{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:20:41Z","timestamp":1790144441702,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Region Hovedstadens Forskningsfond"},{"name":"Rigshospitalets Forskningspuljer"},{"name":"Offerfonden"},{"name":"National Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying covert consciousness in intensive care unit (ICU) patients with coma and other disorders of consciousness (DoC) is crucial for treatment decisions, but sensitive low-cost bedside markers are missing. We investigated whether automated pupillometry combined with passive and active cognitive paradigms can detect residual consciousness in ICU patients with DoC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled clinically low-response or unresponsive patients with traumatic or nontraumatic DoC from ICUs of a tertiary referral center. Age-matched and sex-matched healthy volunteers served as controls. Patients were categorized into clinically unresponsive (coma or unresponsive wakefulness syndrome) or clinically\u00a0low-responsive (minimally conscious state or better). Using automated pupillometry, we recorded pupillary dilation to passive (visual and auditory stimuli) and active (mental arithmetic) cognitive paradigms, with task-specific success criteria (e.g.,\u2009\u2265\u20093 of 5 pupillary dilations on five consecutive mental arithmetic tasks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We obtained 699 pupillometry recordings at 178 time points from 91 ICU patients with brain injury (mean age 60\u2009\u00b1\u200913.8\u00a0years, 31% women, and 49.5% nontraumatic brain injuries). Recordings were also obtained from 26 matched controls (59\u2009\u00b1\u200914.8\u00a0years, 38% women). Passive paradigms yielded limited distinctions between patients and controls. However, active paradigms enabled discrimination between different states of consciousness. With mental arithmetic of moderate complexity,\u2009\u2265\u20093 pupillary dilations were seen in 17.8% of clinically unresponsive\u00a0patients and 50.0% of clinically low-responsive\u00a0patients (odds ratio 4.56, 95% confidence interval 2.09\u201310.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In comparison, 76.9% healthy controls responded with\u2009\u2265\u20093 pupillary dilations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Results remained consistent across sensitivity analyses using different thresholds for success. Spearman\u2019s rank analysis underscored the robust association between pupillary dilations during mental arithmetic and consciousness levels (rho\u2009=\u20091,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Notably, one behaviorally unresponsive patient demonstrated persistent command-following behavior 2\u00a0weeks before overt signs of awareness, suggesting prolonged cognitive motor dissociation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Automated pupillometry combined with mental arithmetic can identify cognitive efforts, and hence covert consciousness, in ICU patients with acute DoC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12028-024-01983-7","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T13:01:29Z","timestamp":1712840489000},"page":"218-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Covert Consciousness in Acute Brain Injury Revealed by Automated Pupillometry and Cognitive Paradigms"],"prefix":"10.1007","volume":"41","author":[{"given":"Marwan H.","family":"Othman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus Harboe","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Irgens Tanderup","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshgan","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Ravnholt","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Nyholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Kjaergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-9808","authenticated-orcid":false,"given":"Daniel","family":"Kondziella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"5","key":"1983_CR1","doi-asserted-by":"publisher","first-page":"fcac188","DOI":"10.1093\/BRAINCOMMS\/FCAC188","volume":"4","author":"D Kondziella","year":"2022","unstructured":"Kondziella D, Amiri M, Othman MH, et al. 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