{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:25:55Z","timestamp":1773307555758,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM109089"],"award-info":[{"award-number":["P20 GM109089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12028-021-01339-5","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:10:57Z","timestamp":1633561857000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Spreading Depolarization After Chronic Subdural Hematoma Evacuation: Associated Clinical Risk Factors and Influence on Clinical Outcome"],"prefix":"10.1007","volume":"35","author":[{"given":"Christine","family":"Meadows","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. William","family":"Shuttleworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Torbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"Alsarah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-3699","authenticated-orcid":false,"given":"Andrew P.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"issue":"5","key":"1339_CR1","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3171\/2014.9.JNS141550","volume":"123","author":"D Balser","year":"2015","unstructured":"Balser D, Farooq S, Mehmood T, Reyes M, Samadani U. Actual and projected incidence rates for chronic subdural hematomas in United States Veterans Administration and civilian populations. J Neurosurg. 2015;123(5):1209\u201315.","journal-title":"J Neurosurg"},{"key":"1339_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jocn.2018.01.050","volume":"50","author":"V Mehta","year":"2018","unstructured":"Mehta V, Harward SC, Sankey EW, Nayar G, Codd PJ. Evidence based diagnosis and management of chronic subdural hematoma: a review of the literature. J Clin Neurosci. 2018;50:7\u201315.","journal-title":"J Clin Neurosci"},{"issue":"6","key":"1339_CR3","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1093\/neuros\/nyy521","volume":"85","author":"TW Link","year":"2019","unstructured":"Link TW, Boddu S, Paine SM, Kamel H, Knopman J. Middle meningeal artery embolization for chronic subdural hematoma: a series of 60 cases. Neurosurgery. 2019;85(6):801\u20137.","journal-title":"Neurosurgery"},{"issue":"2","key":"1339_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3171\/2009.7.JNS09392","volume":"112","author":"AA Rabinstein","year":"2010","unstructured":"Rabinstein AA, Chung SY, Rudzinski LA, Lanzino G. Seizures after evacuation of subdural hematomas: incidence, risk factors, and functional impact. J Neurosurg. 2010;112(2):455\u201360.","journal-title":"J Neurosurg"},{"issue":"5","key":"1339_CR5","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1177\/0271678X16654495","volume":"37","author":"JA Hartings","year":"2017","unstructured":"Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, et al. The continuum of spreading depolarizations in acute cortical lesion development: examining Leao\u2019s legacy. J Cereb Blood Flow Metab. 2017;37(5):1571\u201394.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"1339_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ana.410140508","volume":"14","author":"ML Moster","year":"1983","unstructured":"Moster ML, Johnston DE, Reinmuth OM. Chronic subdural hematoma with transient neurological deficits: a review of 15 cases. Ann Neurol. 1983;14(5):539\u201342.","journal-title":"Ann Neurol"},{"issue":"1","key":"1339_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/neuros\/nyz355","volume":"87","author":"M Levesque","year":"2020","unstructured":"Levesque M, Iorio-Morin C, Bocti C, Vezina C, Deacon C. Nonepileptic, stereotypical, and intermittent symptoms (NESIS) in patients with subdural hematoma: proposal for a new clinical entity with therapeutic and prognostic implications. Neurosurgery. 2020;87(1):96\u2013103.","journal-title":"Neurosurgery"},{"issue":"3","key":"1339_CR8","first-page":"1294","volume":"134","author":"LM Mohammad","year":"2020","unstructured":"Mohammad LM, Abbas M, Shuttleworth CW, Ahmadian R, Bhat A, Hill DA, et al. Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation. J Neurosurg. 2020;134(3):1294\u2013302.","journal-title":"J Neurosurg"},{"issue":"5","key":"1339_CR9","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3171\/2017.12.JNS171665","volume":"130","author":"AP Carlson","year":"2019","unstructured":"Carlson AP, Abbas M, Alunday RL, Qeadan F, Shuttleworth CW. Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial. J Neurosurg. 2019;130(5):1513\u20139.","journal-title":"J Neurosurg"},{"issue":"1","key":"1339_CR10","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s12028-020-00935-1","volume":"34","author":"AP Carlson","year":"2021","unstructured":"Carlson AP, Alchbli A, Hanggi D, Macdonald RL, Shuttleworth CW. Effect of locally delivered nimodipine microparticles on spreading depolarization in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2021;34(1):345\u20139.","journal-title":"Neurocrit Care"},{"issue":"5","key":"1339_CR11","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1177\/0271678X16653135","volume":"37","author":"JA Hartings","year":"2017","unstructured":"Hartings JA, Li C, Hinzman JM, Shuttleworth CW, Ernst GL, Dreier JP, et al. Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations. J Cereb Blood Flow Metab. 2017;37(5):1857\u201370.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"1339_CR12","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1177\/0271678X16654496","volume":"37","author":"JP Dreier","year":"2017","unstructured":"Dreier JP, Fabricius M, Ayata C, Sakowitz OW, William Shuttleworth C, Dohmen C, et al. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group. J Cereb Blood Flow Metab. 2017;37(5):1595\u2013625.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"1339_CR13","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S1474-4422(11)70243-5","volume":"10","author":"JA Hartings","year":"2011","unstructured":"Hartings JA, Bullock MR, Okonkwo DO, Murray LS, Murray GD, Fabricius M, et al. Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. Lancet Neurol. 2011;10(12):1058\u201364.","journal-title":"Lancet Neurol"},{"issue":"Pt 12","key":"1339_CR14","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1093\/brain\/awl297","volume":"129","author":"JP Dreier","year":"2006","unstructured":"Dreier JP, Woitzik J, Fabricius M, Bhatia R, Major S, Drenckhahn C, et al. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain. 2006;129(Pt 12):3224\u201337.","journal-title":"Brain"},{"issue":"8","key":"1339_CR15","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001;98(8):4687\u201392.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1339_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/ana.410090406","volume":"9","author":"J Olesen","year":"1981","unstructured":"Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. 1981;9(4):344\u201352.","journal-title":"Ann Neurol"},{"issue":"1","key":"1339_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2217\/fnl.12.89","volume":"8","author":"A Carlson","year":"2013","unstructured":"Carlson A, Shuttleworth CW. Decreased cortical spreading depolarizations in neurosurgical patients being given ketamine. Future Neurol. 2013;8(1):17\u201320.","journal-title":"Future Neurol"},{"issue":"1","key":"1339_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3171\/2015.11.JNS151871","volume":"126","author":"AP Carlson","year":"2017","unstructured":"Carlson AP, William Shuttleworth C, Mead B, Burlbaw B, Krasberg M, Yonas H. Cortical spreading depression occurs during elective neurosurgical procedures. J Neurosurg. 2017;126(1):266\u201373.","journal-title":"J Neurosurg"},{"issue":"8","key":"1339_CR19","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1161\/STROKEAHA.109.549303","volume":"40","author":"OW Sakowitz","year":"2009","unstructured":"Sakowitz OW, Kiening KL, Krajewski KL, Sarrafzadeh AS, Fabricius M, Strong AJ, et al. Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury. Stroke. 2009;40(8):e519\u201322.","journal-title":"Stroke"},{"issue":"Pt 8","key":"1339_CR20","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1093\/brain\/aws152","volume":"135","author":"DN Hertle","year":"2012","unstructured":"Hertle DN, Dreier JP, Woitzik J, Hartings JA, Bullock R, Okonkwo DO, et al. Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury. Brain. 2012;135(Pt 8):2390\u20138.","journal-title":"Brain"},{"issue":"32","key":"1339_CR21","doi-asserted-by":"publisher","first-page":"8014","DOI":"10.1523\/JNEUROSCI.0765-08.2008","volume":"28","author":"RM Dietz","year":"2008","unstructured":"Dietz RM, Weiss JH, Shuttleworth CW. Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci. 2008;28(32):8014\u201324.","journal-title":"J Neurosci"},{"issue":"9","key":"1339_CR22","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1111\/bph.14611","volume":"176","author":"I Szabo","year":"2019","unstructured":"Szabo I, T\u00f3th OM, Torok Z, Varga DP, Menyhart A, Frank R, et al. The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization. Br J Pharmacol. 2019;176(9):1222\u201334.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1339_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/1570159X17666190927113021","volume":"18","author":"AP Carlson","year":"2020","unstructured":"Carlson AP, Hanggi D, Macdonald RL, Shuttleworth CW. Nimodipine reappraised: an old drug with a future. Curr Neuropharmacol. 2020;18(1):65\u201382.","journal-title":"Curr Neuropharmacol"},{"issue":"4","key":"1339_CR24","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/ana.20778","volume":"59","author":"C Ayata","year":"2006","unstructured":"Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol. 2006;59(4):652\u201361.","journal-title":"Ann Neurol"},{"issue":"2","key":"1339_CR25","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1124\/jpet.106.117101","volume":"321","author":"M Peeters","year":"2007","unstructured":"Peeters M, Gunthorpe MJ, Strijbos PJ, Goldsmith P, Upton N, James MF. Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. J Pharmacol Exp Ther. 2007;321(2):564\u201372.","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"1339_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/jcph.980","volume":"58","author":"M Mokhtari","year":"2018","unstructured":"Mokhtari M, Nayeb-Aghaei H, Kouchek M, Miri MM, Goharani R, Amoozandeh A, et al. Effect of memantine on serum levels of neuron-specific enolase and on the Glasgow coma scale in patients with moderate traumatic brain injury. J Clin Pharmacol. 2018;58(1):42\u20137.","journal-title":"J Clin Pharmacol"},{"issue":"Pt1","key":"1339_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/brain\/awr303","volume":"135","author":"JP Dreier","year":"2012","unstructured":"Dreier JP, Major S, Pannek HW, Woitzik J, Scheel M, Wiesenthal D, COSBID Study Group, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 2012;135(Pt1):259\u201375.","journal-title":"Brain"}],"updated-by":[{"DOI":"10.1007\/s12028-021-01377-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000}}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-021-01339-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-021-01339-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-021-01339-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T18:30:35Z","timestamp":1641580235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-021-01339-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":27,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1339"],"URL":"https:\/\/doi.org\/10.1007\/s12028-021-01339-5","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12028-021-01377-z","asserted-by":"object"}]},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"12 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12028-021-01377-z","URL":"https:\/\/doi.org\/10.1007\/s12028-021-01377-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (UNM HRPO# 16-352 and UNM HRPO# 15-564) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval\/informed consent"}}]}}