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However, for patients with acute brain injury (ABI), the impact of intracranial pressure (ICP) variability on these variables is poorly understood. The present study evaluates the effects of a controlled ICP variation on CrCP and RAP among patients with ABI.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Consecutive neurocritical patients with ICP monitoring were included along with transcranial Doppler and invasive arterial blood pressure monitoring. Internal jugular veins compression was performed for 60\u00a0s for the elevation of intracranial blood volume and ICP. Patients were separated in groups according to previous intracranial hypertension severity, with either no skull opening (Sk1), neurosurgical mass lesions evacuation, or decompressive craniectomy (DC) (patients with DC [Sk3]).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 98 included patients, the correlation between change (\u0394) in ICP and the corresponding \u0394CrCP was strong (group Sk1 <jats:italic>r<\/jats:italic>\u2009=\u20090.643 [<jats:italic>p<\/jats:italic>\u2009=\u20090.0007], group with neurosurgical mass lesions evacuation <jats:italic>r<\/jats:italic>\u2009=\u20090.732 [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001], and group Sk3 <jats:italic>r<\/jats:italic>\u2009=\u20090.580 [<jats:italic>p<\/jats:italic>\u2009=\u20090.003], respectively). Patients from group Sk3 presented a significantly higher \u0394RAP (<jats:italic>p<\/jats:italic>\u2009=\u20090.005); however, for this group, a higher response in mean arterial pressure (change in mean arterial pressure <jats:italic>p<\/jats:italic>\u2009=\u20090.034) was observed. Exclusively, group Sk1 disclosed reduction in ICP before internal jugular veins compression withholding.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study elucidates that CrCP reliably changes in accordance with ICP, being useful to indicate ideal CPP in neurocritical settings. In the early days after DC, cerebrovascular resistance seems to remain elevated, despite exacerbated arterial blood pressure responses in efforts to maintain CPP stable. Patients with ABI with no need of surgical procedures appear to remain with more effective ICP compensatory mechanisms when compared with those who underwent neurosurgical interventions.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12028-023-01691-8","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T23:02:21Z","timestamp":1677884541000},"page":"399-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Critical Closing Pressure and Cerebrovascular Resistance Responses to Intracranial Pressure Variations in Neurocritical Patients"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-9947","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Brasil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Carvalho Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela Salom\u00e3o Macedo","family":"Salinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Harumy","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellingson","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Marcelo S\u00e1","family":"Malbouisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Bor-Seng-Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronney B.","family":"Panerai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"1691_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-7091-0956-4_21","volume":"114","author":"S Mascarenhas","year":"2012","unstructured":"Mascarenhas S, Vilela GH, Carlotti C, et al. 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