{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:34:51Z","timestamp":1774953291251,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s12028-022-01626-9","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T20:57:24Z","timestamp":1667422644000},"page":"640-649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of Administration of Fibrinogen Concentrate as Prevention of Hypofibrinogenemia in Patients with Traumatic Brain Injury with a Higher Risk for Severe Hyperfibrinolysis: Single Center Before-and-After Study"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-9243","authenticated-orcid":false,"given":"Gaku","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobukuni","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"1626_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00268-009-0266-1","volume":"34","author":"J Evans","year":"2009","unstructured":"Evans J, van Wessem K, Mcdougall D, Lee K, Lyons T, Balogh Z. Epidemiology of traumatic deaths: comprehensive population-based assessment. World J Surg. 2009;34:158\u201363.","journal-title":"World J Surg"},{"key":"1626_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1227\/00006123-198407000-00008","volume":"15","author":"HH Kaufman","year":"1984","unstructured":"Kaufman HH, Hui KS, Mattson JC, Borit A, Childs TL, Hoots WK, et al. Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury. Neurosurgery. 1984;15:34\u201342.","journal-title":"Neurosurgery"},{"issue":"4","key":"1626_CR3","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1089\/089771503765172318","volume":"20","author":"S Kushimoto","year":"2003","unstructured":"Kushimoto S, Shibata Y, Yamamoto Y, et al. Implications of fibrinogenolysis in patients with closed head injury. J Neurotrauma. 2003;20(4):357\u201363.","journal-title":"J Neurotrauma"},{"key":"1626_CR4","first-page":"1","volume":"21","author":"M Hayakawa","year":"2017","unstructured":"Hayakawa M, Maekawa K, Kushimoto S, Kato H, Sasaki J, Ogura H, et al. Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study. Crit Care Critical Care. 2017;21:1\u20139.","journal-title":"Crit Care Critical Care"},{"key":"1626_CR5","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1111\/j.1538-7836.2012.04752.x","volume":"10","author":"C Rourke","year":"2012","unstructured":"Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost. 2012;10:1342\u201351.","journal-title":"J Thromb Haemost"},{"key":"1626_CR6","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1007\/s00701-019-04010-3","volume":"161","author":"R Nakae","year":"2019","unstructured":"Nakae R, Yokobori S, Takayama Y, Kanaya T, Fujiki Y, Igarashi Y, et al. A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury. Acta Neurochir. 2019;161:1943\u201353.","journal-title":"Acta Neurochir"},{"key":"1626_CR7","doi-asserted-by":"crossref","unstructured":"Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Critical Care; 2019;1\u201374.","DOI":"10.1186\/s13054-019-2347-3"},{"key":"1626_CR8","doi-asserted-by":"publisher","first-page":"e258","DOI":"10.1016\/S2352-3026(17)30077-7","volume":"4","author":"P Innerhofer","year":"2017","unstructured":"Innerhofer P, Fries D, Mittermayr M, Innerhofer N, von Langen D, Hell T, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. Lancet Haematol. 2017;4:e258\u201371.","journal-title":"Lancet Haematol"},{"key":"1626_CR9","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/bja\/aew343","volume":"117","author":"B Nascimento","year":"2016","unstructured":"Nascimento B, Callum J, Tien H, Peng H, Rizoli S, Karanicolas P, et al. Fibrinogen in the initial resuscitation of severe trauma (FiiRST): a randomized feasibility trial. Br J Anaesth. 2016;117:775\u201382.","journal-title":"Br J Anaesth"},{"key":"1626_CR10","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1186\/cc10078","volume":"15","author":"H Sch\u00f6chl","year":"2011","unstructured":"Sch\u00f6chl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care. 2011;15:R83\u2013R83.","journal-title":"Crit Care"},{"key":"1626_CR11","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1111\/trf.16488","volume":"61","author":"HT Peng","year":"2021","unstructured":"Peng HT, Nascimento B, Rhind SG, da Luz L, Beckett A. Evaluation of trauma-induced coagulopathy in the fibrinogen in the initial resuscitation of severe trauma trial. Transfusion. 2021;61:S49-57.","journal-title":"Transfusion"},{"key":"1626_CR12","unstructured":"Mallett S, Halligan S, Gp MT. Research methods & reporting. 2012;3999:1\u20137."