{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:53:18Z","timestamp":1774957998569,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Department of Neuroscience, Uppsala University."},{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The primary aim was to determine to what extent continuously monitored neurointensive care unit (neuro-ICU) targets predict cerebral blood flow (CBF) and delivery of oxygen (CDO<jats:sub>2<\/jats:sub>) after aneurysmal subarachnoid hemorrhage. The secondary aim was to determine whether CBF and CDO<jats:sub>2<\/jats:sub> were associated with clinical outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this observational study, patients with aneurysmal subarachnoid hemorrhage treated at the neuro-ICU in Uppsala, Sweden, from 2012 to 2020 with at least one xenon-enhanced computed tomography (Xe-CT) obtained within the first 14\u00a0days post ictus were included. CBF was measured with the Xe-CT and CDO<jats:sub>2<\/jats:sub> was calculated based on CBF and arterial oxygen content. Regional cerebral hypoperfusion was defined as CBF\u2009&lt;\u200920\u00a0mL\/100\u00a0g\/min, and poor CDO<jats:sub>2<\/jats:sub> was defined as CDO<jats:sub>2<\/jats:sub>\u2009&lt;\u20093.8\u00a0mL O<jats:sub>2<\/jats:sub>\/100\u00a0g\/min. Neuro-ICU variables including intracranial pressure (ICP), pressure reactivity index, cerebral perfusion pressure (CPP), optimal CPP, and body temperature were assessed in association with the Xe-CT. The acute phase was divided into early phase (day 1\u20133) and vasospasm phase (day 4\u201314).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 148 patients, 27 had underwent a Xe-CT only in the early phase, 74 only in the vasospasm phase, and 47 patients in both phases. The patients exhibited cerebral hypoperfusion and poor CDO<jats:sub>2<\/jats:sub> for medians of 15% and 30%, respectively, of the cortical brain areas in each patient. In multiple regressions, higher body temperature was associated with higher CBF and CDO<jats:sub>2<\/jats:sub> in the early phase. In a similar regression for the vasospasm phase, younger age and longer pulse transit time (lower peripheral resistance) correlated with higher CBF and CDO<jats:sub>2<\/jats:sub>, whereas lower hematocrit only correlated with higher CBF but not with CDO<jats:sub>2<\/jats:sub>. ICP, CPP, and pressure reactivity index exhibited no independent association with CBF and CDO<jats:sub>2<\/jats:sub>. <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> of these regressions were below 0.3. Lower CBF and CDO<jats:sub>2<\/jats:sub> in the early phase correlated with poor outcome, but this only held true for CDO<jats:sub>2<\/jats:sub> in multiple regressions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Systemic and cerebral physiological variables exhibited a modest association with CBF and CDO<jats:sub>2<\/jats:sub>. Still, cerebral hypoperfusion and low CDO<jats:sub>2<\/jats:sub> were common and low CDO<jats:sub>2<\/jats:sub> was associated with poor outcome. Xe-CT imaging could be useful to help detect secondary brain injury not evident by high ICP and low CPP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12028-022-01496-1","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T21:04:46Z","timestamp":1650575086000},"page":"281-292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cerebral Blood Flow and Oxygen Delivery in Aneurysmal Subarachnoid Hemorrhage: Relation to Neurointensive Care Targets"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-5721","authenticated-orcid":false,"given":"Teodor","family":"Svedung Wettervik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Engquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"H\u00e5nell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Howells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Ronne-Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Lew\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"1496_CR1","doi-asserted-by":"crossref","unstructured":"Ryttlefors M, Howells T, Nilsson P, Ronne-Engstr\u00f6m E, Enblad P. Secondary insults in subarachnoid hemorrhage: occurrence and impact on outcome and clinical deterioration. Neurosurgery. 2007;61(4):704\u201314; discussion 14\u20135.","DOI":"10.1227\/01.NEU.0000298898.38979.E3"},{"issue":"2","key":"1496_CR2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s12028-020-01162-4","volume":"34","author":"T Svedung Wettervik","year":"2021","unstructured":"Svedung Wettervik T, Howells T, Lew\u00e9n A, Ronne-Engstr\u00f6m E, Enblad P. Temporal dynamics of ICP, CPP, PRx, and CPPopt in High-grade aneurysmal subarachnoid hemorrhage and the relation to clinical outcome. Neurocrit Care. 2021;34(2):390\u2013402.","journal-title":"Neurocrit Care"},{"issue":"4","key":"1496_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1097\/00003246-200204000-00002","volume":"30","author":"LA Steiner","year":"2002","unstructured":"Steiner LA, Czosnyka M, Piechnik SK, et al. