{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:34:36Z","timestamp":1792175676828,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["103836"],"award-info":[{"award-number":["103836"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["135849"],"award-info":[{"award-number":["135849"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["135849"],"award-info":[{"award-number":["135849"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12028-020-01136-6","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T17:02:44Z","timestamp":1604509364000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-7573","authenticated-orcid":false,"given":"Rebecca A.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaunak N.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeeth V.","family":"Jonathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthews","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bastarache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine B.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"issue":"5","key":"1136_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1001\/jamaneurol.2019.0006","volume":"76","author":"N Etminan","year":"2019","unstructured":"Etminan N, Chang HS, Hackenberg K, et al. Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population: a systematic review and meta-analysis. JAMA Neurol. 2019;76(5):588\u201397.","journal-title":"JAMA Neurol"},{"issue":"1","key":"1136_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1212\/WNL.0000000000002239","volume":"86","author":"MD Vergouwen","year":"2016","unstructured":"Vergouwen MD, Jong-Tjien-Fa AV, Algra A, et al. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. Neurology. 2016;86(1):59\u201363.","journal-title":"Neurology"},{"issue":"8","key":"1136_CR3","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1161\/STROKEAHA.110.581975","volume":"41","author":"T Al-Khindi","year":"2010","unstructured":"Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke. 2010;41(8):e519\u201336.","journal-title":"Stroke"},{"issue":"3","key":"1136_CR4","doi-asserted-by":"publisher","first-page":"149b","DOI":"10.1016\/0002-9149(85)90624-1","volume":"55","author":"GS Allen","year":"1985","unstructured":"Allen GS. Role of calcium antagonists in cerebral arterial spasm. Am J Cardiol. 1985;55(3):149b\u201353b.","journal-title":"Am J Cardiol"},{"issue":"1","key":"1136_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1186\/s13054-016-1447-6","volume":"20","author":"CL Francoeur","year":"2016","unstructured":"Francoeur CL, Mayer SA. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Crit Care. 2016;20(1):277.","journal-title":"Crit Care"},{"key":"1136_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.wneu.2016.10.064","volume":"98","author":"AS Patel","year":"2017","unstructured":"Patel AS, Griessenauer CJ, Gupta R, et al. Safety and efficacy of noncompliant balloon angioplasty for the treatment of subarachnoid hemorrhage-induced vasospasm: a multicenter study. World Neurosurg. 2017;98:189\u201397.","journal-title":"World Neurosurg"},{"key":"1136_CR7","doi-asserted-by":"crossref","unstructured":"Kwon HJ, Lim JW, Koh HS, et al. Stent-retriever angioplasty for recurrent post-subarachnoid hemorrhagic vasospasm\u2014a single center experience with long-term follow-up. Clin Neuroradiol. 2018.","DOI":"10.1007\/s00062-018-0711-3"},{"key":"1136_CR8","doi-asserted-by":"crossref","unstructured":"Zimmermann M, Seifert V. Endothelin and subarachnoid hemorrhage: an overview. Neurosurgery. 1998;43(4):863\u2013875; discussion 875\u2013866.","DOI":"10.1097\/00006123-199810000-00083"},{"issue":"Suppl 1","key":"1136_CR9","first-page":"15","volume":"42","author":"A Pasqualin","year":"1998","unstructured":"Pasqualin A. Epidemiology and pathophysiology of cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg Sci. 1998;42(Suppl 1):15\u201321.","journal-title":"J Neurosurg Sci"},{"issue":"1","key":"1136_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1227\/00006123-198001000-00001","volume":"6","author":"CM Fisher","year":"1980","unstructured":"Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery. 1980;6(1):1\u20139.","journal-title":"Neurosurgery"},{"key":"1136_CR11","doi-asserted-by":"crossref","unstructured":"Frontera JA, Claassen J, Schmidt JM, et al. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery. 2006;59(1):21\u201327; discussion 21\u201327.","DOI":"10.1227\/01.NEU.0000218821.34014.1B"},{"issue":"1","key":"1136_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0090-3019(97)00508-9","volume":"51","author":"K Hosoda","year":"1999","unstructured":"Hosoda K, Fujita S, Kawaguchi T, et al. Effect of clot removal and surgical manipulation on regional cerebral blood flow and delayed vasospasm in early aneurysm surgery for subarachnoid hemorrhage. Surg Neurol. 1999;51(1):81\u20138.","journal-title":"Surg Neurol"},{"issue":"8","key":"1136_CR13","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/01.STR.22.8.971","volume":"22","author":"RL Macdonald","year":"1991","unstructured":"Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 1991;22(8):971\u201382.","journal-title":"Stroke"},{"key":"1136_CR14","doi-asserted-by":"publisher","first-page":"e660","DOI":"10.1016\/j.wneu.2018.08.141","volume":"120","author":"M Hugelshofer","year":"2018","unstructured":"Hugelshofer M, Sikorski CM, Seule M, et al. Cell-free oxyhemoglobin in cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: biomarker and potential therapeutic target. World Neurosurg. 