{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:17:02Z","timestamp":1790435822262,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS090998"],"award-info":[{"award-number":["RO1 NS090998"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12028-019-00735-2","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:42:21Z","timestamp":1558532541000},"page":"476-485","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral Perfusion Pressure Directed-Therapy Modulates Cardiac Dysfunction After Traumatic Brain Injury to Influence Cerebral Autoregulation in Pigs"],"prefix":"10.1007","volume":"31","author":[{"given":"William M.","family":"Armstead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica S.","family":"Vavilala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"735_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/ALN.0b013e31816725d7","volume":"108","author":"SS Freeman","year":"2008","unstructured":"Freeman SS, Udomphorn Y, Armstead WM, Fisk DM, Vavilala MS. Young age as a risk factor for impaired cerebral autoregulation after moderate-severe pediatric brain injury. Anesthesiology. 2008;108:588\u201395.","journal-title":"Anesthesiology"},{"key":"735_CR2","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1089\/neu.2008.0770","volume":"26","author":"O Chaiwat","year":"2009","unstructured":"Chaiwat O, Sharma D, Udomphorn Y, Armstead WM, Vavilala MS. Cerebral hemodynamic predictors of poor 6\u00a0month Glasgow Outcome Score in severe pediatric traumatic brain injury. J Neurotrauma. 2009;26:657\u201363.","journal-title":"J Neurotrauma"},{"key":"735_CR3","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1097\/CCM.0b013e3181e8ac1a","volume":"38","author":"WM Armstead","year":"2010","unstructured":"Armstead WM, Kiessling JW, Kofke WA, Vavilala MS. Impaired cerebral blood flow autoregulation during post traumatic arterial hypotension after fluid percussion brain injury is prevented by phenylephrine in female but exacerbated in male piglets by ERK MAPK upregulation. Crit Care Med. 2010;38:1868\u201374.","journal-title":"Crit Care Med"},{"key":"735_CR4","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1097\/PCC.0b013e3182712b44","volume":"14","author":"WM Armstead","year":"2013","unstructured":"Armstead WM, Riley J, Vavilala MS. Dopamine prevents impairment of autoregulation after TBI in the newborn pig through inhibition of upregulation of ET-1 and ERK MAPK. Pediatr Crit Care Med. 2013;14:e103\u201311.","journal-title":"Pediatr Crit Care Med"},{"key":"735_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.anclin.2016.04.002","volume":"34","author":"WM Armstead","year":"2016","unstructured":"Armstead WM. Cerebral blood flow autoregulation and dysregulation. Anesthesiol Clin. 2016;34:465\u201377.","journal-title":"Anesthesiol Clin"},{"key":"735_CR6","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/0735-1097(94)90008-6","volume":"24","author":"T Kono","year":"1994","unstructured":"Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A. Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol. 1994;24:636\u201340.","journal-title":"J Am Coll Cardiol"},{"key":"735_CR7","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.chest.2015.12.014","volume":"149","author":"V Krishnamoorthy","year":"2016","unstructured":"Krishnamoorthy V, Mackensen GB, Gibbons EF, Vavilala MS. Cardiac dysfunction after neurologic injury. What do we know and Where are we going? Chest. 2016;149:1325\u201331.","journal-title":"Chest"},{"key":"735_CR8","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.3949\/ccjm.75.Suppl_2.S26","volume":"75","author":"HA Mashaly","year":"2008","unstructured":"Mashaly HA, Provencio JJ. Inflammation as a link between brain injury and heart damage: the model of subarachnoid hemorrhage. Clevel Clin J Med. 2008;75:S26\u201330.","journal-title":"Clevel Clin J Med"},{"key":"735_CR9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4037\/ajcc2006.15.5.462","volume":"15","author":"M Bahloul","year":"2006","unstructured":"Bahloul M, Chaari AN, Kallel H, Khabir A, Ayadi A, Charfeddine H, Hergafi L, Chaaari AD, Ben Chelly HE, Hamida C, Rekik N, Bouazizz M. Neurogenic pulmonary edema due to traumatic brain injury: evidence of cardiac dysfunction. Am J Crit Care. 2006;15:462\u201370.","journal-title":"Am J Crit Care"},{"key":"735_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/CCM.0b013e318298a890","volume":"42","author":"S Prathep","year":"2014","unstructured":"Prathep S, Sharma D, Hallman M, Joffe A, Krishnamoorthy V, Mackensen BG, Vavilala MS. Prelilminary report on cardiac dysfunction after isolate traumatic brain injury. Crit Care Med. 2014;42:142\u20137.","journal-title":"Crit Care Med"},{"key":"735_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/2229-5151.158409","volume":"5","author":"V Krishnamoorthy","year":"2015","unstructured":"Krishnamoorthy V, Prathep S, Sharma D, Fujita Y, Armstead W, Vavilala MS. Cardiac dysfunction following brain death after severe pediatric traumatic brain injury: a preliminary study of 32 children. Int J Crit Illn Inj Sci. 2015;5:103\u20137.","journal-title":"Int J Crit Illn Inj Sci"},{"key":"735_CR12","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1097\/PCC.0000000000000397","volume":"16","author":"V Krishnamoorthy","year":"2015","unstructured":"Krishnamoorthy V, Borbely X, Rowhani-Rahbar A, Souter MJ, Gibbons E, Vavilala MS. Cardiac dysfunction following brain death in children: prevalence, normalization, and transplantation. Pediatr Crit Care Med. 2015;16:e107\u201312.","journal-title":"Pediatr Crit Care Med"},{"key":"735_CR13","doi-asserted-by":"publisher","first-page":"570","DOI":"10.4103\/0972-5229.136086","volume":"18","author":"V Krishnamoorthy","year":"2014","unstructured":"Krishnamoorthy V, Prathep S, Sharma D, Gibbons E, Vavilala MS. Association between electrocardiographic findings and cardiac dysfunction in adult isolated traumatic brain injury. Indian J Crit Care Med. 2014;18:570\u20134.","journal-title":"Indian J Crit Care Med"},{"key":"735_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1161\/CIRCULATIONAHA.106.678995","volume":"116","author":"MA Samuels","year":"2007","unstructured":"Samuels MA. The brain-heart connection. Circulation. 