{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:28:40Z","timestamp":1790263720905,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG8F0701"],"award-info":[{"award-number":["CMRPG8F0701"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG8G0252"],"award-info":[{"award-number":["CMRPG8G0252"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2314-B-182A-057-MY3"],"award-info":[{"award-number":["MOST107-2314-B-182A-057-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12028-019-00704-9","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T12:48:08Z","timestamp":1555505288000},"page":"24-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Perampanel Treatment for Refractory Status Epilepticus in a Neurological Intensive Care Unit"],"prefix":"10.1007","volume":"31","author":[{"given":"Chen-Jui","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yuan","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Chen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Han","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"issue":"1","key":"704_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/qjmed\/hcn149","volume":"102","author":"MH Tsai","year":"2009","unstructured":"Tsai MH, Chuang YC, Chang HW, et al. Factors predictive of outcome in patients with de novo status epilepticus. QJM. 2009;102(1):57\u201362.","journal-title":"QJM"},{"issue":"10","key":"704_CR2","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1111\/epi.13121","volume":"56","author":"E Trinka","year":"2015","unstructured":"Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus\u2013report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015;56(10):1515\u201323.","journal-title":"Epilepsia"},{"issue":"3","key":"704_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/ane.12867","volume":"137","author":"L Vilella","year":"2018","unstructured":"Vilella L, Gonzalez Cuevas M, Quintana Luque M, et al. Prognosis of status epilepticus in elderly patients. Acta Neurol Scand. 2018;137(3):321\u20138.","journal-title":"Acta Neurol Scand"},{"issue":"1","key":"704_CR4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1001\/jamaneurol.2013.578","volume":"70","author":"SE Hocker","year":"2013","unstructured":"Hocker SE, Britton JW, Mandrekar JN, Wijdicks EF, Rabinstein AA. Predictors of outcome in refractory status epilepticus. JAMA Neurol. 2013;70(1):72\u20137.","journal-title":"JAMA Neurol."},{"key":"704_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.yebeh.2015.04.065","volume":"49","author":"AM Kantanen","year":"2015","unstructured":"Kantanen AM, Reinikainen M, Parviainen I, et al. Incidence and mortality of super-refractory status epilepticus in adults. Epilepsy Behav. 2015;49:131\u20134.","journal-title":"Epilepsy Behav."},{"issue":"9","key":"704_CR6","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/epi.13837","volume":"58","author":"A Strzelczyk","year":"2017","unstructured":"Strzelczyk A, Ansorge S, Hapfelmeier J, et al. Costs, length of stay, and mortality of super-refractory status epilepticus: a population-based study from Germany. Epilepsia. 2017;58(9):1533\u201341.","journal-title":"Epilepsia"},{"issue":"1","key":"704_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1528-1167.2011.03340.x","volume":"53","author":"NE Hamil","year":"2012","unstructured":"Hamil NE, Cock HR, Walker MC. Acute down-regulation of adenosine A(1) receptor activity in status epilepticus. Epilepsia. 2012;53(1):177\u201388.","journal-title":"Epilepsia"},{"issue":"6","key":"704_CR8","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1111\/epi.14082","volume":"59","author":"A Leo","year":"2018","unstructured":"Leo A, Giovannini G, Russo E, Meletti S. The role of AMPA receptors and their antagonists in status epilepticus. Epilepsia. 2018;59(6):1098\u2013108.","journal-title":"Epilepsia"},{"issue":"42","key":"704_CR9","doi-asserted-by":"publisher","first-page":"26954","DOI":"10.18632\/oncotarget.25485","volume":"9","author":"K Vargas-Sanchez","year":"2018","unstructured":"Vargas-Sanchez K, Mogilevskaya M, Rodriguez-Perez J, et al. Astroglial role in the pathophysiology of status epilepticus: an overview. Oncotarget. 2018;9(42):26954\u201376.","journal-title":"Oncotarget"},{"key":"704_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neulet.2016.12.044","volume":"667","author":"MC Walker","year":"2018","unstructured":"Walker MC. Pathophysiology of status epilepticus. Neurosci Lett. 2018;667:84\u201391.","journal-title":"Neurosci Lett"},{"issue":"1","key":"704_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ana.23570","volume":"72","author":"K Rajasekaran","year":"2012","unstructured":"Rajasekaran K, Todorovic M, Kapur J. Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus. Ann Neurol. 2012;72(1):91\u2013102.","journal-title":"Ann Neurol"},{"issue":"3","key":"704_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s13760-013-0225-3","volume":"114","author":"J Rosche","year":"2014","unstructured":"Rosche J, Kampf C, Benecke R. Possible effect of perampanel on focal status epilepticus after generalized tonic-clonic status epilepticus. Acta Neurol Belg. 2014;114(3):243\u20134.","journal-title":"Acta Neurol Belg"},{"key":"704_CR13","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.yebeh.2015.01.036","volume":"45","author":"J Redecker","year":"2015","unstructured":"Redecker J, Wittstock M, Benecke R, Rosche J. Efficacy of perampanel in refractory nonconvulsive status epilepticus and simple partial status epilepticus. Epilepsy Behav. 