2018;120:e660\u20136.","journal-title":"World Neurosurg."},{"issue":"7","key":"1136_CR15","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41582-018-0020-0","volume":"14","author":"D Bulters","year":"2018","unstructured":"Bulters D, Gaastra B, Zolnourian A, et al. Haemoglobin scavenging in intracranial bleeding: biology and clinical implications. Nat Rev Neurol. 2018;14(7):416\u201332.","journal-title":"Nat Rev Neurol."},{"key":"1136_CR16","doi-asserted-by":"crossref","unstructured":"Shaver CM, Wickersham N, McNeil JB, et al. Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI Insight. 2018;3(2).","DOI":"10.1172\/jci.insight.98546"},{"issue":"6","key":"1136_CR17","first-page":"832","volume":"14","author":"Y Yang","year":"2017","unstructured":"Yang Y, Chen S, Zhang JM. The updated role of oxidative stress in subarachnoid hemorrhage. Curr Drug Deliv. 2017;14(6):832\u201342.","journal-title":"Curr Drug Deliv"},{"issue":"12","key":"1136_CR18","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1136\/jnnp-2013-307314","volume":"85","author":"SB Jeon","year":"2014","unstructured":"Jeon SB, Choi HA, Badjatia N, et al. Hyperoxia may be related to delayed cerebral ischemia and poor outcome after subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2014;85(12):1301\u20137.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"1136_CR19","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/clpt.2008.89","volume":"84","author":"DM Roden","year":"2008","unstructured":"Roden DM, Pulley JM, Basford MA, et al. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther. 2008;84(3):362\u20139.","journal-title":"Clin Pharmacol Ther"},{"key":"1136_CR20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.clineuro.2017.04.009","volume":"157","author":"GM De Marchis","year":"2017","unstructured":"De Marchis GM, Schaad C, Fung C, et al. Gender-related differences in aneurysmal subarachnoid hemorrhage: a hospital based study. Clin Neurol Neurosurg. 2017;157:82\u20137.","journal-title":"Clin Neurol Neurosurg"},{"key":"1136_CR21","doi-asserted-by":"crossref","unstructured":"Krishnamurthy S, Kelleher JP, Lehman EB, et al. Effects of tobacco dose and length of exposure on delayed neurological deterioration and overall clinical outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2007;61(3):475\u2013480; discussion 480\u2013471.","DOI":"10.1227\/01.NEU.0000290892.46954.12"},{"key":"1136_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13054-015-1036-0","volume":"19","author":"H Lantigua","year":"2015","unstructured":"Lantigua H, Ortega-Gutierrez S, Schmidt JM, et al. Subarachnoid hemorrhage: who dies, and why? Crit Care. 2015;19:309.","journal-title":"Crit Care"},{"issue":"2","key":"1136_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377\u201381.","journal-title":"J Biomed Inform"},{"issue":"5","key":"1136_CR24","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","volume":"19","author":"JC van Swieten","year":"1988","unstructured":"van Swieten JC, Koudstaal PJ, Visser MC, et al. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19(5):604\u20137.","journal-title":"Stroke"},{"issue":"1","key":"1136_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","volume":"28","author":"WE Hunt","year":"1968","unstructured":"Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968;28(1):14\u201320.","journal-title":"J Neurosurg"},{"issue":"3","key":"1136_CR26","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00234-019-02161-9","volume":"61","author":"WE van der Steen","year":"2019","unstructured":"van der Steen WE, Leemans EL, van den Berg R, et al. Radiological scales predicting delayed cerebral ischemia in subarachnoid hemorrhage: systematic review and meta-analysis. Neuroradiology. 2019;61(3):247\u201356.","journal-title":"Neuroradiology"},{"key":"1136_CR27","volume-title":"Statistical analysis with missing data","author":"R Little","year":"1987","unstructured":"Little R, Rubin D. Statistical analysis with missing data. New York: Wiley; 1987."},{"issue":"9","key":"1136_CR28","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1161\/hs0901.094622","volume":"32","author":"MT Torbey","year":"2001","unstructured":"Torbey MT, Hauser TK, Bhardwaj A, et al. Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2001;32(9):2005\u201311.","journal-title":"Stroke"},{"issue":"2","key":"1136_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/CCM.0000000000002084","volume":"45","author":"HJ Helmerhorst","year":"2017","unstructured":"Helmerhorst HJ, Arts DL, Schultz MJ, et al. Metrics of arterial hyperoxia and associated outcomes in critical care. Crit Care Med. 2017;45(2):187\u201395.","journal-title":"Crit Care Med"},{"key":"1136_CR30","doi-asserted-by":"crossref","unstructured":"Peixoto MS, de Oliveira Galvao MF, Batistuzzo de Medeiros SR. Cell death pathways of particulate matter toxicity. Chemosphere. 2017;188:32\u201348.","DOI":"10.1016\/j.chemosphere.2017.08.076"},{"issue":"12","key":"1136_CR31","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrd4002","volume":"12","author":"C Gorrini","year":"2013","unstructured":"Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12(12):931\u201347.","journal-title":"Nat Rev Drug Discov."