2007;116:77\u201384.","journal-title":"Circulation"},{"key":"735_CR15","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3171\/jns.1992.77.6.0901","volume":"77","author":"J Pick","year":"1992","unstructured":"Pick J, Chesnut RM, Marshall LF, et al. Extracranial complications of severe head injury. J Neurosurg. 1992;77:901\u20137.","journal-title":"J Neurosurg"},{"key":"735_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12028-007-9036-9","volume":"9","author":"MS Vavilala","year":"2008","unstructured":"Vavilala MS, Tontisirin N, Armstead W, Zimmerman JZ, Chesnut R, Lam AM. Hemispheric differences in cerebral autoregulation in children with moderate and severe traumatic brain injury. Neurocrit Care. 2008;9:45\u201354.","journal-title":"Neurocrit Care"},{"key":"735_CR17","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1089\/neu.2015.4290","volume":"33","author":"WM Armstead","year":"2016","unstructured":"Armstead WM, Riley J, Vavilala MS. Norepinephrine protects autoregulation and reduces hippocampal necrosis after traumatic brain injury via block of ERK MAPK and IL-6 in juvenile pigs. J Neurotrauma. 2016;33:1761\u20137.","journal-title":"J Neurotrauma"},{"key":"735_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1385\/NCC:5:3:243","volume":"5","author":"VH Lee","year":"2006","unstructured":"Lee VH, Oh JK, Sl Mulvagh, Wijdicks EF. Mechanisms in neurogenic stress cardiomyopathy after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2006;5:243\u20139.","journal-title":"Neurocrit Care"},{"key":"735_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1097\/CCM.0000000000002404","volume":"45","author":"V Krishnamoorthy","year":"2017","unstructured":"Krishnamoorthy V, Rowhani-Rahbar A, Gibbons EF, Rivara FP, Temkin NR, Pontius C, Luk K, Graves M, Lozier D, Chaikittisilpia N, Kiatchai T, Vavilala MS. Early systolic dysfunction following traumatic brain injury: a cohort study. Crit Care Med. 2017;45:1028\u201336.","journal-title":"Crit Care Med"},{"key":"735_CR20","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s12028-016-0335-x","volume":"26","author":"V Krishnamoorthy","year":"2017","unstructured":"Krishnamoorthy V, Rowhani-Rahbar A, Chaikittisilpia N, Gibbons EF, Rivara FP, Temkin NR, Quistberg A, Vavilala MS. Association of early hemodynamic profile and the development of systolic dysfunction following traumatic brain injury. Neurocrit Care. 2017;26:379\u201387.","journal-title":"Neurocrit Care"},{"key":"735_CR21","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/jnr.24100","volume":"96","author":"N Chaikittisilpa","year":"2018","unstructured":"Chaikittisilpa N, Krishnamoorthy V, Lele A, Qui Q, Vavilala MS. Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury. J Neuro Res. 2018;96:661\u201370.","journal-title":"J Neuro Res"},{"key":"735_CR22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s11910-009-0071-0","volume":"9","author":"H Nguyen","year":"2009","unstructured":"Nguyen H, Zaroff JG. Neurogenic stunned myocardium. Curr Neurol Neurosci Rep. 2009;9:486\u201391.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"735_CR23","doi-asserted-by":"crossref","unstructured":"Armstead WM. Cerebral blood flow autoregulation and dysautoregulation. In: Kofke WA, editor \u201cAdvances in neuroscience in anesthesia and critical care\u201d issue of anesthesiology clinics, vol. 34. Elsevier; 2016. p. 465\u2013477.","DOI":"10.1016\/j.anclin.2016.04.002"},{"key":"735_CR24","first-page":"744","volume-title":"Scientific foundations of pediatrics","author":"J Dobbing","year":"1981","unstructured":"Dobbing J. The later development of the brain and its vulnerability. In: Davis JA, Dobbing J, editors. Scientific foundations of pediatrics. London: Heineman Medical; 1981. p. 744\u201359."},{"key":"735_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12028-018-0638-1","volume":"10","author":"V Curvello","year":"2018","unstructured":"Curvello V, Pastor P, Hekierksi H, Armstead WM. Inhaled nitric oxide protects cerebral autoregulation and reduces hippocampal necrosis after traumatic brain injury through inhibition of ET-1, ERK MAPK, and IL-6 upregulation in pigs. Neurocrit Care. 2018;10:15. \nhttps:\/\/doi.org\/10.1007\/s12028-018-0638-1\n\n.","journal-title":"Neurocrit Care"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00735-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12028-019-00735-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-019-00735-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:49:30Z","timestamp":1589932170000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12028-019-00735-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["735"],"URL":"https:\/\/doi.org\/10.1007\/s12028-019-00735-2","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]},"assertion":[{"value":"21 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors have no conflict of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This protocol (805388) was approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}