{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T01:14:11Z","timestamp":1781745251879,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS113055"],"award-info":[{"award-number":["R21NS113055"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20POST35210653"],"award-info":[{"award-number":["20POST35210653"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Accelerated Translational Incubator Pilot Grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s12028-021-01303-3","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:59:46Z","timestamp":1627693186000},"page":"404-411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-6444","authenticated-orcid":false,"given":"Murad","family":"Megjhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalijah","family":"Terilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshman","family":"Kalasapudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenity","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Badjatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Velazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"E. S.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-7307","authenticated-orcid":false,"given":"Soojin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"issue":"4","key":"1303_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.jocn.2013.09.001","volume":"21","author":"BP Rosenbaum","year":"2014","unstructured":"Rosenbaum BP, Vadera S, Kelly ML, Kshettry VR, Weil RJ. Ventriculostomy: frequency, length of stay and in-hospital mortality in the United States of America, 1988\u20132010. J Clin Neurosci. 2014;21(4):623\u201332.","journal-title":"J Clin Neurosci"},{"issue":"1","key":"1303_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3109\/02688697.2015.1080222","volume":"30","author":"A Lewis","year":"2016","unstructured":"Lewis A, Wahlster S, Karinja S, Czeisler BM, Kimberly WT, Lord AS. Ventriculostomy-related infections: the performance of different definitions for diagnosing infection. Br J Neurosurg. 2016;30(1):49\u201356.","journal-title":"Br J Neurosurg"},{"key":"1303_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4103\/2152-7806.172533","volume":"6","author":"AR Kirmani","year":"2015","unstructured":"Kirmani AR, Sarmast AH, Bhat AR. Role of external ventricular drainage in the management of intraventricular hemorrhage; its complications and management. Surg Neurol Int. 2015;6:188.","journal-title":"Surg Neurol Int"},{"issue":"2","key":"1303_CR4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3109\/02688697.2014.967753","volume":"29","author":"A Lewis","year":"2015","unstructured":"Lewis A, Irvine H, Ogilvy C, Kimberly WT. Predictors for delayed ventriculoperitoneal shunt placement after external ventricular drain removal in patients with subarachnoid hemorrhage. Br J Neurosurg. 2015;29(2):219\u201324.","journal-title":"Br J Neurosurg"},{"issue":"2","key":"1303_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s12028-018-0532-x","volume":"29","author":"LT Kuo","year":"2018","unstructured":"Kuo LT, Lu HY, Tsai JC, Tu YK. Prediction of shunt dependency after intracerebral hemorrhage and intraventricular hemorrhage. Neurocrit Care. 2018;29(2):233\u201340.","journal-title":"Neurocrit Care"},{"issue":"4","key":"1303_CR6","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.ncl.2017.06.012","volume":"35","author":"KM Busl","year":"2017","unstructured":"Busl KM. Nosocomial infections in the neurointensive care unit. Neurol Clin. 2017;35(4):785\u2013807.","journal-title":"Neurol Clin"},{"key":"1303_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jcrc.2018.01.022","volume":"45","author":"I Savin","year":"2018","unstructured":"Savin I, Ershova K, Kurdyumova N, et al. Healthcare-associated ventriculitis and meningitis in a neuro-ICU: incidence and risk factors selected by machine learning approach. J Crit Care. 2018;45:95\u2013104.","journal-title":"J Crit Care"},{"issue":"Suppl 2","key":"1303_CR8","first-page":"688","volume":"62","author":"AP Lozier","year":"2008","unstructured":"Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES Jr. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2008;62(Suppl 2):688\u2013700.","journal-title":"Neurosurgery"},{"issue":"5","key":"1303_CR9","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3109\/02688697.2011.578770","volume":"25","author":"WJ Kitchen","year":"2011","unstructured":"Kitchen WJ, Singh N, Hulme S, Galea J, Patel HC, King AT. External ventricular drain infection: improved technique can reduce infection rates. Br J Neurosurg. 