},{"key":"1136_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.02.011","volume":"60","author":"SI Liochev","year":"2013","unstructured":"Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med. 2013;60:1\u20134.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"1136_CR33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3390\/ijms17040497","volume":"17","author":"BP Lucke-Wold","year":"2016","unstructured":"Lucke-Wold BP, Logsdon AF, Manoranjan B, et al. Aneurysmal subarachnoid hemorrhage and neuroinflammation: a comprehensive review. Int J Mol Sci. 2016;17(4):497.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1136_CR34","first-page":"1","volume":"36","author":"P Gaetani","year":"1992","unstructured":"Gaetani P, Lombardi D. Brain damage following subarachnoid hemorrhage: the imbalance between anti-oxidant systems and lipid peroxidative processes. J Neurosurg Sci. 1992;36(1):1\u201310.","journal-title":"J Neurosurg Sci"},{"issue":"3","key":"1136_CR35","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1254\/jphs.SC0050160","volume":"100","author":"T Nishihashi","year":"2006","unstructured":"Nishihashi T, Trandafir CC, Wang A, et al. Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage. J Pharmacol Sci. 2006;100(3):234\u20136.","journal-title":"J Pharmacol Sci."},{"issue":"2","key":"1136_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1179\/174313209X393906","volume":"31","author":"GJ Pyne-Geithman","year":"2009","unstructured":"Pyne-Geithman GJ, Caudell DN, Prakash P, et al. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol Res. 2009;31(2):195\u20139.","journal-title":"Neurol Res"},{"issue":"2","key":"1136_CR37","first-page":"120","volume":"6","author":"AV Ciurea","year":"2013","unstructured":"Ciurea AV, Palade C, Voinescu D, et al. Subarachnoid hemorrhage and cerebral vasospasm\u2014literature review. J Med Life. 2013;6(2):120\u20135.","journal-title":"J Med Life"},{"issue":"1","key":"1136_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4187\/respcare.01963","volume":"58","author":"RH Kallet","year":"2013","unstructured":"Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care. 2013;58(1):123\u201341.","journal-title":"Respir Care"},{"issue":"3","key":"1136_CR39","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/JPN.0b013e318226ee2c","volume":"25","author":"C Deuber","year":"2011","unstructured":"Deuber C, Terhaar M. Hyperoxia in very preterm infants: a systematic review of the literature. J Perinat Neonatal Nurs. 2011;25(3):268\u201374.","journal-title":"J Perinat Neonatal Nurs"},{"issue":"12","key":"1136_CR40","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1097\/CCM.0b013e3182656976","volume":"40","author":"DR Janz","year":"2012","unstructured":"Janz DR, Hollenbeck RD, Pollock JS, et al. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med. 2012;40(12):3135\u20139.","journal-title":"Crit Care Med"},{"issue":"6","key":"1136_CR41","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1186\/s13054-014-0711-x","volume":"18","author":"E Damiani","year":"2014","unstructured":"Damiani E, Adrario E, Girardis M, et al. Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Crit Care. 2014;18(6):711.","journal-title":"Crit Care"},{"key":"1136_CR42","doi-asserted-by":"crossref","unstructured":"Fujita M, Oda Y, Yamashita S, et al. Early-stage hyperoxia is associated with favorable neurological outcomes and survival after severe traumatic brain injury: a post-hoc analysis of the brain hypothermia study. J Neurotrauma. 2017.","DOI":"10.1089\/neu.2016.4753"},{"issue":"5","key":"1136_CR43","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/SHK.0000000000001221","volume":"51","author":"S Yokoyama","year":"2019","unstructured":"Yokoyama S, Hifumi T, Kawakita K, et al. Early hyperoxia in the intensive care unit is significantly associated with unfavorable neurological outcomes in patients with mild-to-moderate aneurysmal subarachnoid hemorrhage. Shock. 2019;51(5):593\u20138.","journal-title":"Shock"},{"issue":"4","key":"1136_CR44","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1227\/NEU.0000000000001111","volume":"78","author":"M Lang","year":"2016","unstructured":"Lang M, Raj R, Skrifvars MB, et al. Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2016;78(4):540\u20135.","journal-title":"Neurosurgery"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-020-01136-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-020-01136-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-020-01136-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T16:07:47Z","timestamp":1669478867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-020-01136-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1136"],"URL":"https:\/\/doi.org\/10.1007\/s12028-020-01136-6","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"6 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Author LB Ware has received research support from Global Blood Therapeutics, CSL Behring, and Boehringer Ingelheim in the past and currently receives research support from Genentech. She also has received consulting fees from Citius, Foresee, Boehringer Ingelheim, Quark, CSL Behring and Merck.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"An Institutional Review Board waiver was granted by Vanderbilt University as the study did not meet the definition of human subjects research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}