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We provide an overview of key discoveries of the glymphatic system, which promotes bulk flow of fluid and solutes throughout the brain parenchyma. We also discuss the lymphatic drainage of the central nervous system. Evidence is building that failure of the glymphatic system causes glymphedema in patients commonly managed by neurocritical care and neurosurgery specialists. We review research supporting this for decompressive craniectomy, subarachnoid hemorrhage, and normal-pressure hydrocephalus. We argue that it is time for a paradigm shift from the traditional model of cerebrospinal fluid circulation to a revised model that incorporates the glymphatic pathway and lymphatic clearance. These recent breakthroughs will inspire new therapeutic approaches to recognize, reverse, and restore glymphatic dysfunction and to leverage this pathway to deliver brain-wide therapeutics.<\/jats:p>","DOI":"10.1007\/s12028-021-01224-1","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T12:13:00Z","timestamp":1623327180000},"page":"545-558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does Impaired Glymphatic Drainage Cause Glymphedema? A Review Tailored to Neurocritical Care and Neurosurgery"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-8668","authenticated-orcid":false,"given":"Paul T.","family":"Akins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kern H.","family":"Guppy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780195394023.001.0001","volume-title":"The practice of emergency and critical care neurology","author":"EFM Wijdicks","year":"2010","unstructured":"Wijdicks EFM. The practice of emergency and critical care neurology. 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