2011;25(5):632\u20135.","journal-title":"Br J Neurosurg"},{"issue":"12","key":"1303_CR10","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1086\/324492","volume":"33","author":"KE Lyke","year":"2001","unstructured":"Lyke KE, Obasanjo OO, Williams MA, O\u2019Brien M, Chotani R, Perl TM. Ventriculitis complicating use of intraventricular catheters in adult neurosurgical patients. Clin Infect Dis. 2001;33(12):2028\u201333.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"1303_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3171\/jns.2006.104.1.101","volume":"104","author":"RP Schade","year":"2006","unstructured":"Schade RP, Schinkel J, Roelandse FW, et al. Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis. J Neurosurg. 2006;104(1):101\u20138.","journal-title":"J Neurosurg"},{"issue":"1","key":"1303_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005072-199501000-00001","volume":"54","author":"HB Sarnat","year":"1995","unstructured":"Sarnat HB. Ependymal reactions to injury. A review. J Neuropathol Exp Neurol. 1995;54(1):1\u201315.","journal-title":"J Neuropathol Exp Neurol"},{"key":"1303_CR13","doi-asserted-by":"crossref","unstructured":"Vardakis JC, Tully BJ, Ventikos Y. Multicompartmental poroelasticity as a platform for the integrative modeling of water transport in the brain. In: Computer models in biomechanics. Springer; 2013. p. 305\u201316.","DOI":"10.1007\/978-94-007-5464-5_22"},{"key":"1303_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1017\/S0022112005005707","volume":"539","author":"A Smillie","year":"2004","unstructured":"Smillie A, Sobey I, Molnar Z. A hydro-elastic model of hydrocephalus. J Fluid Mech. 2004;539:417. https:\/\/doi.org\/10.1017\/S0022112005005707.","journal-title":"J Fluid Mech"},{"issue":"1","key":"1303_CR15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12987-019-0129-6","volume":"16","author":"SW Bothwell","year":"2019","unstructured":"Bothwell SW, Janigro D, Patabendige A. Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases. Fluids Barriers CNS. 2019;16(1):9.","journal-title":"Fluids Barriers CNS"},{"key":"1303_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-3-030-59436-7_13","volume":"131","author":"M Megjhani","year":"2021","unstructured":"Megjhani M, Terilli K, Kaplan A, et al. Use of clustering to investigate changes in intracranial pressure waveform morphology in patients with ventriculitis. Acta Neurochir Suppl. 2021;131:59\u201362.","journal-title":"Acta Neurochir Suppl"},{"issue":"5","key":"1303_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","volume":"36","author":"TC Horan","year":"2008","unstructured":"Horan TC, Andrus M, Dudeck MA. CDC\/NHSN surveillance definition of health care\u2014associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309\u201332.","journal-title":"Am J Infect Control"},{"key":"1303_CR18","volume-title":"Comparison between institutionally-defined clinical criteria and CDC-criteria for the diagnosis of ventriculostomy-related infection (P02. 220)","author":"B Czeisler","year":"2012","unstructured":"Czeisler B, Choi HA, Guo K, et al. Comparison between institutionally-defined clinical criteria and CDC-criteria for the diagnosis of ventriculostomy-related infection (P02. 220). AAN Enterprises; 2012."},{"key":"1303_CR19","volume-title":"Wavelets and filter banks","author":"G Strang","year":"1996","unstructured":"Strang G, Nguyen T. Wavelets and filter banks. SIAM; 1996."},{"issue":"3","key":"1303_CR20","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1109\/TBME.2008.2008636","volume":"56","author":"X Hu","year":"2009","unstructured":"Hu X, Xu P, Scalzo F, Vespa P, Bergsneider M. Morphological clustering and analysis of continuous intracranial pressure. IEEE Trans Biomed Eng. 2009;56(3):696\u2013705.","journal-title":"IEEE Trans Biomed Eng"},{"key":"1303_CR21","first-page":"733","volume-title":"On clustering multimedia time series data using k-means and dynamic time warping","author":"V Niennattrakul","year":"2007","unstructured":"Niennattrakul V, Ratanamahatana CA. On clustering multimedia time series data using k-means and dynamic time warping. IEEE; 2007. p. 733\u20138."},{"key":"1303_CR22","first-page":"239","volume-title":"An enhanced representation of time series which allows fast and accurate classification, clustering and relevance feedback","author":"EJ Keogh","year":"1998","unstructured":"Keogh EJ, Pazzani MJ. An enhanced representation of time series which allows fast and accurate classification, clustering and relevance feedback. American Association for Artificial Intelligence Press; 1998. p. 239\u201341."