{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:02:06Z","timestamp":1789128126250,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"FWF","award":["KLI 375"],"award-info":[{"award-number":["KLI 375"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12028-019-00713-8","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T12:19:54Z","timestamp":1556626794000},"page":"135-144","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients"],"prefix":"10.1007","volume":"32","author":[{"given":"Mario","family":"Kofler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Gaasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Rass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois J.","family":"Schiefecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Ianosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rhomberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Pfausler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Schmutzhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Helbok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"713_CR1","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00134-015-3930-y","volume":"41","author":"PJ Hutchinson","year":"2015","unstructured":"Hutchinson PJ, Jalloh I, Helmy A, et al. Consensus statement from the 2014 international microdialysis forum. Intensive Care Med. 2015;41:1517\u201328.","journal-title":"Intensive Care Med."},{"key":"713_CR2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3389\/fneur.2017.00565","volume":"8","author":"R Helbok","year":"2017","unstructured":"Helbok R, Kofler M, Schiefecker AJ, et al. Clinical use of cerebral microdialysis in patients with aneurysmal subarachnoid hemorrhage-state of the art. Front Neurol. 2017;8:565.","journal-title":"Front Neurol."},{"key":"713_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13054-015-0809-9","volume":"19","author":"R Helbok","year":"2015","unstructured":"Helbok R, Schiefecker AJ, Beer R, et al. Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study. Crit Care. 2015;19:75.","journal-title":"Crit Care."},{"key":"713_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1136\/jnnp.2009.198754","volume":"82","author":"R Helbok","year":"2011","unstructured":"Helbok R, Kurtz P, Schmidt JM, et al. Effect of mannitol on brain metabolism and tissue oxygenation in severe haemorrhagic stroke. J Neurol Neurosurg Psychiatry. 2011;82:378\u201383.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"713_CR5","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1177\/0271678X17700434","volume":"38","author":"M Kofler","year":"2018","unstructured":"Kofler M, Schiefecker AJ, Beer R, et al. Enteral nutrition increases interstitial brain glucose levels in poor-grade subarachnoid hemorrhage patients. J Cereb Blood Flow Metab. 2018;38:518\u201327.","journal-title":"J Cereb Blood Flow Metab."},{"key":"713_CR6","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3171\/jns.2005.102.3.0460","volume":"102","author":"M Engstrom","year":"2005","unstructured":"Engstrom M, Polito A, Reinstrup P, et al. Intracerebral microdialysis in severe brain trauma: the importance of catheter location. J Neurosurg. 2005;102:460\u20139.","journal-title":"J Neurosurg."},{"key":"713_CR7","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1097\/00000542-200304000-00004","volume":"98","author":"CH Nordstrom","year":"2003","unstructured":"Nordstrom CH, Reinstrup P, Xu W, Gardenfors A, Ungerstedt U. Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism. Anesthesiology. 2003;98:809\u201314.","journal-title":"Anesthesiology"},{"key":"713_CR8","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1089\/neu.2010.1656","volume":"28","author":"I Timofeev","year":"2011","unstructured":"Timofeev I, Czosnyka M, Carpenter KL, et al. Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location. J Neurotrauma. 2011;28:849\u201360.","journal-title":"J Neurotrauma"},{"key":"713_CR9","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/01.CCM.0000259466.66310.4F","volume":"35","author":"PM Vespa","year":"2007","unstructured":"Vespa PM, O\u2019Phelan K, McArthur D, et al. Pericontusional brain tissue exhibits persistent elevation of lactate\/pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med. 2007;35:1153\u201360.","journal-title":"Crit Care Med."},{"key":"713_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/brain\/awq353","volume":"134","author":"I Timofeev","year":"2011","unstructured":"Timofeev I, Carpenter KL, Nortje J, et al. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain J Neurol. 2011;134:484\u201394.","journal-title":"Brain J Neurol."},{"key":"713_CR11","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1161\/01.STR.0000074036.97859.02","volume":"34","author":"A Sarrafzadeh","year":"2003","unstructured":"Sarrafzadeh A, Haux D, Sakowitz O, et al. Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside microdialysis. Stroke. 2003;34:1382\u20138.","journal-title":"Stroke"},{"key":"713_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s12028-010-9472-9","volume":"14","author":"R Helbok","year":"2011","unstructured":"Helbok R, Madineni RC, Schmidt MJ, et al. Intracerebral monitoring of silent infarcts after subarachnoid hemorrhage. Neurocrit Care. 2011;14:162\u20137.","journal-title":"Neurocrit Care."},{"key":"713_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","volume":"28","author":"WE Hunt","year":"1968","unstructured":"Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968;28:14\u201320.","journal-title":"J Neurosurg."},{"key":"713_CR14","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818\u201329.","journal-title":"Crit Care Med."},{"key":"713_CR15","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1161\/hs0901.095677","volume":"32","author":"J Claassen","year":"2001","unstructured":"Claassen J, Bernardini GL, Kreiter K, et al. Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited. Stroke. 