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Trained investigators extracted data from medical charts. Mental status at symptom onset (categorized as alert\/oriented, alert\/confused, drowsy\/somnolent, coma\/unresponsive\/posturing) and 3-month disability (modified Rankin score, mRS) were assessed through standardized interviews of participants or dedicated proxies. We used logistic regression and mediation analysis to assess relationships between LOC, IVH, and unfavorable outcome (mRS 4\u20136).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two thousand seven hundred and twenty-four patients met inclusion criteria. Median admission Glasgow Coma Score was 15 (interquartile range 11\u201315). 46% had IVH on admission or follow-up CT. Patients with LOC (mental status: coma\/unresponsive,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009352) compared to those without LOC (all other mental status,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092372) were younger (60 vs. 62\u00a0years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and had greater IVH frequency (77 vs. 41%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), greater peak ICH volumes (28 vs. 11\u00a0ml,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), greater admission systolic blood pressure (200 vs. 184\u00a0mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and greater admission serum glucose (158 vs. 127\u00a0mg\/dl,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). LOC was independently associated with IVH presence (odds ratio, OR, 2.6, CI 1.9\u20133.5) and with unfavorable outcome (OR 3.05, CI 1.96\u20134.75). The association between LOC and outcome was significantly mediated by IVH (beta\u2009=\u20090.24, bootstrapped CI 0.17\u20130.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LOC at ICH onset may be a useful pre-hospital marker to identify patients at risk of having or developing IVH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12028-020-01180-2","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:02:35Z","timestamp":1611252155000},"page":"418-427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-851X","authenticated-orcid":false,"given":"Jens","family":"Witsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J.","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey C.","family":"Leasure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Matouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Sansing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-5473","authenticated-orcid":false,"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"1180_CR1","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1001\/jamaneurol.2018.4519","volume":"76","author":"S Marini","year":"2019","unstructured":"Marini S, Crawford K, Morotti A, et al. 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Dr. Falcone has nothing to disclose. Ms. Leasure has nothing to disclose. Dr. Matouk has nothing to disclose. Dr. Endres reports grants from Bayer, grants from German Research Foundation (DFG), grants from German Federal Ministry of Education and Research (BMBF), grants from German Center for Neurodegenerative Diseases (DZNE), grants from German Center for Cardiovascular Research (DZHK), grants from European Union, grants from Corona Foundation, and grants from Fondation Leducq, outside the submitted work. Dr. Sansing reports grants from NIH, non-financial support from Genentech, outside the submitted work. Dr. Woo reports grants from NIH, during the conduct of the study. Dr. Sheth reports grants from NIH, grants from AHA, grants from Novartis, grants from Biogen, grants from Bard, grants from Hyperfine, and grants from Zoll, outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies involving humans were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki declaration and its later amendments. Institutional review boards at each participating institution approved the Ethnic\/Racial Variations of Intracerebral Hemorrhage study (ERICH, NS069763) study protocol.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}