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Crit Care Med. 2002;30(4):733\u20138.","journal-title":"Crit Care Med"},{"issue":"5","key":"1496_CR4","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1097\/CCM.0b013e3181d45530","volume":"38","author":"M Jaeger","year":"2010","unstructured":"Jaeger M, Dengl M, Meixensberger J, Schuhmann MU. Effects of cerebrovascular pressure reactivity-guided optimization of cerebral perfusion pressure on brain tissue oxygenation after traumatic brain injury. Crit Care Med. 2010;38(5):1343\u20137.","journal-title":"Crit Care Med"},{"issue":"14","key":"1496_CR5","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1089\/neu.2020.7290","volume":"38","author":"TS Wettervik","year":"2021","unstructured":"Wettervik TS, Howells T, Hillered L, et al. Autoregulatory or fixed cerebral perfusion pressure targets in traumatic brain injury: determining which is better in an energy metabolic perspective. J Neurotrauma. 2021;38(14):1969\u201378.","journal-title":"J Neurotrauma"},{"issue":"6","key":"1496_CR6","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00701-017-3139-7","volume":"159","author":"U Johnson","year":"2017","unstructured":"Johnson U, Engquist H, Lew\u00e9n A, et al. Increased risk of critical CBF levels in SAH patients with actual CPP below calculated optimal CPP. Acta Neurochir (Wien). 2017;159(6):1065\u201371.","journal-title":"Acta Neurochir (Wien)"},{"issue":"2","key":"1496_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s12028-016-0246-x","volume":"25","author":"T Westermaier","year":"2016","unstructured":"Westermaier T, Stetter C, Kunze E, et al. Controlled hypercapnia enhances cerebral blood flow and brain tissue oxygenation after aneurysmal subarachnoid hemorrhage: results of a phase 1 study. Neurocrit Care. 2016;25(2):205\u201314.","journal-title":"Neurocrit Care"},{"issue":"3","key":"1496_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/ANA.0b013e3182806465","volume":"25","author":"O Solaiman","year":"2013","unstructured":"Solaiman O, Singh JM. Hypocapnia in aneurysmal subarachnoid hemorrhage: incidence and association with poor clinical outcomes. J Neurosurg Anesthesiol. 2013;25(3):254\u201361.","journal-title":"J Neurosurg Anesthesiol"},{"key":"1496_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620944097","author":"TS Wettervik","year":"2020","unstructured":"Wettervik TS, Engquist H, Howells T, et al. Arterial oxygenation in traumatic brain injury-relation to cerebral energy metabolism, autoregulation, and clinical outcome. J Intensive Care Med. 2020. https:\/\/doi.org\/10.1177\/0885066620944097.","journal-title":"J Intensive Care Med"},{"issue":"11","key":"1496_CR10","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1097\/CCM.0000000000002619","volume":"45","author":"DO Okonkwo","year":"2017","unstructured":"Okonkwo DO, Shutter LA, Moore C, et al. Brain oxygen optimization in severe traumatic brain injury phase-II: a phase II randomized trial. Crit Care Med. 2017;45(11):1907\u201314.","journal-title":"Crit Care Med"},{"issue":"4","key":"1496_CR11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1172\/JCI101995","volume":"27","author":"SS Kety","year":"1948","unstructured":"Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxde and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest. 1948;27(4):484\u201392.","journal-title":"J Clin Invest"},{"issue":"19","key":"1496_CR12","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1089\/neu.2017.4992","volume":"34","author":"M Vidal-Jorge","year":"2017","unstructured":"Vidal-Jorge M, S\u00e1nchez-Guerrero A, Mur-Bonet G, et al. Does normobaric hyperoxia cause oxidative stress in the injured brain? A microdialysis study using 8-Iso-Prostaglandin F2\u03b1 as a biomarker. J Neurotrauma. 2017;34(19):2731\u201342.","journal-title":"J Neurotrauma"},{"issue":"1","key":"1496_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12028-020-01136-6","volume":"35","author":"RA Reynolds","year":"2021","unstructured":"Reynolds RA, Amin SN, Jonathan SV, et al. Hyperoxemia and cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2021;35(1):30\u20138.","journal-title":"Neurocrit Care"},{"issue":"1","key":"1496_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3171\/2019.9.JNS19781","volume":"134","author":"S Fukuda","year":"2019","unstructured":"Fukuda S, Koga Y, Fujita M, et al. Hyperoxemia during the hyperacute phase of aneurysmal subarachnoid hemorrhage is associated with delayed cerebral ischemia and poor outcome: a retrospective observational study. J Neurosurg. 