},{"key":"1626_CR13","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/S0140-6736(05)66422-7","volume":"365","author":"DA Grimes","year":"2005","unstructured":"Grimes DA, Schulz KF. Refining clinical diagnosis with likelihood ratios. Lancet. 2005;365:1500\u20135. https:\/\/doi.org\/10.1016\/S0140-6736(05)66422-7.","journal-title":"Lancet"},{"key":"1626_CR14","first-page":"1","volume":"9","author":"P Man","year":"2014","unstructured":"Man P, Lai R, Dasenbrock H, Du R. The association between meteorological parameters and aneurysmal subarachnoid hemorrhage: a nationwide analysis. PLoS ONE. 2014;9:1\u20135.","journal-title":"PLoS ONE"},{"key":"1626_CR15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1055\/s-0033-1357484","volume":"39","author":"SP McCully","year":"2013","unstructured":"McCully SP, Schreiber MA. Traumatic brain injury and its effect on coagulopathy. Semin Thromb Hemost. 2013;39:896\u2013901.","journal-title":"Semin Thromb Hemost"},{"key":"1626_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1055\/s-0034-1398379","volume":"41","author":"M Hayakawa","year":"2015","unstructured":"Hayakawa M, Gando S, Ono Y, Wada T, Yanagida Y, Sawamura A. Fibrinogen level deteriorates before other routine coagulation parameters and massive transfusion in the early phase of severe trauma: a retrospective observational study. Semin Thromb Hemost. 2015;41:35\u201342.","journal-title":"Semin Thromb Hemost"},{"key":"1626_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jocn.2015.11.024","volume":"29","author":"DS Epstein","year":"2016","unstructured":"Epstein DS, Mitra B, Cameron PA, Fitzgerald M, Rosenfeld JV. Normalization of coagulopathy is associated with improved outcome after isolated traumatic brain injury. J Clin Neurosci. 2016;29:64\u20139.","journal-title":"J Clin Neurosci"},{"key":"1626_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40560-016-0196-6","volume":"5","author":"S Kushimoto","year":"2017","unstructured":"Kushimoto S, Kudo D, Kawazoe Y. Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview. J Intensive Care. 2017;5:1\u20137. https:\/\/doi.org\/10.1186\/s40560-016-0196-6.","journal-title":"J Intensive Care"},{"key":"1626_CR19","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1089\/neu.2015.4039","volume":"33","author":"R Nakae","year":"2016","unstructured":"Nakae R, Takayama Y, Kuwamoto K, Naoe Y, Sato H, Yokota H. Time course of coagulation and fibrinolytic parameters in patients with traumatic brain injury. J Neurotrauma. 2016;33:688\u201395.","journal-title":"J Neurotrauma"},{"key":"1626_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13049-017-0471-0","volume":"26","author":"Q Yuan","year":"2018","unstructured":"Yuan Q, Yu J, Wu X, Sun Y-R, Li Z-Q, Du Z-Y, et al. Prognostic value of coagulation tests for in-hospital mortality in patients with traumatic brain injury. Scand J Trauma Resusc Emerg Med. 2018;26:3.","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"1626_CR21","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/SHK.0000000000000542","volume":"45","author":"M Hayakawa","year":"2016","unstructured":"Hayakawa M, Maekawa K, Kushimoto S, Kato H, Sasaki J, Ogura H, et al. High D-dimer levels predict a poor outcome in patients with severe trauma, even with high fibrinogen levels on arrival: a multicenter retrospective study. Shock. 2016;45:308\u201314.","journal-title":"Shock"},{"key":"1626_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01329-7","author":"G Fujiwara","year":"2021","unstructured":"Fujiwara G, Okada Y, Sakakibara T, Yamaki T, Hashimoto N. The association between D-dimer levels and long-term neurological outcomes of patients with traumatic brain injury: an analysis of a nationwide observational neurotrauma database in Japan. Neurocrit Care. 2021. https:\/\/doi.org\/10.1007\/s12028-021-01329-7.","journal-title":"Neurocrit Care"},{"key":"1626_CR23","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/SHK.0000000000000542","volume":"45","author":"M Hayakawa","year":"2016","unstructured":"Hayakawa M, Maekawa K, Kushimoto S, Kato H, Sasaki J, Ogura H, et al. High D-dimer levels predict a poor outcome in patients with severe trauma, even with high fibrinogen levels on arrival. Shock. 2016;45:308\u201314.","journal-title":"Shock"},{"key":"1626_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ajem.2021.03.020","volume":"46","author":"G Fujiwara","year":"2021","unstructured":"Fujiwara G, Okada Y, Ishii W, Iizuka R, Murakami M, Sakakibara T, et al. Association of skull fracture with in-hospital mortality in severe traumatic brain injury patients. Am J Emerg Med. 2021;46:78\u201383. https:\/\/doi.org\/10.1016\/j.ajem.2021.03.020.","journal-title":"Am J Emerg Med"},{"key":"1626_CR25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1089\/neu.2019.6524","volume":"37","author":"L Zvejniece","year":"2020","unstructured":"Zvejniece L, Stelfa G, Vavers E, Kupats E, Kuka J, Svalbe B, et al. Skull fractures induce neuroinflammation and worsen outcomes after closed head injury in mice. J Neurotrauma. 