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Although recruitment maneuvers (RMs) may enhance oxygenation, they could also exert profound undesirable systemic impacts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The single-center, prospective study investigated the effects of RMs (up-titration of positive end-expiratory pressure) on multimodal neuromonitoring in patients with acute brain injury. Our primary focus was on intracranial pressure and secondarily on cerebral perfusion pressure (CPP) and other neurological parameters: cerebral autoregulation [pressure reactivity index (PRx)] and regional cerebral oxygenation (rSO<jats:sub>2<\/jats:sub>). We also assessed blood pressure and right ventricular (RV) function evaluated using tricuspid annular plane systolic excursion. Results are expressed as the difference (\u0394) from baseline values obtained after completing the RMs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-two patients were enrolled in the study. RMs resulted in increased intracranial pressure (\u0394\u2009=\u20094.8\u00a0mm Hg) and reduced CPP (\u0394CPP\u2009=\u2009\u221212.8\u00a0mm Hg) and mean arterial pressure (difference in mean arterial pressure\u2009=\u2009\u22125.2\u00a0mm Hg) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Cerebral autoregulation worsened (\u0394PRx\u2009=\u20090.31 a.u.; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Despite higher systemic oxygenation (difference in partial pressure of O<jats:sub>2<\/jats:sub>\u2009=\u20094\u00a0mm Hg; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and unchanged carbon dioxide levels, rSO<jats:sub>2<\/jats:sub> marginally decreased (\u0394rSO<jats:sub>2<\/jats:sub>\u2009=\u2009\u22120.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.031), with a significant drop in arterial content and increase in the venous content. RV systolic function decreased (difference in tricuspid annular plane systolic excursion\u2009=\u2009\u22120.1\u00a0cm; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with a tendency toward increased RV basal diameter (<jats:italic>p<\/jats:italic>\u2009=\u20090.06). Grouping patients according to \u0394CPP or \u0394PRx revealed that those with poorer tolerance to RMs had higher CPP (<jats:italic>p<\/jats:italic>\u2009=\u20090.040) and a larger RV basal diameter (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) at baseline.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In patients with acute brain injury, RMs appear to have adverse effects on cerebral hemodynamics. These findings might be partially explained by RM\u2019s impact on RV function. Further advanced echocardiography monitoring is required to prove this hypothesis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12028-024-01939-x","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T23:03:17Z","timestamp":1707865397000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Recruitment Maneuvers on Cerebrovascular Dynamics and Right Ventricular Function in Patients with Acute Brain Injury: A Single-Center Prospective Study"],"prefix":"10.1007","volume":"41","author":[{"given":"Filippo","family":"Sanfilippo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Uryga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Battaglini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Giorgia","family":"Iavarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erta","family":"Beqiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Patroniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-3845","authenticated-orcid":false,"given":"Chiara","family":"Robba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"1939_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s12028-022-01593-1","volume":"38","author":"S Taran","year":"2023","unstructured":"Taran S, Cho SM, Stevens RD. 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