2019;134(1):25\u201332.","journal-title":"J Neurosurg"},{"issue":"12","key":"1496_CR15","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1136\/jnnp-2013-307314","volume":"85","author":"SB Jeon","year":"2014","unstructured":"Jeon SB, Choi HA, Badjatia N, et al. Hyperoxia may be related to delayed cerebral ischemia and poor outcome after subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2014;85(12):1301\u20137.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"1496_CR16","doi-asserted-by":"publisher","first-page":"R398","DOI":"10.1152\/ajpregu.00270.2015","volume":"310","author":"RL Hoiland","year":"2016","unstructured":"Hoiland RL, Bain AR, Rieger MG, Bailey DM, Ainslie PN. Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regul Integr Comp Physiol. 2016;310(5):R398\u2013413.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"1496_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s12028-017-0439-y","volume":"28","author":"H Engquist","year":"2018","unstructured":"Engquist H, Rostami E, Ronne-Engstr\u00f6m E, et al. Effect of HHH-therapy on regional CBF after severe subarachnoid hemorrhage studied by bedside xenon-enhanced CT. Neurocrit Care. 2018;28(2):143\u201351.","journal-title":"Neurocrit Care"},{"key":"1496_CR18","unstructured":"Ekelund A, Reinstrup P, Ryding E, et al. Effects of iso- and hypervolemic hemodilution on regional cerebral blood flow and oxygen delivery for patients with vasospasm after aneurysmal subarachnoid hemorrhage. Acta Neurochir (Wien). 2002;144(7):703\u201312; discussion 12\u20133."},{"issue":"10","key":"1496_CR19","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","volume":"41","author":"MD Vergouwen","year":"2010","unstructured":"Vergouwen MD, Vermeulen M, van Gijn J, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391\u20135.","journal-title":"Stroke"},{"issue":"4537","key":"1496_CR20","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1126\/science.7058347","volume":"215","author":"D Gur","year":"1982","unstructured":"Gur D, Good WF, Wolfson SK Jr, Yonas H, Shabason L. In vivo mapping of local cerebral blood flow by xenon-enhanced computed tomography. Science. 1982;215(4537):1267\u20138.","journal-title":"Science"},{"issue":"5","key":"1496_CR21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/jcbfm.1991.128","volume":"11","author":"H Yonas","year":"1991","unstructured":"Yonas H, Darby JM, Marks EC, Durham SR, Maxwell C. CBF measured by Xe-CT: approach to analysis and normal values. J Cereb Blood Flow Metab. 1991;11(5):716\u201325.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"1496_CR22","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S1042-3680(18)30349-8","volume":"7","author":"H Yonas","year":"1996","unstructured":"Yonas H, Pindzola RP, Johnson DW. Xenon\/computed tomography cerebral blood flow and its use in clinical management. Neurosurg Clin N Am. 1996;7(4):605\u201316.","journal-title":"Neurosurg Clin N Am"},{"issue":"2","key":"1496_CR23","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s12028-019-00675-x","volume":"30","author":"H Engquist","year":"2019","unstructured":"Engquist H, Rostami E, Enblad P. Temporal dynamics of cerebral blood flow during the acute course of severe subarachnoid hemorrhage studied by bedside xenon-enhanced CT. Neurocrit Care. 2019;30(2):280\u201390.","journal-title":"Neurocrit Care"},{"issue":"2","key":"1496_CR24","first-page":"554","volume":"134","author":"H Engquist","year":"2020","unstructured":"Engquist H, Lew\u00e9n A, Hillered L, et al. CBF changes and cerebral energy metabolism during hypervolemia, hemodilution, and hypertension therapy in patients with poor-grade subarachnoid hemorrhage. J Neurosurg. 2020;134(2):554\u201364.","journal-title":"J Neurosurg"},{"issue":"1","key":"1496_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1152\/ajplegacy.1945.143.1.53","volume":"143","author":"SS Kety","year":"1945","unstructured":"Kety SS, Schmidt CF. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol. 1945;143(1):53\u201366.","journal-title":"Am J Physiol"},{"issue":"1","key":"1496_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2302\/kjm.43.9","volume":"43","author":"SS Kety","year":"1994","unstructured":"Kety SS. The measurement of cerebral blood flow by means of inert diffusible tracers. Keio J Med. 1994;43(1):9\u201314.","journal-title":"Keio J Med"},{"issue":"9","key":"1496_CR27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00234-006-0111-2","volume":"48","author":"E Fainardi","year":"2006","unstructured":"Fainardi E, Tagliaferri MF, Compagnone C, et al. Regional cerebral blood flow levels as measured by xenon-CT in vascular territorial low-density areas after subarachnoid hemorrhage are not always ischemic. Neuroradiology. 