2020;37:295\u2013304.","journal-title":"J Neurotrauma"},{"key":"1626_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2176\/nmc.oa.2018-0116","volume":"58","author":"T Watanabe","year":"2018","unstructured":"Watanabe T, Kawai Y, Iwamura A, Maegawa N, Fukushima H, Okuchi K. Outcomes after traumatic brain injury with concomitant severe extracranial injuries. Neurol Med Chir (Tokyo). 2018;58:393\u20139.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"1626_CR27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12883-020-1631-9","volume":"20","author":"N Kijpaisalratana","year":"2020","unstructured":"Kijpaisalratana N, Chutinet A, Akarathanawat W, Vongvasinkul P, Suwanwela NC. Outcomes of thrombolytic therapy in acute ischemic stroke: mothership, drip-and-ship, and ship-and-drip paradigms. BMC Neurol. 2020;20:45.","journal-title":"BMC Neurol"},{"key":"1626_CR28","first-page":"360","volume":"81","author":"ST Hiippala","year":"1995","unstructured":"Hiippala ST, Myllyl\u00e4 GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg. 1995;81:360\u20135.","journal-title":"Anesth Analg"},{"key":"1626_CR29","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1161\/01.STR.0000017219.83330.FF","volume":"33","author":"R Gerlach","year":"2002","unstructured":"Gerlach R, T\u00f6lle F, Raabe A, Zimmermann M, Siegemund A, Seifert V. Increased risk for postoperative hemorrhage after intracranial surgery in patients with decreased factor XIII activity: implications of a prospective study. Stroke. 2002;33:1618\u201323.","journal-title":"Stroke"},{"key":"1626_CR30","first-page":"1410","volume":"69","author":"T Lustenberger","year":"2010","unstructured":"Lustenberger T, Talving P, Kobayashi L, Barmparas G, Inaba K, Lam L, et al. Early coagulopathy after isolated severe traumatic brain injury: relationship with hypoperfusion challenged. J Trauma. 2010;69:1410\u20134.","journal-title":"J Trauma"},{"key":"1626_CR31","doi-asserted-by":"crossref","unstructured":"Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, et al. Trauma-induced coagulopathy. Nat Rev Dis Prim. 2021;7.","DOI":"10.1038\/s41572-021-00264-3"},{"key":"1626_CR32","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1213\/00000539-199609000-00003","volume":"83","author":"TM McLoughlin","year":"1996","unstructured":"McLoughlin TM, Fontana JL, Alving B, Mongan PD, B\u00fcnger R. Profound normovolemic hemodilution: hemostatic effects in patients and in a porcine model. Anesth Analg. 1996;83:459\u201365.","journal-title":"Anesth Analg"},{"key":"1626_CR33","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/S0140-6736(19)32233-0","volume":"394","author":"I Roberts","year":"2019","unstructured":"Roberts I, Shakur-Still H, Aeron-Thomas A, Belli A, Brenner A, Chaudary MA, et al. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019;394:1713\u201323. https:\/\/doi.org\/10.1016\/S0140-6736(19)32233-0.","journal-title":"Lancet"},{"key":"1626_CR34","first-page":"6","volume":"18","author":"K Sugiyama","year":"2020","unstructured":"Sugiyama K, Fujita H, Nishimura S. Effects of in-house cryoprecipitate on transfusion usage and mortality in patients with multiple trauma with severe traumatic brain injury: a retrospective cohort study. Blood Transfus. 2020;18:6\u201312.","journal-title":"Blood Transfus"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-022-01626-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-022-01626-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-022-01626-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T18:14:53Z","timestamp":1685988893000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-022-01626-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1626"],"URL":"https:\/\/doi.org\/10.1007\/s12028-022-01626-9","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"8 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest associated with this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This study was approved by institutional review board of the Japanese Red Cross Society Kyoto Daini Hospital and received ethical clearance (approval ID: Sp2021-20).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\/Informed Consent"}}]}}