2015;45:176\u20139.","journal-title":"Epilepsy Behav"},{"key":"704_CR14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.yebeh.2015.04.005","volume":"49","author":"A Rohracher","year":"2015","unstructured":"Rohracher A, Hofler J, Kalss G, et al. Perampanel in patients with refractory and super-refractory status epilepticus in a neurological intensive care unit. Epilepsy Behav. 2015;49:354\u20138.","journal-title":"Epilepsy Behav"},{"issue":"52","key":"704_CR15","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/epi.14494","volume":"59","author":"A Rohracher","year":"2018","unstructured":"Rohracher A, Kalss G, Neuray C, et al. Perampanel in patients with refractory and super-refractory status epilepticus in a neurological intensive care unit: a single-center audit of 30 patients. Epilepsia. 2018\u200b;59(52):\u200b234\u201342.","journal-title":"Epilepsia"},{"key":"704_CR16","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ebcr.2015.06.007","volume":"4","author":"E Santamarina","year":"2015","unstructured":"Santamarina E, Sueiras M, Lidon RM, et al. Use of perampanel in one case of super-refractory hypoxic myoclonic status: case report. Epilepsy Behav Case Rep. 2015;4:56\u20139.","journal-title":"Epilepsy Behav Case Rep."},{"key":"704_CR17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.yebeh.2015.05.007","volume":"49","author":"M Leitinger","year":"2015","unstructured":"Leitinger M, Beniczky S, Rohracher A, et al. Salzburg consensus criteria for non-convulsive status epilepticus\u2013approach to clinical application. Epilepsy Behav. 2015;49:158\u201363.","journal-title":"Epilepsy Behav."},{"issue":"Pt 8","key":"704_CR18","first-page":"2314","volume":"135","author":"M Ferlisi","year":"2012","unstructured":"Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain. 2012;135(Pt 8):2314\u201328.","journal-title":"Brain"},{"issue":"4","key":"704_CR19","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/epi.14016","volume":"59","author":"LJ Hirsch","year":"2012","unstructured":"Hirsch LJ, Gaspard N, van Baalen A, et al. Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. Epilepsia. 2018;59(4):739\u201344.","journal-title":"Epilepsia"},{"issue":"10","key":"704_CR20","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1007\/s00415-008-0989-1","volume":"255","author":"AO Rossetti","year":"2008","unstructured":"Rossetti AO, Logroscino G, Milligan TA, et al. Status Epilepticus Severity Score (STESS): a tool to orient early treatment strategy. J Neurol. 2008;255(10):1561\u20136.","journal-title":"J Neurol"},{"issue":"2","key":"704_CR21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12028-014-0080-y","volume":"22","author":"M Leitinger","year":"2015","unstructured":"Leitinger M, Holler Y, Kalss G, et al. Epidemiology-based mortality score in status epilepticus (EMSE). Neurocrit Care. 2015;22(2):273\u201382.","journal-title":"Neurocrit Care"},{"issue":"8","key":"704_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1089\/neu.1998.15.573","volume":"15","author":"JT Wilson","year":"1998","unstructured":"Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15(8):573\u201385.","journal-title":"J Neurotrauma."},{"key":"704_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.yebeh.2018.07.004","volume":"86","author":"F Brigo","year":"2018","unstructured":"Brigo F, Lattanzi S, Rohracher A, et al. Perampanel in the treatment of status epilepticus: a systematic review of the literature. Epilepsy Behav. 2018;86:179\u201386.","journal-title":"Epilepsy Behav."},{"issue":"6","key":"704_CR24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S1474-4422(15)00042-3","volume":"14","author":"JP Betjemann","year":"2015","unstructured":"Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol. 2015;14(6):615\u201324.","journal-title":"Lancet Neurol."},{"key":"704_CR25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuroscience.2016.04.024","volume":"327","author":"SL Malkin","year":"2016","unstructured":"Malkin SL, Amakhin DV, Veniaminova EA, et al. Changes of AMPA receptor properties in the neocortex and hippocampus following pilocarpine-induced status epilepticus in rats. Neuroscience. 2016;327:146\u201355.","journal-title":"Neuroscience"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00704-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12028-019-00704-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00704-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:15:24Z","timestamp":1584490524000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12028-019-00704-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["704"],"URL":"https:\/\/doi.org\/10.1007\/s12028-019-00704-9","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"19 March 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The conflict of interest statement for all authors is included.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors confirm that they have read the Journal\u2019s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. This study was approved by the local human research ethics committees (Chang Gung Medical Foundation Institutional Reviewer Board 103-3665B and 201800677B0).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Publication Statement"}}]}}