2006;48(9):685\u201390.","journal-title":"Neuroradiology"},{"issue":"4","key":"1496_CR28","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/jcbfm.1981.45","volume":"1","author":"M Kusunoki","year":"1981","unstructured":"Kusunoki M, Kimura K, Nakamura M, et al. Effects of hematocrit variations on cerebral blood flow and oxygen transport in ischemic cerebrovascular disease. J Cereb Blood Flow Metab. 1981;1(4):413\u20137.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"8","key":"1496_CR29","doi-asserted-by":"publisher","first-page":"565","DOI":"10.4070\/kcj.2006.36.8.565","volume":"36","author":"Y-S Lee","year":"2006","unstructured":"Lee Y-S, Kim K-S, Nam C-W, et al. Clinical implication of carotid-radial pulse wave velocity for patients with coronary artery disease. J Korean Circ J. 2006;36(8):565\u201372.","journal-title":"J Korean Circ J"},{"issue":"3","key":"1496_CR30","doi-asserted-by":"publisher","first-page":"E300","DOI":"10.1093\/neuros\/nyz515","volume":"86","author":"T Svedung Wettervik","year":"2020","unstructured":"Svedung Wettervik T, Howells T, Lew\u00e9n A, Enblad P. Blood pressure variability and optimal cerebral perfusion pressure-new therapeutic targets in traumatic brain injury. Neurosurgery. 2020;86(3):E300\u20139.","journal-title":"Neurosurgery"},{"issue":"2","key":"1496_CR31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/HJH.0b013e3280115bea","volume":"25","author":"T Tillin","year":"2007","unstructured":"Tillin T, Chambers J, Malik I, et al. Measurement of pulse wave velocity: site matters. J Hypertens. 2007;25(2):383\u20139.","journal-title":"J Hypertens"},{"issue":"1","key":"1496_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/00006123-199707000-00005","volume":"41","author":"M Czosnyka","year":"1997","unstructured":"Czosnyka M, Smielewski P, Kirkpatrick P, et al. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997;41(1):11\u20139.","journal-title":"Neurosurgery"},{"issue":"11","key":"1496_CR33","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1089\/neu.2018.6157","volume":"36","author":"TM Svedung Wettervik","year":"2019","unstructured":"Svedung Wettervik TM, Howells T, Enblad P, Lew\u00e9n A. Temporal neurophysiological dynamics in traumatic brain injury: role of pressure reactivity and optimal cerebral perfusion pressure for predicting outcome. J Neurotrauma. 2019;36(11):1818\u201327.","journal-title":"J Neurotrauma"},{"issue":"8","key":"1496_CR34","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1097\/CCM.0b013e3182514eb6","volume":"40","author":"MJ Aries","year":"2012","unstructured":"Aries MJ, Czosnyka M, Budohoski KP, et al. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit Care Med. 2012;40(8):2456\u201363.","journal-title":"Crit Care Med"},{"issue":"2","key":"1496_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3171\/jns.2005.102.2.0311","volume":"102","author":"T Howells","year":"2005","unstructured":"Howells T, Elf K, Jones PA, et al. Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma. J Neurosurg. 2005;102(2):311\u20137.","journal-title":"J Neurosurg"},{"issue":"8","key":"1496_CR36","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1089\/neu.1998.15.573","volume":"15","author":"JL Wilson","year":"1998","unstructured":"Wilson JL, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15(8):573\u201385.","journal-title":"J Neurotrauma"},{"issue":"8","key":"1496_CR37","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1089\/neu.1998.15.587","volume":"15","author":"GM Teasdale","year":"1998","unstructured":"Teasdale GM, Pettigrew LE, Wilson JT, Murray G, Jennett B. Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. J Neurotrauma. 1998;15(8):587\u201397.","journal-title":"J Neurotrauma"},{"key":"1496_CR38","doi-asserted-by":"publisher","first-page":"688362","DOI":"10.3389\/fneur.2021.688362","volume":"12","author":"D Lidington","year":"2021","unstructured":"Lidington D, Wan H, Bolz SS. Cerebral autoregulation in subarachnoid hemorrhage. Front Neurol. 2021;12:688362.","journal-title":"Front Neurol."},{"issue":"1","key":"1496_CR39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s12028-016-0240-3","volume":"25","author":"U Johnson","year":"2016","unstructured":"Johnson U, Engquist H, Howells T, et al. Bedside Xenon-CT shows lower CBF in SAH patients with impaired CBF pressure autoregulation as defined by pressure reactivity index (PRx). Neurocrit Care. 2016;25(1):47\u201355.","journal-title":"Neurocrit Care"},{"issue":"4","key":"1496_CR40","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1227\/NEU.0000000000001111","volume":"78","author":"M L\u00e5ng","year":"2016","unstructured":"L\u00e5ng M, Raj R, Skrifvars MB, et al. Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2016;78(4):540\u20135.","journal-title":"Neurosurgery"},{"key":"1496_CR41","doi-asserted-by":"publisher","DOI":"10.1177\/08850666221080054","author":"T Svedung Wettervik","year":"2022","unstructured":"Svedung Wettervik T, H\u00e5nell A, Howells T, et al. Association of arterial metabolic content with cerebral blood flow regulation and cerebral energy metabolism\u2014a multimodality analysis in aneurysmal subarachnoid hemorrhage. J Intensive Care Med. 2022. https:\/\/doi.org\/10.1177\/08850666221080054.","journal-title":"J Intensive Care Med"},{"issue":"3","key":"1496_CR42","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/ane.12258","volume":"130","author":"A Jacobsen","year":"2014","unstructured":"Jacobsen A, Nielsen TH, Nilsson O, Schal\u00e9n W, Nordstr\u00f6m CH. Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage. Acta Neurol Scand. 2014;130(3):156\u201363.","journal-title":"Acta Neurol Scand"},{"issue":"2","key":"1496_CR43","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s12028-011-9582-z","volume":"15","author":"PD Le Roux","year":"2011","unstructured":"Le Roux PD. Anemia and transfusion after subarachnoid hemorrhage. Neurocrit Care. 2011;15(2):342\u201353.","journal-title":"Neurocrit Care"},{"issue":"4","key":"1496_CR44","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/ANA.0000000000000695","volume":"33","author":"TM Svedung Wettervik","year":"2021","unstructured":"Svedung Wettervik TM, Engquist H, Lenell S, et al. Systemic hyperthermia in traumatic brain injury-relation to intracranial pressure dynamics, cerebral energy metabolism, and clinical outcome. J Neurosurg Anesthesiol. 2021;33(4):329\u201336.","journal-title":"J Neurosurg Anesthesiol"},{"issue":"10","key":"1496_CR45","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1212\/WNL.56.10.1299","volume":"56","author":"J Oliveira-Filho","year":"2001","unstructured":"Oliveira-Filho J, Ezzeddine MA, Segal AZ, et al. Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome. Neurology. 2001;56(10):1299\u2013304.","journal-title":"Neurology"},{"issue":"4","key":"1496_CR46","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1227\/NEU.0b013e3181ed11ab","volume":"67","author":"M Ryttlefors","year":"2010","unstructured":"Ryttlefors M, Enblad P, Ronne-Engstr\u00f6m E, et al. Patient age and vasospasm after subarachnoid hemorrhage. Neurosurgery. 2010;67(4):911\u20137.","journal-title":"Neurosurgery"},{"key":"1496_CR47","doi-asserted-by":"crossref","unstructured":"Ryttlefors M, Howells T, Ronne-Engstr\u00f6m E, Nilsson P, Enblad P. Neurointensive care is justified in elderly patients with severe subarachnoid hemorrhage--an outcome and secondary insults study. Acta Neurochir (Wien). 2010;152(2):241\u20139; discussion 9.","DOI":"10.1007\/s00701-009-0496-x"},{"issue":"6","key":"1496_CR48","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.3171\/2016.11.JNS161140","volume":"128","author":"E Rostami","year":"2018","unstructured":"Rostami E, Engquist H, Howells T, et al. Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage. J Neurosurg. 2018;128(6):1762\u201370.","journal-title":"J Neurosurg"}],"updated-by":[{"DOI":"10.1007\/s12028-022-01528-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000}}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-022-01496-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-022-01496-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-022-01496-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T21:08:00Z","timestamp":1657832880000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-022-01496-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1496"],"URL":"https:\/\/doi.org\/10.1007\/s12028-022-01496-1","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12028-022-01528-w","asserted-by":"object"}]},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,21]]},"assertion":[{"value":"14 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12028-022-01528-w","URL":"https:\/\/doi.org\/10.1007\/s12028-022-01528-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in the studies involving humans were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments. The study was approved by the regional ethical board (2010\/138 and 2010\/138\/1) and the Swedish Ethical Review Authority (2020-05462).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\/Informed Consent"}}]}}