},{"issue":"1","key":"1303_CR23","doi-asserted-by":"publisher","first-page":"015002","DOI":"10.1088\/1361-6579\/aaf979","volume":"40","author":"M Megjhani","year":"2019","unstructured":"Megjhani M, Alkhachroum A, Terilli K, et al. An active learning framework for enhancing identification of non-artifactual intracranial pressure waveforms. Physiol Meas. 2019;40(1):015002.","journal-title":"Physiol Meas"},{"key":"1303_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/2110-5820-1-53","volume":"1","author":"MA Flierl","year":"2011","unstructured":"Flierl MA, Rittirsch D, Weckbach S, et al. Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis. Ann Intensive Care. 2011;1:53.","journal-title":"Ann Intensive Care"},{"key":"1303_CR25","first-page":"1","volume-title":"Visual cetegoration with bags of keypoints. Workshop on statistical learning in computer vision","author":"G Csurka","year":"2004","unstructured":"Csurka G, Bray C, Dance C, Fan L. Visual cetegoration with bags of keypoints. Workshop on statistical learning in computer vision. ECCV; 2004. p. 1\u201322."},{"key":"1303_CR26","doi-asserted-by":"crossref","unstructured":"Sivic J, Zisserman A. Video Google: a text retrieval approach to object matching in videos. Computer Vision, IEEE International Conference on 2003;3:1470.","DOI":"10.1109\/ICCV.2003.1238663"},{"issue":"3","key":"1303_CR27","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","volume":"148","author":"JA Hanley","year":"1983","unstructured":"Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148(3):839\u201343.","journal-title":"Radiology"},{"key":"1303_CR28","first-page":"2825","volume":"12","author":"F Pedregosa","year":"2011","unstructured":"Pedregosa F, Varoquaux G, Gramfort A, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825\u201330.","journal-title":"J Mach Learn Res"},{"key":"1303_CR29","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1186\/s12879-016-1711-z","volume":"16","author":"J Bodilsen","year":"2016","unstructured":"Bodilsen J, Dalager-Pedersen M, Schonheyder HC, Nielsen H. Time to antibiotic therapy and outcome in bacterial meningitis: a Danish population-based cohort study. BMC Infect Dis. 2016;16:392.","journal-title":"BMC Infect Dis"},{"issue":"6","key":"1303_CR30","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jinf.2008.09.033","volume":"57","author":"R Koster-Rasmussen","year":"2008","unstructured":"Koster-Rasmussen R, Korshin A, Meyer CN. Antibiotic treatment delay and outcome in acute bacterial meningitis. J Infect. 2008;57(6):449\u201354.","journal-title":"J Infect"},{"issue":"4","key":"1303_CR31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/qjmed\/hci047","volume":"98","author":"N Proulx","year":"2005","unstructured":"Proulx N, Frechette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM. 2005;98(4):291\u20138.","journal-title":"QJM"},{"issue":"4","key":"1303_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s15010-007-6202-0","volume":"35","author":"D Lepur","year":"2007","unstructured":"Lepur D, Barsic B. Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome. Infection. 2007;35(4):225\u201331.","journal-title":"Infection"},{"issue":"11","key":"1303_CR33","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1097\/01.CCM.0000239434.26669.65","volume":"34","author":"M Auburtin","year":"2006","unstructured":"Auburtin M, Wolff M, Charpentier J, et al. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit Care Med. 2006;34(11):2758\u201365.","journal-title":"Crit Care Med"},{"issue":"11","key":"1303_CR34","doi-asserted-by":"publisher","first-page":"862","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00004","volume":"129","author":"SI Aronin","year":"1998","unstructured":"Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med. 1998;129(11):862\u20139.","journal-title":"Ann Intern Med"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-021-01303-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-021-01303-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-021-01303-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T06:10:21Z","timestamp":1648534221000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-021-01303-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1303"],"URL":"https:\/\/doi.org\/10.1007\/s12028-021-01303-3","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]},"assertion":[{"value":"7 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"NM reports funding from Accelerated Translational Incubator Pilot Grant through the University of Maryland Baltimore Institute of Clinical and Translational Research unrelated to this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the institutional review boards at the respective centers.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\/Informed Consent"}}]}}