2001;32:2012\u201320.","journal-title":"Stroke"},{"key":"713_CR16","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1161\/01.STR.0000015624.29071.1F","volume":"33","author":"J Claassen","year":"2002","unstructured":"Claassen J, Carhuapoma JR, Kreiter KT, Du EY, Connolly ES, Mayer SA. Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome. Stroke. 2002;33:1225\u201332.","journal-title":"Stroke"},{"key":"713_CR17","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/01.STR.21.8.1156","volume":"21","author":"A Hijdra","year":"1990","unstructured":"Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21:1156\u201361.","journal-title":"Stroke"},{"key":"713_CR18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000346087","volume":"35","author":"T Steiner","year":"2013","unstructured":"Steiner T, Juvela S, Unterberg A, et al. European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis. 2013;35:93\u2013112.","journal-title":"Cerebrovasc Dis."},{"key":"713_CR19","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","volume":"43","author":"ES Connolly Jr","year":"2012","unstructured":"Connolly ES Jr, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2012;43:1711\u201337.","journal-title":"Stroke"},{"key":"713_CR20","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","volume":"41","author":"MD Vergouwen","year":"2010","unstructured":"Vergouwen MD, Vermeulen M, van Gijn J, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41:2391\u20135.","journal-title":"Stroke"},{"key":"713_CR21","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1007\/s00134-004-2461-8","volume":"30","author":"BM Bellander","year":"2004","unstructured":"Bellander BM, Cantais E, Enblad P, et al. Consensus meeting on microdialysis in neurointensive care. Intensive Care Med. 2004;30:2166\u20139.","journal-title":"Intensive Care Med."},{"key":"713_CR22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00234-006-0111-2","volume":"48","author":"E Fainardi","year":"2006","unstructured":"Fainardi E, Tagliaferri MF, Compagnone C, et al. Regional cerebral blood flow levels as measured by xenon-CT in vascular territorial low-density areas after subarachnoid hemorrhage are not always ischemic. Neuroradiology. 2006;48:685\u201390.","journal-title":"Neuroradiology"},{"key":"713_CR23","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1227\/01.NEU.0000370893.04586.73","volume":"66","author":"M Zetterling","year":"2010","unstructured":"Zetterling M, Hallberg L, Hillered L, Karlsson T, Enblad P, Ronne Engstrom E. Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema. Neurosurgery. 2010;66:1102\u201310.","journal-title":"Neurosurgery"},{"key":"713_CR24","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1161\/STROKEAHA.108.536037","volume":"40","author":"AR Zazulia","year":"2009","unstructured":"Zazulia AR, Videen TO, Powers WJ. Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage. Stroke. 2009;40:1638\u201343.","journal-title":"Stroke"},{"key":"713_CR25","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1097\/00003246-200205000-00018","volume":"30","author":"AS Sarrafzadeh","year":"2002","unstructured":"Sarrafzadeh AS, Sakowitz OW, Kiening KL, Benndorf G, Lanksch WR, Unterberg AW. Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? Crit Care Med. 2002;30:1062\u201370.","journal-title":"Crit Care Med."},{"key":"713_CR26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/ane.12258","volume":"130","author":"A Jacobsen","year":"2014","unstructured":"Jacobsen A, Nielsen TH, Nilsson O, Schalen W, Nordstrom CH. Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage. Acta Neurol Scand. 2014;130:156\u201363.","journal-title":"Acta Neurol Scand."},{"key":"713_CR27","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1161\/STROKEAHA.111.648568","volume":"43","author":"M Oddo","year":"2012","unstructured":"Oddo M, Levine JM, Frangos S, et al. Brain lactate metabolism in humans with subarachnoid hemorrhage. Stroke. 2012;43:1418\u201321.","journal-title":"Stroke"},{"key":"713_CR28","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.2174\/1389450117666160201111804","volume":"18","author":"AJ Schiefecker","year":"2017","unstructured":"Schiefecker AJ, Dietmann A, Beer R, et al. Neuroinflammation is associated with brain extracellular TAU-protein release after spontaneous subarachnoid hemorrhage. Curr Drug Targ. 2017;18:1408\u201316.","journal-title":"Curr Drug Targ."},{"key":"713_CR29","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1161\/STROKEAHA.110.604488","volume":"42","author":"R Helbok","year":"2011","unstructured":"Helbok R, Ko SB, Schmidt JM, et al. Global cerebral edema and brain metabolism after subarachnoid hemorrhage. Stroke. 2011;42:1534\u20139.","journal-title":"Stroke"},{"key":"713_CR30","first-page":"701","volume":"47","author":"P Reinstrup","year":"2000","unstructured":"Reinstrup P, Stahl N, Mellergard P, Uski T, Ungerstedt U, Nordstrom CH. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery. 2000;47:701\u20139 (discussion 9\u201310).","journal-title":"Neurosurgery"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00713-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12028-019-00713-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00713-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:26:06Z","timestamp":1588029966000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12028-019-00713-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1007\/s12028-019-00713-8","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]},"assertion":[{"value":"29 April 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors report that they do not have any financial or non-financial conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This study has been approved by the institutional ethics committee and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\/informed consent"}}]}}