A, Hart G, Barry E. Nonconvulsive status epilepticus: value of a benzodiazepine trial for predicting outcomes. Neurologist. 2011;17(6):325\u20139.","journal-title":"Neurologist"},{"issue":"3","key":"477_CR50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12028-009-9295-8","volume":"11","author":"J Claassen","year":"2009","unstructured":"Claassen J. How I treat patients with EEG patterns on the ictal\u2013interictal continuum in the neuro ICU. Neurocrit Care. 2009;11(3):437\u201344.","journal-title":"Neurocrit Care"},{"issue":"5","key":"477_CR51","first-page":"965","volume":"15","author":"S Warach","year":"1994","unstructured":"Warach S, Levin JM, Schomer DL, et al. Hyperperfusion of ictal seizure focus demonstrated by MR perfusion imaging. Am J Neuroradiol. 1994;15(5):965\u20138.","journal-title":"Am J Neuroradiol"},{"issue":"2\u20133","key":"477_CR52","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.eplepsyres.2010.07.019","volume":"91","author":"N Canas","year":"2010","unstructured":"Canas N, Breia P, Soares P, et al. The electroclinical-imagiological spectrum and long-term outcome of transient periictal MRI abnormalities. Epilepsy Res. 2010;91(2\u20133):240\u201352.","journal-title":"Epilepsy Res"},{"issue":"1\u20132","key":"477_CR53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jns.2014.06.001","volume":"343","author":"T Xiang","year":"2014","unstructured":"Xiang T, Li G, Liang Y, Zhou J. A wide spectrum of variably periictal MRI abnormalities induced by a single or a cluster of seizures. J Neurol Sci. 2014;343(1\u20132):167\u201372.","journal-title":"J Neurol Sci"},{"issue":"4","key":"477_CR54","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1528-1157.1994.tb02526.x","volume":"35","author":"A Handforth","year":"1994","unstructured":"Handforth A, Cheng JT, Mandelkern MA, Treiman DM. Markedly increased mesiotemporal lobe metabolism in a case with PLEDs: further evidence that PLEDs are a manifestation of partial status epilepticus. Epilepsia. 1994;35(4):876\u201381.","journal-title":"Epilepsia"},{"issue":"3","key":"477_CR55","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12028-016-0245-y","volume":"24","author":"AF Struck","year":"2016","unstructured":"Struck AF, Westover MB, Hall LT, et al. Metabolic correlates of the ictal\u2013interictal continuum: FDG-PET during continuous EEG. Neurocrit Care. 2016;24(3):324\u201331.","journal-title":"Neurocrit Care"},{"issue":"4","key":"477_CR56","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/seiz.2000.0506","volume":"10","author":"F Assal","year":"2001","unstructured":"Assal F, Papazyan JP, Slosman DO, et al. SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus? Seizure. 2001;10(4):260\u20134.","journal-title":"Seizure"},{"issue":"4","key":"477_CR57","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/155005940203300407","volume":"33","author":"MF Bozkurt","year":"2002","unstructured":"Bozkurt MF, Saygi S, Erbas B. SPECT in a patient with postictal PLEDs: is hyperperfusion evidence of electrical seizure? Clin Electroencephalogr. 2002;33(4):171\u20133.","journal-title":"Clin Electroencephalogr"},{"issue":"6","key":"477_CR58","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/WNL.45.6.1134","volume":"45","author":"CM DeGiorgio","year":"1995","unstructured":"DeGiorgio CM, Correale JD, Gott PS, et al. Serum neuron-specific enolase in human status epilepticus. Neurology. 1995;45(6):1134\u20137.","journal-title":"Neurology"},{"issue":"4","key":"477_CR59","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1212\/WNL.52.4.746","volume":"52","author":"CM DeGiorgio","year":"1999","unstructured":"DeGiorgio CM, Heck CN, Rabinowicz AL, et al. Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology. 1999;52(4):746\u20139.","journal-title":"Neurology"},{"issue":"11","key":"477_CR60","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1528-1157.2003.21603.x","volume":"44","author":"CA Gurnett","year":"2003","unstructured":"Gurnett CA, Landt M, Wong M. Analysis of cerebrospinal fluid glial fibrillary acidic protein after seizures in children. Epilepsia. 2003;44(11):1455\u20138.","journal-title":"Epilepsia"},{"issue":"4","key":"477_CR61","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.24606","volume":"79","author":"P Vespa","year":"2016","unstructured":"Vespa P, Tubi M, Claassen J, et al. Metabolic crisis occurs with seizures and periodic discharges after brain trauma. Ann Neurol. 2016;79(4):579\u201390.","journal-title":"Ann Neurol"},{"key":"477_CR62","first-page":"1","volume":"10032","author":"J Witsch","year":"2017","unstructured":"Witsch J, Frey H, Schmidt JM, et al. Electroencephalographic periodic discharges and frequency-dependent brain tissue hypoxia in acute brain injury. JAMA Neurol. 2017;10032:1\u201310.","journal-title":"JAMA Neurol"},{"issue":"2","key":"477_CR63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11940-015-0391-0","volume":"18","author":"A Sivaraju","year":"2016","unstructured":"Sivaraju A, Gilmore EJ. Understanding and managing the ictal\u2013interictal continuum in neurocritical care. Curr Treat Options Neurol. 2016;18(2):1\u201313.","journal-title":"Curr Treat Options Neurol"},{"issue":"4","key":"477_CR64","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.clinph.2016.02.003","volume":"127","author":"V Rodr\u00edguez","year":"2016","unstructured":"Rodr\u00edguez V, Rodden MF, LaRoche SM. Ictal\u2013interictal continuum: a proposed treatment algorithm. Clin Neurophysiol. 2016;127(4):2056\u201364.","journal-title":"Clin Neurophysiol"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12028-017-0477-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-017-0477-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-017-0477-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T11:04:16Z","timestamp":1534503856000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12028-017-0477-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["477"],"URL":"https:\/\/doi.org\/10.1007\/s12028-017-0477-5","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,14]]}}}