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To improve the value of ptO<jats:sub>2<\/jats:sub> monitoring, placement of the probe into a specific area of interest is desirable. We present a technique using CT-guidance to place the ptO<jats:sub>2<\/jats:sub> probe in a particular area of interest based on the individual patient\u2019s pathology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective cohort study, we analyzed imaging and clinical data from all patients who underwent CT-guided ptO<jats:sub>2<\/jats:sub> probe placement at our institution between October 2017 and April 2019. Primary endpoint was successful placement of the probe in a particular area of interest rated by two independent reviewers. Secondary outcomes were complications from probe insertion, clinical consequences from ptO<jats:sub>2<\/jats:sub> measurements, clinical outcome according to the modified Rankin Scale (mRS) as well as development of ischemia on follow-up imaging. A historical control group was selected from patients who underwent conventional ptO<jats:sub>2<\/jats:sub> probe placement between January 2010 and October 2017.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eleven patients had 16 CT-guided probes inserted. In 15 (93.75%) probes, both raters agreed on the correct placement in the area of interest. Each probe triggered on average 0.48 diagnostic or therapeutic adjustments per day. Only one infarction within the vascular territory of a probe was found on follow-up imaging. Eight out of eleven patients (72.73%) reached a good outcome (mRS\u2009\u2264\u20093). In comparison, conventionally placed probes triggered less diagnostic and therapeutic adjustment per day (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Outcome was worse in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.024).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CT-guided probe insertion is a reliable and easy technique to place a ptO<jats:sub>2<\/jats:sub> probe in a particular area of interest in patients with potentially reduced cerebral oxygen supply. By adjusting treatment aggressively according to this individualized monitoring data, clinical outcome may improve.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12028-020-01171-3","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T15:04:21Z","timestamp":1608131061000},"page":"197-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Individualized Brain Tissue Oxygen-Monitoring Probe Placement Helps to Guide Therapy and Optimizes Outcome in Neurocritical Care"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-7138","authenticated-orcid":false,"given":"Levin","family":"H\u00e4ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario D.","family":"Ropelato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nowacki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"S\u00f6ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Haenggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J.","family":"Z\u2019Graggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"1171_CR1","doi-asserted-by":"crossref","unstructured":"Le Roux P, Menon DK, Citerio G, et al. 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